Iron in Neurodegenerative Disorders of Protein Misfolding: A Case of Prion Disorders and Parkinson's Disease

Prion Protein Regulates Iron Transport by Functioning as a Ferrireductase

(2018) Ajay Singh et al.   JOURNAL OF ALZHEIMERS DISEASE

A Low-Molecular-Weight Ferroxidase Is Increased in the CSF of sCJD Cases: CSF Ferroxidase and Transferrin as Diagnostic Biomarkers for sCJD

(2013) Swati Haldar et al.   ANTIOXIDANTS & REDOX SIGNALING

Prion protein conversion induced by trivalent iron in vesicular trafficking

(2013) Bo-Ran Choi et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

TOM40 Mediates Mitochondrial Dysfunction Induced by α-Synuclein Accumulation in Parkinson’s Disease

(2013) Andreas Bender et al.   PLoS One

Prions disturb post-Golgi trafficking of membrane proteins

(2013) Keiji Uchiyama et al.   Nature Communications

A delicate balance: Iron metabolism and diseases of the brain

(2013) Dominic Hare et al.   Frontiers in Aging Neuroscience

Isoform specific regulation of divalent metal (ion) transporter (DMT1) by proteasomal degradation

(2012) Michael D. Garrick et al.   BIOMETALS

The dopamine metabolite aminochrome inhibits mitochondrial complex I and modifies the expression of iron transporters DMT1 and FPN1

(2012) Pabla Aguirre et al.   BIOMETALS

Mitochondrial dysfunction in Parkinson's disease: molecular mechanisms and pathophysiological consequences

(2012) Nicole Exner et al.   EMBO JOURNAL

Mitochondrial metabolism in Parkinson's disease impairs quality control autophagy by hampering microtubule-dependent traffic

(2012) Daniela M. Arduíno et al.   HUMAN MOLECULAR GENETICS

Development and Characterization of a New Parkinson's Disease Model Resulting from Impaired Autophagy

(2012) I. Ahmed et al.   JOURNAL OF NEUROSCIENCE

The neuropathology of genetic Parkinson's disease

(2012) Markos Poulopoulos et al.   MOVEMENT DISORDERS

Prion propagation, toxicity and degradation

(2012) Adriano Aguzzi et al.   NATURE NEUROSCIENCE

Update on Genetics of Parkinsonism

(2012) Shinsuke Fujioka et al.   Neurodegenerative Diseases

α-Synuclein expression is modulated at the translational level by iron

(2012) Fabia Febbraro et al.   NEUROREPORT

Kinases and kinase signaling pathways: Potential therapeutic targets in Parkinson's disease

(2012) Gang Wang et al.   PROGRESS IN NEUROBIOLOGY

Pathological  -Synuclein Transmission Initiates Parkinson-like Neurodegeneration in Nontransgenic Mice

(2012) K. C. Luk et al.   SCIENCE

Mitochondrial Quality Control Mediated by PINK1 and Parkin: Links to Parkinsonism

(2012) D. Narendra et al.   Cold Spring Harbor Perspectives in Biology

Pathogenic protein seeding in alzheimer disease and other neurodegenerative disorders

(2011) Mathias Jucker et al.   ANNALS OF NEUROLOGY

Mitochondrial Dysfunction in Genetic Animal Models of Parkinson's Disease

(2011) Alzbeta Trancikova et al.   ANTIOXIDANTS & REDOX SIGNALING

Effect of mitochondrial complex I inhibition on Fe–S cluster protein activity

(2011) Natalia P. Mena et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

α-Synuclein Aggregation and Transmission Are Enhanced by Leucine-Rich Repeat Kinase 2 in Human Neuroblastoma SH-SY5Y Cells

(2011) Kazunari Kondo et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

Expression of divalent metal transporter 1 in primary hippocampal neurons: reconsidering its role in non-transferrin-bound iron influx

(2011) Ilaria Pelizzoni et al.   JOURNAL OF NEUROCHEMISTRY

Prion protein expression level alters regional copper, iron and zinc content in the mouse brain

(2011) M. Jake Pushie et al.   Metallomics

Milestones in PD genetics

(2011) Thomas Gasser et al.   MOVEMENT DISORDERS

Change in the characteristics of ferritin induces iron imbalance in prion disease affected brains

(2011) Ajay Singh et al.   NEUROBIOLOGY OF DISEASE

Changes in iron-regulatory gene expression occur in human cell culture models of Parkinson’s disease

(2011) C.B. Carroll et al.   NEUROCHEMISTRY INTERNATIONAL

Decreased CSF Transferrin in sCJD: A Potential Pre-Mortem Diagnostic Test for Prion Disorders

(2011) Ajay Singh et al.   PLoS One

Alpha-Synuclein Is a Cellular Ferrireductase

(2011) Paul Davies et al.   PLoS One

Ultra-Efficient PrPSc Amplification Highlights Potentialities and Pitfalls of PMCA Technology

(2011) Gian Mario Cosseddu et al.   PLoS Pathogens

Could a dysfunction of ferritin be a determinant factor in the aetiology of some neurodegenerative diseases?

(2010) Carmen Quintana et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

The Parkinson-associated protein PINK1 interacts with Beclin1 and promotes autophagy

(2010) S Michiorri et al.   CELL DEATH AND DIFFERENTIATION

Up-regulation of divalent metal transporter 1 in 6-hydroxydopamine intoxication is IRE/IRP dependent

(2010) Hong Jiang et al.   CELL RESEARCH

Inhibition of mitochondrial fusion by α-synuclein is rescued by PINK1, Parkin and DJ-1

(2010) Frits Kamp et al.   EMBO JOURNAL

Loss of the Parkinson's disease-linked gene DJ-1 perturbs mitochondrial dynamics

(2010) I. Irrcher et al.   HUMAN MOLECULAR GENETICS

The Transgenic Overexpression of α-Synuclein and Not Its Related Pathology Associates with Complex I Inhibition

(2010) Virginie Loeb et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

α-Synuclein impairs macroautophagy: implications for Parkinson’s disease

(2010) Ashley R. Winslow et al.   JOURNAL OF CELL BIOLOGY

Parkin regulates metal transport via proteasomal degradation of the 1B isoforms of divalent metal transporter 1

(2010) Jerome A. Roth et al.   JOURNAL OF NEUROCHEMISTRY

The relevance of iron in the pathogenesis of Parkinson’s disease

(2010) Jeswinder Sian-Hülsmann et al.   JOURNAL OF NEUROCHEMISTRY

Missing pieces in the Parkinson's disease puzzle

(2010) Jose A Obeso et al.   NATURE MEDICINE

Protein aggregation diseases: pathogenicity and therapeutic perspectives

(2010) Adriano Aguzzi et al.   NATURE REVIEWS DRUG DISCOVERY

Mitochondrial alpha-synuclein accumulation impairs complex I function in dopaminergic neurons and results in increased mitophagy in vivo

(2010) Shankar J. Chinta et al.   NEUROSCIENCE LETTERS

Mechanisms of rotenone-induced proteasome inhibition

(2010) Arthur P. Chou et al.   NEUROTOXICOLOGY

Paradoxical Role of Prion Protein Aggregates in Redox-Iron Induced Toxicity

(2010) Dola Das et al.   PLoS One

Biological metals and Alzheimer's disease: Implications for therapeutics and diagnostics

(2010) James A. Duce et al.   PROGRESS IN NEUROBIOLOGY

Comparative profiling of highly enriched 22L and Chandler mouse scrapie prion protein preparations

(2010) Roger A. Moore et al.   PROTEOMICS

Generating a Prion with Bacterially Expressed Recombinant Prion Protein

(2010) F. Wang et al.   SCIENCE

Iron content of ferritin modulates its uptake by intestinal epithelium: implications for co-transport of prions

(2010) Solomon RB Sunkesula et al.   Molecular Brain

Getting a Grip on Prions: Oligomers, Amyloids, and Pathological Membrane Interactions

(2009) Byron Caughey et al.   Annual Review of Biochemistry

A Disruption in Iron-Sulfur Center Biogenesis via Inhibition of Mitochondrial Dithiol Glutaredoxin 2 May Contribute to Mitochondrial and Cellular Iron Dysregulation in Mammalian Glutathione-Depleted Dopaminergic Cells: Implications for Parkinson's Disease

(2009) Donna W. Lee et al.   ANTIOXIDANTS & REDOX SIGNALING

Redox Control of Prion and Disease Pathogenesis

(2009) Neena Singh et al.   ANTIOXIDANTS & REDOX SIGNALING

Autophagy induction by trehalose counter-acts cellular prion-infection

(2009) Yasmine Aguib et al.   Autophagy

Mitochondrial dysfunction in Parkinson's disease

(2009) Konstanze F. Winklhofer et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

LRRK2 enhances oxidative stress-induced neurotoxicity via its kinase activity

(2009) Hye Young Heo et al.   EXPERIMENTAL CELL RESEARCH

Ferroportin 1 but not hephaestin contributes to iron accumulation in a cell model of Parkinson's disease

(2009) Ning Song et al.   FREE RADICAL BIOLOGY AND MEDICINE

Leucine-rich repeat kinase 2 interacts with Parkin, DJ-1 and PINK-1 in a Drosophila melanogaster model of Parkinson's disease

(2009) K. Venderova et al.   HUMAN MOLECULAR GENETICS

Alpha-synuclein overexpression and aggregation exacerbates impairment of mitochondrial functions by augmenting oxidative stress in human neuroblastoma cells

(2009) Mordhwaj S. Parihar et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Binding of α-synuclein with Fe(III) and with Fe(II) and biological implications of the resultant complexes

(2009) Yong Peng et al.   JOURNAL OF INORGANIC BIOCHEMISTRY

Lithium induces clearance of protease resistant prion protein in prion-infected cells by induction of autophagy

(2009) Andreas Heiseke et al.   JOURNAL OF NEUROCHEMISTRY

Parkin Protects against LRRK2 G2019S Mutant-Induced Dopaminergic Neurodegeneration in Drosophila

(2009) C.-H. Ng et al.   JOURNAL OF NEUROSCIENCE

α-Synuclein is differentially expressed in mitochondria from different rat brain regions and dose-dependently down-regulates complex I activity

(2009) Guangwei Liu et al.   NEUROSCIENCE LETTERS

Prions: Protein Aggregation and Infectious Diseases

(2009) Adriano Aguzzi et al.   PHYSIOLOGICAL REVIEWS

Prion Protein Modulates Cellular Iron Uptake: A Novel Function with Implications for Prion Disease Pathogenesis

(2009) Ajay Singh et al.   PLoS One

Prion Protein (PrP) Knock-Out Mice Show Altered Iron Metabolism: A Functional Role for PrP in Iron Uptake and Transport

(2009) Ajay Singh et al.   PLoS One

Human variant Creutzfeldt-Jakob disease and sheep scrapie PrPres detection using seeded conversion of recombinant prion protein

(2009) C. D. Orru et al.   PROTEIN ENGINEERING DESIGN & SELECTION

Abnormal Brain Iron Homeostasis in Human and Animal Prion Disorders

(2009) Ajay Singh et al.   PLoS Pathogens

Redox imbalance in Parkinson's disease

(2008) Shankar J. Chinta et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Amyloid precursor protein and alpha synuclein translation, implications for iron and inflammation in neurodegenerative diseases

(2008) Catherine M. Cahill et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Mitochondrial association of alpha-synuclein causes oxidative stress

(2008) M. S. Parihar et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Dcytb (Cybrd1) functions as both a ferric and a cupric reductase in vitro

(2008) Steven Wyman et al.   FEBS LETTERS

Single Particle Characterization of Iron-induced Pore-forming α-Synuclein Oligomers

(2008) Marcus Kostka et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mitochondrial Import and Accumulation of α-Synuclein Impair Complex I in Human Dopaminergic Neuronal Cultures and Parkinson Disease Brain

(2008) Latha Devi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Neuroprotective actions of deferiprone in cultured cortical neurones and SHSY-5Y cells

(2008) Francisco Molina-Holgado et al.   JOURNAL OF NEUROCHEMISTRY

Pathogenic mutations in the glycosylphosphatidylinositol signal peptide of PrP modulate its topology in neuroblastoma cells

(2008) Yaping Gu et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Midbrain iron content in early Parkinson disease: A potential biomarker of disease status

(2008) W. R. W. Martin et al.   NEUROLOGY

Mitochondrial localization of alpha-synuclein protein in alpha-synuclein overexpressing cells

(2008) Shaik Shavali et al.   NEUROSCIENCE LETTERS

GATA transcription factors directly regulate the Parkinson's disease-linked gene  -synuclein

(2008) C. R. Scherzer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Divalent metal transporter 1 (DMT1) contributes to neurodegeneration in animal models of Parkinson's disease

(2008) J. Salazar et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mitochondrial biology and oxidative stress in Parkinson disease pathogenesis

(2008) Claire Henchcliffe et al.   Nature clinical practice. Neurology

Neuroprotective effect of the natural iron chelator, phytic acid in a cell culture model of Parkinson's disease

(2007) Qi Xu et al.   TOXICOLOGY