Journal
INTERNATIONAL JOURNAL OF CANCER
Volume 140, Issue 6, Pages 1436-1446Publisher
WILEY
DOI: 10.1002/ijc.30558
Keywords
colorectal cancer; blood-based biomarkers; detection
Categories
Funding
- Andersen Isted Fund
- Augustinus Foundation
- Beckett Fund
- Inger Bonnen Fund
- Hans & Nora Buchard Fund
- Walter Christensen Family Fund
- P.M. Christiansen Family Fund
- Aase & Ejnar Danielsen Fund
- Erichsen Family Fund
- Knud & Edith Eriksen Fund
- Svend Espersen Fund
- Elna and Jorgen Fagerholt Fund
- Sofus Carl Emil Friis Fund
- Torben & Alice Frimodt Fund
- Eva & Henry Frnkel Fund
- Gangsted Fund
- Thora & Viggo Grove Fund
- H Foundation
- Erna Hamilton Fund
- Sven & Ina Hansen Fund
- Soren & Helene Hempel Fund
- Henrik Henriksen Fund
- Jorgen Holm Family Fund
- Foundation Jochum
- KID Fund
- Kornerup Fund
- Linex Fund
- Dagmar Marshall Fund
- Midtjyske Bladfund
- Axel Muusfeldt Fund
- Borge Nielsen Family Fund
- Michael Hermann Nielsen Fund
- Arvid Nilsson Fund
- Obel Family Fund
- Krista & Viggo Petersen Fund
- Willy & Ingeborg Reinhard Fund
- Kathrine & Vigo Skovgaard Fund
- Toyota Fund
- Vissing Fund
- Wedell-Wedellsborg Fund
- Hvidovre University Hospital (The Capital Region of Denmark)
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Serological biomarkers may be an option for early detection of colorectal cancer (CRC). The present study assessed eight cancer-associated protein biomarkers in plasma from subjects undergoing first time ever colonoscopy due to symptoms attributable to colorectal neoplasia. Plasma AFP, CA19-9, CEA, hs-CRP, CyFra21-1, Ferritin, Galectin-3 and TIMP-1 were determined in EDTA-plasma using the Abbott ARCHITECT (R) automated immunoassay platform. Primary end points were detection of (i) CRC and high-risk adenoma and (ii) CRC. Logistic regression was performed. Final reduced models were constructed selecting the four biomarkers with the highest likelihood scores. Subjects (N - 4,698) were consecutively included during 2010-2012. Colonoscopy detected 512 CRC patients, 319 colonic cancer and 193 rectal cancer. Extra colonic malignancies were detected in 177 patients, 689 had adenomas of which 399 were high-risk, 1,342 had nonneoplastic bowell disease and 1,978 subjects had 'clean' colorectum. Univariable analysis demonstrated that all biomarkers were statistically significant. Multivariate logistic regression demonstrated that the blood-based biomarkers in combination significantly predicted the endpoints. The reduced model resulted in the selection of CEA, hs-CRP, CyFra21-1 and Ferritin for the two endpoints; AUCs were 0.76 and 0.84, respectively. The postive predictive value at 90% sensitivity was 25% for endpoint 1 and the negative predictive value
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