Pharmacokinetic Comparison To Determine the Mechanisms Underlying the Differential Efficacies of Cationic Diamidines against First- and Second-Stage Human African Trypanosomiasis

Pharmacokinetics, Trypanosoma brucei gambiense Efficacy, and Time of Drug Action of DB829, a Preclinical Candidate for Treatment of Second-Stage Human African Trypanosomiasis

(2013) Tanja Wenzler et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Trypanosoma brucei aquaglyceroporin 2 is a high-affinity transporter for pentamidine and melaminophenyl arsenic drugs and the main genetic determinant of resistance to these drugs

(2013) J. C. Munday et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Methodologies to Assess Drug Permeation Through the Blood–Brain Barrier for Pharmaceutical Research

(2013) Céline Passeleu-Le Bourdonnec et al.   PHARMACEUTICAL RESEARCH

Trypanocidal Furamidine Analogues: Influence of Pyridine Nitrogens on Trypanocidal Activity, Transport Kinetics, and Resistance Patterns

(2011) Christopher P. Ward et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Development of novel drugs for human African trypanosomiasis

(2011) Reto Brun et al.   Future Microbiology

Mechanisms Underlying Differences in Systemic Exposure of Structurally Similar Active Metabolites: Comparison of Two Preclinical Hepatic Models

(2011) G. Z. Yan et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

The Human African Trypanosomiasis Control and Surveillance Programme of the World Health Organization 2000–2009: The Way Forward

(2011) Pere P. Simarro et al.   PLoS Neglected Tropical Diseases

Defining Desirable Central Nervous System Drug Space through the Alignment of Molecular Properties, in Vitro ADME, and Safety Attributes

(2010) Travis T. Wager et al.   ACS Chemical Neuroscience

Novel Arylimidamides for Treatment of Visceral Leishmaniasis

(2010) M. Z. Wang et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Comparison of in vitro cell models in predicting in vivo brain entry of drugs

(2010) Jenni J. Hakkarainen et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Membrane transporters in drug development

(2010)   NATURE REVIEWS DRUG DISCOVERY

Xenobiotic, Bile Acid, and Cholesterol Transporters: Function and Regulation

(2010) C. D. Klaassen et al.   PHARMACOLOGICAL REVIEWS

New Treatment Option for Second-Stage African Sleeping Sickness: In Vitro and In Vivo Efficacy of Aza Analogs of DB289

(2009) T. Wenzler et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Pentamidine Movement across the Murine Blood-Brain and Blood-Cerebrospinal Fluid Barriers: Effect of Trypanosome Infection, Combination Therapy, P-Glycoprotein, and Multidrug Resistance-Associated Protein

(2009) L. Sanderson et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Human African trypanosomiasis

(2009) Reto Brun et al.   LANCET

Transport of Dicationic Drugs Pentamidine and Furamidine by Human Organic Cation Transporters

(2008) X. Ming et al.   DRUG METABOLISM AND DISPOSITION

Pentamidine Dosage: A Base/Salt Confusion

(2008) Thomas P. C. Dorlo et al.   PLoS Neglected Tropical Diseases