History of antibiotic adaptation influences microbial evolutionary dynamics during subsequent treatment

Evolution of Pseudomonas aeruginosa Antimicrobial Resistance and Fitness under Low and High Mutation Rates

(2016) Gabriel Cabot et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Dynamics of Mutations during Development of Resistance by Pseudomonas aeruginosa against Five Antibiotics

(2016) Yanfang Feng et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Contrasting effects of historical contingency on phenotypic and genomic trajectories during a two-step evolution experiment with bacteria

(2016) Jessica Plucain et al.   BMC EVOLUTIONARY BIOLOGY

Pyomelanin-producing Pseudomonas aeruginosa selected during chronic infections have a large chromosomal deletion which confers resistance to pyocins

(2016) Didier Hocquet et al.   ENVIRONMENTAL MICROBIOLOGY

Antibiotic resistance in Pseudomonas aeruginosa and alternative therapeutic options

(2016) Maitrayee Chatterjee et al.   INTERNATIONAL JOURNAL OF MEDICAL MICROBIOLOGY

Response of single bacterial cells to stress gives rise to complex history dependence at the population level

(2016) Roland Mathis et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Resistance fighters

(2016) K. Kupferschmidt   SCIENCE

Temporal variation in antibiotic environments slows down resistance evolution in pathogenicPseudomonas aeruginosa

(2015) Roderich Roemhild et al.   Evolutionary Applications

Collateral Resistance and Sensitivity Modulate Evolution of High-Level Resistance to Drug Combination Treatment in Staphylococcus aureus

(2015) Mari Rodriguez de Evgrafov et al.   MOLECULAR BIOLOGY AND EVOLUTION

Adaptive Landscapes of Resistance Genes Change as Antibiotic Concentrations Change

(2015) Portia M. Mira et al.   MOLECULAR BIOLOGY AND EVOLUTION

A new antibiotic kills pathogens without detectable resistance

(2015) Losee L. Ling et al.   NATURE

Elucidating the molecular architecture of adaptation via evolve and resequence experiments

(2015) Anthony Long et al.   NATURE REVIEWS GENETICS

Multidrug evolutionary strategies to reverse antibiotic resistance

(2015) M. Baym et al.   SCIENCE

Collateral sensitivity of antibiotic-resistant microbes

(2015) Csaba Pál et al.   TRENDS IN MICROBIOLOGY

Using a Sequential Regimen to Eliminate Bacteria at Sublethal Antibiotic Dosages

(2015) Ayari Fuentes-Hernandez et al.   PLOS BIOLOGY

Steering Evolution with Sequential Therapy to Prevent the Emergence of Bacterial Antibiotic Resistance

(2015) Daniel Nichol et al.   PLoS Computational Biology

Detecting rare structural variation in evolving microbial populations from new sequence junctions using breseq

(2015) Daniel E. Deatherage et al.   Frontiers in Genetics

Adaptive Resistance in Bacteria Requires Epigenetic Inheritance, Genetic Noise, and Cost of Efflux Pumps

(2015) Santiago Sandoval Motta et al.   PLoS One

Experimental evolution as an efficient tool to dissect adaptive paths to antibiotic resistance

(2014) Gunther Jansen et al.   DRUG RESISTANCE UPDATES

Strength of Selection Pressure Is an Important Parameter Contributing to the Complexity of Antibiotic Resistance Evolution

(2014) Tugce Oz et al.   MOLECULAR BIOLOGY AND EVOLUTION

Convergent evolution and adaptation of Pseudomonas aeruginosa within patients with cystic fibrosis

(2014) Rasmus Lykke Marvig et al.   NATURE GENETICS

Alternating antibiotic treatments constrain evolutionary paths to multidrug resistance

(2014) Seungsoo Kim et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Selection history and epistatic interactions impact dynamics of adaptation to novel environmental stresses

(2014) M. Lagator et al.   PROCEEDINGS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Prediction of resistance development against drug combinations by collateral responses to component drugs

(2014) C. Munck et al.   Science Translational Medicine

The effects of active efflux pumps on antibiotic resistance in Pseudomonas aeruginosa

(2014) Huseyin Agah Terzi et al.   WORLD JOURNAL OF MICROBIOLOGY & BIOTECHNOLOGY

Environmental Heterogeneity Drives Within-Host Diversification and Evolution of Pseudomonas aeruginosa

(2014) T. Markussen et al.   mBio

Prediction of antibiotic resistance by gene expression profiles

(2014) Shingo Suzuki et al.   Nature Communications

Genome-wide analysis captures the determinants of the antibiotic cross-resistance interaction network

(2014) Viktória Lázár et al.   Nature Communications

Coexistence and Within-Host Evolution of Diversified Lineages of Hypermutable Pseudomonas aeruginosa in Long-term Cystic Fibrosis Infections

(2014) Sofía Feliziani et al.   PLoS Genetics

Memory and Fitness Optimization of Bacteria under Fluctuating Environments

(2014) Guillaume Lambert et al.   PLoS Genetics

Cycling Empirical Antibiotic Therapy in Hospitals: Meta-Analysis and Models

(2014) Pia Abel zur Wiesch et al.   PLoS Pathogens

Functional characterization of the NfxB repressor of the mexCD-oprJ multidrug efflux operon of Pseudomonas aeruginosa

(2013) A. Purssell et al.   MICROBIOLOGY-SGM

Bacterial evolution of antibiotic hypersensitivity

(2013) V. Lazar et al.   Molecular Systems Biology

Understanding, predicting and manipulating the genotypic evolution of antibiotic resistance

(2013) Adam C. Palmer et al.   NATURE REVIEWS GENETICS

Use of Collateral Sensitivity Networks to Design Drug Cycling Protocols That Avoid Resistance Development

(2013) L. Imamovic et al.   Science Translational Medicine

Deletion and acquisition of genomic content during early stage adaptation of Pseudomonas aeruginosa to a human host environment

(2012) Martin H. Rau et al.   ENVIRONMENTAL MICROBIOLOGY

Genomic Variation among Contemporary Pseudomonas aeruginosa Isolates from Chronically Infected Cystic Fibrosis Patients

(2012) Jade C. S. Chung et al.   JOURNAL OF BACTERIOLOGY

A 9-Year retrospective review of antibiotic cycling in a surgical intensive care unit

(2012) Shiva Sarraf-Yazdi et al.   JOURNAL OF SURGICAL RESEARCH

Repeated, Selection-Driven Genome Reduction of Accessory Genes in Experimental Populations

(2012) Ming-Chun Lee et al.   PLoS Genetics

MexXY multidrug efflux system of Pseudomonas aeruginosa

(2012) Yuji Morita et al.   Frontiers in Microbiology

Creeping baselines and adaptive resistance to antibiotics

(2011) Lucía Fernández et al.   DRUG RESISTANCE UPDATES

Adaptive resistance to cationic compounds in Pseudomonas aeruginosa

(2011) Anna Skiada et al.   INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS

Microbial laboratory evolution in the era of genome-scale science

(2011) T. M. Conrad et al.   Molecular Systems Biology

Fix the antibiotics pipeline

(2011) Matthew A. Cooper et al.   NATURE

Evolutionary paths to antibiotic resistance under dynamically sustained drug selection

(2011) Erdal Toprak et al.   NATURE GENETICS

Pseudomonas Genome Database: improved comparative analysis and population genomics capability for Pseudomonas genomes

(2010) G. L. Winsor et al.   NUCLEIC ACIDS RESEARCH

Antibacterial-Resistant Pseudomonas aeruginosa: Clinical Impact and Complex Regulation of Chromosomally Encoded Resistance Mechanisms

(2009) P. D. Lister et al.   CLINICAL MICROBIOLOGY REVIEWS

Circos: An information aesthetic for comparative genomics

(2009) M. Krzywinski et al.   GENOME RESEARCH

Inactivation of the hmgA gene of Pseudomonas aeruginosa leads to pyomelanin hyperproduction, stress resistance and increased persistence in chronic lung infection

(2009) A. Rodriguez-Rojas et al.   MICROBIOLOGY-SGM

Novel Genetic Determinants of Low-Level Aminoglycoside Resistance in Pseudomonas aeruginosa

(2008) K. N. Schurek et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Epigenetic inheritance based evolution of antibiotic resistance in bacteria

(2008) Mike Adam et al.   BMC EVOLUTIONARY BIOLOGY

Memory in Microbes: Quantifying History-Dependent Behavior in a Bacterium

(2008) Denise M. Wolf et al.   PLoS One