Article
Microbiology
Ye Liu, Qiao You, Fang Zhang, Deyan Chen, Zhenping Huang, Zhiwei Wu
Summary: Harringtonine (HT) significantly inhibited HSV-1 infection and two ACV-resistant strains by mainly targeting HVEM and reducing the early stage of HSV-1 infection. The study demonstrated that HT could be a promising therapeutic candidate for mitigating HSV-1-induced pathogenesis.
FRONTIERS IN MICROBIOLOGY
(2021)
Article
Integrative & Complementary Medicine
Tong Liu, Qing-qing Shao, Wen-jia Wang, Tian-li Liu, Xi-ming Jin, Li-jun Xu, Guang-ying Huang, Zhuo Chen
Summary: The objective of this study was to investigate the effect of HSV-2 on pyroptosis of VK2/E6E7 cells and the potential anti-HSV-2 activity of JZ-1. The results showed that JZ-1 effectively inhibited HSV-2 infection in VK2/E6E7 cells and suppressed HSV-2-induced pyroptosis. These findings enhance our understanding of the pathogenesis of HSV-2 infection and provide experimental evidence for the anti-HSV-2 activity of JZ-1.
JOURNAL OF INTEGRATIVE MEDICINE-JIM
(2023)
Article
Integrative & Complementary Medicine
Yi-Wei Zhu, Du Li, Ting-Jie Ye, Feng-Jun Qiu, Xiao-Ling Wang, Xiao-Feng Yan, Yan-Lin Lu, Wei Xu, Hua Li, Xu-Dong Hu
Summary: Our study explored the molecular mechanism of Yin-Chen-Hao-Tang (YCHT) in improving hepatocyte steatosis in alcoholic fatty liver disease (AFLD) through network pharmacology and RNA sequencing. The results revealed that PPAR gamma and PPAR alpha are key targets in the prevention and treatment of AFLD with YCHT, and the PPAR signaling pathway plays a crucial role in this process.
EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE
(2021)
Article
Virology
Mashidur Rana, Mizumi Setia, Pratima K. Suvas, Anish Chakraborty, Susmit Suvas
Summary: Reactive oxygen species (ROS) play a crucial role in herpes stromal keratitis (HSK), with neutrophils being the primary cells responsible for ROS generation. NOX2 is involved in ROS production in neutrophils. However, manipulating ROS levels in neutrophils may help alleviate the severity of HSK, and NOX2 is not the main contributor to ROS generation in neutrophils.
JOURNAL OF VIROLOGY
(2022)
Article
Microbiology
Kevin Danastas, Gerry Guo, Jessica Merjane, Nathan Hong, Ava Larsen, Monica Miranda-Saksena, Anthony L. Cunningham
Summary: This study explores the effects of interferons (IFNs) on herpes simplex virus-1 (HSV-1) and reveals that IFNs have the potential to block virus release from nerve endings, thereby preventing transmission into the skin. The study also highlights the potential wider antiviral effects of IFN-γ in neurons, suggesting its role in HSV-1 reactivation. These findings identify new targets for the development of immunotherapies to impede HSV-1 spread from nerves to the skin.
Article
Plant Sciences
Tingting Guo, Yinan Guo, Qingbing Liu, Yan Xu, Lina Wei, Zhongtian Wang, Si Chen, Caiwen Wang, Ye Tian, Jie Cui, Yijie Wang, Yanbo Wang, Liping Sun
Summary: This study found that Ma-xing-shi-gan-tang (MXSGT) is an effective inhibitor of PLY, a key virulence factor for Streptococcus pneumoniae. MXSGT inhibits PLY oligomerization without impacting bacterial growth or PLY production, and demonstrates effectiveness against S. pneumoniae infection both in vitro and in vivo.
JOURNAL OF ETHNOPHARMACOLOGY
(2021)
Article
Pharmacology & Pharmacy
Qianni Duan, Tong Liu, Cong Huang, Qingqing Shao, Yonggui Ma, Wenjia Wang, Tianli Liu, Jun Sun, Jianguo Fang, Guangying Huang, Zhuo Chen
Summary: JieZe-1 demonstrates significant anti-HSV-2 efficacy in vivo by inhibiting membrane fusion, the Toll-like receptor signaling pathway, inflammatory cytokines, and cellular immunity. However, berberine, the main component of JieZe-1, did not show efficacy at the tested concentration.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Virology
Lefang Jiang, Yang Yu, Zhuogang Li, Yarou Gao, Haonan Zhang, Mingxin Zhang, Weihua Cao, Qun Peng, Xulin Chen
Summary: CDK inhibitors, such as BMS-265246, have shown potential as effective antiviral agents against HSV-1 infection by inhibiting viral replication at multiple stages.
Article
Microbiology
Zhi Liu, Likun Xia
Summary: This study found that RNF5 limits the type I interferon antiviral response in herpes simplex virus-induced corneal epithelitis by inhibiting the STING/IRF3 signaling pathway. Silencing RNF5 promotes IFN-I expression, inhibits viral replication, alleviates inflammation, and reduces corneal inflammatory damage.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Virology
Maimoona S. Bhutta, Oren Shechter, Elisa S. Gallo, Stephen D. Martin, Esther Jones, Gustavo F. Doncel, Ronen Borenstein
Summary: Research has shown that ginkgolic acid has antiviral activity against HSV-1 by disrupting viral structure and blocking fusion, and it efficiently inhibits ACV(R)-HSV strains. The mechanism of action includes virucidal activity and fusion inhibition, indicating potential for treatment of additional cutaneous and systemic viral infections.
Article
Immunology
Mette Ratzer Freytag, Sofie Eg Jorgensen, Michelle Molgaard Thomsen, Ali Al-Mousawi, Alon Schneider Hait, David Olagnier, Jakob T. Bay, Marie Helleberg, Trine H. Mogensen
Summary: This study describes a 19-year-old woman with systemic HSV-1 infection and HLH, as well as a fatal course of neonatal herpesvirus infection postpartum. Investigation showed impaired antiviral responses in the mother's cells, potentially caused by variants in CASP8 or other noncoding regions of the genome.
JOURNAL OF INFECTIOUS DISEASES
(2022)
Article
Chemistry, Medicinal
Kai Jiang, Jing Feng, Xia Qi, Lili Ran, Lixin Xie
Summary: This study validated the inhibitory effect of oridonin on herpes simplex virus type 1 and demonstrated its potential in alleviating herpes simplex keratitis infection in mice.
DRUG DESIGN DEVELOPMENT AND THERAPY
(2022)
Article
Biochemistry & Molecular Biology
Pu Huang, Xu Wang, Mengyue Lei, Ying Ma, Hongli Chen, Jing Sun, Yunzhang Hu, Jiandong Shi
Summary: This study investigates the metabolic interaction between host cells and HSV-1. By analyzing the metabolic profiles in HSV-1-infected lung fibroblasts, the researchers found that HSV-1 induces metabolic reprogramming in host cells to promote or resist viral replication. They confirmed that the addition of the tryptophan metabolite kynurenine promotes viral replication, while the addition of 25-Hydroxycholesterol inhibits replication. Additionally, HSV-1 replication was enhanced in choline metabolic rate-limiting enzyme-deficient mouse macrophages.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Microbiology
Jie Wang, Kun-Te Shang, Qiong-Hong Ma, Zhao-Ying Dong, Yi-Hong Chen, Yu-Feng Yao
Summary: This study aimed to determine whether HSV-1 can be transmitted through TNTs and to investigate the effect of inhibiting the Arp2/3 complex on the intercellular transmission of HSV-1. The results showed that HSV-1 can be transmitted through TNTs and that inhibiting the Arp2/3 complex reduces the number of TNTs and the spread of HSV-1. This finding provides new insights into the transmission mode of HSV-1 and suggests a potential new antiviral target.
Article
Virology
Yue Yin, Nicolas Romero, Herman W. Favoreel
Summary: This study reveals a novel evasion mechanism of type I and III interferons by alphaherpesviruses, in which the porcine alphaherpesvirus pseudorabies virus triggers degradation of key Janus kinases Jak1 and Tyk2 to inhibit IFN signaling. This inhibition is not caused by incoming virions and does not depend on viral protein expression or genome replication.
JOURNAL OF VIROLOGY
(2021)
Article
Food Science & Technology
Liang-Tzung Lin, Ying-Jang Lai, She-Ching Wu, Wei-Hsuan Hsu, Chen-Jei Tai
JOURNAL OF FOOD AND DRUG ANALYSIS
(2018)
Article
Food Science & Technology
Yu-Ting Kuo, Chih-Chan Lin, Hsiao-Tzu Kuo, Jui-Hsiang Hung, Ching-Hsuan Liu, Alagie Jassey, Ming-Hong Yen, Shu-Jing Wu, Liang-Tzung Lin
JOURNAL OF FOOD AND DRUG ANALYSIS
(2019)
Article
Plant Sciences
Ting-Chun Hung, Alagie Jassey, Ching-Hsuan Liu, Chien-Ju Lin, Chun-Ching Lin, Shu Hui Wong, Jonathan Y. Wang, Ming-Hong Yen, Liang-Tzung Lin
Article
Food Science & Technology
Chi-Hsin Lee, Sy-Jye Leu, Yu-Ching Lee, Chia-I Liu, Liang-Tzung Lin, Pharaoh Fellow Mwale, Jen-Ron Chiang, Bor-Yu Tsai, Chi-Ching Chen, Ching-Sheng Hung, Yi-Yuan Yang
Article
Immunology
Chien-Ju Lin, Ching-Hsuan Liu, Jonathan Y. Wang, Chun-Ching Lin, Yi-Fang Li, Christopher D. Richardson, Liang-Tzung Lin
EMERGING MICROBES & INFECTIONS
(2018)
Article
Virology
Ting-Chun Hung, Alagie Jassey, Chien-Ju Lin, Ching-Hsuan Liu, Chun-Ching Lin, Ming-Hong Yen, Liang-Tzung Lin
Article
Cell Biology
Alagie Jassey, Ching-Hsuan Liu, Chun A. Changou, Christopher D. Richardson, Hsue-Yin Hsu, Liang-Tzung Lin
Article
Biotechnology & Applied Microbiology
Pharaoh Fellow Mwale, Chi-Hsin Lee, Sy-Jye Leu, Yu-Ching Lee, Hsueh-Hsia Wu, Liang-Tzung Lin, Tony Eight Lin, Yun-Ju Huang, Yi-Yuan Yang
APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
(2019)
Review
Biochemistry & Molecular Biology
Ching-Hsuan Liu, Alagie Jassey, Hsin-Ya Hsu, Liang-Tzung Lin
Article
Biochemistry & Molecular Biology
Liang-Tzung Lin, Wu-Ching Uen, Chen-Yen Choong, Yeu-Ching Shi, Bao-Hong Lee, Cheng-Jeng Tai, Chen-Jei Tai
Article
Multidisciplinary Sciences
Chen-Jei Tai, Ching-Hsuan Liu, Yu-Chi Pan, Shu Hui Wong, Cheng-Jeng Tai, Christopher D. Richardson, Liang-Tzung Lin
SCIENTIFIC REPORTS
(2019)
Article
Multidisciplinary Sciences
Jonathan Y. Wang, Chien-Ju Lin, Ching-Hsuan Liu, Liang-Tzung Lin
JOVE-JOURNAL OF VISUALIZED EXPERIMENTS
(2019)
Review
Immunology
Shu Hui Wong, Alagie Jassey, Jonathan Y. Wang, Wei-Cheng Wang, Ching-Hsuan Liu, Liang-Tzung Lin
Article
Cell Biology
Yujia Li, MaX Xuezhong Ma, Bo Qin, Liang-Tzung Lin, Christopher D. Richardson, Jordan Feld, Ian D. McGilvray, Limin Chen
MEDIATORS OF INFLAMMATION
(2019)
Article
Biochemistry & Molecular Biology
Pharaoh Fellow Mwale, Chi-Hsin Lee, Liang-Tzung Lin, Sy-Jye Leu, Yun-Ju Huang, Liao-Chun Chiang, Yan-Chiao Mao, Yi-Yuan Yang
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2020)
