Article
Pediatrics
Ryan M. Hanson, Amy J. Wagner
Summary: Severe, complicated Clostridium difficile colitis is rare in pediatric patients and little is known about its medical and surgical management in this population. A case report of a 15-year-old female patient with severe, complicated C difficile colitis successfully treated with diverting loop ileostomy and colonic lavage is presented. This approach, instead of subtotal colectomy and end ileostomy, should be considered as an alternative for pediatric patients with severe, complicated C difficile colitis.
Article
Biotechnology & Applied Microbiology
Meng Wang, Zifeng Deng, Yanmei Li, Yi Ma, Jufang Wang
Summary: A novel lytic protein Cw1-CWB2 with high binding specificity and strong lytic activity has been designed in this study for combating C. difficile.
APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
(2022)
Article
Infectious Diseases
Raina Gay Leahy, Alisa W. Serio, Kelly Wright, Maria M. Traczewski, S. Ken Tanaka
Summary: The study assessed the in vitro activity of omadacycline against Clostridioides difficile infection and its efficacy in a hamster model of C. difficile-associated diarrhoea. Omadacycline showed potent in vitro activity against C. difficile and demonstrated efficacy in the animal model.
JOURNAL OF GLOBAL ANTIMICROBIAL RESISTANCE
(2022)
Review
Medicine, General & Internal
Ibrahim A. Al-Zahrani
Summary: Clostridioides difficile (C. difficile) infection is a global threat to many healthcare settings. Excessive use of antimicrobials, lack of optimal antibiotic policies, and suboptimal infection control practices have fueled the development of this health issue. Prudent use of antimicrobials and simple infection control measures can significantly reduce infection rates.
SAUDI MEDICAL JOURNAL
(2023)
Article
Infectious Diseases
Radek Sleha, Vera Radochova, Alexander Mikyska, Milan Houska, Radka Bolehovska, Sylva Janovska, Jaroslav Pejchal, Lubica Muckova, Pavel Cermak, Pavel Bostik
Summary: Limited treatment options are available for C. difficile infections, and the use of xanthohumol and beta acids from hops has shown notable antimicrobial effects, making them promising choices for treating such infections.
Article
Multidisciplinary Sciences
Ashleigh S. Paparella, Briana L. Aboulache, Rajesh K. Harijan, Kathryn S. Potts, Peter C. Tyler, Vern L. Schramm
Summary: Clostridium difficile produces toxins TcdA and TcdB causing diarrhea by affecting host cell functions using UDP-glucose, leading to disease onset. Researchers identified potential therapeutic approach using transition state analogue iminosugars.
NATURE COMMUNICATIONS
(2021)
Article
Microbiology
Brintha P. Girinathan, Nicholas DiBenedetto, Jay N. Worley, Johann Peltier, Mario L. Arrieta-Ortiz, Selva Rupa Christinal Immanuel, Richard Lavin, Mary L. Delaney, Christopher K. Cummins, Maria Hoffman, Yan Luo, Narjol Gonzalez-Escalona, Marc Allard, Andrew B. Onderdonk, Georg K. Gerber, Abraham L. Sonenshein, Nitin S. Baliga, Bruno Dupuy, Lynn Bry
Summary: Different species of Clostridia can protect against or worsen Clostridioides difficile infection in mice by modulating the pathogen's colonization, growth, and virulence through altering the gut-nutrient environment. This research lays the groundwork for mechanistically informed therapies to counter C. difficile disease using systems biology approaches to define host-commensal-pathogen interactions in vivo.
CELL HOST & MICROBE
(2021)
Review
Biochemistry & Molecular Biology
Andrea Piccioni, Federico Rosa, Federica Manca, Giulia Pignataro, Christian Zanza, Gabriele Savioli, Marcello Covino, Veronica Ojetti, Antonio Gasbarrini, Francesco Franceschi, Marcello Candelli
Summary: The composition of the human microbiome plays a crucial role in health, and alterations in the microbiota can lead to Clostridium difficile infection.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Surgery
Alexis Hess, Saskya Byerly, Emily Lenart, Cory Evans, Andrew Kerwin, Dina Filiberto
Summary: This study aimed to identify predictors of Clostridium Difficile Infection (CDI) in general surgery patients. Patients who underwent general surgery operations were analyzed, and it was found that older age, emergent operation, increased time to operation, infections at surgical sites, deep organ space infections, steroid use, metastatic cancer, smoking, and decreased body mass index (BMI) were independent predictors of CDI.
AMERICAN JOURNAL OF SURGERY
(2023)
Article
Rehabilitation
Justin Weppner, Joelle Gabet, Mark Linsenmeyer, Mohamed Yassin, Gary Galang
Summary: The study found the presence of C difficile spores in an acute rehabilitation environment and showed that proper disinfection methods can effectively reduce the risk of infection. It is important to sporicidally disinfect surfaces such as beds and wheelchairs to decrease the rates of C difficile infection.
AMERICAN JOURNAL OF PHYSICAL MEDICINE & REHABILITATION
(2021)
Article
Immunology
Jen-Chieh Lee, Yuan -Pin Hung, Bo -Yang Tsai, Pei -Jane Tsai, Wen -Chien Ko
Summary: Severe CDIs in the ICU were not rare in this study. The ileus group tended to have more severe presentation, with severe and fulminant CDIs accounting for 65.2% and an ICU mortality rate of 39.1%. Clinicians should be aware of abdominal symptoms and signs other than diarrhea, such as ileus, for timely diagnosis and management of CDI.
JOURNAL OF MICROBIOLOGY IMMUNOLOGY AND INFECTION
(2021)
Article
Gastroenterology & Hepatology
Anqi Jin, Tony Chien, Qiwen Huang, Pragati Kenkare, Mai Vu, Sandra Wilson, Edward S. Huang
Summary: The study found that cholecystectomy is associated with a slightly increased risk of incident CDI, but this effect is not influenced by the use of proton pump inhibitors, antibiotics, or hospitalization.
DIGESTIVE DISEASES AND SCIENCES
(2021)
Article
Veterinary Sciences
Jeffrey Scott Weese, Nathan Slovis, Joyce Rousseau
Summary: This study longitudinally evaluated Clostridium difficile shedding in neonatal foals and mares in a referral hospital neonatal intensive care unit. The results showed Clostridium difficile was isolated from 25% of samples, with at least one positive sample in 40% of foals and 31% of mares. Various ribotypes were identified, with ribotype 078 predominating.
JOURNAL OF VETERINARY INTERNAL MEDICINE
(2021)
Article
Multidisciplinary Sciences
Hiroshi Yamada, So-Ichiro Sasaki, Hideki Tani, Mayu Somekawa, Hitoshi Kawasuji, Yumiko Saga, Yoshihiro Yoshida, Yoshihiro Yamamoto, Yoshihiro Hayakawa, Yoshitomo Morinaga
Summary: SARS-CoV-2, a BSL-3 pathogen, limits the research environment. Pseudotyped viruses are widely used for in vitro evaluation, but in vivo application is insufficient. Using hamster models inoculated with luciferase-expressing VSV-based SARS-CoV-2 pseudotyped viruses, lung luminescence increased in a dose-dependent manner. This model provides insights into the viral entry process.
SCIENTIFIC REPORTS
(2022)
Article
Public, Environmental & Occupational Health
Dong Youn Kim, Yu-Mi Lee, Ki-Ho Park, Young Jin Kim, Kyung-Chung Kang, Chang Kyun Lee, Mi Suk Lee
Summary: The study revealed that the incidence of hospital-acquired CDI among patients who underwent orthopedic surgery was 0.7%, with factors such as age, preoperative hospital stay, operating time, and antibiotic use associated with CDI. The impact of CDI on excess length of stay was more significant in patients over 65 years old and those with comorbidities.
AMERICAN JOURNAL OF INFECTION CONTROL
(2022)
Article
Microbiology
Jane Freeman, Jonathan Vernon, Richard Vickers, Mark H. Wilcox
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2016)
Article
Infectious Diseases
Richard Vickers, Neil Robinson, Emma Best, Roger Echols, Glenn Tillotson, Mark Wilcox
BMC INFECTIOUS DISEASES
(2015)
Article
Infectious Diseases
Abdul Sattar, Pia Thommes, Lloyd Payne, Peter Warn, Richard J. Vickers
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
(2015)
Article
Infectious Diseases
D. Corbett, A. Wise, S. Birchall, P. Warn, S. D. Baines, G. Crowther, J. Freeman, C. H. Chilton, J. Vernon, M. H. Wilcox, R. J. Vickers
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
(2015)
Review
Biochemistry & Molecular Biology
John Mann, Peter W. Taylor, Colin R. Dorgan, Peter D. Johnson, Francis X. Wilson, Richard Vickers, Aaron G. Dale, Stephen Neidle
Article
Microbiology
Bradley T. Endres, Eugenie Basseres, Ali Memariani, Long Chang, M. Jahangir Alam, Richard J. Vickers, Ioannis A. Kakadiaris, Kevin W. Garey
Review
Infectious Diseases
Richard J. Vickers, Glenn Tillotson, Ellie J. C. Goldstein, Diane M. Citron, Kevin W. Garey, Mark H. Wilcox
INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS
(2016)
Article
Infectious Diseases
Eugenie Basseres, Bradley T. Endres, Mohammed Khaleduzzaman, Faranak Miraftabi, M. Jahangir Alam, Richard J. Vickers, Kevin W. Garey
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
(2016)
Article
Infectious Diseases
Richard J. Vickers, Glenn S. Tillotson, Richard Nathan, Sabine Hazan, John Pullman, Christopher Lucasti, Kenneth Deck, Bruce Yacyshyn, Benedict Maliakkal, Yves Pesant, Bina Tejura, David Roblin, Dale N. Gerding, Mark H. Wilcox
LANCET INFECTIOUS DISEASES
(2017)
Article
Infectious Diseases
David R. Snydman, Laura A. McDermott, Cheleste M. Thorpe, Justin Chang, Jenna Wick, Seth T. Walk, Richard J. Vickers
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
(2018)
Article
Biochemistry & Molecular Biology
Joshua Odingo, Theresa O'Malley, Edward A. Kesicki, Torey Alling, Mai Ann Bailey, Julie Early, Juliane Ollinger, Suryakanta Dalai, Naresh Kumar, Ravindra Vikram Singh, Philip A. Hipskind, Jeffrey W. Cramer, Thomas Ioerger, James Sacchettini, Richard Vickers, Tanya Parish
BIOORGANIC & MEDICINAL CHEMISTRY
(2014)
Article
Infectious Diseases
S. D. Baines, G. S. Crowther, J. Freeman, S. Todhunter, R. Vickers, M. H. Wilcox
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
(2015)
Article
Multidisciplinary Sciences
Cheleste M. Thorpe, Anne Kane, Justin Chang, Albert Tai, Richard J. Vickers, David R. Snydman
Article
Microbiology
Richard J. Vickers, Matteo Bassetti, Cornelius J. Clancy, Kevin W. Garey, David E. Greenberg, Minh-Hong Nguyen, David Roblin, Glenn S. Tillotson, Mark H. Wilcox
FUTURE MICROBIOLOGY
(2019)