Pharmacology of Iron Transport

Calcium-channel blockers do not affect iron transport mediated by divalent metal-ion transporter-1

(2012) B. Mackenzie et al.   BLOOD

Zip14 is a complex broad-scope metal-ion transporter whose functional properties support roles in the cellular uptake of zinc and nontransferrin-bound iron

(2011) Jorge J. Pinilla-Tenas et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Cell sensitivity to oxidative stress is influenced by ferritin autophagy

(2011) Tino Kurz et al.   FREE RADICAL BIOLOGY AND MEDICINE

Intestinal DMT1 Cotransporter Is Down-regulated by Hepcidin via Proteasome Internalization and Degradation

(2011) Carole Brasse–Lagnel et al.   GASTROENTEROLOGY

Minihepcidins are rationally designed small peptides that mimic hepcidin activity in mice and may be useful for the treatment of iron overload

(2011) Gloria C. Preza et al.   JOURNAL OF CLINICAL INVESTIGATION

Anticancer activity of the iron facilitator LS081

(2011) Zhen Li et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Role of TRP Channels in the Regulation of the Endosomal Pathway

(2011) Ken Abe et al.   PHYSIOLOGY

Interaction of calcium with the human divalent metal-ion transporter-1

(2010) Ali Shawki et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Two routes of iron accumulation in astrocytes: ascorbate-dependent ferrous iron uptake via the divalent metal transporter (DMT1) plus an independent route for ferric iron

(2010) Darius J.R. Lane et al.   BIOCHEMICAL JOURNAL

Identification of an “α-helix-extended segment-α-helix” conformation of the sixth transmembrane domain in DMT1

(2010) Shuyan Xiao et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Structure and metal ion binding of the first transmembrane domain of DMT1

(2010) Dan Wang et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Iron-Export Ferroxidase Activity of β-Amyloid Precursor Protein Is Inhibited by Zinc in Alzheimer's Disease

(2010) James A. Duce et al.   CELL

A Mammalian Siderophore Synthesized by an Enzyme with a Bacterial Homolog Involved in Enterobactin Production

(2010) Laxminarayana R. Devireddy et al.   CELL

The iron-chelating potential of silybin in patients with hereditary haemochromatosis

(2010) C Hutchinson et al.   EUROPEAN JOURNAL OF CLINICAL NUTRITION

Novel drug targets based on metallobiology of Alzheimer's disease

(2010) Sanghamitra Bandyopadhyay et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Human iron transporters

(2010) Michael D. Garrick   Genes and Nutrition

ZRT/IRT-like Protein 14 (ZIP14) Promotes the Cellular Assimilation of Iron from Transferrin

(2010) Ningning Zhao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Iron traffics in circulation bound to a siderocalin (Ngal)–catechol complex

(2010) Guanhu Bao et al.   Nature Chemical Biology

Small molecule inhibitors of divalent metal transporter-1

(2009) Peter D. Buckett et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Oral Iron Chelators

(2009) Maria Domenica Cappellini et al.   Annual Review of Medicine

Transmembrane Topology of the Mammalian Slc11a2 Iron Transporter

(2009) Maciej Czachorowski et al.   BIOCHEMISTRY

Not all DMT1 mutations lead to iron overload

(2009) Esther Blanco et al.   BLOOD CELLS MOLECULES AND DISEASES

Reduced serum hepcidin levels in patients with chronic hepatitis C

(2009) Domenico Girelli et al.   JOURNAL OF HEPATOLOGY

Thiosemicarbazones from the Old to New: Iron Chelators That Are More Than Just Ribonucleotide Reductase Inhibitors

(2009) Yu Yu et al.   JOURNAL OF MEDICINAL CHEMISTRY

Recycling Iron in Normal and Pathological States

(2009) Carole Beaumont et al.   SEMINARS IN HEMATOLOGY

Antitumor activity and mechanism of action of the iron chelator, Dp44mT, against leukemic cells

(2008) Egarit Noulsri et al.   AMERICAN JOURNAL OF HEMATOLOGY

Amyloid precursor protein and alpha synuclein translation, implications for iron and inflammation in neurodegenerative diseases

(2008) Catherine M. Cahill et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Curcumin, a cancer chemopreventive and chemotherapeutic agent, is a biologically active iron chelator

(2008) Y. Jiao et al.   BLOOD

Identification of a Steap3 endosomal targeting motif essential for normal iron metabolism

(2008) T. Lambe et al.   BLOOD

A phase 2 consortium (P2C) trial of 3-aminopyridine-2-carboxaldehyde thiosemicarbazone (3-AP) for advanced adenocarcinoma of the pancreas

(2008) Steven Attia et al.   INVESTIGATIONAL NEW DRUGS

Solute Carrier 11 Cation Symport Requires Distinct Residues in Transmembrane Helices 1 and 6

(2008) Pascal Courville et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Hepcidin Regulation of Iron Transport

(2008) James F. Collins et al.   JOURNAL OF NUTRITION

The type IV mucolipidosis-associated protein TRPML1 is an endolysosomal iron release channel

(2008) Xian-Ping Dong et al.   NATURE

Hepcidin inhibits apical iron uptake in intestinal cells

(2007) Natalia P. Mena et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY