Regulators of Glucose Metabolism in CD4+ and CD8+ T Cells

Glucose Metabolism Regulates T Cell Activation, Differentiation, and Functions

(2015) Clovis S. Palmer et al.   Frontiers in Immunology

The Glucose Transporter Glut1 Is Selectively Essential for CD4 T Cell Activation and Effector Function

(2014) Andrew N. Macintyre et al.   Cell Metabolism

Glucose Uptake Is Limiting in T Cell Activation and Requires CD28-Mediated Akt-Dependent and Independent Pathways

(2014) S. R. Jacobs et al.   JOURNAL OF IMMUNOLOGY

Bcl-6 directly represses the gene program of the glycolysis pathway

(2014) Kenneth J Oestreich et al.   NATURE IMMUNOLOGY

Metabolic Reprogramming towards Aerobic Glycolysis Correlates with Greater Proliferative Ability and Resistance to Metabolic Inhibition in CD8 versus CD4 T Cells

(2014) Yilin Cao et al.   PLoS One

Increased glucose metabolic activity is associated with CD4+ T-cell activation and depletion during chronic HIV infection

(2013) Clovis S. Palmer et al.   AIDS

Phosphoinositide 3-kinase gamma in T cell biology and disease therapy

(2013) Wai-Ping Fung-Leung   Annals of the New York Academy of Sciences

Metabolic Regulation of T Lymphocytes

(2013) Nancie J. MacIver et al.   Annual Review of Immunology

A multicenter phase 1 study of PX-866 in combination with docetaxel in patients with advanced solid tumours

(2013) D W Bowles et al.   BRITISH JOURNAL OF CANCER

Targeting Activated Akt with GDC-0068, a Novel Selective Akt Inhibitor That Is Efficacious in Multiple Tumor Models

(2013) J. Lin et al.   CLINICAL CANCER RESEARCH

Metabolic Pathways in Immune Cell Activation and Quiescence

(2013) Erika L. Pearce et al.   IMMUNITY

Inhibiting glycolytic metabolism enhances CD8+ T cell memory and antitumor function

(2013) Madhusudhanan Sukumar et al.   JOURNAL OF CLINICAL INVESTIGATION

The transcription factor IRF4 is essential for TCR affinity–mediated metabolic programming and clonal expansion of T cells

(2013) Kevin Man et al.   NATURE IMMUNOLOGY

Rapid effector function of memory CD8+ T cells requires an immediate-early glycolytic switch

(2013) Patrick M Gubser et al.   NATURE IMMUNOLOGY

Targeting the PI3K-AKT-mTOR signaling network in cancer

(2013) Khurum H. Khan et al.   Chinese Journal of Cancer

Regulation of Immune Responses by mTOR

(2012) Jonathan D. Powell et al.   Annual Review of Immunology

Targeting the PI3K Pathway in the Brain--Efficacy of a PI3K Inhibitor Optimized to Cross the Blood-Brain Barrier

(2012) L. Salphati et al.   CLINICAL CANCER RESEARCH

Perifosine, an oral, anti-cancer agent and inhibitor of the Akt pathway: mechanistic actions, pharmacodynamics, pharmacokinetics, and clinical activity

(2012) Paul G Richardson et al.   Expert Opinion on Drug Metabolism & Toxicology

mTOR, metabolism, and the regulation of T-cell differentiation and function

(2012) Adam T. Waickman et al.   IMMUNOLOGICAL REVIEWS

PDK1 regulation of mTOR and hypoxia-inducible factor 1 integrate metabolism and migration of CD8+T cells

(2012) David K. Finlay et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Blockade of Phosphatidylinositol 3-Kinase (PI3K)δ or PI3Kγ Reduces IL-17 and Ameliorates Imiquimod-Induced Psoriasis-like Dermatitis

(2012) Anne Roller et al.   JOURNAL OF IMMUNOLOGY

A selective inhibitor reveals PI3Kγ dependence of TH17 cell differentiation

(2012) Giovanna Bergamini et al.   Nature Chemical Biology

Metabolic checkpoints in activated T cells

(2012) Ruoning Wang et al.   NATURE IMMUNOLOGY

PI3Kγ Drives Priming and Survival of Autoreactive CD4+ T Cells during Experimental Autoimmune Encephalomyelitis

(2012) Iain Comerford et al.   PLoS One

Metabolic pathways in T cell fate and function

(2012) Valerie A. Gerriets et al.   TRENDS IN IMMUNOLOGY

A novel approach to cancer therapy using PX-478 as a HIF-1α inhibitor

(2011) Kyeong Lee et al.   ARCHIVES OF PHARMACAL RESEARCH

Control of TH17/Treg Balance by Hypoxia-Inducible Factor 1

(2011) Eric V. Dang et al.   CELL

mTOR as a multifunctional therapeutic target in HIV infection

(2011) Ferdinando Nicoletti et al.   DRUG DISCOVERY TODAY

The Transcription Factor Myc Controls Metabolic Reprogramming upon T Lymphocyte Activation

(2011) Ruoning Wang et al.   IMMUNITY

Protein Kinase B Controls Transcriptional Programs that Direct Cytotoxic T Cell Fate but Is Dispensable for T Cell Metabolism

(2011) Andrew N. Macintyre et al.   IMMUNITY

HIF1α–dependent glycolytic pathway orchestrates a metabolic checkpoint for the differentiation of TH17 and Tregcells

(2011) Lewis Z. Shi et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Cutting Edge: Distinct Glycolytic and Lipid Oxidative Metabolic Programs Are Essential for Effector and Regulatory CD4+ T Cell Subsets

(2011) R. D. Michalek et al.   JOURNAL OF IMMUNOLOGY

Everolimus in Combination with Pemetrexed in Patients with Advanced Non-small Cell Lung Cancer Previously Treated with Chemotherapy: A Phase I Study Using a Novel, Adaptive Bayesian Dose-Escalation Model

(2011) Johan Vansteenkiste et al.   Journal of Thoracic Oncology

GDC-0980 Is a Novel Class I PI3K/mTOR Kinase Inhibitor with Robust Activity in Cancer Models Driven by the PI3K Pathway

(2011) J. J. Wallin et al.   MOLECULAR CANCER THERAPEUTICS

Identification and Characterization of NVP-BKM120, an Orally Available Pan-Class I PI3-Kinase Inhibitor

(2011) S.-M. Maira et al.   MOLECULAR CANCER THERAPEUTICS

Inhibition of PI3K/mTOR pathways in glioblastoma and implications for combination therapy with temozolomide

(2011) G. Prasad et al.   NEURO-ONCOLOGY

Subcellular Localization of Hexokinases I and II Directs the Metabolic Fate of Glucose

(2011) Scott John et al.   PLoS One

Characterization of the Metabolic Phenotype of Rapamycin-Treated CD8+ T Cells with Augmented Ability to Generate Long-Lasting Memory Cells

(2011) Shan He et al.   PLoS One

Requirement for ribosomal protein S6 kinase 1 to mediate glycolysis and apoptosis resistance induced by Pten deficiency

(2011) P. Tandon et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

HIV-Associated Nephropathy

(2010) Dileep Kumar et al.   AMERICAN JOURNAL OF PATHOLOGY

Interleukin-2 and Inflammation Induce Distinct Transcriptional Programs that Promote the Differentiation of Effector Cytolytic T Cells

(2010) Matthew E. Pipkin et al.   IMMUNITY

The Transcriptional Repressor Bcl-6 Directs T Follicular Helper Cell Lineage Commitment

(2009) Di Yu et al.   IMMUNITY

The mTOR Kinase Differentially Regulates Effector and Regulatory T Cell Lineage Commitment

(2009) Greg M. Delgoffe et al.   IMMUNITY

Development of HIF-1 inhibitors for cancer therapy

(2009) Barbara Onnis et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

MAPK, Phosphatidylinositol 3-Kinase, and Mammalian Target of Rapamycin Pathways Converge at the Level of Ribosomal Protein S6 Phosphorylation to Control Metabolic Signaling in CD8 T Cells

(2009) R. J. Salmond et al.   JOURNAL OF IMMUNOLOGY

mTOR regulates memory CD8 T-cell differentiation

(2009) Koichi Araki et al.   NATURE

The nuts and bolts of AGC protein kinases

(2009) Laura R. Pearce et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The novel orally bioavailable inhibitor of phosphoinositol-3-kinase and mammalian target of rapamycin, NVP-BEZ235, inhibits growth and proliferation in multiple myeloma

(2008) Philipp Baumann et al.   EXPERIMENTAL CELL RESEARCH

The AKT–mTOR axis regulates de novo differentiation of CD4+Foxp3+cells

(2008) Sokol Haxhinasto et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Glucose metabolism in lymphocytes is a regulated process with significant effects on immune cell function and survival

(2008) Nancie J. MacIver et al.   JOURNAL OF LEUKOCYTE BIOLOGY

HIV infection-associated immune activation occurs by two distinct pathways that differentially affect CD4 and CD8 T cells

(2008) M. Catalfamo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA