Akt Inhibitor MK2206 Prevents Influenza pH1N1 Virus InfectionIn Vitro

Crosstalk between ERK, AKT, and cell survival

(2014) Paul Dent   CANCER BIOLOGY & THERAPY

Spatial Control of the TSC Complex Integrates Insulin and Nutrient Regulation of mTORC1 at the Lysosome

(2014) Suchithra Menon et al.   CELL

The nitric oxide-cGKII system relays death and survival signals during embryonic retinal development via AKT-induced CREB1 activation

(2014) R Socodato et al.   CELL DEATH AND DIFFERENTIATION

A Single Amino Acid in the Stalk Region of the H1N1pdm Influenza Virus HA Protein Affects Viral Fusion, Stability and Infectivity

(2014) Christopher R. Cotter et al.   PLoS Pathogens

Inhibition of Influenza A Virus Infection in Vitro by Saliphenylhalamide-Loaded Porous Silicon Nanoparticles

(2013) Luis M. Bimbo et al.   ACS Nano

Influenza virus resistance to neuraminidase inhibitors

(2013) Mélanie Samson et al.   ANTIVIRAL RESEARCH

Development of cellular signaling pathway inhibitors as new antivirals against influenza

(2013) Oliver Planz   ANTIVIRAL RESEARCH

HSV activates Akt to trigger calcium release and promote viral entry: novel candidate target for treatment and suppression

(2013) Natalia Cheshenko et al.   FASEB JOURNAL

Endosomal acidification by Na+/H+ exchanger NHE5 regulates TrkA cell-surface targeting and NGF-induced PI3K signaling

(2013) Graham H. Diering et al.   MOLECULAR BIOLOGY OF THE CELL

α-santalol inhibits the angiogenesis and growth of human prostate tumor growth by targeting vascular endothelial growth factor receptor 2-mediated AKT/mTOR/P70S6K signaling pathway

(2013) Sarita Saraswati et al.   Molecular Cancer

AKT activation by N-cadherin regulates beta-catenin signaling and neuronal differentiation during cortical development

(2013) Jianing Zhang et al.   Neural Development

Anticancer compound ABT-263 accelerates apoptosis in virus-infected cells and imbalances cytokine production and lowers survival rates of infected mice

(2013) L Kakkola et al.   Cell Death & Disease

Role of PRAS40 in Akt and mTOR signaling in health and disease

(2012) Claudia Wiza et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

EPs® 7630 (Umckaloabo®), an extract from Pelargonium sidoides roots, exerts anti-influenza virus activity in vitro and in vivo

(2012) Linda L. Theisen et al.   ANTIVIRAL RESEARCH

Newer influenza antivirals, biotherapeutics and combinations

(2012) Frederick G. Hayden   Influenza and Other Respiratory Viruses

Obatoclax, Saliphenylhalamide, and Gemcitabine Inhibit Influenza A Virus Infection

(2012) Oxana V. Denisova et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Akt1 promotes focal adhesion disassembly and cell motility through phosphorylation of FAK in growth factor-stimulated cells

(2012) M. Higuchi et al.   JOURNAL OF CELL SCIENCE

Natural and long-lasting cellular immune responses against influenza in the M2e-immune host

(2012) M Schotsaert et al.   Mucosal Immunology

Innate Immune Response to Influenza A Virus in Differentiated Human Alveolar Type II Cells

(2011) Jieru Wang et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Oxidized LDL at low concentration promotes in-vitro angiogenesis and activates nitric oxide synthase through PI3K/Akt/eNOS pathway in human coronary artery endothelial cells

(2011) Shan Yu et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The proton translocation domain of cellular vacuolar ATPase provides a target for the treatment of influenza A virus infections

(2011) Konstantin H Müller et al.   BRITISH JOURNAL OF PHARMACOLOGY

Hsp27 silencing coordinately inhibits proliferation and promotes Fas-induced apoptosis by regulating the PEA-15 molecular switch

(2011) N Hayashi et al.   CELL DEATH AND DIFFERENTIATION

Suppression of AMPK Activation via S485 Phosphorylation by IGF-I during Hyperglycemia Is Mediated by AKT Activation in Vascular Smooth Muscle Cells

(2011) Junyu Ning et al.   ENDOCRINOLOGY

Emerging cellular targets for influenza antiviral agents

(2011) Konstantin H. Müller et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Late-penetrating viruses

(2011) Pierre-Yves Lozach et al.   Current Opinion in Virology

Cytosolic RNA Recognition Pathway Activates 14-3-3 Protein Mediated Signaling and Caspase-Dependent Disruption of Cytokeratin Network in Human Keratinocytes

(2010) Tiina Öhman et al.   JOURNAL OF PROTEOME RESEARCH

Targeting cell signalling pathways to fight the flu: towards a paradigm change in anti-influenza therapy

(2009) S. Ludwig   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Zanamivir-Resistant Influenza Viruses with a Novel Neuraminidase Mutation

(2009) A. C. Hurt et al.   JOURNAL OF VIROLOGY

Origins and evolutionary genomics of the 2009 swine-origin H1N1 influenza A epidemic

(2009) Gavin J. D. Smith et al.   NATURE

Evaluating the potential of Vacuolar ATPase inhibitors as anticancer agents and multigram synthesis of the potent salicylihalamide analog saliphenylhalamide

(2008) Sylvain Lebreton et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS