Endoplasmic Reticulum Stress and the Unfolded Protein Response in Nonalcoholic Fatty Liver Disease

Pathways underlying iron accumulation in human nonalcoholic fatty liver disease

(2018) Elmar Aigner et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Nonalcoholic Fatty Liver Disease in Humans Is Associated with Increased Plasma Endotoxin and Plasminogen Activator Inhibitor 1 Concentrations and with Fructose Intake

(2018) Sabine Thuy et al.   JOURNAL OF NUTRITION

Regulation of ER stress-induced macroautophagy by protein kinase C

(2014) Kenjiro Sakaki et al.   Autophagy

Linking endoplasmic reticulum stress to cell death in hepatocytes: roles of C/EBP homologous protein and chemical chaperones in palmitate-mediated cell death

(2010) Kyle T. Pfaffenbach et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Double-Stranded RNA-Dependent Protein Kinase Links Pathogen Sensing with Stress and Metabolic Homeostasis

(2010) Takahisa Nakamura et al.   CELL

Endoplasmic Reticulum Stress and the Inflammatory Basis of Metabolic Disease

(2010) Gökhan S. Hotamisligil   CELL

Circadian Clock-Coordinated 12 Hr Period Rhythmic Activation of the IRE1α Pathway Controls Lipid Metabolism in Mouse Liver

(2010) Gaspard Cretenet et al.   Cell Metabolism

Insulin Resistance in Nonalcoholic Fatty Liver Disease

(2010) E. Bugianesi et al.   CURRENT PHARMACEUTICAL DESIGN

Intrahepatic cholesterol influences progression, inhibition and reversal of non-alcoholic steatohepatitis in hyperlipidemic mice

(2010) Kristiaan Wouters et al.   FEBS LETTERS

Calcium as a Crucial Cofactor for Low Density Lipoprotein Receptor Folding in the Endoplasmic Reticulum

(2010) Florentina Pena et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Distinct gene expression profiles characterize cellular responses to palmitate and oleate

(2010) Swapan K. Das et al.   JOURNAL OF LIPID RESEARCH

Rapamycin Inhibits Postprandial-Mediated X-Box-Binding Protein-1 Splicing in Rat Liver

(2010) Kyle T. Pfaffenbach et al.   JOURNAL OF NUTRITION

Flavonol Activation Defines an Unanticipated Ligand-Binding Site in the Kinase-RNase Domain of IRE1

(2010) R. Luke Wiseman et al.   MOLECULAR CELL

A regulatory subunit of phosphoinositide 3-kinase increases the nuclear accumulation of X-box–binding protein-1 to modulate the unfolded protein response

(2010) Jonathon N Winnay et al.   NATURE MEDICINE

The regulatory subunits of PI3K, p85α and p85β, interact with XBP-1 and increase its nuclear translocation

(2010) Sang Won Park et al.   NATURE MEDICINE

Hepatic Gene Networks in Morbidly Obese Patients With Nonalcoholic Fatty Liver Disease

(2010) Samer Gawrieh et al.   OBESITY SURGERY

Predicting Fibrosis Worsening in Obese Patients With NASH Through Parenchymal Fibronectin, HOMA-IR and Hypertension

(2009) Paolo Sorrentino et al.   AMERICAN JOURNAL OF GASTROENTEROLOGY

Hexosamine biosynthesis pathway flux promotes endoplasmic reticulum stress, lipid accumulation, and inflammatory gene expression in hepatic cells

(2009) Andrew T Sage et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Deletion of nuclear factor-E2-related factor-2 leads to rapid onset and progression of nutritional steatohepatitis in mice

(2009) Hirokazu Sugimoto et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

From Sugar to Fat

(2009) Laurie H. Glimcher et al.   Annals of the New York Academy of Sciences

Mechanisms and Implications of Reactive Oxygen Species Generation During the Unfolded Protein Response: Roles of Endoplasmic Reticulum Oxidoreductases, Mitochondrial Electron Transport, and NADPH Oxidase

(2009) Célio X.C. Santos et al.   ANTIOXIDANTS & REDOX SIGNALING

Oxidative Folding: Cellular Strategies for Dealing with the Resultant Equimolar Production of Reactive Oxygen Species

(2009) Yuichiro Shimizu et al.   ANTIOXIDANTS & REDOX SIGNALING

Effects of weight loss on liver and erythrocyte polyunsaturated fatty acid pattern and oxidative stress status in obese patients with non-alcoholic fatty liver disease

(2009) ALEJANDRA ELIZONDO et al.   BIOLOGICAL RESEARCH

Induction of Hepatitis by JNK-Mediated Expression of TNF-α

(2009) Madhumita Das et al.   CELL

Preventing oxidative stress: a new role for XBP1

(2009) Y Liu et al.   CELL DEATH AND DIFFERENTIATION

The IRE1α-XBP1 Pathway of the Unfolded Protein Response Is Required for Adipogenesis

(2009) Haibo Sha et al.   Cell Metabolism

Prevention of Steatosis by Hepatic JNK1

(2009) Guadalupe Sabio et al.   Cell Metabolism

IRE-1 and HSP-4 Contribute to Energy Homeostasis via Fasting-Induced Lipases in C. elegans

(2009) Hyunsun Jo et al.   Cell Metabolism

Repression of PKR mediates palmitate-induced apoptosis in HepG2 cells through regulation of Bcl-2

(2009) Xuerui Yang et al.   CELL RESEARCH

Predictors of Steatohepatitis and Advanced Fibrosis in Non-Alcoholic Fatty Liver Disease

(2009) Mangesh Pagadala et al.   Clinics in Liver Disease

Role of Insulin Resistance and Lipotoxicity in Non-Alcoholic Steatohepatitis

(2009) Kenneth Cusi   Clinics in Liver Disease

Apoptosis and Cytokines in Non-Alcoholic Steatohepatitis

(2009) Wing-Kin Syn et al.   Clinics in Liver Disease

Epidemiology and Natural History of Non-Alcoholic Steatohepatitis

(2009) Curtis K. Argo et al.   Clinics in Liver Disease

Grp78 Heterozygosity Promotes Adaptive Unfolded Protein Response and Attenuates Diet-Induced Obesity and Insulin Resistance

(2009) R. Ye et al.   DIABETES

Atf4 Regulates Obesity, Glucose Homeostasis, and Energy Expenditure

(2009) J. Seo et al.   DIABETES

Increased intestinal permeability and tight junction alterations in nonalcoholic fatty liver disease

(2009) Luca Miele et al.   HEPATOLOGY

Apolipoprotein B100 acts as a molecular link between lipid-induced endoplasmic reticulum stress and hepatic insulin resistance

(2009) Qiaozhu Su et al.   HEPATOLOGY

Hepatic Lipid Partitioning and Liver Damage in Nonalcoholic Fatty Liver Disease

(2009) Zheng Zheng Li et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Adipocyte Apoptosis, a Link between Obesity, Insulin Resistance, and Hepatic Steatosis

(2009) Naim Alkhouri et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Role of ERO1-α–mediated stimulation of inositol 1,4,5-triphosphate receptor activity in endoplasmic reticulum stress–induced apoptosis

(2009) Gang Li et al.   JOURNAL OF CELL BIOLOGY

GRP78 expression inhibits insulin and ER stress–induced SREBP-1c activation and reduces hepatic steatosis in mice

(2009) Hélène L. Kammoun et al.   JOURNAL OF CLINICAL INVESTIGATION

Activation of the Akt-NF- B Pathway by Subtilase Cytotoxin through the ATF6 Branch of the Unfolded Protein Response

(2009) H. Yamazaki et al.   JOURNAL OF IMMUNOLOGY

Glucosamine-induced endoplasmic reticulum stress attenuates apolipoprotein B100 synthesis via PERK signaling

(2009) Wei Qiu et al.   JOURNAL OF LIPID RESEARCH

Depletion of phosphatidylcholine affects endoplasmic reticulum morphology and protein traffic at the Golgi complex

(2009) Nicole Testerink et al.   JOURNAL OF LIPID RESEARCH

Reduced endoplasmic reticulum luminal calcium links saturated fatty acid-mediated endoplasmic reticulum stress and cell death in liver cells

(2009) Yuren Wei et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

BAX Inhibitor-1 Is a Negative Regulator of the ER Stress Sensor IRE1α

(2009) Fernanda Lisbona et al.   MOLECULAR CELL

Fine-Tuning of the Unfolded Protein Response: Assembling the IRE1α Interactome

(2009) Claudio Hetz et al.   MOLECULAR CELL

CHOP-independent apoptosis and pathway-selective induction of the UPR in developing plasma cells

(2009) Silvia Masciarelli et al.   MOLECULAR IMMUNOLOGY

Autophagy regulates lipid metabolism

(2009) Rajat Singh et al.   NATURE

Adaptive suppression of the ATF4–CHOP branch of the unfolded protein response by toll-like receptor signalling

(2009) Connie W. Woo et al.   NATURE CELL BIOLOGY

ER Stress-Inducible Factor CHOP Affects the Expression of Hepcidin by Modulating C/EBPalpha Activity

(2009) Susana J. Oliveira et al.   PLoS One

ER Stress Controls Iron Metabolism Through Induction of Hepcidin

(2009) C. Vecchi et al.   SCIENCE

Effect of pioglitazone treatment on endoplasmic reticulum stress response in human adipose and in palmitate-induced stress in human liver and adipose cell lines

(2008) Swapan K. Das et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

CHOP deficiency attenuates cholestasis-induced liver fibrosis by reduction of hepatocyte injury

(2008) Nobuyuki Tamaki et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Autophagy in the Pathogenesis of Disease

(2008) Beth Levine et al.   CELL

Loss of Autophagy Diminishes Pancreatic β Cell Mass and Function with Resultant Hyperglycemia

(2008) Hye Seung Jung et al.   Cell Metabolism

Dephosphorylation of Translation Initiation Factor 2α Enhances Glucose Tolerance and Attenuates Hepatosteatosis in Mice

(2008) Seiichi Oyadomari et al.   Cell Metabolism

UPR Pathways Combine to Prevent Hepatic Steatosis Caused by ER Stress-Mediated Suppression of Transcriptional Master Regulators

(2008) D. Thomas Rutkowski et al.   DEVELOPMENTAL CELL

Endoplasmic Reticulum Stress Is Reduced in Tissues of Obese Subjects After Weight Loss

(2008) M. F. Gregor et al.   DIABETES

Increase in Endoplasmic Reticulum Stress-Related Proteins and Genes in Adipose Tissue of Obese, Insulin-Resistant Individuals

(2008) G. Boden et al.   DIABETES

Liver, Muscle, and Adipose Tissue Insulin Action Is Directly Related to Intrahepatic Triglyceride Content in Obese Subjects

(2008) Kevin M. Korenblat et al.   GASTROENTEROLOGY

Hepatocyte nuclear factor 4α is implicated in endoplasmic reticulum stress-induced acute phase response by regulating expression of cyclic adenosine monophosphate responsive element binding protein H

(2008) Jennifer Luebke-Wheeler et al.   HEPATOLOGY

Analysis of hepatic genes involved in the metabolism of fatty acids and iron in nonalcoholic fatty liver disease

(2008) Hironori Mitsuyoshi et al.   HEPATOLOGY RESEARCH

Genetic Delineation of the Pathways Mediated by Bid and JNK in Tumor Necrosis Factor-α-induced Liver Injury in Adult and Embryonic Mice

(2008) Hong-Min Ni et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Endoplasmic Reticulum Stress Markers Are Associated with Obesity in Nondiabetic Subjects

(2008) Neeraj K. Sharma et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Inhibition of apolipoprotein B100 secretion by lipid-induced hepatic endoplasmic reticulum stress in rodents

(2008) Tsuguhito Ota et al.   JOURNAL OF CLINICAL INVESTIGATION

Chop deletion reduces oxidative stress, improves β cell function, and promotes cell survival in multiple mouse models of diabetes

(2008) Benbo Song et al.   JOURNAL OF CLINICAL INVESTIGATION

Dissection of endoplasmic reticulum stress signaling in alcoholic and non-alcoholic liver injury

(2008) Cheng Ji   JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY

Loss of the Tuberous Sclerosis Complex Tumor Suppressors Triggers the Unfolded Protein Response to Regulate Insulin Signaling and Apoptosis

(2008) Umut Ozcan et al.   MOLECULAR CELL

From endoplasmic-reticulum stress to the inflammatory response

(2008) Kezhong Zhang et al.   NATURE

Cell death and endoplasmic reticulum stress: disease relevance and therapeutic opportunities

(2008) Inki Kim et al.   NATURE REVIEWS DRUG DISCOVERY

Membrane lipids: where they are and how they behave

(2008) Gerrit van Meer et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

PERK-dependent regulation of lipogenesis during mouse mammary gland development and adipocyte differentiation

(2008) E. Bobrovnikova-Marjon et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Antioxidants reduce endoplasmic reticulum stress and improve protein secretion

(2008) J. D. Malhotra et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Regulation of Hepatic Lipogenesis by the Transcription Factor XBP1

(2008) A.-H. Lee et al.   SCIENCE

Activation and Dysregulation of the Unfolded Protein Response in Nonalcoholic Fatty Liver Disease

(2007) Puneet Puri et al.   GASTROENTEROLOGY

Nutritional assessment and hepatic fatty acid composition in non-alcoholic fatty liver disease (NAFLD): A cross-sectional study

(2007) Johane P. Allard et al.   JOURNAL OF HEPATOLOGY