In VitroandIn VivoActivities of the Nitroimidazole TBA-354 against Mycobacterium tuberculosis

Contribution of the Nitroimidazoles PA-824 and TBA-354 to the Activity of Novel Regimens in Murine Models of Tuberculosis

(2014) Rokeya Tasneen et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Efficacy and Safety of Metronidazole for Pulmonary Multidrug-Resistant Tuberculosis

(2013) Matthew W. Carroll et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Potent Rifamycin-Sparing Regimen Cures Guinea Pig Tuberculosis as Rapidly as the Standard Regimen

(2013) Noton K. Dutta et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

PA-824, moxifloxacin and pyrazinamide combination therapy for tuberculosis

(2013) Rodney Dawson et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

Dose-ranging activity of the newly registered antituberculosis drug bedaquiline (TMC207)

(2013) Jacques H Grosset et al.   Expert Review of Anti-Infective Therapy

TMC207 becomes bedaquiline, a new anti-TB drug

(2013) Juan Carlos Palomino et al.   Future Microbiology

Sterilizing Activities of Novel Combinations Lacking First- and Second-Line Drugs in a Murine Model of Tuberculosis

(2012) Kathy Williams et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Phase II Dose-Ranging Trial of the Early Bactericidal Activity of PA-824

(2012) Andreas H. Diacon et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Randomized Pilot Trial of Eight Weeks of Bedaquiline (TMC207) Treatment for Multidrug-Resistant Tuberculosis: Long-Term Outcome, Tolerability, and Effect on Emergence of Drug Resistance

(2012) A. H. Diacon et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

14-day bactericidal activity of PA-824, bedaquiline, pyrazinamide, and moxifloxacin combinations: a randomised trial

(2012) Andreas H Diacon et al.   LANCET

A novel F420-dependent anti-oxidant mechanism protectsMycobacterium tuberculosisagainst oxidative stress and bactericidal agents

(2012) Meera Gurumurthy et al.   MOLECULAR MICROBIOLOGY

Delamanid for Multidrug-Resistant Pulmonary Tuberculosis

(2012) Maria Tarcela Gler et al.   NEW ENGLAND JOURNAL OF MEDICINE

Comprehensive analysis of methods used for the evaluation of compounds against Mycobacterium tuberculosis

(2012) Scott G. Franzblau et al.   TUBERCULOSIS

Nitroimidazoles for the treatment of TB: past, present and future

(2011) Tathagata Mukherjee et al.   Future Medicinal Chemistry

Early bactericidal activity of delamanid (OPC-67683) in smear-positive pulmonary tuberculosis patients

(2011) A. H. Diacon et al.   INTERNATIONAL JOURNAL OF TUBERCULOSIS AND LUNG DISEASE

Dry Powder PA-824 Aerosols for Treatment of Tuberculosis in Guinea Pigs

(2010) L. Garcia-Contreras et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

PA-824 Exhibits Time-Dependent Activity in a Murine Model of Tuberculosis

(2010) Zahoor Ahmad et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Synthesis and Structure−Activity Relationships of Aza- and Diazabiphenyl Analogues of the Antitubercular Drug (6S)-2-Nitro-6-{[4-(trifluoromethoxy)benzyl]oxy}-6,7-dihydro-5H-imidazo[2,1-b][1,3]oxazine (PA-824)

(2010) Iveta Kmentova et al.   JOURNAL OF MEDICINAL CHEMISTRY

Powerful Bactericidal and Sterilizing Activity of a Regimen Containing PA-824, Moxifloxacin, and Pyrazinamide in a Murine Model of Tuberculosis

(2008) E. Nuermberger et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

PA-824 Kills Nonreplicating Mycobacterium tuberculosis by Intracellular NO Release

(2008) R. Singh et al.   SCIENCE