An Anti-C1s Monoclonal, TNT003, Inhibits Complement Activation Induced by Antibodies Against HLA

Time-Dependent Specificity of Immunopathologic (C4d-CD68) and Histologic Criteria of Antibody-Mediated Rejection for Donor-Specific Antibodies and Allograft Dysfunction in Heart Transplantation

(2015) Patrick Yerly et al.   TRANSPLANTATION

The perfect storm: HLA antibodies, complement, FcγRs, and endothelium in transplant rejection

(2015) Kimberly A. Thomas et al.   TRENDS IN MOLECULAR MEDICINE

Banff 2013 Meeting Report: Inclusion of C4d-Negative Antibody-Mediated Rejection and Antibody-Associated Arterial Lesions

(2014) M. Haas et al.   AMERICAN JOURNAL OF TRANSPLANTATION

TNT003, an inhibitor of the serine protease C1s, prevents complement activation induced by cold agglutinins

(2014) J. Shi et al.   BLOOD

Recent trials in immunosuppression and their consequences for current therapy

(2014) Mariana Wohlfahrtova et al.   Current Opinion in Organ Transplantation

Immunosuppression following heart transplantation: prospects and challenges

(2014) David H Chang et al.   Immunotherapy

Pre-transplant donor HLA-specific antibodies: Characteristics causing detrimental effects on survival after lung transplantation

(2014) John D. Smith et al.   JOURNAL OF HEART AND LUNG TRANSPLANTATION

De novo donor HLA-specific antibodies predict development of bronchiolitis obliterans syndrome after lung transplantation

(2014) Shahideh Safavi et al.   JOURNAL OF HEART AND LUNG TRANSPLANTATION

Anti-MHC Class I Antibody Activation of Proliferation and Survival Signaling in Murine Cardiac Allografts

(2014) P. T. Jindra et al.   JOURNAL OF IMMUNOLOGY

Detection of C3d-Binding Donor-Specific Anti-HLA Antibodies at Diagnosis of Humoral Rejection Predicts Renal Graft Loss

(2014) A. Sicard et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Complement Is Activated by IgG Hexamers Assembled at the Cell Surface

(2014) C. A. Diebolder et al.   SCIENCE

Antibody-mediated rejection despite inhibition of terminal complement

(2014) Andrew Bentall et al.   TRANSPLANT INTERNATIONAL

Eculizumab and Splenectomy as Salvage Therapy for Severe Antibody-Mediated Rejection After HLA–Incompatible Kidney Transplantation

(2014) Babak J. Orandi et al.   TRANSPLANTATION

Deciphering Complement Interference in Anti–Human Leukocyte Antigen Antibody Detection With Flow Beads Assays

(2014) Jonathan Visentin et al.   TRANSPLANTATION

Report of the Inefficacy of Eculizumab in Two Cases of Severe Antibody-Mediated Rejection of Renal Grafts

(2014) Maren Burbach et al.   TRANSPLANTATION

Complement modulation in solid-organ transplantation

(2014) Maxime Touzot et al.   Transplantation Reviews

Immune Cell-Derived C3a and C5a Costimulate Human T Cell Alloimmunity

(2013) P. Cravedi et al.   AMERICAN JOURNAL OF TRANSPLANTATION

De NovoDonor-Specific HLA Antibodies Decrease Patient and Graft Survival in Liver Transplant Recipients

(2013) H. Kaneku et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Alloantibody and Complement Promote T Cell–Mediated Cardiac Allograft Vasculopathy Through Noncanonical Nuclear Factor-κB Signaling in Endothelial Cells

(2013) Dan Jane-wit et al.   CIRCULATION

The use of eculizumab in renal transplantation

(2013) A. Nicholas R. Barnett et al.   CLINICAL TRANSPLANTATION

Signaling through C5a receptor and C3a receptor diminishes function of murine natural regulatory T cells

(2013) Wing-hong Kwan et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The 2013 International Society for Heart and Lung Transplantation Working Formulation for the standardization of nomenclature in the pathologic diagnosis of antibody-mediated rejection in heart transplantation

(2013) Gerald J. Berry et al.   JOURNAL OF HEART AND LUNG TRANSPLANTATION

HLA Class I Antibodies Trigger Increased Adherence of Monocytes to Endothelial Cells by Eliciting an Increase in Endothelial P-Selectin and, Depending on Subclass, by Engaging Fc Rs

(2013) N. M. Valenzuela et al.   JOURNAL OF IMMUNOLOGY

Complement-Binding Anti-HLA Antibodies and Kidney-Allograft Survival

(2013) Alexandre Loupy et al.   NEW ENGLAND JOURNAL OF MEDICINE

Plasmapheresis-resistant acute humoral rejection successfully treated with anti-C5 antibody

(2013) Giulia Ghirardo et al.   PEDIATRIC TRANSPLANTATION

Anaphylatoxins in organ transplantation

(2013) Ke Li et al.   SEMINARS IN IMMUNOLOGY

Complement Regulation of T-Cell Alloimmunity

(2013) Paolo Cravedi et al.   SEMINARS IN NEPHROLOGY

The Role of Immunoglobulin-G Subclasses and C1q in De Novo HLA-DQ Donor-Specific Antibody Kidney Transplantation Outcomes

(2013) Maria Cecilia S. Freitas et al.   TRANSPLANTATION

Systematic Comparison of Four Cell- and Luminex-Based Methods for Assessment of Complement-Activating HLA Antibodies

(2013) Nils Lachmann et al.   TRANSPLANTATION

HLA class I-mediated stress fiber formation requires ERK1/2 activation in the absence of an increase in intracellular Ca2+ in human aortic endothelial cells

(2012) Mary E. Ziegler et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Blockade of P-Selectin Is Sufficient to Reduce MHC I Antibody-Elicited Monocyte RecruitmentIn VitroandIn Vivo

(2012) N. M. Valenzuela et al.   AMERICAN JOURNAL OF TRANSPLANTATION

New approaches for detecting complement-fixing antibodies

(2012) Dolly B. Tyan   Current Opinion in Organ Transplantation

Role of complement and NK cells in antibody mediated rejection

(2012) Takurin Akiyoshi et al.   HUMAN IMMUNOLOGY

Morphologic and immunohistochemical findings in antibody-mediated rejection of the cardiac allograft

(2012) Gregory A. Fishbein et al.   HUMAN IMMUNOLOGY

Role of complement and perspectives for intervention in transplantation

(2012) Gang Chen et al.   IMMUNOBIOLOGY

The role of therapeutic apheresis in the treatment of acute antibody-mediated kidney rejection

(2012) Tahmeena Ahmed et al.   JOURNAL OF CLINICAL APHERESIS

Treatment of hyperacute antibody-mediated lung allograft rejection with eculizumab

(2012) Kyle L. Dawson et al.   JOURNAL OF HEART AND LUNG TRANSPLANTATION

Persistent strong anti-HLA antibody at high titer is complement binding and associated with increased risk of antibody-mediated rejection in heart transplant recipients

(2012) Adriana Zeevi et al.   JOURNAL OF HEART AND LUNG TRANSPLANTATION

Donor-specific human leukocyte antigen antibodies of the immunoglobulin G3 subclass are associated with Chronic rejection and graft loss after liver transplantation

(2012) Hugo Kaneku et al.   LIVER TRANSPLANTATION

Absence of signaling into CD4+ cells via C3aR and C5aR enables autoinductive TGF-β1 signaling and induction of Foxp3+ regulatory T cells

(2012) Michael G Strainic et al.   NATURE IMMUNOLOGY

The role of complement in antibody-mediated rejection in kidney transplantation

(2012) Mark D. Stegall et al.   Nature Reviews Nephrology

Detection of complement-fixing and non-fixing antibodies specific for endothelial precursor cells and lymphocytes using flow cytometry

(2012) A. AlMahri et al.   TISSUE ANTIGENS

Solid phase detection of C4d-fixing HLA antibodies to predict rejection in high immunological risk kidney transplant recipients

(2012) Gregor Bartel et al.   TRANSPLANT INTERNATIONAL

Guidelines for the Diagnosis of Antibody-Mediated Rejection in Pancreas Allografts-Updated Banff Grading Schema

(2011) C. B. Drachenberg et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Terminal Complement Inhibition Decreases Antibody-Mediated Rejection in Sensitized Renal Transplant Recipients

(2011) M. D. Stegall et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Modifiers of complement activation for prevention of antibody-mediated injury to allografts

(2011) Peter D. Hughes et al.   Current Opinion in Organ Transplantation

Regulation of immunity and inflammation by intravenous immunoglobulin: relevance to solid organ transplantation

(2011) Stanley C Jordan et al.   Expert Review of Clinical Immunology

Novel C1q assay reveals a clinically relevant subset of human leukocyte antigen antibodies independent of immunoglobulin G strength on single antigen beads

(2011) G. Chen et al.   HUMAN IMMUNOLOGY

Report from a consensus conference on antibody-mediated rejection in heart transplantation

(2011) Jon Kobashigawa et al.   JOURNAL OF HEART AND LUNG TRANSPLANTATION

The ISHLT working formulation for pathologic diagnosis of antibody-mediated rejection in heart transplantation: Evolution and current status (2005–2011)

(2011) Gerald J. Berry et al.   JOURNAL OF HEART AND LUNG TRANSPLANTATION

Complement-fixing donor-specific antibodies identified by a novel C1q assay are associated with allograft loss

(2011) Scott M. Sutherland et al.   PEDIATRIC TRANSPLANTATION

Pre- and posttransplantation allosensitization in heart allograft recipients: Major impact of de novo alloantibody production on allograft survival

(2010) Eric K. Ho et al.   HUMAN IMMUNOLOGY

Controversies in defining cardiac antibody-mediated rejection: Need for updated criteria

(2010) Abdallah G. Kfoury et al.   JOURNAL OF HEART AND LUNG TRANSPLANTATION

Clinical usefulness of a novel C1q assay to detect immunoglobulin G antibodies capable of fixing complement in sensitized pediatric heart transplant patients

(2010) Clifford Chin et al.   JOURNAL OF HEART AND LUNG TRANSPLANTATION

C1 inhibitor, a multi-functional serine protease inhibitor

(2010) Fengxin Lu et al.   THROMBOSIS AND HAEMOSTASIS

C1q-Fixing Human Leukocyte Antigen Antibodies Are Specific for Predicting Transplant Glomerulopathy and Late Graft Failure After Kidney Transplantation

(2010) Julie M. Yabu et al.   TRANSPLANTATION

Solid phase assays for HLA antibody detection in clinical transplantation

(2009) Brian D Tait   CURRENT OPINION IN IMMUNOLOGY

Clinical relevance of complement-fixing antibodies in cardiac transplantation

(2009) Marlene L. Rose et al.   HUMAN IMMUNOLOGY

Mechanisms of complement activation, C4d deposition, and their contribution to the pathogenesis of antibody-mediated rejection

(2009) Kazunori Murata et al.   Transplantation Reviews