Article
Multidisciplinary Sciences
S. Mansoori, M. Fryknas, C. Alvfors, A. Loskog, R. Larsson, P. Nygren
Summary: This study investigated the safety and efficacy of individualized dose adjusted mebendazole in patients with advanced gastrointestinal cancer. While mebendazole was found to be safe and well tolerated, all patients experienced rapid disease progression. Further exploration of mebendazole as an anticancer drug may require new approaches such as prodrug development and combination therapy with other anticancer drugs.
SCIENTIFIC REPORTS
(2021)
Article
Pharmacology & Pharmacy
Amin Aliabadi, Mohammad Reza Haghshenas, Razie Kiani, Omid Koohi-Hosseinabadi, Azar Purkhosrow, Fatema Pirsalami, Mohammad Reza Panjehshahin, Nasrollah Erfani
Summary: Mebendazole (MBZ) has shown promising anticancer activity and selectivity against colon cancer cells. In vitro and in vivo studies demonstrated that MBZ effectively inhibited cell proliferation and induced apoptosis in colon cancer cells, while having minimal impact on normal cells. Additionally, MBZ significantly reduced tumor growth and increased lifespan in mice with colon cancer.
NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
David Reigada, Rodrigo M. Maza, Teresa Munoz-Galdeano, Maria Asuncion Barreda-Manso, Altea Soto, Dan Lindholm, Rosa Navarro-Ruiz, Manuel Nieto-Diaz
Summary: Mechanical trauma to the spinal cord leads to neuronal death and loss of sensory-motor and autonomic functions. Overexpression of XIAP in neurons can improve survival and functional recovery after SCI by inhibiting caspase activity and apoptosis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Sadeeshkumar Velayutham, Ryan Seerattan, Maab Sultan, Trisha Seal, Samaya Danthurthy, Baskaran Chinnappan, Jessica Landi, Kaitlyn Pearl, Aveta Singh, Keiran S. M. Smalley, Julia Zaias, Jun Yong Choi, Dmitriy Minond
Summary: This study demonstrates the potential therapeutic efficacy of targeting spliceosomal proteins hnRNPH1 and H2 in reducing the growth of melanoma.
Article
Chemistry, Medicinal
Jie Yin, Gangyin Zhao, Helen Kalirai, Sarah E. Coupland, Aart G. Jochemsen, Gabriel Forn-Cuni, Annemijn P. A. Wierenga, Martine J. Jager, B. Ewa Snaar-Jagalska, Arwin Groenewoud
Summary: Given the rarity of uveal melanoma and the lack of effective treatments, researchers have developed a method to collect and preserve limited tissue samples from primary tumors and metastases for advanced research and drug screening.
Review
Biochemistry & Molecular Biology
Sha Zhu, Qifeng Bai, Lanqing Li, Tingyang Xu
Summary: Drug repositioning plays a significant role in drug development and machine learning methods can accelerate this process. This article focuses on the repurposing potential of type 2 diabetes mellitus drugs for various diseases.
COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL
(2022)
Article
Biochemistry & Molecular Biology
Maurizio Viale, Giovanni Lentini, Rosaria Gangemi, Patrizio Castagnola, Gualtiero Milani, Silvia Ravera, Nadia Bertola, Antonio Carrieri, Maria Maddalena Cavalluzzi
Summary: This study investigated the potential of the anti-ischemic drug Lube S as an enhancer of anticancer chemotherapy. The results showed that Lube S can effectively improve the antitumor activity of doxorubicin through various mechanisms, including the inhibition of MDR1 gene expression and increased accumulation of doxorubicin in resistant cells.
Article
Medicine, Research & Experimental
Hua Chen, Xi Liu, Yun Wu, Xiayin Wu, Xiaoli Wen, Yanan Lu, Xingsheng Zhao
Summary: Atherosclerosis is a serious disease, and miR-616-3p promotes endothelial cell apoptosis by inhibiting the expression of XIAP mRNA, thus playing a role in the development of atherosclerosis.
EXPERIMENTAL AND THERAPEUTIC MEDICINE
(2021)
Article
Oncology
Chuanhui Lu, Ming Hong, Bo Chen, Kaihua Liu, You Lv, Xin Zhou, Guoqiang Su
Summary: The study demonstrated that miR-215 promotes apoptosis in colon cancer cells by inhibiting XIAP expression. There is an interaction mechanism between miR-215 and XIAP.
CANCER BIOTHERAPY AND RADIOPHARMACEUTICALS
(2021)
Article
Multidisciplinary Sciences
Kevin Lou, Douglas R. Wassarman, Tangpo Yang, YiTing Paung, Ziyang Zhang, Thomas A. O'Loughlin, Megan K. Moore, Regina K. Egan, Patricia Greninger, Cyril H. Benes, Markus A. Seeliger, Jack Taunton, Luke A. Gilbert, Kevan M. Shokat
Summary: The traditional search for cell-permeable drugs has focused on small, nonpolar, rigid chemical structures. However, emerging therapeutic strategies have introduced flexible chemical entities composed of multiple ligands. This study identified an endogenous chemical uptake pathway involving interferon-induced transmembrane proteins (IFITMs) that modulate the cell permeability of specific inhibitors. The study also found that IFITMs moderately assist certain proteolysis-targeting chimeras and investigated the physicochemical requirements for involvement in this uptake pathway.
Review
Oncology
Fangting You, Caiyi Zhang, Xiaoxiao Liu, Daofei Ji, Tong Zhang, Rutong Yu, Shangfeng Gao
Summary: Psychotropic drugs, in addition to their use in mental disorders, have potential for cancer therapy, particularly for glioma. They can inhibit malignant progression of glioma by targeting signaling pathways or increasing sensitivity of glioma cells to conventional treatments. Repurposing established psychotropic drugs as anticancer agents provides new options for glioma treatment.
Article
Biochemistry & Molecular Biology
Adriana Celesia, Marzia Franzo, Diana Di Liberto, Marianna Lauricella, Daniela Carlisi, Antonella D'Anneo, Antonietta Notaro, Mario Allegra, Michela Giuliano, Sonia Emanuele
Summary: We previously showed that the HDAC inhibitor ITF2357 targets oncogenic BRAF in melanoma cells. In this study, we found that oncogenic BRAF localizes to the nucleus of these cells and ITF2357 reduces both nuclear and cytosolic BRAF levels. We also observed an interaction between BRAF and oncogenic p53, and ITF2357 decreased levels of both proteins in certain melanoma cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Cell Biology
Angela Rizzo, Carmen Maresca, Carmen D'Angelo, Manuela Porru, Serena Di Vito, Erica Salvati, Andrea Sacconi, Francesco Berardinelli, Antonella Sgura, Sergey Kuznetsov, Swapnil Potdar, Antti Hassinen, Antonella Stoppacciaro, Pasquale Zizza, Annamaria Biroccio
Summary: Drug repositioning strategy is an effective tool for accelerating drug development by discovering new applications for existing compounds. This study identified FK866 as a molecule that can induce telomere damage and tumor cell death, providing a potential therapeutic strategy for triple-negative breast cancer.
Article
Oncology
Karl Knipper, Su Ir Lyu, Heike Goebel, Alexander I. Damanakis, Yue Zhao, Christiane J. Bruns, Thomas Schmidt, Hamid Kashkar, Alexander Quaas, Lars M. Schiffmann, Felix C. Popp
Summary: This study examined the role of XIAP in patients with PDAC in relation to the inflammatory microenvironment. The results showed that XIAP-positive patients had significantly better survival in lymph node-positive subgroups and in T-cell-rich or neutrophil-rich tumors. However, there was no correlation between XIAP expression and survival in the total population.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2023)
Article
Oncology
Tomoyuki Nakano, Kenji Fujimoto, Arata Tomiyama, Masamichi Takahashi, Takamune Achiha, Hideyuki Arita, Daisuke Kawauchi, Mami Yasukawa, Kenkichi Masutomi, Akihide Kondo, Yoshitaka Narita, Taketoshi Maehara, Koichi Ichimura
Summary: Eribulin demonstrated strong inhibitory effects on cell proliferation, induced apoptosis, and suppressed cell migration in malignant meningioma cell lines, leading to significantly prolonged survival in orthotopic xenograft mouse models.
Review
Dermatology
Jason F. Wang, Seth J. Orlow
AMERICAN JOURNAL OF CLINICAL DERMATOLOGY
(2018)
Article
Dermatology
Lauren E. Wiznia, Suneet Bhansali, Nooshin Brinster, Yasir M. Al-Qaqaa, Seth J. Orlow, Vikash Oza
PEDIATRIC DERMATOLOGY
(2019)
Article
Dermatology
Nekma Meah, Dmitri Wall, Katherine York, Bevin Bhoyrul, Laita Bokhari, Daniel Asz Sigall, Wilma F. Bergfeld, Regina C. Betz, Ulrike Blume-Peytavi, Valerie Callender, Vijaya Chitreddy, Andrea Combalia, George Cotsarelis, Brittany Craiglow, Jeff Donovan, Samantha Eisman, Paul Farrant, Jack Green, Ramon Grimalt, Matthew Harries, Maria Hordinsky, Alan D. Irvine, Satoshi Itami, Victoria Jolliffe, Brett King, Won-Soo Lee, Amy McMichael, Andrew Messenger, Paradi Mirmirani, Elise Olsen, Seth J. Orlow, Bianca Maria Piraccini, Adriana Rakowska, Pascal Reygagne, Janet L. Roberts, Lidia Rudnicka, Jerry Shapiro, Pooja Sharma, Antonella Tosti, Annika Vogt, Martin Wade, Leona Yip, Abraham Zlotogorski, Rodney Sinclair
JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY
(2020)
Article
Dermatology
Jorge Roman, Loren D. Krueger, Trevor K. Young, Evan A. Rieder, Lisa R. Rothman, Nikita Lakdawala, Arielle R. Nagler, Shane A. Meehan, Seth J. Orlow, Vikash S. Oza
Summary: This study identified a novel clinical phenotype called nasal papules, which are skin-colored dome-shaped papules concentrated on the nose and chin, potentially an under-recognized sequelae of acne disproportionately affecting adolescents with skin of color. Histopathologically, these lesions are indistinguishable from angiofibromas, indicating a need for further research and awareness of this condition.
PEDIATRIC DERMATOLOGY
(2021)
Article
Dermatology
Nekma Meah, Dmitri Wall, Katherine York, Bevin Bhoyrul, Laita Bokhari, Daniel Asz-Sigall, Wilma F. Bergfeld, Regina C. Betz, Ulrike Blume-Peytavi, Valerie Callender, Vijaya Chitreddy, Andrea Combalia, George Cotsarelis, Brittany Craiglow, Jeff Donovan, Samantha Eisman, Paul Farrant, Jack Green, Ramon Grimalt, Matthew Harries, Maria Hordinsky, Alan D. Irvine, Satoshi Itami, Victoria Jolliffe, Brett King, Won-Soo Lee, Amy McMichael, Andrew Messenger, Paradi Mirmirani, Elise Olsen, Seth J. Orlow, Bianca Maria Piraccini, Adriana Rakowska, Pascal Reygagne, Janet L. Roberts, Lidia Rudnicka, Jerry Shapiro, Pooja Sharma, Antonella Tosti, Annika Vogt, Martin Wade, Leona Yip, Abraham Zlotogorski, Rodney D. Sinclair
Summary: The international expert consensus on diagnosis and laboratory evaluation of alopecia areata revealed a high level of agreement in these aspects, while showing lower consensus in etiopathogenesis. This study highlights areas where future clinical research could focus to address unresolved hypotheses in patient care for alopecia areata.
JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY
(2021)
Article
Dermatology
Trevor K. Young, Katharina S. Shaw, Jinal K. Shah, Asif Noor, Risa A. Alperin, Adam J. Ratner, Seth J. Orlow, Rebecca A. Betensky, Gail F. Shust, Philip J. Kahn, Vikash S. Oza
Summary: During the peak of the COVID-19 pandemic in New York City in 2020, a study of 35 hospitalized children with suspected MIS-C found that 83% of them exhibited a variety of transient mucocutaneous symptoms including conjunctival injection, palmoplantar erythema, and lip hyperemia. These findings, occurring on average 2.7 days after the onset of fever, can be important clues for the recognition of MIS-C.
Article
Dermatology
Nkemjika Ugonabo, Elyse Love, Priscilla W. Wong, Evan A. Rieder, Seth J. Orlow, Randie H. Kim, Arielle R. Nagler
Summary: Acne patients prescribed isotretinoin were less likely to have psychiatric disorders and engage in suicidal behavior compared to the general population and acne patients prescribed antibiotics. The prevalence of suicidal behavior was lower during isotretinoin treatment than before or after treatment, highlighting the need for further exploration into the increase in suicidal behavior seen in isotretinoin patients one year after therapy.
JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY
(2021)
Article
Dermatology
Jason F. Wang, Trevor K. Young, Laura E. Melnick, Seth J. Orlow, Vikash S. Oza
Summary: The study found that most pediatric patients presenting to the emergency department for AD were either not prescribed a topical corticosteroid (TCS) or were prescribed a weak TCS, often over-the-counter. This may indicate a practice gap in AD management in the pediatric emergency department.
PEDIATRIC DERMATOLOGY
(2021)
Review
Dermatology
Dmitri Wall, Nekma Meah, Katherine York, Bevin Bhoyrul, Laita Bokhari, Leonardo Spagnol Abraham, Roisin Adams, Wilma Bergfeld, Regina C. Betz, Ulrike Blume-Peytavi, Valerie Callender, Chel Campbell, Jen Chambers, Gang Chen, Vijaya Chitreddy, George Cotsarelis, Brittany Craiglow, Rachita Dhurat, Ncoza Dlova, Jeff Donovan, Bruna Duque-Estrada, Samantha Eisman, Abby Ellison, Paul Farrant, Juan Ferrando Barbera, Aida Gadzhigoroeva, Ramon Grimalt, Matthew Harries, Maria Hordinsky, Alan D. Irvine, Victoria Jolliffe, Leslie Jones, Brett King, Won-Soo Lee, Nino Lortkipanidze, Amy McMichael, Andrew Messenger, Paradi Mirmirani, Elise Olsen, Seth J. Orlow, Yuliya Ovcharenko, Bianca Maria Piraccini, Rodrigo Pirmez, Adriana Rakowska, Pascal Reygagne, Melissa Riley, Lidia Rudnicka, David Saceda Corralo, Jerry Shapiro, Pooja Sharma, Tatiana Silyuk, Spartak Kaiumov, Desmond J. Tobin, Antonella Tosti, Sergio Vano-Galvan, Annika Vogt, Martin Wade, Leona Yip, Abraham Zlotogorski, Cheng Zhou, Rodney Sinclair
Summary: This study identified the domains and domain items needed to develop a global network of alopecia areata registries, which will facilitate a standardized approach for recording comprehensive, comparable data sets. This will enable oversight of new therapies introduction and utilization of real-world evidence, supporting the positive disruption in the alopecia areata treatment paradigm.
Article
Pharmacology & Pharmacy
Olga Lavinda, Prashiela Manga, Seth J. Orlow, Timothy Cardozo
Summary: The study demonstrates the importance of the TYR-TYRP1-TYRP2 complex in melanogenesis, suggesting that the formation of this complex may help stabilize the TYR protein and influence melanin production.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Oncology
Sara A. Byron, William P. D. Hendricks, Abhinav B. Nagulapally, Jacqueline M. Kraveka, William S. Ferguson, Valerie Brown, Don E. Eslin, Deanna Mitchell, Albert Cornelius, William Roberts, Michael S. Isakoff, Javier E. Oesterheld, Randal K. Wada, Jawhar Rawwas, Kathleen Neville, Peter E. Zage, Virginia L. Harrod, Genevieve Bergendahl, Elizabeth VanSickle, Karl Dykema, Jeffrey Bond, Hsien-Chao Chou, Jun S. Wei, Xinyu Wen, Hue Reardon, Alison Roos, Sara Nasser, Tyler Izatt, Daniel Enriquez, Apurva M. Hegde, Faith Cisneros, Austin Christofferson, Bryce Turner, Szabolcs Szelinger, Jonathan J. Keats, Rebecca F. Halperin, Javed Khan, Giselle L. Saulnier Sholler, Jeffrey M. Trent
Article
Pathology
Asmerom T. Sengal, Deborah Smith, Cameron E. Snell, Samuel Leung, Aline Talhouk, Elizabeth D. Williams, Jessica N. McAlpine, Pamela M. Pollock
Summary: FGFR2b is specifically expressed in the epithelial compartment of the normal endometrium and hyperplasia without atypia. FGFR2b+/FGFR2c- expression is associated with favorable clinicopathologic markers and clinical outcomes. If confirmed in an independent cohort, FGFR2b could play a role in tailoring the management of EEC patients.
JOURNAL OF PATHOLOGY CLINICAL RESEARCH
(2022)
Article
Cell Biology
Karan K. Budhraja, Bradon R. McDonald, Michelle D. Stephens, Tania Contente-Cuomo, Havell Markus, Maria Farooq, Patricia F. Favaro, Sydney Connor, Sara A. Byron, Jan B. Egan, Brenda Ernst, Timothy K. McDaniel, Aleksandar Sekulic, Nhan L. Tran, Michael D. Prados, Mitesh J. Borad, Michael E. Berens, Barbara A. Pockaj, Patricia M. LoRusso, Alan Bryce, Jeffrey M. Trent, Muhammed Murtaza
Summary: The fragmentation patterns of cell-free DNA (cfDNA) in plasma are influenced by cellular origin and can be used to detect tumor-derived DNA. Researchers developed a metric called iwFAF, which is based on fragment positioning and correlates with tumor fraction. They also used machine learning to differentiate healthy individuals from cancer patients based on iwFAF and nucleotide frequencies.
SCIENCE TRANSLATIONAL MEDICINE
(2023)
Article
Veterinary Sciences
Sharadha Sakthikumar, Salvatore Facista, Derick Whitley, Sara A. A. Byron, Zeeshan Ahmed, Manisha Warrier, Zhanyang Zhu, Esther Chon, Kathryn Banovich, David Haworth, William P. D. Hendricks, Guannan Wang
Summary: The accumulation of cancer mutation data has greatly improved human oncology and can also contribute to advancements in canine oncology. However, interpreting and using this data in dogs is challenging due to the lack of direct functional data. By analyzing the conservation and conversion of human mutations to the canine genome, we can bridge this knowledge gap and facilitate the advancement of canine precision medicine.
VETERINARY AND COMPARATIVE ONCOLOGY
(2023)
Review
Dermatology
Christine C. Akoh, Seth J. Orlow
JOURNAL OF DRUGS IN DERMATOLOGY
(2020)