Methodologies to Assess Drug Permeation Through the Blood–Brain Barrier for Pharmaceutical Research
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Title
Methodologies to Assess Drug Permeation Through the Blood–Brain Barrier for Pharmaceutical Research
Authors
Keywords
blood–brain barrier, central nervous system, drug delivery systems, pharmacokinetics
Journal
PHARMACEUTICAL RESEARCH
Volume 30, Issue 11, Pages 2729-2756
Publisher
Springer Nature
Online
2013-06-26
DOI
10.1007/s11095-013-1119-z
References
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Note: Only part of the references are listed.- Kinetic Analysis of the Toxicity of Pharmaceutical Excipients Cremophor EL and RH40 on Endothelial and Epithelial Cells
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- (2012) Brian P. Daniels et al. JOURNAL OF NEUROSCIENCE METHODS
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- (2012) Sumio Ohtsuki et al. MOLECULAR PHARMACEUTICS
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- (2012) R. E. Cannon et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
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- (2011) Alex Avdeef EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
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- (2010) R. Nau et al. CLINICAL MICROBIOLOGY REVIEWS
- Murine in vitro model of the blood–brain barrier for evaluating drug transport
- (2010) Gilda Shayan et al. EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
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- (2010) Jurgen Mensch et al. EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS
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- (2010) Michael J Waring Expert Opinion on Drug Discovery
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- Brain Endothelial Cell-Cell Junctions: How to “Open” the Blood Brain Barrier
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- (2008) Li Di et al. JOURNAL OF PHARMACEUTICAL SCIENCES
- A new blood–brain barrier model using primary rat brain endothelial cells, pericytes and astrocytes
- (2008) Shinsuke Nakagawa et al. NEUROCHEMISTRY INTERNATIONAL
- An in vitro blood-brain barrier model for high throughput (HTS) toxicological screening
- (2008) Maxime Culot et al. TOXICOLOGY IN VITRO
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