Resistance Analysis of the Hepatitis C Virus NS3 Protease Inhibitor Asunaprevir

Single- and Multiple-Ascending-Dose Studies of the NS3 Protease Inhibitor Asunaprevir in Subjects with or without Chronic Hepatitis C

(2012) Claudio Pasquinelli et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Preliminary Study of Two Antiviral Agents for Hepatitis C Genotype 1

(2012) Anna S. Lok et al.   NEW ENGLAND JOURNAL OF MEDICINE

In VitroResistance Profile of the Hepatitis C Virus NS3 Protease Inhibitor BI 201335

(2011) Lisette Lagacé et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Development of a chimeric replicon system for phenotypic analysis of NS3 protease sequences from HCV clinical isolates

(2011) Amy K Sheaffer et al.   ANTIVIRAL THERAPY

Multiple ascending dose study of BMS-790052, a nonstructural protein 5A replication complex inhibitor, in patients infected with hepatitis C virus genotype 1

(2011) Richard E. Nettles et al.   HEPATOLOGY

Dual therapy with the nonstructural protein 5A inhibitor, daclatasvir, and the nonstructural protein 3 protease inhibitor, asunaprevir, in hepatitis C virus genotype 1b-infected null responders

(2011) Kazuaki Chayama et al.   HEPATOLOGY

1195 BMS-650032, AN NS3 INHIBITOR, IN COMBINATION WITH PEGINTERFERON ALPHA-2A AND RIBAVIRIN IN TREATMENT-NAIVE SUBJECTS WITH GENOTYPE 1 CHRONIC HEPATITIS C INFECTION

(2011) J.-P. Bronowicki et al.   JOURNAL OF HEPATOLOGY

1223 NO EARLY VIROLOGIC BREAKTHROUGH OBSERVED WITH THE HCV NS3 PROTEASE INHIBITOR BMS-650032 IN MULTIPLE DOSE MONOTHERAPY STUDIES AND PHASE 2A COMBINATION STUDIES WITH PEGIFNα/RBV

(2011) F. McPhee et al.   JOURNAL OF HEPATOLOGY

Distinct Functions of NS5A in Hepatitis C Virus RNA Replication Uncovered by Studies with the NS5A Inhibitor BMS-790052

(2011) R. A. Fridell et al.   JOURNAL OF VIROLOGY

Boceprevir for Untreated Chronic HCV Genotype 1 Infection

(2011) Fred Poordad et al.   NEW ENGLAND JOURNAL OF MEDICINE

Boceprevir for Previously Treated Chronic HCV Genotype 1 Infection

(2011) Bruce R. Bacon et al.   NEW ENGLAND JOURNAL OF MEDICINE

Telaprevir for Previously Untreated Chronic Hepatitis C Virus Infection

(2011) Ira M. Jacobson et al.   NEW ENGLAND JOURNAL OF MEDICINE

Resistance Analysis of the Hepatitis C Virus NS5A Inhibitor BMS-790052 in an In Vitro Replicon System

(2010) R. A. Fridell et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

In Vitro Resistance Profile of the Hepatitis C Virus NS3/4A Protease Inhibitor TMC435

(2010) O. Lenz et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Hepatitis C Virus Non-structural Protein 3 (HCV NS3): A Multifunctional Antiviral Target

(2010) Kevin D. Raney et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

761 IDENTIFICATION AND PRECLINICAL PROFILE OF THE NOVEL HCV NS3 PROTEASE INHIBITOR BMS-650032

(2010) F. McPhee   JOURNAL OF HEPATOLOGY

Tracking the Evolution of Multiple In Vitro Hepatitis C Virus Replicon Variants under Protease Inhibitor Selection Pressure by 454 Deep Sequencing

(2010) T. Verbinnen et al.   JOURNAL OF VIROLOGY

Chemical genetics strategy identifies an HCV NS5A inhibitor with a potent clinical effect

(2010) Min Gao et al.   NATURE

Drug resistance against HCV NS3/4A inhibitors is defined by the balance of substrate recognition versus inhibitor binding

(2010) K. P. Romano et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

MK-7009, a Potent and Selective Inhibitor of Hepatitis C Virus NS3/4A Protease

(2009) N. J. Liverton et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

HCV genetic variability: from quasispecies evolution to genotype classification

(2009) Claudio Argentini et al.   Future Microbiology

Characterization of resistance to the protease inhibitor boceprevir in hepatitis C virus-infected patients

(2009) Simone Susser et al.   HEPATOLOGY

Peginterferon Alfa-2b or Alfa-2a with Ribavirin for Treatment of Hepatitis C Infection

(2009) John G. McHutchison et al.   NEW ENGLAND JOURNAL OF MEDICINE

Identification of HCV protease inhibitor resistance mutations by selection pressure-based method

(2009) P. Qiu et al.   NUCLEIC ACIDS RESEARCH

Characterization of resistance mutations against HCV ketoamide protease inhibitors

(2008) X TONG et al.   ANTIVIRAL RESEARCH

Hepatitis C virus drug resistance and immune-driven adaptations: Relevance to new antiviral therapy

(2008) Silvana Gaudieri et al.   HEPATOLOGY

Diagnosis, management, and treatment of hepatitis C: An update

(2008) Marc G. Ghany et al.   HEPATOLOGY