Targeting Mycobacterium tuberculosis Topoisomerase I by Small-Molecule Inhibitors

Reduction in DNA topoisomerase I level affects growth, phenotype and nucleoid architecture of Mycobacterium smegmatis

(2015) Wareed Ahmed et al.   MICROBIOLOGY-SGM

Molecular Basis for the Differential Quinolone Susceptibility of Mycobacterial DNA Gyrase

(2014) Rupesh Kumar et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Conditional silencing of topoisomerase I gene ofMycobacterium tuberculosisvalidates its essentiality for cell survival

(2014) Wareed Ahmed et al.   FEMS MICROBIOLOGY LETTERS

Fluoroquinolone susceptibility in Mycobacterium tuberculosis after pre-diagnosis exposure to older- versus newer-generation fluoroquinolones

(2013) Yuri F. van der Heijden et al.   INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS

Advances in the development of new tuberculosis drugs and treatment regimens

(2013) Alimuddin Zumla et al.   NATURE REVIEWS DRUG DISCOVERY

Tuberculosis

(2013) Alimuddin Zumla et al.   NEW ENGLAND JOURNAL OF MEDICINE

Rising to the challenge: new therapies for tuberculosis

(2013) Emily B. Wong et al.   TRENDS IN MICROBIOLOGY

Drugging Topoisomerases: Lessons and Challenges

(2012) Yves Pommier   ACS Chemical Biology

Characterization of DNA topoisomerase I from Mycobacterium tuberculosis: DNA cleavage and religation properties and inhibition of its activity

(2012) Adwait Anand Godbole et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Surveillance of anti-tuberculosis drug resistance in the world: an updated analysis, 2007–2010

(2012) Matteo Zignol et al.   BULLETIN OF THE WORLD HEALTH ORGANIZATION

Exploiting bacterial DNA gyrase as a drug target: current state and perspectives

(2011) Frédéric Collin et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

New tuberculosis drugs on the horizon

(2011) Stewart T Cole et al.   CURRENT OPINION IN MICROBIOLOGY

In silico repositioning of approved drugs for rare and neglected diseases

(2011) Sean Ekins et al.   DRUG DISCOVERY TODAY

Essential Metabolites of Mycobacterium tuberculosis and Their Mimics

(2011) G. Lamichhane et al.   mBio

DNA Topoisomerases and Their Poisoning by Anticancer and Antibacterial Drugs

(2010) Yves Pommier et al.   CHEMISTRY & BIOLOGY

Multidrug-resistant and extensively drug-resistant tuberculosis: a threat to global control of tuberculosis

(2010) Neel R Gandhi et al.   LANCET

Evasion of innate immunity by Mycobacterium tuberculosis: is death an exit strategy?

(2010) Samuel M. Behar et al.   NATURE REVIEWS MICROBIOLOGY

Deciphering the Distinct Role for the Metal Coordination Motif in the Catalytic Activity of Mycobacterium smegmatis Topoisomerase I

(2009) Anuradha Gopal Bhat et al.   JOURNAL OF MOLECULAR BIOLOGY

Effects of magnesium and related divalent metal ions in topoisomerase structure and function

(2009) C. Sissi et al.   NUCLEIC ACIDS RESEARCH