microRNAs as Mediators of Drug Toxicity

MiRNA-34 intrinsically links p53 tumor suppressor and Wnt signaling

(2012) Yong Hoon Cha et al.   CELL CYCLE

Plasma MicroRNA Profiles in Rat Models of Hepatocellular Injury, Cholestasis, and Steatosis

(2012) Yu Yamaura et al.   PLoS One

Involvement of immune-related factors in diclofenac-induced acute liver injury in mice

(2012) Azusa Yano et al.   TOXICOLOGY

Aryl hydrocarbon receptor nuclear translocator in human liver is regulated by miR-24

(2012) Yuki Oda et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Targeting of microRNA-142-3p in dendritic cells regulates endotoxin-induced mortality

(2011) Y. Sun et al.   BLOOD

A genome-wide survey for SNPs altering microRNA seed sites identifies functional candidates in GWAS

(2011) Kris Richardson et al.   BMC GENOMICS

MiR-28 regulates Nrf2 expression through a Keap1-independent mechanism

(2011) Muhua Yang et al.   BREAST CANCER RESEARCH AND TREATMENT

Hepatic mRNA, microRNA, and miR-34a-Target responses in mice after 28 days exposure to doses of benzo(a)pyrene that elicit DNA damage and mutation

(2011) Amal I. Malik et al.   ENVIRONMENTAL AND MOLECULAR MUTAGENESIS

Differential allelic expression of c.1568C>A at UGT2B15 is due to variation in a novel cis-regulatory element in the 3′UTR

(2011) Chang Sun et al.   GENE

Circulating microRNAs as potential markers of human drug-induced liver injury

(2011) Philip J. Starkey Lewis et al.   HEPATOLOGY

Involvement of Th2 cytokines in the mouse model of flutamide-induced acute liver injury

(2011) Satonori Higuchi et al.   JOURNAL OF APPLIED TOXICOLOGY

miR-200a Regulates Nrf2 Activation by TargetingKeap1mRNA in Breast Cancer Cells

(2011) Gabriel Eades et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Epigenetic regulation of microRNAs in cancer: An integrated review of literature

(2011) Tanja Kunej et al.   MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS

Extracellular microRNA: A new source of biomarkers

(2011) Alton Etheridge et al.   MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS

PPARα Is Regulated by miR-21 and miR-27b in Human Liver

(2011) Katsuhiko Kida et al.   PHARMACEUTICAL RESEARCH

Identification of Urinary microRNA Profiles in Rats That May Diagnose Hepatotoxicity

(2011) Xi Yang et al.   TOXICOLOGICAL SCIENCES

Involvement of MicroRNAs in Dioxin-Induced Liver Damage in the Mouse

(2011) Wataru Yoshioka et al.   TOXICOLOGICAL SCIENCES

Aberrant Expression of miR-638 Contributes to Benzo(a)pyrene-Induced Human Cell Transformation

(2011) Daochuan Li et al.   TOXICOLOGICAL SCIENCES

Pulmonary gene and microRNA expression changes in mice exposed to benzo(a)pyrene by oral gavage

(2011) Sabina Halappanavar et al.   TOXICOLOGY

Regulation of mRNA Translation and Stability by microRNAs

(2010) Marc Robert Fabian et al.   Annual Review of Biochemistry

miR-27a is a negative regulator of adipocyte differentiation via suppressing PPARγ expression

(2010) Sang Yun Kim et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Interplay between cholesterol and drug metabolism

(2010) Tadeja Rezen et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

A potential role for intragenic miRNAs on their hosts' interactome

(2010) Ludwig Hinske et al.   BMC GENOMICS

Epigenetically Deregulated microRNA-375 Is Involved in a Positive Feedback Loop with Estrogen Receptor   in Breast Cancer Cells

(2010) P. de Souza Rocha Simonini et al.   CANCER RESEARCH

Plasma MicroRNA-122 as a Biomarker for Viral-, Alcohol-, and Chemical-Related Hepatic Diseases

(2010) Y. Zhang et al.   CLINICAL CHEMISTRY

MicroRNA-27a Indirectly Regulates Estrogen Receptor α Expression and Hormone Responsiveness in MCF-7 Breast Cancer Cells

(2010) Xiangrong Li et al.   ENDOCRINOLOGY

An estrogen receptor α suppressor, microRNA-22, is downregulated in estrogen receptor α-positive human breast cancer cell lines and clinical samples

(2010) Jianhua Xiong et al.   FEBS Journal

MicroRNA-27b Contributes to Lipopolysaccharide-mediated Peroxisome Proliferator-activated Receptor γ (PPARγ) mRNA Destabilization

(2010) Carla Jennewein et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mechanistic Role of MicroRNA-146a in Endotoxin-Induced Differential Cross-Regulation of TLR Signaling

(2010) M. A. Nahid et al.   JOURNAL OF IMMUNOLOGY

Dose-responsiveness and persistence of microRNA expression alterations induced by cigarette smoke in mouse lung

(2010) Alberto Izzotti et al.   MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS

Lack of change in microRNA expression in adult mouse liver following treatment with benzo(a)pyrene despite robust mRNA transcriptional response

(2010) Carole Lyn Yauk et al.   MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS

The widespread regulation of microRNA biogenesis, function and decay

(2010) Jacek Krol et al.   NATURE REVIEWS GENETICS

Role of primary miRNA polymorphic variants in metastatic colon cancer patients treated with 5-fluorouracil and irinotecan

(2010) V Boni et al.   PHARMACOGENOMICS JOURNAL

miR-17* Suppresses Tumorigenicity of Prostate Cancer by Inhibiting Mitochondrial Antioxidant Enzymes

(2010) Yong Xu et al.   PLoS One

Functional Genetic Variants in the 3′-Untranslated Region of Sulfotransferase Isoform 1A1 (SULT1A1) and Their Effect on Enzymatic Activity

(2010) Xinfeng Yu et al.   TOXICOLOGICAL SCIENCES

Interleukin-17 is involved in α-naphthylisothiocyanate-induced liver injury in mice

(2010) Masanori Kobayashi et al.   TOXICOLOGY

IL-4 mediates dicloxacillin-induced liver injury in mice

(2010) Satonori Higuchi et al.   TOXICOLOGY LETTERS

microRNA miR-27b impairs human adipocyte differentiation and targets PPARγ

(2009) Michael Karbiener et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Human CYP2E1 is regulated by miR-378

(2009) Takuya Mohri et al.   BIOCHEMICAL PHARMACOLOGY

MicroRNA-125a-5p partly regulates the inflammatory response, lipid uptake, and ORP9 expression in oxLDL-stimulated monocyte/macrophages

(2009) Ting Chen et al.   CARDIOVASCULAR RESEARCH

Interleukin-6 Modulates the Expression of the Bone Morphogenic Protein Receptor Type II Through a Novel STAT3–microRNA Cluster 17/92 Pathway

(2009) Matthias Brock et al.   CIRCULATION RESEARCH

Plasma MicroRNAs as Sensitive and Specific Biomarkers of Tissue Injury

(2009) O. F. Laterza et al.   CLINICAL CHEMISTRY

Mechanisms of miRNA-mediated post-transcriptional regulation in animal cells

(2009) Marina Chekulaeva et al.   CURRENT OPINION IN CELL BIOLOGY

MicroRNA 18 and 124a Down-Regulate the Glucocorticoid Receptor: Implications for Glucocorticoid Responsiveness in the Brain

(2009) Erno Vreugdenhil et al.   ENDOCRINOLOGY

Ambient Fine Particulate Matter Exposure and Myocardial Ischemia in the Environmental Epidemiology of Arrhythmogenesis in the Women’s Health Initiative (EEAWHI) Study

(2009) Zhu-ming Zhang et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

A role ofmiR-27in the regulation of adipogenesis

(2009) Qun Lin et al.   FEBS Journal

Over-expressed microRNA-27a and 27b influence fat accumulation and cell proliferation during rat hepatic stellate cell activation

(2009) Juling Ji et al.   FEBS LETTERS

MicroRNA regulates human vitamin D receptor

(2009) Takuya Mohri et al.   INTERNATIONAL JOURNAL OF CANCER

miR-146a Is Critical for Endotoxin-induced Tolerance

(2009) Md A. Nahid et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

MicroRNAs Regulate Human Hepatocyte Nuclear Factor 4α, Modulating the Expression of Metabolic Enzymes and Cell Cycle

(2009) Shingo Takagi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

miR-22 Inhibits Estrogen Signaling by Directly Targeting the Estrogen Receptor   mRNA

(2009) D. P. Pandey et al.   MOLECULAR AND CELLULAR BIOLOGY

Human CYP24 Catalyzing the Inactivation of Calcitriol Is Post-Transcriptionally Regulated by miR-125b

(2009) S. Komagata et al.   MOLECULAR PHARMACOLOGY

MicroRNA polymorphisms: the future of pharmacogenomics, molecular epidemiology and individualized medicine

(2009) Prasun J Mishra et al.   PHARMACOGENOMICS

MicroRNAs as modulators of smoking-induced gene expression changes in human airway epithelium

(2009) F. Schembri et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Circulating microRNAs, potential biomarkers for drug-induced liver injury

(2009) K. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Halothane-Induced Liver Injury is Mediated by Interleukin-17 in Mice

(2009) Eisuke Kobayashi et al.   TOXICOLOGICAL SCIENCES

Detection of elevated levels of tumour-associated microRNAs in serum of patients with diffuse large B-cell lymphoma

(2008) Charles H. Lawrie et al.   BRITISH JOURNAL OF HAEMATOLOGY

Identification of Hypoxia-Inducible Factor-1  as a Novel Target for miR-17-92 MicroRNA Cluster

(2008) A. Taguchi et al.   CANCER RESEARCH

Curcumin attenuates cytochrome P450 induction in response to 2,3,7,8-tetrachlorodibenzo-p-dioxin by ROS-dependently degrading AhR and ARNT

(2008) Hyunsung Choi et al.   CANCER SCIENCE

Differential expression of microRNAs in early-stage neoplastic transformation in the lungs of F344 rats chronically treated with the tobacco carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone

(2008) Stephen Kalscheuer et al.   CARCINOGENESIS

Regulation of Hepatocyte Nuclear Factor 4α-mediated Transcription

(2008) Frank J. Gonzalez   Drug Metabolism and Pharmacokinetics

Most mammalian mRNAs are conserved targets of microRNAs

(2008) R. C. Friedman et al.   GENOME RESEARCH

Post-transcriptional Regulation of Human Pregnane X Receptor by Micro-RNA Affects the Expression of Cytochrome P450 3A4

(2008) Shingo Takagi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

MicroRNA-221/222 Negatively Regulates Estrogen Receptorα and Is Associated with Tamoxifen Resistance in Breast Cancer

(2008) Jian-Jun Zhao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The impact of microRNAs on protein output

(2008) Daehyun Baek et al.   NATURE

MicroRNA target site polymorphisms and human disease

(2008) Praveen Sethupathy et al.   TRENDS IN GENETICS

CYP2E1 and oxidative liver injury by alcohol

(2007) Yongke Lu et al.   FREE RADICAL BIOLOGY AND MEDICINE