Article
Multidisciplinary Sciences
Shinhyeung Kwak, Jeong Yeon Kim, Heeyeon Cho
Summary: This retrospective study conducted at Samsung Medical Center in Seoul, South Korea, aimed to investigate the prevalence and risk factors of vancomycin-induced nephrotoxicity in non-ICU pediatric patients. The study found that a longer hospital stay, concomitant use of piperacillin-tazobactam, and a serum trough level of vancomycin above 24.35 mu g/mL were independently associated with VIN. The study suggests that measuring serum trough level of vancomycin can help clinicians prevent VIN in pediatric patients.
SCIENTIFIC REPORTS
(2021)
Article
Oncology
Bernhard Neumann, Julia Onken, Nicole Koenig, Henning Stetefeld, Sebastian Luger, Anna-Luisa Luger, Felix Schlachetzki, Ralf Linker, Peter Hau, Elisabeth Bumes
Summary: This study analyzed the reasons for ICU admission and outcomes of patients with glioblastoma who required invasive mechanical ventilation (IMV) treatment. The main reasons for ICU admission were infection, status epilepticus, and elevated intracranial pressure. Younger age, shorter duration of IMV, better Karnofsky Performance Status Scale, and elevated intracranial pressure as the cause of ICU admission were associated with positive prognostic outcomes.
JOURNAL OF NEURO-ONCOLOGY
(2023)
Article
Medicine, General & Internal
Thomas J. Breen, Mitchell Padkins, Courtney E. Bennett, Nandan S. Anavekar, Joseph G. Murphy, Malcolm R. Bell, Gregory W. Barsness, Jacob C. Jentzer
Summary: This study retrospectively reviewed 12,428 adult CICU patients and found that M-CARS accurately predicts 1-year mortality. The 1-year survival decreased incrementally with increasing M-CARS, especially for patients with scores below 3. Significant predictors of 1-year mortality among hospital survivors included markers of frailty and chronic illness.
MAYO CLINIC PROCEEDINGS
(2021)
Article
Medicine, General & Internal
Irit Nachtigall, Marzia Bonsignore, Petra Thuermann, Sven Hohenstein, Katarzyna Jozwiak, Michael Hauptmann, Sandra Eifert, Julius Dengler, Andreas Bollmann, Heinrich Groesdonk, Ralf Kuhlen, Andreas Meier-Hellmann
Summary: Males have a higher risk of receiving intensive care and mechanical ventilation in COVID-19 infection, with a greater increase in mortality risk after the age of 60. The most significant gender gap in the ICU is observed among patients aged 90 and above. Understanding sex differences in COVID-19 can help in personalized treatment approaches.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Pharmacology & Pharmacy
Alzbeta Zavrelova, Martin Sima, Jana Malakova, Petra Rozsivalova, Pavla Paterova, Pavel Zak, Benjamin Visek, Danica Michalickova, Ondrej Slanar, Jakub Radocha
Summary: This study aims to evaluate the pharmacokinetics of off-label high-dose ceftazidime in cancer patients with extensively drug-resistant Pseudomonas aeruginosa infections. The study found that the high-dose regimen had a significantly higher probability of achieving the pharmacokinetic/pharmacodynamic target with a low occurrence of adverse effects.
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY
(2023)
Review
Medicine, General & Internal
Ut-Sam Lao, Chak-Fun Law, Daniel T. Baptista-Hon, Brian Tomlinson
Summary: There is mounting evidence that the use of statins is associated with reduced mortality, ICU admission, and mechanical ventilation in COVID-19 patients. However, current studies mainly focus on the use of statins before or after hospital admission, and more research is needed on the use of statins after developing COVID-19 infection.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Cardiac & Cardiovascular Systems
Andrea Montisci, Vittorio Palmieri, Jennifer E. Liu, Maria T. Vietri, Silvia Cirri, Francesco Donatelli, Claudio Napoli
Summary: The increasing number of cancer survivors is attributed to more effective therapies, but chemotherapy regimens are often toxic, especially causing cardiac damage. Mechanisms of chemotherapy-induced cardiac toxicity include direct myocyte damage, arrhythmia induction, coronary vasospasm, and accelerated atherosclerosis. Management of critically ill cancer patients with acute cardiac toxicity poses a unique challenge, as there is no etiologic therapy available and only supportive measures can be implemented.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Article
Critical Care Medicine
L. Imeen van der Wal, Chloe C. A. Grim, Michael R. del Prado, David J. van Westerloo, E. Christiaan Boerma, Hilda G. Rijnhart-de Jong, Auke C. Reidinga, Bert G. Loef, Pim L. J. van der Heiden, Marnix J. Sigtermans, Frederique Paulus, Alexander D. Cornet, Maurizio Loconte, F. Jeannette Schoonderbeek, Nicolette F. de Keizer, Ferishta Bakhshi-Raiez, Saskia Le Cessie, Ary Serpa Neto, Paolo Pelosi, Marcus J. Schultz, Hendrik J. F. Helmerhorst, Evert de Jonge
Summary: A low-oxygenation strategy did not result in a reduction of 28-day mortality compared with a high-oxygenation strategy in mechanically ventilated ICU patients.
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2023)
Article
Computer Science, Interdisciplinary Applications
Cong Zhou, J. Geoffrey Chase, Jennifer Knopp, Qianhui Sun, Merryn Tawhai, Knut Moller, Serge J. Heines, Dennis C. Bergmans, Geoffrey M. Shaw, Thomas Desaive
Summary: The study develops a digital clone model to predict lung mechanics in response to changes in mechanical ventilation, enabling personalised care. Results show that the virtual patient model accurately predicts patient-specific lung responses, guiding personalised and optimised mechanical ventilation therapy.
COMPUTER METHODS AND PROGRAMS IN BIOMEDICINE
(2021)
Article
Pediatrics
Mukesh Kumar Jain, Sibabratta Patnaik, Bandya Sahoo, Reshmi Mishra, Jyoti Ranjan Behera
Summary: This study evaluated the indications, timing, complications, and outcomes of tracheostomy in children, finding that prolonged mechanical ventilation is the most common indication, with some patients experiencing complications post-operatively. However, the majority of patients were successfully discharged, and tracheostomy did not directly result in mortality.
INDIAN JOURNAL OF PEDIATRICS
(2021)
Review
Multidisciplinary Sciences
Lichen Ouyang, Muqing Yu, Yan Zhu, Jie Gong
Summary: A systematic review of 40 studies involving 15320 COVID-19 patients revealed varying rates of IMV application in different continents, with higher mortality in patients treated with IMV compared to non-IMV respiratory support.
Article
Orthopedics
Sheetal Gandotra, D. Clark Files, Katherine L. Shields, Michael Berry, Rita N. Bakhru
Summary: The study found that physical activity levels increased as critically ill patients transitioned from ICU to hospital wards and back to the community, with significantly higher activity levels post-hospital discharge. Despite poor physical function scores at ICU and hospital discharge, there was moderate correlation with physical activity levels immediately upon return home.
Article
Microbiology
Jolien Seinen, Rudolf Engelke, Mohammed R. Abdullah, Franziska Voss, Stephan Michalik, Vishnu M. Dhople, Willem Dieperink, Anne Marie G. A. de Smet, Uwe Voelker, Jan Maarten van Dijl, Frank Schmidt, Sven Hammerschmidt
Summary: Proteomic analysis of sputa from mechanically ventilated patients revealed distinct protein signatures related to antimicrobial activity, including elevated levels of antimicrobial host proteins, antibiotics, and S. pneumoniae-specific antibodies. Additionally, changes in sputum composition over time were observed in some patients. These findings suggest a potential novel tool for monitoring infection-related conditions in the lungs of ventilated patients.
Article
Health Care Sciences & Services
Hiroyuki Ohbe, Yusuke Sasabuchi, Hayato Yamana, Hiroki Matsui, Hideo Yasunaga
Summary: For mechanically ventilated patients with pneumonia, critical care in the ICU was associated with a 7.2% decrease in 30-day in-hospital mortality compared to care in the HDU. The study utilized propensity score matching analysis, multivariable regression, overlap weighting, and instrumental variable analyses to evaluate the robustness of the findings.
LANCET REGIONAL HEALTH-WESTERN PACIFIC
(2021)
Article
Multidisciplinary Sciences
Tamara M. Welte, Maria Gabriel, Ruediger Hopfengaertner, Stefan Rampp, Stephanie Gollwitzer, Johannes D. Lang, Jenny Stritzelberger, Caroline Reindl, Dominik Madzar, Maximilian Spruegel, Hagen B. Huttner, Joji B. Kuramatsu, Stefan Schwab, Hajo M. Hamer
Summary: This prospective study aimed to analyze whether quantitative EEG monitoring can predict successful extubation in neurocritical patients. The study found that stable EEG power values are an important indicator for successful weaning.
SCIENTIFIC REPORTS
(2022)
Article
Infectious Diseases
Julien Cazavet, Fanny Vardon Bounes, Stephanie Ruiz, Thierry Seguin, Laure Crognier, Antoine Rouget, Olivier Fourcade, Vincent Minville, Jean-Marie Conil, Bernard Georges
EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES
(2020)
Article
Pharmacology & Pharmacy
Basile Coutens, Celine Derreumaux, Francois Labaste, Vincent Minville, Bruno Pierre Guiard, Lionel Mouledous, Vincent Bounes, Anne Roussin, Bernard Frances
EUROPEAN JOURNAL OF PHARMACOLOGY
(2020)
Letter
Pharmacology & Pharmacy
Francois Montastruc, Charles Romano, Jean-Louis Montastruc, Stein Silva, Thierry Seguin, Vincent Minville, Bernard Georges, Beatrice Riu-Poulenc, Olivier Fourcade
Article
Anesthesiology
Fabrice Ferre, Alexis Krin, Marion Sanchez, David Ancelin, Etienne Cavaignac, Amaury Charre, Mehdi Bennis, Philippe Marty, Cedric Dray, Anne Brouchet, Matt Kurrek, Vincent Minville
BRITISH JOURNAL OF ANAESTHESIA
(2020)
Letter
Hematology
Julien Maquet, Margaux Lafaurie, Agnes Sommet, Guillaume Moulis
BRITISH JOURNAL OF HAEMATOLOGY
(2020)
Letter
Anesthesiology
Paul Bousquet, Francois Labaste, Julie Gobin, Bertrand Marcheix, Vincent Minville
JOURNAL OF CARDIOTHORACIC AND VASCULAR ANESTHESIA
(2021)
Letter
Clinical Neurology
Louis Delamarre, Cedric Gollion, Gaspard Grouteau, David Rousset, Guillaume Jimena, Jerome Roustan, Francois Gaussiat, Etienne Aldige, Charlene Gaffard, Julien Duplantier, Charlotte Martin, Olivier Fourcade, Chloe Bost, Francoise Fortenfant, Pierre Delobel, Guillaume Martin-Blondel, Jeremie Pariente, Fabrice Bonneville, Thomas Geeraerts
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
(2020)
Article
Anesthesiology
Lionel Velly, Etienne Gayat, Herve Quintard, Emmanuel Weiss, Audrey De Jong, Philippe Cuvillon, Gerard Audibert, Julien Amour, Marc Beaussier, Matthieu Biais, Sebastien Bloc, Marie Pierre Bonnet, Pierre Bouzat, Gilles Brezac, Claire Dahyot-Fizelier, Souhayl Dahmani, Mathilde de Queiroz, Sophie Di Maria, Claude Ecoffey, Emmanuel Futier, Thomas Geeraerts, Haithem Jaber, Laurent Heyer, Rim Hoteit, Olivier Joannes-Boyau, Delphine Kern, Olivier Langeron, Sigismond Lasocki, Yoan Launey, Frederic le Sache, Anne Claire Lukaszewicz, Axel Maurice-Szamburski, Nicolas Mayeur, Fabrice Michel, Vincent Minville, Sebastien Mirek, Philippe Montravers, Estelle Morau, Laurent Muller, Jane Muret, Karine Nouette-Gaulain, Jean Christophe Orban, Gilles Orliaguet, Pierre Francois Perrigault, Florence Plantet, Julien Pottecher, Christophe Quesnel, Vanessa Reubrecht, Bertrand Rozec, Benoit Tavernier, Benoit Veber, Francis Veyckmans, Helene Charbonneau, Isabelle Constant, Denis Frasca, Marc-Olivier Fischer, Catherine Huraux, Alice Blet, Marc Garnier
ANAESTHESIA CRITICAL CARE & PAIN MEDICINE
(2020)
Editorial Material
Endocrinology & Metabolism
Matthieu Wargny, Pierre Gourdy, Lisa Ludwig, Dominique Seret-Begue, Olivier Bourron, Patrice Darmon, Coralie Amadou, Matthieu Pichelin, Louis Potier, Charles Thivolet, Jean-Francois Gautier, Samy Hadjadj, Bertrand Cariou
Article
Critical Care Medicine
Fabrice Ferre, Morgane Viarnes, Charlotte Martin, Laetitia Bosch, Frederic Bouisset, Thibault Lhermusier, Nicolas Reina, Olivier Lairez, Vincent Minville
Summary: This study evaluated the effect of preoperative balloon aortic valvuloplasty (BAV) on severe AS patients undergoing hip fracture surgery, finding that preoperative BAV can reduce mortality despite prolonged time to operation. Postoperative delirium and acute congestive heart failure were identified as predictive factors for 30-day mortality.
INJURY-INTERNATIONAL JOURNAL OF THE CARE OF THE INJURED
(2021)
Article
Cardiac & Cardiovascular Systems
Olivier Lairez, Virginie Blanchard, Valerie Houard, Fanny Vardon-Bounes, Maeva Lemasle, Eve Cariou, Yoan Lavie-Badie, Stephanie Ruiz, Stephanie Cazalbou, Clement Delmas, Bernard Georges, Michel Galinier, Didier Carrie, Jean-Marie Conil, Vincent Minville
Summary: The study found that biological myocardial injury in COVID-19 patients has a low functional impact on left ventricular systolic function.
INTERNATIONAL JOURNAL OF CARDIOVASCULAR IMAGING
(2021)
Letter
Anesthesiology
Francois Labaste, Valentin Rey, Helene Gonzalez, Bertrand Marcheix, Olivier Fourcade, Vincent Minville
JOURNAL OF CARDIOTHORACIC AND VASCULAR ANESTHESIA
(2021)
Article
Obstetrics & Gynecology
Vincent Minville, Fabien Vidal, Olivier Loutrel, Adeline Castel, Loriane Jacques, Christophe Vayssiere, Olivier Parant, Paul Guerby, Karim Asehnoune
Summary: This study aimed to identify predictive factors for ICU admission in patients with pregnancy-related hypertensive complications. The results showed that high APACHE II and SAPS 2 scores, as well as elevated uricemia, were associated with the need for ICU admission. This study may prompt reflection on the value of obstetric intensive care units.
JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE
(2022)
Article
Infectious Diseases
S. Ruiz, D. Concordet, T. Lanot, B. Georges, P. Goudy, S. Baklouti, C. Mane, E. Losha, H. Vinour, D. Rousset, M. Lavit, V Minville, J-M Conil, P. Gandia
Summary: The study evaluated hydroxychloroquine concentrations in the lung epithelial lining fluid in critically ill COVID-19 patients. Results showed that lung exposure may be higher than plasma concentrations, indicating that low plasma concentrations should not lead to increased drug dosage.
INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS
(2021)
Review
Cell Biology
Cedric Garcia, Baptiste Compagnon, Michael Poette, Marie-Pierre Gratacap, Francois-Xavier Lapebie, Sophie Voisin, Vincent Minville, Bernard Payrastre, Fanny Vardon-Bounes, Agnes Ribes
Summary: Platelets play a crucial role in hemostasis and thrombosis, but they are also involved in mechanisms associated with inflammation, thrombosis, and the immune system in various diseases. During sepsis, platelets enhance the recruitment and activation of immune cells and contribute to pathogen elimination. However, these mechanisms can also lead to severe organ dysfunction.