Viral Miniproteins

Structure, domain organization, and different conformational states of stem cell factor-induced intact KIT dimers

(2014) Yarden Opatowsky et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Virus Budding and the ESCRT Pathway

(2013) Jörg Votteler et al.   Cell Host & Microbe

A Single Amino Acid Substitution Converts a Transmembrane Protein Activator of the Platelet-derived Growth Factor β Receptor into an Inhibitor

(2013) Lisa M. Petti et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Amphipathic Helix of Influenza A Virus M2 Protein Is Required for Filamentous Bud Formation and Scission of Filamentous and Spherical Particles

(2013) K. L. Roberts et al.   JOURNAL OF VIROLOGY

Compensatory Mutants of the Bovine Papillomavirus E5 Protein and the Platelet-Derived Growth Factor   Receptor Reveal a Complex Direct Transmembrane Interaction

(2013) A. P. B. Edwards et al.   JOURNAL OF VIROLOGY

Direct Formation of Vaccinia Virus Membranes from the Endoplasmic Reticulum in the Absence of the Newly Characterized L2-Interacting Protein A30.5

(2013) L. Maruri-Avidal et al.   JOURNAL OF VIROLOGY

De novo selection of oncogenes

(2013) K. M. Chacon et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Role of the vaccinia virus O3 protein in cell entry can be fulfilled by its Sequence flexible transmembrane domain

(2013) P.S. Satheshkumar et al.   VIROLOGY

The E5 proteins

(2013) Daniel DiMaio et al.   VIROLOGY

Bovine papillomavirus E5 and E7 oncoproteins in naturally occurring tumors: are two better than one?

(2013) Annunziata Corteggio et al.   Infectious Agents and Cancer

Sites of Action of HIV-1 Vpu in BST-2/Tetherin Downregulation

(2012) Juan F. Arias et al.   CURRENT HIV RESEARCH

The Small Hydrophobic Protein of the Human Respiratory Syncytial Virus Forms Pentameric Ion Channels

(2012) Siok-Wan Gan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

High-Risk Human Papillomavirus E5 Oncoprotein Displays Channel-Forming Activity Sensitive to Small-Molecule Inhibitors

(2012) L. F. Wetherill et al.   JOURNAL OF VIROLOGY

Transmembrane Protein Aptamers That Inhibit CCR5 Expression and HIV Coreceptor Function

(2012) E. H. Scheideman et al.   JOURNAL OF VIROLOGY

Biogenesis of the Vaccinia Virus Membrane: Genetic and Ultrastructural Analysis of the Contributions of the A14 and A17 Proteins

(2012) B. Unger et al.   JOURNAL OF VIROLOGY

Viroporins: structure and biological functions

(2012) José Luis Nieva et al.   NATURE REVIEWS MICROBIOLOGY

Decoding Human Cytomegalovirus

(2012) N. Stern-Ginossar et al.   SCIENCE

An expanding universe of small proteins

(2011) Errett C Hobbs et al.   CURRENT OPINION IN MICROBIOLOGY

Structural and dynamic mechanisms for the function and inhibition of the M2 proton channel from influenza A virus

(2011) Jun Wang et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Discovery and annotation of small proteins using genomics, proteomics, and computational approaches

(2011) X. Yang et al.   GENOME RESEARCH

Membrane Localization of Small Proteins inEscherichia coli

(2011) Fanette Fontaine et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

HIV-1 Vpu Protein Antagonizes Innate Restriction Factor BST-2 via Lipid-embedded Helix-Helix Interactions

(2011) Mark Skasko et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Molecular Dynamics Simulation Directed Rational Design of Inhibitors Targeting Drug-Resistant Mutants of Influenza A Virus M2

(2011) Jun Wang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Transmembrane Domain Determinants of CD4 Downregulation by HIV-1 Vpu

(2011) J. G. Magadan et al.   JOURNAL OF VIROLOGY

Participation of Vaccinia Virus L2 Protein in the Formation of Crescent Membranes and Immature Virions

(2011) L. Maruri-Avidal et al.   JOURNAL OF VIROLOGY

Sequence-Divergent Chordopoxvirus Homologs of the O3 Protein Maintain Functional Interactions with Components of the Vaccinia Virus Entry-Fusion Complex

(2011) P. S. Satheshkumar et al.   JOURNAL OF VIROLOGY

Modulation of HIV-1-host interaction: role of the Vpu accessory protein

(2011) Mathieu Dubé et al.   Retrovirology

HIV-1 Vpu Antagonizes BST-2 by Interfering Mainly with the Trafficking of Newly Synthesized BST-2 to the Cell Surface

(2011) Mathieu Dubé et al.   TRAFFIC

Ion channel activity of HIV-1 Vpu is dispensable for counteraction of CD317

(2011) Sebastian Bolduan et al.   VIROLOGY

Orf-I and Orf-II-Encoded Proteins in HTLV-1 Infection and Persistence

(2011) Dustin Edwards et al.   Viruses-Basel

Exploring the Requirements for the Hydrophobic Scaffold and Polar Amine in Inhibitors of M2 from Influenza A Virus

(2011) Jun Wang et al.   ACS Medicinal Chemistry Letters

The SV40 Late Protein VP4 Is a Viroporin that Forms Pores to Disrupt Membranes for Viral Release

(2011) Smita Raghava et al.   PLoS Pathogens

Structural Basis for the Antiviral Activity of BST-2/Tetherin and Its Viral Antagonism

(2011) Juan F. Arias et al.   Frontiers in Microbiology

Conformational plasticity of the influenza A M2 transmembrane helix in lipid bilayers under varying pH, drug binding, and membrane thickness

(2010) Fanghao Hu et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Towards a structural understanding of the smallest known oncoprotein: Investigation of the bovine papillomavirus E5 protein using solution-state NMR

(2010) Gavin King et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Structural Role of the Conserved Cysteines in the Dimerization of the Viral Transmembrane Oncoprotein E5

(2010) Dirk Windisch et al.   BIOPHYSICAL JOURNAL

Influenza Virus M2 Protein Mediates ESCRT-Independent Membrane Scission

(2010) Jeremy S. Rossman et al.   CELL

CD317/Tetherin Is Enriched in the HIV-1 Envelope and Downregulated from the Plasma Membrane upon Virus Infection

(2010) A. Habermann et al.   JOURNAL OF VIROLOGY

Function of the Small Hydrophobic Protein of J Paramyxovirus

(2010) Z. Li et al.   JOURNAL OF VIROLOGY

Structure of the amantadine binding site of influenza M2 proton channels in lipid bilayers

(2010) Sarah D. Cady et al.   NATURE

Structures of a platelet-derived growth factor/propeptide complex and a platelet-derived growth factor/receptor complex

(2010) A. Hye-Ryong Shim et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Construction and genetic selection of small transmembrane proteins that activate the human erythropoietin receptor

(2010) Tobin J. Cammett et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structure and mechanism of proton transport through the transmembrane tetrameric M2 protein bundle of the influenza A virus

(2010) R. Acharya et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mechanisms of Proton Conduction and Gating in Influenza M2 Proton Channels from Solid-State NMR

(2010) F. Hu et al.   SCIENCE

Multilayered Mechanism of CD4 Downregulation by HIV-1 Vpu Involving Distinct ER Retention and ERAD Targeting Steps

(2010) Javier G. Magadán et al.   PLoS Pathogens

The Human Polyoma JC Virus Agnoprotein Acts as a Viroporin

(2010) Tadaki Suzuki et al.   PLoS Pathogens

Design and Pharmacological Characterization of Inhibitors of Amantadine-Resistant Mutants of the M2 Ion Channel of Influenza A Virus

(2009) Victoria Balannik et al.   BIOCHEMISTRY

Functional Studies and Modeling of Pore-Lining Residue Mutants of the Influenza A Virus M2 Ion Channel

(2009) Victoria Balannik et al.   BIOCHEMISTRY

Tetherin Inhibits HIV-1 Release by Directly Tethering Virions to Cells

(2009) David Perez-Caballero et al.   CELL

HIV-1 Accessory Protein Vpu Internalizes Cell-surface BST-2/Tetherin through Transmembrane Interactions Leading to Lysosomes

(2009) Yukie Iwabu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Artificial Transmembrane Oncoproteins Smaller than the Bovine Papillomavirus E5 Protein Redefine Sequence Requirements for Activation of the Platelet-Derived Growth Factor   Receptor

(2009) K. Talbert-Slagle et al.   JOURNAL OF VIROLOGY

Influenza A Virus Lacking M2 Protein as a Live Attenuated Vaccine

(2009) S. Watanabe et al.   JOURNAL OF VIROLOGY

Characterization of a Newly Identified 35-Amino-Acid Component of the Vaccinia Virus Entry/Fusion Complex Conserved in All Chordopoxviruses

(2009) P. S. Satheshkumar et al.   JOURNAL OF VIROLOGY

Hydrophobic peptides: novel regulators within bacterial membrane

(2009) Eric Alix et al.   MOLECULAR MICROBIOLOGY

Solution structure and functional analysis of the influenza B proton channel

(2009) Junfeng Wang et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Identification of the functional core of the influenza A virus A/M2 proton-selective ion channel

(2009) C. Ma et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Budding of filamentous and non-filamentous influenza A virus occurs via a VPS4 and VPS28-independent pathway

(2009) Emily A. Bruce et al.   VIROLOGY

Species-Specific Activity of HIV-1 Vpu and Positive Selection of Tetherin Transmembrane Domain Variants

(2009) Matthew W. McNatt et al.   PLoS Pathogens

Membrane remodelling during vaccinia virus morphogenesis

(2008) Francisco Javier Chichón et al.   BIOLOGY OF THE CELL

The Interferon-Induced Protein BST-2 Restricts HIV-1 Release and Is Downregulated from the Cell Surface by the Viral Vpu Protein

(2008) Nanette Van Damme et al.   Cell Host & Microbe

Peptide-assisted degradation of the Salmonella MgtC virulence factor

(2008) Eric Alix et al.   EMBO JOURNAL

Vaccinia Virus Encodes I5, a Small Hydrophobic Virion Membrane Protein That Enhances Replication and Virulence in Mice

(2008) C. L. Sood et al.   JOURNAL OF VIROLOGY

Human Metapneumovirus Small Hydrophobic Protein Inhibits NF- B Transcriptional Activity

(2008) X. Bao et al.   JOURNAL OF VIROLOGY

The Vaccinia Virus Gene I2L Encodes a Membrane Protein with an Essential Role in Virion Entry

(2008) R. J. Nichols et al.   JOURNAL OF VIROLOGY

Small membrane proteins found by comparative genomics and ribosome binding site models

(2008) Matthew R. Hemm et al.   MOLECULAR MICROBIOLOGY

Structure and mechanism of the M2 proton channel of influenza A virus

(2008) Jason R. Schnell et al.   NATURE

Tetherin inhibits retrovirus release and is antagonized by HIV-1 Vpu

(2008) Stuart J. D. Neil et al.   NATURE

Functional studies indicate amantadine binds to the pore of the influenza A virus M2 proton-selective ion channel

(2008) X. Jing et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Interplay of Functional Tuning, Drug Resistance, and Thermodynamic Stability in the Evolution of the M2 Proton Channel from the Influenza A Virus

(2008) Amanda L. Stouffer et al.   STRUCTURE

Functional Characterization of the Vaccinia Virus I5 Protein

(2008) Bethany Unger et al.   Virology Journal

Mechanisms for enveloped virus budding: Can some viruses do without an ESCRT?

(2007) Benjamin J. Chen et al.   VIROLOGY