Article
Biochemistry & Molecular Biology
Xucai Zheng, Shengying Wang, Shikai Hong, Jianjun Liu, Chenghao Jiang
Summary: The study revealed that elevated expression of eIF3a in human thyroid cancer is associated with tumor grade, and knockdown of eIF3a significantly reduces cell proliferation, increases apoptosis, and arrests cell cycle progression. These findings suggest that eIF3a may be a promising target for gene therapy in thyroid cancer.
Article
Biochemistry & Molecular Biology
Yonggang Zhang, Meng Zhu, Surapaneni Krishna Mohan, Zhi Hao
Summary: Crocin has been shown to inhibit the proliferation of follicular thyroid carcinoma cells and promote apoptosis in vitro. It achieves its anticancer effects by regulating oxidative stress, mitochondrial membrane potential, protease activity, and other pathways. Crocin may have potential as a therapeutic agent for thyroid cancer.
JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY
(2021)
Article
Oncology
Ryan P. Mackay, Paul M. Weinberger, John A. Copland, Elahe Mahdavian, Qinqin Xu
Summary: Anaplastic thyroid cancer (ATC) is a highly aggressive form of cancer with few effective treatment options. YM155, previously identified as a survivin inhibitor, showed promise in killing ATC cells in laboratory and animal studies. However, clinical trials did not show a correlation between survivin expression and response to YM155. Despite this setback, alternative mechanisms for YM155 are currently being investigated.
MOLECULAR CANCER THERAPEUTICS
(2022)
Article
Biotechnology & Applied Microbiology
Jing Zhang, Xinyan Xu, Yongfeng Chen, Xiaoju Guan, Hong Zhu, Yuhong Qi
Summary: In this study, the regulatory effect of the CRM1-Survivin axis on the progression of ovarian cancer was explored. The results showed that CRM1 silencing inhibited the proliferation and colony formation of ovarian cancer cells and promoted cell apoptosis by promoting Caspase-3 activation. Survivin was positively regulated by CRM1 and promoted the development of ovarian cancer. This suggests that the CRM1-Survivin axis may serve as a potential therapeutic target for ovarian cancer.
Article
Biochemistry & Molecular Biology
Chang-Hoon Hwang, Na-Kyoung Lee, Hyun-Dong Paik
Summary: Recent research has focused on the anti-cancer properties of Lactobacillus strains isolated from fermented foods. The study found that their anti-cancer effects are achieved by inducing apoptosis in cancer cells. However, consuming living organisms can lead to sepsis, especially in cancer patients with reduced immunity.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Chemistry, Analytical
Bo Hu, Qin Zhang, Xiaonan Gao, Kehua Xu, Bo Tang
Summary: By designing a multicolor fluorescent nanoprobe Cas-NP, the activation of caspases-1/3/4 during pyroptosis can be accurately monitored, revealing the pathways of pyroptosis under different stimuli. Through studying the pyroptosis process in cancer cells, it was first discovered that LPS stimulation can induce caspase-3 activation, and the activation sequence of caspases-1/3/4 was verified.
ANALYTICAL CHEMISTRY
(2021)
Review
Biochemistry & Molecular Biology
Siarhei A. Dabravolski, Nikita G. Nikiforov, Alexander D. Zhuravlev, Nikolay A. Orekhov, Liudmila M. Mikhaleva, Alexander N. Orekhov
Summary: This paper discusses the relationship between the etiology of thyroid cancer and mitochondrial function, and explores the use of known drugs and induction of mitochondria-mediated apoptosis as a new direction in anti-thyroid cancer therapy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cell Biology
Yi-Fei Zhang, Lu Zhou, Han-Qing Mao, Fu-Hua Yang, Zhi Chen, Lu Zhang
Summary: The study found that cytosolic mtDNA regulates odontoblast inflammation through GSDMD-mediated pyroptosis, while STING-dependent inflammation may serve as a compensatory mechanism to control GSDMD-mediated pyroptosis, promoting the immune inflammatory response. These findings provide important clues to understand the role of mtDNA-GSDMD-STING in regulating odontoblast inflammation.
CELL DEATH DISCOVERY
(2021)
Article
Cell Biology
Yaoquan Cao, Haibo Tang, Guohui Wang, Pengzhou Li, Zhi Song, Weizheng Li, Xulong Sun, Xiaoxiao Zhong, Qianqian Yu, Shaihong Zhu, Liyong Zhu
Summary: In this study, it was found that Tanshinone IIA has a critical regulatory role in inhibiting the development of colorectal cancer and reversing chemotherapy resistance by modulating the expression and phosphorylation of the survivin protein. Tanshinone IIA suppressed the Akt/WEE1/CDK1 signaling pathway, leading to the downregulation of survivin phosphorylation and promoting its degradation through ubiquitination. Furthermore, Tanshinone IIA significantly increased the sensitivity of chemoresistant colorectal cancer cells to 5-Fu.
CELL DEATH DISCOVERY
(2023)
Review
Oncology
Philipp Wolf
Summary: Evasion from cell death is a characteristic of cancer, which is promoted by IAPs through suppressing the induction of cell death. Overexpression of IAPs in cancerous tissues contributes to therapeutic resistance.
FRONTIERS IN ONCOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Blassan P. George, Naresh K. Rajendran, Nicolette N. Houreld, Heidi Abrahamse
Summary: This study synthesized zinc oxide nanoparticles using Rubus fairholmianus root extract and found that it can induce apoptosis in breast cancer cells through the mitochondria-mediated apoptotic pathway.
Review
Pharmacology & Pharmacy
Gautam Sethi, Prangya Rath, Abhishek Chauhan, Anuj Ranjan, Renuka Choudhary, Seema Ramniwas, Katrin Sak, Diwakar Aggarwal, Isha Rani, Hardeep Singh Tuli
Summary: Due to the rising incidence rates of liver cancer and concerns regarding toxicity of current chemotherapy drugs, there is an increasing need for alternative treatment methods. Quercetin, a flavonoid found in fruits, vegetables, and herbs, has shown promising results in inducing apoptotic cell death in cancer cells. It targets apoptosis-related proteins and has the potential for chemoprevention. This review discusses the mechanisms of action, nanodelivery strategies, and other potential cellular effects of quercetin in liver cancer.
Article
Chemistry, Medicinal
Cijo George Vazhappilly, Rawad Hodeify, Shoib Sarwar Siddiqui, Amina Jamal Laham, Varsha Menon, Raafat El-Awady, Rachel Matar, Maxime Merheb, John Marton, Hussain Abdel Karim Al Zouabi, Rajan Radhakrishnan
Summary: The study found that catechol exhibited concentration-dependent cytotoxicity and anti-proliferative effects in breast cancer cells, while showing minimal effects on noncancerous cells. Furthermore, catechol activated the ATM/ATR pathways to induce DNA damage and cell death mechanisms through regulation of cell cycle proteins. Overall, catechol demonstrated a favorable safety profile for noncancerous cells and targeted multiple signaling cascades to inhibit breast cancer cell proliferation.
PHYTOTHERAPY RESEARCH
(2021)
Article
Cell Biology
Chakravarthy Garlapati, Shriya Joshi, Shristi Bhattarai, Jayashree Krishnamurthy, Ravi Chakra Turaga, Thi Nguyen, Xiaoxian Li, Ritu Aneja
Summary: Protein diversity, as a result of alternative mRNA splicing or post-translational modifications, is crucial for various cellular functions. High expression levels of the kinases PLK1 and AURKB in African American TNBC cells suggest their potential role in racial disparities in TNBC cell proliferation. Inhibition of PLK1 and AURKB may be a promising therapeutic strategy for African American TNBC patients.
CELL DEATH & DISEASE
(2023)
Article
Microbiology
Madeline M. Vroom, Angel Troncoso-Garcia, Alexandrea A. Duscher, Jamie S. Foster
Summary: The study found that modeled microgravity alters the apoptotic cell death process induced by beneficial microbes, by increasing the activity of caspases. However, this increase can be mitigated by using caspase inhibitors, which may have implications for maintaining animal-microbial homeostasis in spaceflight.
Review
Biochemistry & Molecular Biology
Linnea Hojer Wang, Markus Wehland, Petra M. M. Wise, Manfred Infanger, Daniela Grimm, Michael C. C. Kreissl
Summary: This manuscript investigates four tyrosine kinase inhibitors (TKIs), cabozantinib, vandetanib, pralsetinib, and selpercatinib, used for treating advanced and/or metastatic medullary thyroid cancer (MTC). The focus is on treatment-related hypertension, a well-known adverse effect (AE) of these TKIs. While TKI-induced hypertension is rarely a dose-limiting side effect, complications associated with hypertension can increase with longer patient survival without proper medication.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Justina Joksiene, Jayashree Sahana, Markus Wehland, Herbert Schulz, Jose Luis Cortes-Sanchez, Judit Prat-Duran, Daniela Grimm, Ulf Simonsen
Summary: A diabetogenic state induced by spaceflight causes stress and health problems in astronauts. Microgravity is a main stressor in space that leads to hyperglycaemia. The molecular pathways and synergistic effects of microgravity and hyperglycaemia are not fully understood.
Review
Cell Biology
Thomas J. Corydon, Herbert Schulz, Peter Richter, Sebastian M. Strauch, Maik Boehmer, Dario A. Ricciardi, Markus Wehland, Marcus Krueger, Gilmar S. Erzinger, Michael Lebert, Manfred Infanger, Petra M. Wise, Daniela Grimm
Summary: Microgravity has a significant impact on the health of space explorers, affecting cell proliferation, differentiation, and growth. With the planning of deep space exploration and the commercialization of space travel, researchers are focusing on gene regulation in cells and organisms exposed to real and simulated microgravity. Cancer and metastasis research in particular benefit from these findings.
Review
Biochemistry & Molecular Biology
Urjosee Sahana, Markus Wehland, Ulf Simonsen, Herbert Schulz, Daniela Grimm
Summary: Despite recent advances in HF therapy, CV mortality, morbidity, and HFH remain challenges. Vericiguat activates sGC to improve CV function and has shown efficacy in reducing CV death and HFH in HFrEF patients. However, it has no therapeutic effect on HFpEF. Common adverse events of vericiguat include hypotension, syncope, and anemia. Larger studies are needed to investigate the potential effect in HFpEF patients.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Editorial Material
Biochemistry & Molecular Biology
Daniela Grimm
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Multidisciplinary Sciences
Francesca Cialdai, Austin M. Brown, Cory W. Baumann, Debora Angeloni, Sarah Baatout, Alexandra Benchoua, Juergen Bereiter-Hahn, Daniele Bottai, Judith-Irina Buchheim, Marco Calvaruso, Eugenie Carnero-Diaz, Sara Castiglioni, Duccio Cavalieri, Gabriele Ceccarelli, Alexander Chouker, Gianni Ciofani, Giuseppe Coppola, Gabriella Cusella, Andrea Degl'Innocenti, Jean-Francois Desaphy, Jean-Pol Frippiat, Michael Gelinsky, Giada Genchi, Maria Grano, Daniela Grimm, Alain Guignandon, Christiane Hahn, Jason Hatton, Raul Herranz, Christine E. Hellweg, Carlo Saverio Iorio, Thodoris Karapantsios, Jack van Loon, Matteo Lulli, Jeanette Maier, Jos Malda, Emina Mamaca, Lucia Morbidelli, Angelique van Ombergen, Andreas Osterman, Aleksandr Ovsianikov, Francesco Pampaloni, Elizabeth Pavezlorie, Veronica Pereda-Campos, Cyrille Przybyla, Christopher Puhl, Petra Rettberg, Chiara Risaliti, Angela Maria Rizzo, Kate Robson-Brown, Leonardo Rossi, Giorgio Russo, Alessandra Salvetti, Daniela Santucci, Matthias Sperl, Felice Strollo, Kevin Tabury, Sara Tavella, Christiane Thielemann, Ronnie Willaert, Nathaniel J. Szewczyk, Monica Monici
Summary: This white paper presents the indications and recommendations of the SciSpacE Science Community on filling the gaps of knowledge regarding the effects of gravity alterations on animal and human systems at a cellular and tissue level. Despite previous studies, a comprehensive integrated model of the changes occurring at different system and functional levels is still lacking, making it difficult to predict the long-term consequences of human adaptation to the space environment and implement effective medical support plans.
Review
Biochemistry & Molecular Biology
Silvana Miranda, Shannon Marchal, Lina Cumps, Jenne Dierckx, Marcus Kruger, Daniela Grimm, Sarah Baatout, Kevin Tabury, Bjorn Baselet
Summary: The lunar dust problem arose from NASA's Apollo missions in 1969, as exposure to lunar dust became unavoidable. Several astronauts suffered allergy-like symptoms due to lunar dust inhalation. Research into the toxic effects of lunar dust gained significant interest and expanded to include other organ systems. With plans for future moon missions and potentially Mars missions, dust mitigation strategies are crucial for sustainable space exploration.
Review
Biochemistry & Molecular Biology
Niklas S. Jensen, Markus Wehland, Petra M. Wise, Daniela Grimm
Summary: Hypertension is a major global health burden, with an increasing prevalence due to aging populations and sedentary lifestyles. While there is evidence of the role of vitamin D in regulating blood pressure, its direct antihypertensive effect remains unclear. However, supplementing vitamin D in combination with other antihypertensive agents may have promising results.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Jayashree Sahana, Jose Luis Cortes-Sanchez, Viviann Sandt, Daniela Melnik, Thomas J. Corydon, Herbert Schulz, Zexi Cai, Katja Evert, Daniela Grimm, Markus Wehland
Summary: This study cultured breast cancer cell lines MCF-7 and MDA-MB-231 under simulated microgravity conditions and investigated the gene expression pattern and cellular signaling pathways involved. The results showed that the engineered three-dimensional multicellular spheroid model can be used to study breast cancer cell behavior and evaluate the efficacy of drugs against breast cancer.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Cell Biology
Jose Luis Cortes-Sanchez, Daniela Melnik, Viviann Sandt, Stefan Kahlert, Shannon Marchal, Ian R. D. Johnson, Marco Calvaruso, Christian Liemersdorf, Simon L. Wuest, Daniela Grimm, Marcus Krueger
Summary: In the preparation of space and microgravity experiments, the use of ground-based facilities for initial experiments and feasibility studies is common. One approach to simulate microgravity conditions on Earth is to use a random positioning machine (RPM) as a rotary bioreactor. Combined with a suitable low-mass model system, such as cell cultures, these devices have been shown to produce results similar to those obtained in actual space experiments under real microgravity conditions. The RPM serves as a simulator of microgravity by randomizing the impact of Earth's gravity vector especially for suspended cells, and it also simulates physiological shear forces on the adherent cell layer.