Article
Biochemistry & Molecular Biology
Jan Bobek, Eliska Filipova, Natalie Bergman, Matous Cihak, Miroslav Petricek, Ana Catalina Lara, Vaclav Kristufek, Melinda Megyes, Theresa Wurzer, Alica Chronakova, Katerina Petrickova
Summary: Streptomyces are of great interest in the pharmaceutical industry due to their production of secondary metabolites with antibacterial and antifungal properties. This study examined the production of hemolytic compounds in different strains of Streptomyces and found that the ability to produce cytolytic compounds is an intrinsic feature of the bacteria in the soil environment, which could serve as a virulence factor when colonizing host organisms. The study also reviewed the literature on hemolytic metabolites produced by Streptomyces.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Multidisciplinary Sciences
Matthieu Bouaziz, Jimmy Mullaert, Benedetta Bigio, Yoann Seeleuthner, Jean-Laurent Casanova, Alexandre Alcai, Laurent Abel, Aurelie Cobat
Summary: Population stratification is a confounder of genetic association studies, especially in analyses of rare variants. Correction methods based on principal components and linear mixed models may yield conflicting conclusions. A simulation study involving various population structures and sample sizes found that a novel local permutation method maintained correct type-I-errors across all scenarios. Properly controlling type-I-errors is crucial in genetic association studies involving population stratification.
SCIENTIFIC REPORTS
(2021)
Article
Biotechnology & Applied Microbiology
Mie Bech Lukassen, Simon Menanteau-Ledouble, Nadieh de Jonge, Edward Schram, Jeppe Lund Nielsen
Summary: This study found that geosmin is related to the composition of bacteria and water quality parameters in RAS systems, specifically with the presence of geosmin-producing bacteria and geosmin production.
JOURNAL OF APPLIED MICROBIOLOGY
(2022)
Review
Medicine, General & Internal
Margarida T. R. I. N. D. A. D. E. Torres, Beatriz S. O. U. S. A. Nunes, Luis Varandas, Fernando Maltez
Summary: Mycetoma is a condition caused by inoculation of filamentous fungi or bacteria. Cellulosimicrobium cellulans, a gram-positive bacterium, rarely causes human disease. Diagnosis relies on clinical presentation and identification of the causative microorganism. This case report describes a young man diagnosed with actinomycetoma due to Cellulo-simicrobium cellulans and treated with a combination of amikacin and sulfamethoxazole/trimethoprim (Welsh regimen).
ACTA MEDICA PORTUGUESA
(2023)
Article
Dermatology
Domenico Santoro, Linda Archer, Lana Fagman
Summary: This study evaluated the clinical effects of heat-killed actinomycetales in treating feline atopic syndrome. The results showed sustained improvement with GB treatment and a reduction in pruritus score with RC treatment after 365 days. The use of multiple intradermal injections of heat-killed GB shows promise as an effective and well-tolerated treatment for FAS.
VETERINARY DERMATOLOGY
(2021)
Article
Genetics & Heredity
Chelsea Trotter, Hyeonju Kim, Gregory Farage, Pjotr Prins, Robert W. Williams, Karl W. Broman, Saunak Sen
Summary: A new algorithm and code have been developed to achieve real-time whole-genome quantitative trait locus (QTL) scans for large-scale genotype-phenotype relations, which is over 700 times faster than existing methods, utilizing multi-threading and GPU parallelization techniques.
G3-GENES GENOMES GENETICS
(2021)
Article
Infectious Diseases
Saray Mormeneo Bayo, Maria Pilar Palacian Ruiz, Uxua Asin Samper, Maria Isabel Millan Lou, Ascension Pascual Catalan, Maria Cruz Villuendas Uson
Summary: We present the second case in the world of endocarditis caused by Gordonia bronchialis and review all endocarditis cases caused by Gordonia spp. Gordonia bronchialis was identified using matrix-assisted desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS) and 16S rRNA gene sequencing. This case highlights the pathogenic role of Gordonia bronchialis as an opportunistic pathogen and emphasizes the high risk of infections caused by environmental bacteria.
ENFERMEDADES INFECCIOSAS Y MICROBIOLOGIA CLINICA
(2022)
Article
Veterinary Sciences
Mateusz Sypniewski, Maciej Szydlowski
Summary: This study looked at the genes linked to obesity in humans and found a variant in the ADCY3 gene that is also associated with weight in Labrador Retriever dogs. These findings provide valuable information for canine obesity research.
VETERINARY SCIENCES
(2023)
Article
Genetics & Heredity
Chelsea Trotter, Hyeonju Kim, Gregory Farage, Pjotr Prins, Robert W. Williams, Karl W. Broman, Saunak Sen
Summary: The BXD family of mouse strains, fully sequenced and deeply phenotyped, are utilized as an important reference population. New algorithms and code have been developed to enable efficient whole-genome quantitative trait locus (QTL) scans, particularly suitable for interactive web services. The use of parallelizable operations, including matrix multiplication and GPU parallelization, significantly improves the speed and performance of the scans, making real-time display of results feasible.
G3-GENES GENOMES GENETICS
(2021)
Article
Agriculture, Dairy & Animal Science
Lina Zhao, Qinggang Xie, Fengyi Shi, Shengnan Liang, Qingxue Chen, Smith Etareri Evivie, Ji Qiu, Bailiang Li, Guicheng Huo
Summary: This study aimed to reduce cow milk protein allergenicity by fermenting skim milk protein with Lactobacillus helveticus and Lactobacillus plantarum strains. The fermentation process inhibited antigenicity of specific milk proteins and cleaved major allergic epitopes, demonstrating a potential method for reducing milk sensitization.
JOURNAL OF DAIRY SCIENCE
(2021)
Article
Agriculture, Dairy & Animal Science
Krzysztof Kotlarz, Barbara Kosinska-Selbi, Zexi Cai, Goutam Sahana, Joanna Szyda
Summary: This study aimed to estimate the effects of KEGG pathways on stature in three Nordic dairy cattle breeds using SNP effects from GWAS. The results showed that the D-amino acid metabolism pathway was significant for stature in two of the analyzed breeds and borderline significant in the third breed.
GENETICS SELECTION EVOLUTION
(2022)
Article
Genetics & Heredity
Veronica Mixao, Valentina del Olmo, Eva Hegedusova, Ester Saus, Leszek Pryszcz, Andrea Cillingova, Jozef Nosek, Toni Gabaldon
Summary: This study indicates the presence of additional hybrid species in the complex of Candida parapsilosis and multiple independent occurrences of linear configuration in mitochondrial genomes of Candida species. These findings reinforce the hypothesis that hybridization is widespread among Candida species and potentially contributes to the emergence of lineages with opportunistic pathogenic behavior.
Article
Plant Sciences
Ruoran Li, Xuli Jia, Jing Zhang, Shangang Jia, Tao Liu, Jiangyong Qu, Xumin Wang
Summary: The study assembled seven plastid genomes of Sargassum, revealing the presence of 139 protein-coding genes, 28 tRNAs, and 6 rRNAs. Compared to other Fucales plastid genomes, 136 PCGs were conserved, with some shared with other species like Coccophora langsdorfii. The phylogenetic analysis showed the evolutionary history of brown algae and highlighted the speciation events within the Sargassum genus.
FRONTIERS IN PLANT SCIENCE
(2021)
Article
Plant Sciences
I. I. Adejumobi, Paterne A. A. Agre, A. S. Adewumi, T. E. Shonde, I. M. Cipriano, J. L. Komoy, J. G. Adheka, D. O. Onautshu
Summary: This study analyzed the diversity and marker-trait association of 182 yam accessions from six species using SNP markers, and identified 22 SNP markers related to yield, plant vigor, and disease resistance. These findings provide valuable insights into the genetic control of important traits in yam and have implications for marker-assisted selection in multiple yam species.
Article
Microbiology
Mira M. Shenouda, Ryan S. Noyce, Stephen Z. Lee, Jun Li Wang, Yi-Chan Lin, Nicole A. Favis, Megan A. Desaulniers, David H. Evans
Summary: Poxvirus genomes possess hairpin structures that play a crucial role in genome packaging and replication. Through mutant vaccinia virus construction and experimental testing, it was found that the hairpin structure, rather than its sequence, determines its function. Mismatches within the hairpin were shown to be critical for genome packaging, and the study also provided insights into the arrangement of VACV flip and flop telomeres.