Effects of Ionizing Radiation on Biological Molecules—Mechanisms of Damage and Emerging Methods of Detection

An Ammonium Bicarbonate-Enhanced Stable Isotope Dilution UHPLC-MS/MS Method for Sensitive and Accurate Quantification of Acrolein–DNA Adducts in Human Leukocytes

(2013) Ruichuan Yin et al.   ANALYTICAL CHEMISTRY

Silencing of mitochondrial NADP+-dependent isocitrate dehydrogenase gene enhances glioma radiosensitivity

(2013) Sung Youl Kim et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Oxidation of Methionine 216 in Sheep and Elk Prion Protein Is Highly Dependent upon the Amino Acid at Position 218 but Is Not Important for Prion Propagation

(2013) Christopher J. Silva et al.   BIOCHEMISTRY

A Survivin-Associated Adaptive Response in Radiation Therapy

(2013) D. J. Grdina et al.   CANCER RESEARCH

Cytoplasmic Irradiation Results in Mitochondrial Dysfunction and DRP1-Dependent Mitochondrial Fission

(2013) B. Zhang et al.   CANCER RESEARCH

Acetylation dynamics of human nuclear proteins during the ionizing radiation-induced DNA damage response

(2013) Martin Bennetzen et al.   CELL CYCLE

Cysteine-Mediated Redox Signaling: Chemistry, Biology, and Tools for Discovery

(2013) Candice E. Paulsen et al.   CHEMICAL REVIEWS

Thiol-blocking electrophiles interfere with labeling and detection of protein sulfenic acids

(2013) Julie A. Reisz et al.   FEBS Journal

Parkinson disease: from pathology to molecular disease mechanisms

(2013) David T. Dexter et al.   FREE RADICAL BIOLOGY AND MEDICINE

Effects of ionizing radiation on mitochondria

(2013) Winnie Wai-Ying Kam et al.   FREE RADICAL BIOLOGY AND MEDICINE

The use of the methods of radiolysis to explore the mechanisms of free radical modifications in proteins

(2013) Chantal Houée-Levin et al.   Journal of Proteomics

Chemical approaches to detect and analyze protein sulfenic acids

(2013) Cristina M. Furdui et al.   MASS SPECTROMETRY REVIEWS

Relative quantification of proteasome activity by activity-based protein profiling and LC-MS/MS

(2013) Nan Li et al.   Nature Protocols

Dopamine-Mediated Oxidation of Methionine 127 in α-Synuclein Causes Cytotoxicity and Oligomerization of α-Synuclein

(2013) Kazuhiro Nakaso et al.   PLoS One

Involvement of ERK-Nrf-2 Signaling in Ionizing Radiation Induced Cell Death in Normal and Tumor Cells

(2013) Raghavendra S. Patwardhan et al.   PLoS One

Conditional Radioresistance of tet-Inducible Manganese Superoxide Dismutase Bone Marrow Stromal Cell Lines

(2013) Michael W. Epperly et al.   RADIATION RESEARCH

Enalapril Mitigates Radiation-Induced Pneumonitis and Pulmonary Fibrosis if Started 35 Days after Whole-Thorax Irradiation

(2013) Feng Gao et al.   RADIATION RESEARCH

Cisplatin Enhances the Formation of DNA Single- and Double-Strand Breaks by Hydrated Electrons and Hydroxyl Radicals

(2013) Mohammad Rezaee et al.   RADIATION RESEARCH

The expanding field of SILAC

(2012) Shao-En Ong   ANALYTICAL AND BIOANALYTICAL CHEMISTRY

An insight into iTRAQ: where do we stand now?

(2012) Caroline Evans et al.   ANALYTICAL AND BIOANALYTICAL CHEMISTRY

Simultaneous Detection of Low and High Molecular Weight Carbonylated Compounds Derived from Lipid Peroxidation by Electrospray Ionization-Tandem Mass Spectrometry

(2012) Ivana Milic et al.   ANALYTICAL CHEMISTRY

Chemoselective Ligation of Sulfinic Acids with Aryl-Nitroso Compounds

(2012) Mauro Lo Conte et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

The Chemical Biology of S-Nitrosothiols

(2012) Katarzyna A. Broniowska et al.   ANTIOXIDANTS & REDOX SIGNALING

Chemical Methods for the Direct Detection and Labeling of S-Nitrosothiols

(2012) Erika Bechtold et al.   ANTIOXIDANTS & REDOX SIGNALING

Selenocysteine in Thiol/Disulfide-Like Exchange Reactions

(2012) Robert J. Hondal et al.   ANTIOXIDANTS & REDOX SIGNALING

Reductive Stress Linked to Small HSPs, G6PD, and Nrf2 Pathways in Heart Disease

(2012) Alison C. Brewer et al.   ANTIOXIDANTS & REDOX SIGNALING

Kinetics and Mechanisms of Thiol–Disulfide Exchange Covering Direct Substitution and Thiol Oxidation-Mediated Pathways

(2012) Péter Nagy   ANTIOXIDANTS & REDOX SIGNALING

Oxidative stress-induced posttranslational modifications of human hemoglobin in erythrocytes

(2012) Wei Xiang et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

A simple and effective strategy for labeling cysteine sulfenic acid in proteins by utilization of β-ketoesters as cleavable probes

(2012) Jiang Qian et al.   CHEMICAL COMMUNICATIONS

Quantitative Proteomics for Cancer Biomarker Discovery

(2012) Shufang Liang et al.   COMBINATORIAL CHEMISTRY & HIGH THROUGHPUT SCREENING

Mitigation of Radiation Injuries via Suppression of the Renin-Angiotensin System: Emphasis on Radiation Nephropathy

(2012) E. P. Cohen et al.   CURRENT DRUG TARGETS

Renin-angiotensin System Blockers and Modulation of Radiation-Induced Brain Injury

(2012) M. E. Robbins et al.   CURRENT DRUG TARGETS

Mechanisms of S-nitrosothiol formation and selectivity in nitric oxide signaling

(2012) Brian C Smith et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Novel Therapeutic Approaches in Limiting Oxidative Stress and Inflammation

(2012) Agnieszka Spychalowicz et al.   CURRENT PHARMACEUTICAL BIOTECHNOLOGY

Adaptive radiation-induced epigenetic alterations mitigated by antioxidants

(2012) Autumn J. Bernal et al.   FASEB JOURNAL

Manganese superoxide dismutase interacts with a large scale of cellular and mitochondrial proteins in low-dose radiation-induced adaptive radioprotection

(2012) Angela Eldridge et al.   FREE RADICAL BIOLOGY AND MEDICINE

Redox regulation of the epigenetic landscape in Cancer: A role for metabolic reprogramming in remodeling the epigenome

(2012) Michael J. Hitchler et al.   FREE RADICAL BIOLOGY AND MEDICINE

Ionizing radiation induces mitochondrial reactive oxygen species production accompanied by upregulation of mitochondrial electron transport chain function and mitochondrial content under control of the cell cycle checkpoint

(2012) Tohru Yamamori et al.   FREE RADICAL BIOLOGY AND MEDICINE

Assays for urinary biomarkers of oxidatively damaged nucleic acids

(2012) Allan Weimann et al.   FREE RADICAL RESEARCH

Mechanisms of free radical-induced damage to DNA

(2012) Miral Dizdaroglu et al.   FREE RADICAL RESEARCH

Biological effects of low-dose radiation from computed tomography scanning

(2012) Shumei Ma et al.   INTERNATIONAL JOURNAL OF RADIATION BIOLOGY

Residual metals cause variability in methionine oxidation measurements in protein pharmaceuticals using LC-UV/MS peptide mapping

(2012) Li Zang et al.   JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES

Use of Tanning Beds and Incidence of Skin Cancer

(2012) Mingfeng Zhang et al.   JOURNAL OF CLINICAL ONCOLOGY

Analysis of oxidative stress-induced protein carbonylation using fluorescent hydrazides

(2012) Jordi Tamarit et al.   Journal of Proteomics

Dose-modifying factor for captopril for mitigation of radiation injury to normal lung

(2012) M. Medhora et al.   JOURNAL OF RADIATION RESEARCH

Mitochondria-Targeted Superoxide Dismutase (SOD2) Regulates Radiation Resistance and Radiation Stress Response in HeLa Cells

(2012) Ayaka HOSOKI et al.   JOURNAL OF RADIATION RESEARCH

Angiotensin Converting Enzyme Inhibitors Mitigate Collagen Synthesis Induced by a Single Dose of Radiation to the Whole Thorax

(2012) Lakhan KMA et al.   JOURNAL OF RADIATION RESEARCH

Radiation exposure from CT scans in childhood and subsequent risk of leukaemia and brain tumours: a retrospective cohort study

(2012) Mark S Pearce et al.   LANCET

Metabolomic response of human skin tissue to low dose ionizing radiation

(2012) Ze-Ping Hu et al.   Molecular BioSystems

Radiation Survivors: Understanding and Exploiting the Phenotype following Fractionated Radiation Therapy

(2012) A. Y. Makinde et al.   MOLECULAR CANCER RESEARCH

Recognition, signaling, and repair of DNA double-strand breaks produced by ionizing radiation in mammalian cells: The molecular choreography

(2012) Larry H. Thompson   MUTATION RESEARCH-REVIEWS IN MUTATION RESEARCH

Extreme anti-oxidant protection against ionizing radiation in bdelloid rotifers

(2012) A. Krisko et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Selection of candidate radiation biomarkers in the serum of rats exposed to gamma-rays byGC/TOFMS-based metabolomics

(2012) H. Liu et al.   RADIATION PROTECTION DOSIMETRY

Radiation Dose Detection by Imaging Response in Biological Targets

(2012) B. Jakob et al.   RADIATION RESEARCH

Chronic Administration of the Angiotensin-Converting Enzyme Inhibitor, Ramipril, Prevents Fractionated Whole-Brain Irradiation-Induced Perirhinal Cortex-Dependent Cognitive Impairment

(2012) Tammy C. Lee et al.   RADIATION RESEARCH

Radiation Metabolomics. 5. Identification of Urinary Biomarkers of Ionizing Radiation Exposure in Nonhuman Primates by Mass Spectrometry-Based Metabolomics

(2012) Caroline H. Johnson et al.   RADIATION RESEARCH

Protein carbonyls and traditional biomarkers in pigs exposed to low-dose γ-radiation

(2012) Miriam Smutná et al.   RESEARCH IN VETERINARY SCIENCE

Mitigation of radiation induced pulmonary vascular injury by delayed treatment with captopril

(2012) ROBERT C. MOLTHEN et al.   RESPIROLOGY

Radiation, Inflammation, and Immune Responses in Cancer

(2012) Gabriele Multhoff et al.   Frontiers in Oncology

Silencing Prx1 and/or Prx5 sensitizes human esophageal cancer cells to ionizing radiation and increases apoptosis via intracellular ROS accumulation

(2011) Mai-cang Gao et al.   ACTA PHARMACOLOGICA SINICA

Cancer induction caused by radiation due to computed tomography: a critical note

(2011) Ernest K J Pauwels et al.   ACTA RADIOLOGICA

Isotope-coded chemical reporter and acid-cleavable affinity reagents for monitoring protein sulfenic acids

(2011) Thu H. Truong et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

S-Nitrosylation of mitogen activated protein kinase phosphatase-1 suppresses radiation-induced apoptosis

(2011) Weiping Guan et al.   CANCER LETTERS

Ionizing radiation-induced metabolic oxidative stress and prolonged cell injury

(2011) Edouard I. Azzam et al.   CANCER LETTERS

Simple synthesis of 1,3-cyclopentanedione derived probes for labeling sulfenic acid proteins

(2011) Jiang Qian et al.   CHEMICAL COMMUNICATIONS

Exploring the Biology of Lipid Peroxidation-Derived Protein Carbonylation

(2011) Kristofer S. Fritz et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Characterization of oxidation products from 1-palmitoyl-2-linoleoyl-sn-glycerophosphatidylcholine in aqueous solutions and their reactions with cysteine, histidine and lysine residues

(2011) Ivana Milic et al.   CHEMISTRY AND PHYSICS OF LIPIDS

Oxidative stress and diabetes mellitus

(2011) Hui Yang et al.   CLINICAL CHEMISTRY AND LABORATORY MEDICINE

FTIR markers of methionine oxidation for early detection of oxidized protein therapeutics

(2011) Jascindra Ravi et al.   EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS

Immunochemical detection of oxidatively damaged DNA

(2011) Pavel Rossner et al.   FREE RADICAL RESEARCH

Model for the Exceptional Reactivity of Peroxiredoxins 2 and 3 with Hydrogen Peroxide

(2011) Péter Nagy et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Reversible Hydrogen Transfer Reactions of Cysteine Thiyl Radicals in Peptides: the Conversion of Cysteine into Dehydroalanine and Alanine, and of Alanine into Dehydroalanine

(2011) Olivier Mozziconacci et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Integrated Analysis of ATM Mediated Gene and Protein Expression Impacting Cellular Metabolism

(2011) Amrita K. Cheema et al.   JOURNAL OF PROTEOME RESEARCH

A Genetically Encoded Probe for the Identification of Proteins that Form Sulfenic Acid in Response to H2O2inSaccharomyces cerevisiae

(2011) Christina L. Takanishi et al.   JOURNAL OF PROTEOME RESEARCH

Non-invasive proteomic analysis of human skin keratins: Screening of methionine oxidation in keratins by mass spectrometry

(2011) Seon Hwa Lee et al.   Journal of Proteomics

To tag or not to tag: A comparative evaluation of immunoaffinity-labeling and tandem mass spectrometry for the identification and localization of posttranslational protein carbonylation by 4-hydroxy-2-nonenal, an end-product of lipid peroxidation

(2011) Jia Guo et al.   Journal of Proteomics

Identification of carbonylated peptides by tandem mass spectrometry using a precursor ion-like scan in negative ion mode

(2011) Ravi Ch. Bollineni et al.   Journal of Proteomics

Radiation-induced reductive modifications of sulfur-containing amino acids within peptides and proteins

(2011) Chryssostomos Chatgilialoglu et al.   Journal of Proteomics

Redox Proteomics of Protein-bound Methionine Oxidation

(2011) Bart Ghesquière et al.   MOLECULAR & CELLULAR PROTEOMICS

NADPH oxidase inhibition attenuates total body irradiation-induced haematopoietic genomic instability

(2011) S. K. Pazhanisamy et al.   MUTAGENESIS

Repeated exposure of human fibroblasts to ionizing radiation reveals an adaptive response that is not mediated by interleukin-6 or TGF-β

(2011) Birger Dieriks et al.   MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS

Vitamin C for DNA damage prevention

(2011) Radim J. Sram et al.   MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS

Melatonin protection from chronic, low-level ionizing radiation

(2011) Russel J. Reiter et al.   MUTATION RESEARCH-REVIEWS IN MUTATION RESEARCH

Peroxide-dependent sulfenylation of the EGFR catalytic site enhances kinase activity

(2011) Candice E Paulsen et al.   Nature Chemical Biology

Linoleic acid peroxidation vs. isomerization: a biomimetic model of free radical reactivity in the presence of thiols

(2011) Branka Mihaljević et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Isoform-specific regulation of Akt by PDGF-induced reactive oxygen species

(2011) R. Wani et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Proteomic identification of radiation response markers in mouse intestine and brain

(2011) Young-Bin Lim et al.   PROTEOMICS

Rapid proteomic remodeling of cardiac tissue caused by total body ionizing radiation

(2011) Omid Azimzadeh et al.   PROTEOMICS

Identification of Urinary Biomarkers from X-Irradiated Mice Using NMR Spectroscopy

(2011) Congju Chen et al.   RADIATION RESEARCH

Cancer-Prone Mice Expressing the Ki-rasG12CGene Show Increased Lung Carcinogenesis after CT Screening Exposures

(2011) Michael T. Munley et al.   RADIATION RESEARCH

Nitration Activates Tyrosine toward Reaction with the Hydrated Electron

(2011) Wei-Qun Shi et al.   RADIATION RESEARCH

Radiation Metabolomics. 4. UPLC-ESI-QTOFMS-Based Metabolomics for Urinary Biomarker Discovery in Gamma-Irradiated Rats

(2011) Caroline H Johnson et al.   RADIATION RESEARCH

The Effect of Radiation Quality on Genomic DNA Methylation Profiles in Irradiated Human Cell Lines

(2011) Wilfried Goetz et al.   RADIATION RESEARCH

Expression of thioredoxin system and related peroxiredoxin proteins is associated with clinical outcome in radiotherapy treated early stage breast cancer

(2011) Caroline M. Woolston et al.   RADIOTHERAPY AND ONCOLOGY

Investigations into the role of inflammation in normal tissue response to irradiation

(2011) Richard Peter Hill et al.   RADIOTHERAPY AND ONCOLOGY

DNA methylation changes in cells regrowing after fractioned ionizing radiation

(2011) Christine Kuhmann et al.   RADIOTHERAPY AND ONCOLOGY

The ATM protein kinase and cellular redox signaling: beyond the DNA damage response

(2011) Scott Ditch et al.   TRENDS IN BIOCHEMICAL SCIENCES

Water-Soluble Triarylphosphines as Biomarkers for ProteinS-Nitrosation

(2010) Erika Bechtold et al.   ACS Chemical Biology

The Redox Basis of Epigenetic Modifications: From Mechanisms to Functional Consequences

(2010) Anthony R. Cyr et al.   ANTIOXIDANTS & REDOX SIGNALING

Cysteine sulfenic Acid as an Intermediate in Disulfide Bond Formation and Nonenzymatic Protein Folding

(2010) Douglas S. Rehder et al.   BIOCHEMISTRY

Mechanism of genotoxicity induced by targeted cytoplasmic irradiation

(2010) M Hong et al.   BRITISH JOURNAL OF CANCER

Mitochondrial ROS and radiation induced transformation in mouse embryonic fibroblasts

(2010) Changbin Du et al.   CANCER BIOLOGY & THERAPY

Role of H2O2 in RET/PTC1 Chromosomal Rearrangement Produced by Ionizing Radiation in Human Thyroid Cells

(2010) R. Ameziane-El-Hassani et al.   CANCER RESEARCH

Ionizing Radiation Activates the Nrf2 Antioxidant Response

(2010) J. T. McDonald et al.   CANCER RESEARCH

Proteomic approaches to the characterization of protein thiol modification

(2010) Edward T Chouchani et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Metabolomic studies of radiation-induced apoptosis of human leukocytes by capillary electrophoresis-mass spectrometry and flow cytometry: Adaptive cellular responses to ionizing radiation

(2010) Richard Lee et al.   ELECTROPHORESIS

Focus on Molecules: Methionine sulfoxide reductase A

(2010) Marc Kantorow et al.   EXPERIMENTAL EYE RESEARCH

DNA methylation profiling in cancer

(2010) Yutaka Kondo et al.   EXPERT REVIEWS IN MOLECULAR MEDICINE

Oxidative stress, inflammation, and cancer: How are they linked?

(2010) Simone Reuter et al.   FREE RADICAL BIOLOGY AND MEDICINE

Degradation and oxidation postmortem of myofibrillar proteins in porcine skeleton muscle revealed by high resolution mass spectrometric proteome analysis

(2010) Bogdan Bernevic et al.   INTERNATIONAL JOURNAL OF MASS SPECTROMETRY

Nuclear magnetic resonance spectroscopy-based metabonomic investigation of biochemical effects in serum of γ-irradiated mice

(2010) Ahmad Raza Khan et al.   INTERNATIONAL JOURNAL OF RADIATION BIOLOGY

Lipid raft localization of EGFR alters the response of cancer cells to the EGFR tyrosine kinase inhibitor gefitinib

(2010) Mary E. Irwin et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Chemical probes for analysis of carbonylated proteins: A review

(2010) Liang-Jun Yan et al.   JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES

Analysis of LC−MS Data for Characterizing the Metabolic Changes in Response to Radiation

(2010) Rency S. Varghese et al.   JOURNAL OF PROTEOME RESEARCH

NMR Metabolomic Profiling Reveals New Roles of SUMOylation in DNA Damage Response

(2010) Kristin E. Cano et al.   JOURNAL OF PROTEOME RESEARCH

Proteomic Identification of Carbonylated Proteins and Their Oxidation Sites

(2010) Ashraf G. Madian et al.   JOURNAL OF PROTEOME RESEARCH

Novel Oxidative Modifications in Redox-Active Cysteine Residues

(2010) Jaeho Jeong et al.   MOLECULAR & CELLULAR PROTEOMICS

Site-specific Phosphorylation Dynamics of the Nuclear Proteome during the DNA Damage Response

(2010) Martin V. Bennetzen et al.   MOLECULAR & CELLULAR PROTEOMICS

Human serum albumin modifications associated with reductive radical stress

(2010) Anna Maria Salzano et al.   Molecular BioSystems

Plasma membrane signaling induced by ionizing radiation

(2010) Isabelle Corre et al.   MUTATION RESEARCH-REVIEWS IN MUTATION RESEARCH

53BP1-dependent robust localized KAP-1 phosphorylation is essential for heterochromatic DNA double-strand break repair

(2010) Angela T. Noon et al.   NATURE CELL BIOLOGY

Global analysis of CpG methylation reveals epigenetic control of the radiosensitivity in lung cancer cell lines

(2010) E-H Kim et al.   ONCOGENE

Reductive Ligation Mediated One-Step Disulfide Formation ofS-Nitrosothiols

(2010) Jiming Zhang et al.   ORGANIC LETTERS

Phosphoproteomics Profiling of Human Skin Fibroblast Cells Reveals Pathways and Proteins Affected by Low Doses of Ionizing Radiation

(2010) Feng Yang et al.   PLoS One

Pathology tissue-chromatin immunoprecipitation, coupled with high-throughput sequencing, allows the epigenetic profiling of patient samples

(2010) M. Fanelli et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Protein damage and death by radiation in Escherichia coli and Deinococcus radiodurans

(2010) A. Krisko et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Sensitivity to Low-Dose/Low-LET Ionizing Radiation in Mammalian Cells Harboring Mutations in Succinate Dehydrogenase Subunit C is Governed by Mitochondria-Derived Reactive Oxygen Species

(2010) Nukhet Aykin-Burns et al.   RADIATION RESEARCH

ATM Activation by Oxidative Stress

(2010) Z. Guo et al.   SCIENCE

ATM-Dependent and -Independent Dynamics of the Nuclear Phosphoproteome After DNA Damage

(2010) A. Bensimon et al.   Science Signaling

Use of γH2AX and Other Biomarkers of Double-Strand Breaks During Radiotherapy

(2010) Ali Sak et al.   SEMINARS IN RADIATION ONCOLOGY

Elementary Lesions in DNA Subunits: Electron, Hydrogen Atom, Proton, and Hydride Transfers

(2009) Richard H. Duncan Lyngdoh et al.   ACCOUNTS OF CHEMICAL RESEARCH

Mining the Thiol Proteome for Sulfenic Acid Modifications Reveals New Targets for Oxidation in Cells

(2009) Stephen E. Leonard et al.   ACS Chemical Biology

Orchestrating Redox Signaling Networks through Regulatory Cysteine Switches

(2009) Candice E. Paulsen et al.   ACS Chemical Biology

Coupling oxidative signals to protein phosphorylation via methionine oxidation inArabidopsis

(2009) Shane C. Hardin et al.   BIOCHEMICAL JOURNAL

Radiation Chemical Studies of Methionine in Aqueous Solution: Understanding the Role of Molecular Oxygen

(2009) Sebastián Barata-Vallejo et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Fluorogenic Tagging of Peptide and Protein 3-Nitrotyrosine with 4-(Aminomethyl)benzenesulfonic Acid for Quantitative Analysis of Protein Tyrosine Nitration

(2009) Victor S. Sharov et al.   CHROMATOGRAPHIA

Protein carbonylation: 2,4-dinitrophenylhydrazine reacts with both aldehydes/ketones and sulfenic acids

(2009) Isabella Dalle-Donne et al.   FREE RADICAL BIOLOGY AND MEDICINE

Formation of a Stabilized Cysteine Sulfinic Acid Is Critical for the Mitochondrial Function of the Parkinsonism Protein DJ-1

(2009) Jeff Blackinton et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Bond Breaks of Nucleotides by Dissociative Electron Transfer of Nonequilibrium Prehydrated Electrons: A New Molecular Mechanism for Reductive DNA Damage

(2009) Chun-Rong Wang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Proteomic analysis of S-nitrosylation and denitrosylation by resin-assisted capture

(2009) Michael T Forrester et al.   NATURE BIOTECHNOLOGY

Rules Governing Selective Protein Carbonylation

(2009) Etienne Maisonneuve et al.   PLoS One

Quantifying the global cellular thiol-disulfide status

(2009) R. E. Hansen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Profiling protein thiol oxidation in tumor cells using sulfenic acid-specific antibodies

(2009) Y. H. Seo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Radiation Nephropathy is not Mitigated by Antagonists of Oxidative Stress

(2009) Eric P. Cohen et al.   RADIATION RESEARCH

Radiation Metabolomics. 2. Dose- and Time-Dependent Urinary Excretion of Deaminated Purines and Pyrimidines after Sublethal Gamma-Radiation Exposure in Mice

(2009) John B. Tyburski et al.   RADIATION RESEARCH

Radiation Metabolomics. 3. Biomarker Discovery in the Urine of Gamma-Irradiated Rats Using a Simplified Metabolomics Protocol of Gas Chromatography-Mass Spectrometry Combined with Random Forests Machine Learning Algorithm

(2009) Christian Lanz et al.   RADIATION RESEARCH

Genetic variants and normal tissue toxicity after radiotherapy: A systematic review

(2009) Christian Nicolaj Andreassen et al.   RADIOTHERAPY AND ONCOLOGY

Protein carbonylation: avoiding pitfalls in the 2,4-dinitrophenylhydrazine assay

(2009) Shen Luo et al.   REDOX REPORT

Genetic variations in DNA repair genes, radiosensitivity to cancer and susceptibility to acute tissue reactions in radiotherapy-treated cancer patients

(2008) Dimitry A. Chistiakov et al.   ACTA ONCOLOGICA

UPLC-ESI-TOFMS-Based Metabolomics and Gene Expression Dynamics Inspector Self-Organizing Metabolomic Maps as Tools for Understanding the Cellular Response to Ionizing Radiation

(2008) Andrew D. Patterson et al.   ANALYTICAL CHEMISTRY

Development of a Selective ESI-MS Derivatization Reagent: Synthesis and Optimization for the Analysis of Aldehydes in Biological Mixtures

(2008) Mark Eggink et al.   ANALYTICAL CHEMISTRY

Characterization of 4-Hydroxy-2-nonenal-Modified Peptides by Liquid Chromatography−Tandem Mass Spectrometry Using Data-Dependent Acquisition: Neutral Loss-Driven MS3versus Neutral Loss-Driven Electron Capture Dissociation

(2008) Navin Rauniyar et al.   ANALYTICAL CHEMISTRY

Fast Reductive Ligation ofS-Nitrosothiols

(2008) Hua Wang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Marked difference in cytochrome c oxidation mediated by HO· and/or O2·− free radicals in vitro

(2008) Juliette Thariat et al.   BIOCHIMIE

Facile synthesis and biological evaluation of a cell-permeable probe to detect redox-regulated proteins

(2008) Young Ho Seo et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Matrix Metalloproteinase-9 Is Required for Tumor Vasculogenesis but Not for Angiogenesis: Role of Bone Marrow-Derived Myelomonocytic Cells

(2008) G-One Ahn et al.   CANCER CELL

Differential Effects of Methionine and Cysteine Oxidation on [Ca2+]i in Cultured Hippocampal Neurons

(2008) Li-Hong Long et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

Inflammation and Chronic Oxidative Stress in Radiation-Induced Late Normal Tissue Injury: Therapeutic Implications

(2008) Weiling Zhao et al.   CURRENT MEDICINAL CHEMISTRY

Discovering mechanisms of signaling-mediated cysteine oxidation

(2008) Leslie B Poole et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Detection of carbonyl-modified proteins in interfibrillar rat mitochondria usingN′-aminooxymethylcarbonylhydrazino-D-biotin as an aldehyde/keto-reactive probe in combination with Western blot analysis and tandem mass spectrometry

(2008) Woon-Gye Chung et al.   ELECTROPHORESIS

Methionine in proteins defends against oxidative stress

(2008) Shen Luo et al.   FASEB JOURNAL

NADPH oxidase mediates radiation-induced oxidative stress in rat brain microvascular endothelial cells

(2008) J. Racquel Collins-Underwood et al.   FREE RADICAL BIOLOGY AND MEDICINE

Copper dependence of the biotin switch assay: Modified assay for measuring cellular and blood nitrosated proteins

(2008) Xunde Wang et al.   FREE RADICAL BIOLOGY AND MEDICINE

Redox-based regulation of signal transduction: Principles, pitfalls, and promises

(2008) Yvonne M.W. Janssen-Heininger et al.   FREE RADICAL BIOLOGY AND MEDICINE

Thiol chemistry and specificity in redox signaling

(2008) Christine C. Winterbourn et al.   FREE RADICAL BIOLOGY AND MEDICINE

Malondialdehyde, carbonyl proteins and albumin-disulphide as useful oxidative markers in mild cognitive impairment and Alzheimer's disease

(2008) J. Greilberger et al.   FREE RADICAL RESEARCH

The AT1 Receptor Antagonist, L-158,809, Prevents or Ameliorates Fractionated Whole-Brain Irradiation–Induced Cognitive Impairment

(2008) Mike E. Robbins et al.   INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS

Identification of Intact Protein Thiosulfinate Intermediate in the Reduction of Cysteine Sulfinic Acid in Peroxiredoxin by Human Sulfiredoxin

(2008) Thomas J. Jönsson et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Reductive Desulfurization of Met and Cys Residues in Bovine RNase A Is Associated withtransLipids Formation in a Mimetic Model of Biological Membranes

(2008) Carla Ferreri et al.   JOURNAL OF PROTEOME RESEARCH

Proteomic Analysis of Ionizing Radiation-Induced Proteins at the Subcellular Level

(2008) Ru-Xian Lin et al.   JOURNAL OF PROTEOME RESEARCH

A chemical approach for detecting sulfenic acid-modified proteins in living cells

(2008) Khalilah G. Reddie et al.   Molecular BioSystems

ATM Signaling Facilitates Repair of DNA Double-Strand Breaks Associated with Heterochromatin

(2008) Aaron A. Goodarzi et al.   MOLECULAR CELL

Quantifying changes in the thiol redox proteome upon oxidative stress in vivo

(2008) L. I. Leichert et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Functional site profiling and electrostatic analysis of cysteines modifiable to cysteine sulfenic acid

(2008) Freddie R. Salsbury et al.   PROTEIN SCIENCE

Radiation Metabolomics. 1. Identification of Minimally Invasive Urine Biomarkers for Gamma-Radiation Exposure in Mice

(2008) John B. Tyburski et al.   RADIATION RESEARCH

Refinement of the Dichlorofluorescein Assay for Flow Cytometric Measurement of Reactive Oxygen Species in Irradiated and Bystander Cell Populations

(2008) Kurt Hafer et al.   RADIATION RESEARCH

Differential regulation of cell death in head and neck cell carcinoma through alteration of cholesterol levels in lipid rafts microdomains

(2007) Clara Bionda et al.   BIOCHEMICAL PHARMACOLOGY

A novel role for protein kinase Cδ-mediated phosphorylation of acid sphingomyelinase in UV light-induced mitochondrial injury

(2007) Youssef H. Zeidan et al.   FASEB JOURNAL

Captopril to Mitigate Chronic Renal Failure After Hematopoietic Stem Cell Transplantation: A Randomized Controlled Trial

(2007) Eric P. Cohen et al.   INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS