Article
Pharmacology & Pharmacy
Huai-Rong Xiang, Yun Li, Xuan Cheng, Bei He, Hua -Min Li, Qi-Zhi Zhang, Bin Wang, Wen-Xing Peng
Summary: This study explores the potential value of serum glutamate dehydrogenase (GLDH) combined with inflammatory cytokines as diagnostic biomarkers for anti-tuberculosis drug-induced liver injury (ATB-DILI). The study collected residual serum from patients who met the criteria after liver function tests and examined GLDH levels and cytokines. The results showed that GLDH, IL-6, and IL-10 alone had good diagnostic efficacy as markers for ATB-DILI. The logistic regression model established by GLDH and IL-10 had better diagnostic efficacy, and IL-6 may be an early predictor of liver injury in the setting of ATB poisoning.
TOXICOLOGY AND APPLIED PHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Michal Tomaszewski, Paulina Mertowska, Martyna Janczewska, Agnieszka Styczen, Sebastian Mertowski, Kamil Jonas, Ewelina Grywalska, Grzegorz Kopec
Summary: Pulmonary arterial hypertension (PAH) is a complex disorder where cytokines play a crucial role in deregulation of the immune system. This study found that PAH patients have abnormal immune function with decreased percentages of immune cell subpopulations and changes in cytokine concentration. Furthermore, significant differences were observed between PAH subtypes and immunological parameters, suggesting the important role of the immune system in the pathogenesis of PAH.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biology
Julie Y. Zhou, Carlos A. Alvarez, Brian A. Cobb
Summary: Cells integrate concurrent signaling initiated by different cytokines to produce specific responses, and the combinatorial effects of different cytokines can lead to distinct biological outcomes, understanding this signaling pathway is crucial for addressing diseases.
Review
Medicine, Research & Experimental
Narendra Kumar, Salim Surani, George Udeani, Sara Mathew, Sharon John, Soniya Sajan, Jayshree Mishra
Summary: Drug-induced liver injury (DILI) is a common cause of liver failure and transplant, with factors such as age, ethnicity, gender, liver diseases, renal function, pregnancy, alcohol consumption, and drug interactions affecting its severity. Characteristics of DILI-associated inflammation include hepatocyte apoptosis and necrosis, with therapeutic approaches depending on the type of inflammation. Treatment may involve discontinuing the causative medication, vaccination, and dietary supplements.
Article
Plant Sciences
Soon-Young Lee, Min-Hee Kim, Seung-Hyun Kim, Taeho Ahn, Sung-Won Kim, Yi-Seong Kwak, Ik-Hyun Cho, Seung-Yeol Nah, Seung-Sik Cho, Kyung Mok Park, Dae-Hun Park, Chun-Sik Bae
Summary: Asthma is a common disease, and Korean Red Ginseng can treat asthma by inhibiting inflammation and altering cytokine levels.
JOURNAL OF GINSENG RESEARCH
(2021)
Article
Immunology
Xiao Huan, Rui Zhao, Jie Song, Huahua Zhong, Manqiqige Su, Chong Yan, Ying Wang, Sheng Chen, Zhirui Zhou, Jiahong Lu, Jianying Xi, Sushan Luo, Chongbo Zhao
Summary: Using ultrasensitive measurement, this study found elevated levels of IL-2, IL-4, IL-5, and IL-12p70 in patients with generalized myasthenia gravis (gMG) of the anti-acetylcholine receptor (AChR) subtype. Subgroup analysis revealed specific differences in cytokine levels based on the age of onset, MGFA classification, and disease duration. Serum cytokines with very low concentrations may serve as potential biomarkers in stratifying gMG patients in future prospective cohort studies.
Article
Medicine, General & Internal
Mojtaba Norouzi, Majid Pirestani, Ehsan Arefian, Abdolhossein Dalimi, Javid Sadraei, Hamed Mirjalali
Summary: This study is the first to report the release of exosome-like vesicles by the human parasite Blastocystis, demonstrating the role of this parasite, particularly ST1, in proinflammatory and anti-inflammatory cytokines and modulating the host response.
FRONTIERS IN MEDICINE
(2022)
Article
Developmental Biology
Pascal Philibert, Stephanie Dejardin, Nelly Pirot, Alain Pruvost, Anvi Laetitia Nguyen, Florence Bernex, Francis Poulat, Brigitte Boizet-Bonhoure
Summary: This study shows that the PGD2 pathway plays a major role in protecting the endometrium against adenomyosis development in the uterus. Lack of PGD2 leads to dysregulation of PGE2 production and the steroidogenic pathway. Additional experiments are needed to fully understand the molecular mechanisms and confirm if the mouse strain is a suitable model for studying human adenomyosis.
MOLECULAR HUMAN REPRODUCTION
(2021)
Article
Oncology
Jun Pan, Leyi Zhang, Jian Huang
Summary: The study indicated that PTGDS may play a significant role in modulating breast cancer growth, with high expression levels associated with reduced tumor proliferation. Treatment with PGD(2) significantly inhibited breast cancer cell proliferation and migration, mediated by decreased expression of TWIST2. Overexpression of TWIST2 reversed the inhibitory effects of PGD(2) on breast cancer cell proliferation.
Article
Biochemistry & Molecular Biology
Jihye Jeong, Jongseon Choe
Summary: This study aimed to investigate the role of Akt protein in the induction and inhibition of prostaglandin production in human follicular dendritic cell-like cells. The results showed that Akt knockdown increased COX-2 expression and prostaglandin production induced by IL-1β, while IL-4 inhibited COX-2 and prostaglandin production through STAT6. Additionally, STAT1 and STAT3 played regulatory roles in IL-1β-induced COX-2 expression.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Dermatology
Chloe Grolleau, Andreea Calugareanu, Sarah Demouche, Audrey Nosbaum, Delphine Staumont-Salle, Helene Aubert, Charles Cassius, Marie Jachiet, Anne Saussine, Martine Bagot, Herve Bachelez, Maxime Battistella, Claire Hotz, Aurelie Du Thanh, Marie-Noelle Crepy, David Bergerat, Marine Merandet, Rachel Onifarasoaniaina, Antonio Alberdi, Alexandre How-Kit, Jean-David Bouaziz, Helene Le-Buanec
Summary: Dupilumab, a therapeutic antibody targeting IL-4 and IL-13 receptor subunit alpha, has been used for treating atopic dermatitis (AD). Recent reports have shown cases of psoriasis-like reactions induced by dupilumab treatment for AD. The pathogenesis of dupilumab-induced psoriatic eruption (DI-Pso) involves a shift in skin immune responses from T helper 2 to IL-36 and T helper 17 polarization, as well as intensified skin barrier alterations.
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2023)
Article
Immunology
Cecile Apert, Ariel O. Galindo-Albarran, Sarah Castan, Claire Detraves, Heloise Michaud, Nicola McJannett, Bart Haegeman, Simon Fillatreau, Bernard Malissen, Georg Hollander, Saulius Zuklys, Jeremy C. Santamaria, Olivier P. Joffre, Paola Romagnoli, Joost P. M. van Meerwijk
Summary: This study reevaluated the role of IL-2 and IL-15 in the development of regulatory T-lymphocytes (Treg) and found that IL-2 and IL-15 play important non-redundant quantitative and qualitative roles in intrathymic Treg development.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Medicine, Research & Experimental
Juan-Manuel Leyva-Castillo, Mrinmoy Das, Jennifer Kane, Maria Strakosha, Sonal Singh, Daniel Sen Hoi Wong, Alexander R. Horswill, Hajime Karasuyama, Frank Brombacher, Lloyd S. Miller, Raif S. Geha
Summary: Research has shown that mechanical injury to mouse skin through tape stripping predisposes the skin to superficial infection with S. aureus. This infection is promoted by basophil-derived IL-4, which inhibits the production of IL-17A and facilitates S. aureus infection. IL-4 acts on multiple checkpoints to suppress the cutaneous IL-17A response, but blocking the IL-4 receptor can enhance Il17a expression and bacterial clearance.
Article
Medicine, Research & Experimental
Julia Yago-Ibanez, Laura Munoz-Moreno, Beatriz Gallego-Tamayo, Francisco Javier Lucio-Cazana, Ana Belen Fernandez-Martinez
Summary: Inflammatory cytokines contribute to proximal tubular cell injury, and PGE2 re-uptake by PGT is critical for PGE2-mediated injury. This study investigates the effects of pro-inflammatory cytokines in PTC and their prevention by PGT targeting.
Article
Microbiology
Zane Vitenberga-Verza, Mara Pilmane, Ksenija Serstnova, Ivars Melderis, Lukasz Gontar, Maksymilian Kochanski, Andzelika Drutowska, Gergely Maroti, Beatriz Prieto-Simon
Summary: This study aimed to investigate the inflammatory and regulatory cytokines in the milk of dairy cows with subclinical and clinical mastitis. The results showed that IL-1 alpha, IL-4, and IL-17A drive the inflammatory responses in mastitis cases. Furthermore, the host defense response in mastitis is characterized by the continuation or resolution of the initial inflammation.
Article
Immunology
Shin Shimoyama, Kazuhito Kawata, Kazuyoshi Ohta, Takeshi Chida, Tetsuro Suzuki, Koichi Tsuneyama, Shinji Shimoda, Nobuhito Kurono, Patrick S. C. Leung, M. Eric Gershwin, Takafumi Suda, Yoshimasa Kobayashi
Summary: The primary treatment for primary biliary cholangitis (PBC), ursodeoxycholic acid (UDCA), works by suppressing the production of IFN-gamma and CX3CL1 to reduce inflammation, ultimately decreasing the chemotactic and adhesive abilities of liver-infiltrating T cells in PBC.
EUROPEAN JOURNAL OF IMMUNOLOGY
(2021)
Article
Pathology
Mayuko Ichimura-Shimizu, Yosuke Tsuchiyama, Yuki Morimoto, Minoru Matsumoto, Tomoko Kobayashi, Satoshi Sumida, Takumi Kakimoto, Takeshi Oya, Hirohisa Ogawa, Michiko Yamashita, Satoru Matsuda, Katsuhisa Omagari, Shu Taira, Koichi Tsuneyama
Summary: This study utilized a HFCC diet to induce a NASH-related fibrosis model in A/J mice, showing aggravated inflammation and fibrosis in the liver tissue compared to C57BL/6J mice. The presence of lipid-laden macrophage aggregation and cholesterol crystals adjacent to fibrotic lesions provided histological evidence of fibrosis initiation. Mass spectrometry analysis identified specific molecules in the aggregated macrophages, shedding light on the pathophysiology of NASH-related fibrosis.
AMERICAN JOURNAL OF PATHOLOGY
(2022)
Article
Pharmacology & Pharmacy
Mai Nagaoka, Tatsuki Fukami, Fumiya Kisui, Takuya Yamada, Yoshiyuki Sakai, Kiyomichi Tashiro, Takuo Ogiso, Keigo Konishi, Shiori Honda, Keiya Hirosawa, Masataka Nakano, Miki Nakajima
Summary: This study demonstrated the significance of AADAC in ketoconazole-induced toxicity through experiments on Aadac knockout mice, showing that AADAC deficiency exacerbates liver injury and steroidogenesis inhibition caused by ketoconazole. The findings suggest that the hydrolysis of ketoconazole by AADAC can mitigate ketoconazole-induced toxicities.
BIOCHEMICAL PHARMACOLOGY
(2022)
Article
Oncology
Julio C. Valencia, Rebecca A. Erwin-Cohen, Paul E. Clavijo, Clint Allen, Michael E. Sanford, Chi-Ping Day, Megan M. Hess, Morgan Johnson, Jie Yin, John M. Fenimore, Ian A. Bettencourt, Koichi Tsuneyama, Maria E. Romero, Kimberly D. Klarmann, Peng Jiang, Heekyong R. Bae, Daniel W. McVicar, Glenn Merlino, Elijah F. Edmondson, Niroshana Anandasabapathy, Howard A. Young
Summary: The relationship between cancer and autoimmunity is complex, with MDSCs inducing macrophage reprogramming and affecting tumor progression, immune therapy resistance, and autoimmune disease development.
Article
Oncology
Katsuki Miyazaki, Yuji Morine, Shinichiro Yamada, Yu Saito, Kazunori Tokuda, Shohei Okikawa, Shoko Yamashita, Takeshi Oya, Tetsuya Ikemoto, Satoru Imura, Haun Hu, Hisayoshi Morioka, Koichi Tsuneyama, Mitsuo Shimada
Summary: Stromal TILs, especially in the marginal area, may have significant prognostic impact in patients with IHCC. Low TILs in the marginal area are associated with poorer survival rates and with lymph node metastasis and portal vein invasion. Additionally, ADC values from MRI may predict TILs in IHCC tumor tissue.
INTERNATIONAL JOURNAL OF CLINICAL ONCOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Mayuko Ichimura-Shimizu, Takeshi Kageyama, Takeshi Oya, Hirohisa Ogawa, Minoru Matsumoto, Satoshi Sumida, Takumi Kakimoto, Yuko Miyakami, Ryosuke Nagatomo, Koichi Inoue, Chunmei Cheng, Koichi Tsuneyama
Summary: Metabolic syndrome is a risk factor for various diseases, with hyperglycemia being associated with liver carcinogenesis in NASH. Studies using TSOD mice demonstrated that milk-derived oligosaccharides have a lowering effect on blood glucose levels and may prevent liver carcinogenesis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Immunology
Hitoshi Nishijima, Minoru Matsumoto, Junko Morimoto, Kazuyoshi Hosomichi, Nobuko Akiyama, Taishin Akiyama, Takeshi Oya, Koichi Tsuneyama, Hideyuki Yoshida, Mitsuru Matsumoto
Summary: The deficiency of Aire leads to autoimmunity, and Aire indirectly induces the expression of TRAs by controlling the heterogeneity of mTECs. Analysis of transcriptomic data from Aire-augmented and Aire-deficient mTECs reveals that many Aire-dependent genes may not be direct transcriptional targets of Aire, while Ccl25 is identified as a canonical target of Aire.
JOURNAL OF IMMUNOLOGY
(2022)
Article
Cell Biology
Junko Morimoto, Minoru Matsumoto, Ryuichiro Miyazawa, Hideyuki Yoshida, Koichi Tsuneyama, Mitsuru Matsumoto
Summary: This study reveals the significance of the interaction between mTECs and DCs coordinated by Aire in establishing thymic tolerance. Aire deficiency leads to abnormal expression of CTLA-4 in mTECs, which removes CD80/CD86 ligands from DCs, attenuating their ability to provide co-stimulatory signals and present self-antigens transferred from mTECs, resulting in impaired Treg production and organ-specific autoimmunity.
Article
Cell Biology
Yasu-Taka Azuma, Takashi Fujita, Takeshi Izawa, Kana Hirota, Kazuhiro Nishiyama, Airi Ikegami, Tomoko Aoyama, Mikihito Ike, Yumi Ushikai, Mitsuru Kuwamura, Hideki Fujii, Koichi Tsuneyama
Summary: IL-19, a member of the IL-10 family, plays a crucial role in NAFLD/NASH models by regulating liver metabolism and affecting steatosis and fibrosis. In vitro, IL-19's action can suppress lipid metabolism.
Article
Biochemistry & Molecular Biology
Takeo Minamikawa, Eiji Hase, Mayuko Ichimura-Shimizu, Yuki Morimoto, Akihiro Suzuki, Takeshi Yasui, Satoko Nakamura, Akemi Tsutsui, Koichi Takaguchi, Koichi Tsuneyama
Summary: In this study, second-harmonic generation microscopy was used to quantitatively assess the ultra-early stage of fibrosis in NAFLD patients. The results showed that SHG microscopy can effectively visualize fibrotic structures and early fibrosis in liver tissues, which is challenging to identify with conventional histopathological methods. Additionally, SHG emission directionality analysis can assess the maturation of collagen fibers in each patient.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Chemistry, Multidisciplinary
Mayuko Ichimura-Shimizu, Soichiro Ishimaru, Christine (Yee-Yan) Wai, Takeo Minamikawa, Takaaki Tsunematsu, Aiko Endo, Takumi Kojima, Minoru Matsumoto, Tomoko Kobayashi, Satoshi Sumida, Takumi Kakimoto, Yuko Miyakami, Hirohisa Ogawa, Takeshi Oya, Koichi Tsuneyama
Summary: This study generated a mouse model of shellfish allergy through epicutaneous sensitization, which can be used to explore the pathogenesis of skin sensitization. Raman microscopy may also provide valuable insights into subtle skin changes leading to sensitization.
APPLIED SCIENCES-BASEL
(2022)
Article
Biochemistry & Molecular Biology
Wenhua Shao, Orgil Jargalsaikhan, Mayuko Ichimura-Shimizu, Qinyi Cai, Hirohisa Ogawa, Yuko Miyakami, Kengo Atsumi, Mitsuru Tomita, Mitsuko Sutoh, Shunji Toyohara, Ryoji Hokao, Yasusei Kudo, Takeshi Oya, Koichi Tsuneyama
Summary: The GS-negative tumors of TSOD mice exhibit characteristics similar to various subtypes of human hepatocellular adenoma (HCA), suggesting that TSOD mice may share similar mechanisms of HCA development as in humans.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Yuki Tada, Kaichi Kasai, Nana Makiuchi, Naoya Igarashi, Koudai Kani, Shun Takano, Hiroe Honda, Tsutomu Yanagibashi, Yasuharu Watanabe, Fumitake Usui-Kawanishi, Yukihiro Furusawa, Mayuko Ichimura-Shimizu, Yoshiaki Tabuchi, Kiyoshi Takatsu, Koichi Tsuneyama, Yoshinori Nagai
Summary: Macrophages play a critical role in the development of non-alcoholic steatohepatitis (NASH), but it is unclear which macrophage subset is specifically involved in inflammation and fibrosis. In this study, we found that in TSNO mice with advanced liver fibrosis resembling human NASH, recruited macrophages were more abundant than Kupffer cells (KCs) and formed hepatic crown-like structures (hCLS). The recruited macrophages consisted of CD11c(+)/Ly6C(-) and CD11c(-)/Ly6C(+) subsets, with CD11c(+)/Ly6C(-) cells promoting liver fibrosis and hepatic stellate cell (HSC) activation, while CD11c(-)/Ly6C(+) cells exhibited an anti-inflammatory role and promoted tissue repair.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Kaichi Kasai, Naoya Igarashi, Yuki Tada, Koudai Kani, Shun Takano, Tsutomu Yanagibashi, Fumitake Usui-Kawanishi, Shiho Fujisaka, Shiro Watanabe, Mayuko Ichimura-Shimizu, Kiyoshi Takatsu, Kazuyuki Tobe, Koichi Tsuneyama, Yukihiro Furusawa, Yoshinori Nagai
Summary: The gut microbiota plays a potential role in the development of non-alcoholic fatty liver disease. Antibiotic treatments in non-obese mice fed a high-fat/cholesterol/cholate-based diet exacerbated liver damage, steatohepatitis, and fibrosis. This effect was attributed to changes in gut microbiota, particularly an increase in Gram-positive organisms, and the modulation of bile acid levels and composition.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Mayuko Ichimura-Shimizu, Shiro Watanabe, Yuka Kashirajima, Ami Nagatomo, Hitomi Wada, Koichi Tsuneyama, Katsuhisa Omagari
Summary: This study demonstrates the direct impact of dietary cholic acid (CA) on the progression of nonalcoholic steatohepatitis (NASH) induced by a high-fat and high-cholesterol diet. Adding CA to the diet exacerbates hepatic steatosis, inflammation, and fibrosis, leading to cirrhosis. These findings provide further evidence of the hepatotoxicity of CA.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
