Review
Oncology
Thomas L. Sutton, Ranish K. Patel, Ashley N. Anderson, Stephen G. Bowden, Riley Whalen, Nicole R. Giske, Melissa H. Wong
Summary: In cancer, circulating tumor cells (CTCs) have historically been the focus of study, but recently discovered tumor-immune hybrid cells offer a more accessible and potentially effective biomarker option. These hybrid cells have shown promise in early detection and assessing treatment response, indicating their importance in cancer research and patient care.
Review
Oncology
Zuxi Li, Meijuan Song, Shangjun Han, Chuanwei Jin, Jing Yang
Summary: Circulating tumor cells (CTC) are associated with the prognosis of patients with gastric cancer. Gastric cancer patients with positive CTC may have a poorer prognosis compared to those with CTC-negative tumors. CTC-positive patients have more advanced TNM staging, poorer tumor differentiation, and earlier distant metastasis.
FRONTIERS IN ONCOLOGY
(2022)
Review
Gastroenterology & Hepatology
Pai-Chi Teng, Vatche G. Agopian, Ting-Yi Lin, Sungyong You, Yazhen Zhu, Hsian-Rong Tseng, Ju Dong Yang
Summary: Serum alpha-fetoprotein and radiologic imaging are commonly used tests for early diagnosis and treatment monitoring of hepatocellular carcinoma (HCC), but their accuracy is limited. Developing novel HCC biomarkers reflecting tumor biology is an unmet need. Circulating tumor cells (CTCs) have potential as a noninvasive biomarker for HCC, offering molecular and functional data that can reflect the underlying tumor.
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
(2022)
Review
Oncology
Dmitry Enikeev, Andrey Morozov, Diana Babaevskaya, Andrey Bazarkin, Bernard Malavaud
Summary: Liquid biopsy, which combines cell-dependent and cell-independent information from the blood stream, has the potential to revolutionize cancer management. However, the science behind liquid biopsies is not widely utilized. In this systematic review, the use of CTCs in prostate cancer management was summarized, highlighting their predictive value for disease progression, survival, and response to therapy.
Review
Biochemistry & Molecular Biology
Jerry Xiao, Paula R. Pohlmann, Claudine Isaacs, Benjamin A. Weinberg, Aiwu R. He, Richard Schlegel, Seema Agarwal
Summary: CTCs play a crucial role in predicting patient survival and understanding the metastasis of cancer, with potential implications for disease management and treatment strategies.
Review
Pharmacology & Pharmacy
Daniel J. Smit, Klaus Pantel, Manfred Juecker
Summary: CTCs play a crucial role in cancer metastasis and their analysis in liquid biopsies can be valuable for prognosis prediction and real-time therapy monitoring. Research on CTCs may lead to new treatment strategies for preventing metastasis or maintaining stable diseases. Studies on inhibitors targeting CTCs have shown promising results, suggesting CTCs may be useful for personalized drug susceptibility testing.
BIOCHEMICAL PHARMACOLOGY
(2021)
Review
Chemistry, Analytical
Fulai Li, Hengyi Xu, Yufen Zhao
Summary: As a new type of liquid biopsy, circulating tumor cell (CTC) detection and analysis offer the possibility of real-time monitoring of metastatic development, cancer recurrence, and therapeutic efficacy. The rarity and heterogeneity of CTCs present great challenges, and magnetic particle-based methods show promise for effective CTC capture. Progress has been made in utilizing magnetic particles to enhance CTC capture, which is crucial for cancer diagnosis and prognosis.
TRAC-TRENDS IN ANALYTICAL CHEMISTRY
(2021)
Review
Oncology
Qiong Chen, Jueyao Zou, Yong He, Yanhong Pan, Gejun Yang, Han Zhao, Ying Huang, Yang Zhao, Aiyun Wang, Wenxing Chen, Yin Lu
Summary: Circulating tumor cells (CTCs) play a crucial role in tumor metastasis and can be used for tumor diagnosis, prognosis, and recurrence monitoring. Clustered CTCs have been found to have stronger metastasis ability and can bind with non-tumor cells in the blood, promoting tumor growth and development.
FRONTIERS IN ONCOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Jozsef Petrik, Donatella Verbanac, Marija Fabijanec, Andrea Hulina-Tomaskovic, Andrea Ceri, Anita Somborac-Bacura, Roberta Petlevski, Marija Grdic Rajkovic, Lada Rumora, Bozo Kruslin, Mario Stefanovic, Neven Ljubicic, Neven Barsic, Antonija Hanzek, Luka Bockor, Ivana Celap, Alma Demirovic, Karmela Barisic
Summary: This review provides an overview of the research conducted on circulating tumor cells (CTCs) with the aim of finding suitable detection systems and assessing the possibility of clinical applications in patients with colorectal cancer.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Oncology
Pawel Mach, Rainer Kimmig, Sabine Kasimir-Bauer, Paul Buderath
Summary: The study found that sB7-H4 and CTCs can serve as independent prognostic biomarkers in EOC, affecting overall survival.
FRONTIERS IN ONCOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Weiwei Mu, Qihui Chu, Huizhen Yang, Li Guan, Shunli Fu, Tong Gao, Xiao Sang, Zipeng Zhang, Shuang Liang, Yongjun Liu, Na Zhang
Summary: This study develops a nanodevice targeting the elimination of primary tumors and inhibiting the spread of associated-CTCs, which shows promising results in the treatment of hepatocellular carcinoma. The multipoint costriking strategy may open a new model for cancer therapy.
Article
Cell Biology
Hsueh-Yao Chu, Chih-Yung Yang, Ping-Hao Yeh, Chun-Jieh Hsu, Lu-Wei Chang, Wei-Jen Chan, Chien-Ping Lin, You-You Lyu, Wei-Cheng Wu, Chun-Wei Lee, Jen-Kuei Wu, Jeng-Kai Jiang, Fan-Gang Tseng
Summary: CTCs can be used for predicting recurrence in CRC patients. CTC clusters/microemboli have higher correlation with metastasis, and when both the number of CTCs and serum CEA levels are high, the prognosis in CRC patients may be worse.
Review
Oncology
Anna Szczerba, Aleksandra Sliwa, Pawel P. Pieta, Anna Jankowska
Summary: This review focuses on the biology of ovarian circulating tumor cells (CTCs) and their role in the diagnosis and therapy of ovarian cancer.
Article
Biochemistry & Molecular Biology
Mandy Gruijs, Carolien Zeelen, Tessa Hellingman, Jasper Smit, Frank J. Borm, Geert Kazemier, Chris Dickhoff, Idris Bahce, Joop de Langen, Egbert F. Smit, Koen J. Hartemink, Marjolein van Egmond
Summary: Circulating tumor cells (CTCs) have been found in various solid malignancies and are associated with worse survival outcomes. The CellSearch method is currently the only FDA-approved technique for CTC detection, but its use is limited to certain cancer types. This study aimed to develop a new method using Attune NxT, a flow cytometry-based application that does not require enrichment, to detect CTCs. The results showed promising recovery yield and a detection range of 1000-10 cells per sample. However, morphological confirmation is crucial for distinguishing CTCs from false positive events.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Medical Laboratory Technology
Junliang Chen, Huaitao Wang, Lei Zhou, Zhihao Liu, Xiaodong Tan
Summary: This study found that circulating tumor cells (CTCs) could be used for the diagnosis of pancreatic ductal adenocarcinoma (PDAC) and had comparable sensitivity and specificity to CA199. Combining CA199 and CTC number could significantly improve the diagnostic performance of PDAC. CTC subtype was inferior to CTC number as a diagnostic marker.
JOURNAL OF CLINICAL LABORATORY ANALYSIS
(2022)
Article
Medicine, Research & Experimental
Flemming Lund, Mette N. Hermansen, Merete F. Pedersen, Thore Hillig, Henrik Toft-Hansen, Gyorgy Soletormos
SCANDINAVIAN JOURNAL OF CLINICAL & LABORATORY INVESTIGATION
(2015)
Article
Oncology
Thore Hillig, Peer Horn, Ann-Britt Nygaard, Anastasiya S. Haugaard, Sarah Nejlund, Ivan Brandslund, Gyorgy Soletormos
Article
Cell Biology
Sarah Nejlund, Julie Smith, Jaco Kraan, Henrik Stender, Mai N. Van, Sven T. Langkjer, Mikkel T. Nielsen, Gyorgy Soletormos, Thore Hillig
BIOPRESERVATION AND BIOBANKING
(2016)
Article
Medicine, Research & Experimental
Flemming Lund, Mette N. Hermansen, Merete F. Pedersen, Thore Hillig, Ewa Lavant, Camilla Valtonen-Andre, Gyorgy Soletormos
SCANDINAVIAN JOURNAL OF CLINICAL & LABORATORY INVESTIGATION
(2016)
Article
Medicine, Research & Experimental
Thore Hillig, Torben Kjaer Nielsen, Steen Ingemann Hansen, Ann-Britt Nygaard, Gyorgy Soletormos
SCANDINAVIAN JOURNAL OF CLINICAL & LABORATORY INVESTIGATION
(2017)
Article
Cell Biology
Sarah Nejlund, Julie Smith, Jaco Kraan, Henrik Stender, Mai N. Van, Sven T. Langkjer, Mikkel T. Nielsen, Gyorgy Soletormos, Thore Hillig
BIOPRESERVATION AND BIOBANKING
(2016)
Article
Oncology
Michael Wilhelmsen, Ib J. Christensen, Louise Rasmussen, Lars N. Jorgensen, Mogens R. Madsen, Jesper Vilandt, Thore Hillig, Michael Klaeke, Knud T. Nielsen, Soren Laurberg, Nils Brunner, Susan Gawel, Xiaoqing Yang, Gerard Davis, Annemieke Heijboer, Frans Martens, Hans J. Nielsen
INTERNATIONAL JOURNAL OF CANCER
(2017)
Article
Oncology
Mathias Mertz-Petersen, Thomas B. Piper, Jakob Kleif, Linnea Ferm, Ib Jarle Christensen, Hans J. Nielsen
Article
Immunology
Thore Hillig, Jorgen Thode, Marie F. Breinholt, Maria-Benedicte Franzmann, Carsten Pedersen, Flemming Lund, Henrik Mygind, Gyorgy Soletormos, Martin Rudnicki
Article
Biochemistry & Molecular Biology
Signe Ingvarsen, Daniel H. Madsen, Thore Hillig, Leif R. Lund, Kenn Holmbeck, Niels Behrendt, Lars H. Engelholm
BIOLOGICAL CHEMISTRY
(2008)
Article
Biochemistry & Molecular Biology
Lars H. Engelholm, Signe Ingvarsen, Henrik J. Jurgensen, Thore Hillig, Daniel H. Madsen, Boye S. Nielsen, Niels Behrendt
FRONTIERS IN BIOSCIENCE-LANDMARK
(2009)
Article
Biochemistry & Molecular Biology
Thore Hillig, Lars H. Engelholm, Signe Ingvarsen, Daniel H. Madsen, Henrik Gardsvoll, Jorgen K. Larsen, Michael Ploug, Keld Dano, Lars Kjoller, Niels Behrendt
JOURNAL OF BIOLOGICAL CHEMISTRY
(2008)
Article
Oncology
Mikail Gogenur, Thore Hillig, Ismail Gogenur
ANTICANCER RESEARCH
(2017)
Article
Biochemistry & Molecular Biology
Daniel H. Madsen, Lars H. Engelholm, Signe Ingvarsen, Thore Hillig, Rebecca A. Wagenaar-Miller, Lars Kjoller, Henrik Gardsvoll, Gunilla Hoyer-Hansen, Kenn Holmbeck, Thomas H. Bugge, Niels Behrendt
JOURNAL OF BIOLOGICAL CHEMISTRY
(2007)