Inhibition of Hepatitis C Virus Replication by GS-6620, a PotentC-Nucleoside Monophosphate Prodrug

Metabolism and Pharmacokinetics of the Anti-Hepatitis C Virus Nucleotide Prodrug GS-6620

(2014) Eisuke Murakami et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

The Increasing Burden of Mortality From Viral Hepatitis in the United States Between 1999 and 2007

(2013) Kathleen N. Ly et al.   ANNALS OF INTERNAL MEDICINE

In vitro efficacy of approved and experimental antivirals against novel genotype 3 hepatitis C virus subgenomic replicons

(2013) Mei Yu et al.   ANTIVIRAL RESEARCH

Expanded classification of hepatitis C virus into 7 genotypes and 67 subtypes: Updated criteria and genotype assignment web resource

(2013) Donald B. Smith et al.   HEPATOLOGY

Discovery of the First C-Nucleoside HCV Polymerase Inhibitor (GS-6620) with Demonstrated Antiviral Response in HCV Infected Patients

(2013) Aesop Cho et al.   JOURNAL OF MEDICINAL CHEMISTRY

Sofosbuvir for Hepatitis C Genotype 2 or 3 in Patients without Treatment Options

(2013) Ira M. Jacobson et al.   NEW ENGLAND JOURNAL OF MEDICINE

Preclinical Characterization of GS-9669, a Thumb Site II Inhibitor of the Hepatitis C Virus NS5B Polymerase

(2012) M. Fenaux et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Development of Robust Hepatitis C Virus Genotype 4 Subgenomic Replicons

(2012) Betty Peng et al.   GASTROENTEROLOGY

Structure of Hepatitis C Virus Polymerase in Complex with Primer-Template RNA

(2012) R. T. Mosley et al.   JOURNAL OF VIROLOGY

Tegobuvir (GS-9190) potency against HCV chimeric replicons derived from consensus NS5B sequences from genotypes 2b, 3a, 4a, 5a, and 6a

(2012) Kelly A. Wong et al.   VIROLOGY

Sensitivity of Mitochondrial Transcription and Resistance of RNA Polymerase II Dependent Nuclear Transcription to Antiviral Ribonucleosides

(2012) Jamie J. Arnold et al.   PLoS Pathogens

Selection of Clinically Relevant Protease Inhibitor-Resistant Viruses Using the Genotype 2a Hepatitis C Virus Infection System

(2011) Guofeng Cheng et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

HBV DNA replication mediated by cloned patient HBV reverse transcriptase genes from HBV genotypes A–H and its use in antiviral phenotyping assays

(2011) Yuao Zhu et al.   JOURNAL OF VIROLOGICAL METHODS

Novel Mutations in a Tissue Culture-Adapted Hepatitis C Virus Strain Improve Infectious-Virus Stability and Markedly Enhance Infection Kinetics

(2011) M. V. Pokrovskii et al.   JOURNAL OF VIROLOGY

The role of triple therapy with protease inhibitors in hepatitis C virus genotype 1 naïve patients

(2011) David R. Nelson   LIVER INTERNATIONAL

Turning Hepatitis C into a Real Virus

(2010) Catherine L. Murray et al.   Annual Review of Microbiology

Novel Hepatitis C Virus Reporter Replicon Cell Lines Enable Efficient Antiviral Screening against Genotype 1a

(2010) M. Robinson et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Identification of Multiple Rate-limiting Steps during the Human Mitochondrial Transcription Cyclein Vitro

(2010) Maria F. Lodeiro et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structural basis for active site closure by the poliovirus RNA-dependent RNA polymerase

(2010) P. Gong et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Progress towards improving antiviral therapy for hepatitis C with hepatitis C virus polymerase inhibitors. Part I: Nucleoside analogues

(2009) Nathaniel A Brown   EXPERT OPINION ON INVESTIGATIONAL DRUGS

Robust Antiviral Efficacy upon Administration of a Nucleoside Analog to Hepatitis C Virus-Infected Chimpanzees

(2008) S. S. Carroll et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Development of Intergenotypic Chimeric Replicons To Determine the Broad-Spectrum Antiviral Activities of Hepatitis C Virus Polymerase Inhibitors

(2008) K. J. Herlihy et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Diagnosis, management, and treatment of hepatitis C: An update

(2008) Marc G. Ghany et al.   HEPATOLOGY

Structural Insights into Mechanisms of Catalysis and Inhibition in Norwalk Virus Polymerase

(2008) Dmitry F. Zamyatkin et al.   JOURNAL OF BIOLOGICAL CHEMISTRY