Heart Regeneration with Engineered Myocardial Tissue

Differential and synergistic effects of mechanical stimulation and growth factor presentation on vascular wall function

(2013) Mao-Shih Liang et al.   BIOMATERIALS

Subepicardial endothelial cells invade the embryonic ventricle wall to form coronary arteries

(2013) Xueying Tian et al.   CELL RESEARCH

Generation of Functional Thymic Epithelium from Human Embryonic Stem Cells that Supports Host T Cell Development

(2013) Audrey V. Parent et al.   Cell Stem Cell

Directed Differentiation of Human Embryonic Stem Cells into Thymic Epithelial Progenitor-like Cells Reconstitutes the Thymic Microenvironment In Vivo

(2013) Xiaoning Sun et al.   Cell Stem Cell

Patching the Heart

(2013) Lei Ye et al.   CIRCULATION RESEARCH

Molecular Signatures of Tissue-Specific Microvascular Endothelial Cell Heterogeneity in Organ Maintenance and Regeneration

(2013) Daniel J. Nolan et al.   DEVELOPMENTAL CELL

SLIT3–ROBO4 activation promotes vascular network formation in human engineered tissue and angiogenesis in vivo

(2013) Jonathan D. Paul et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

HLA Engineering of Human Pluripotent Stem Cells

(2013) Laura Riolobos et al.   MOLECULAR THERAPY

Induced regeneration—the progress and promise of direct reprogramming for heart repair

(2013) Russell C Addis et al.   NATURE MEDICINE

Focus on cardiac pericytes

(2013) Stephan Nees et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Effects of Cell Grafting on Coronary Remodeling After Myocardial Infarction

(2013) Jill J. Weyers et al.   Journal of the American Heart Association

A review of trends and limitations in hydrogel-rapid prototyping for tissue engineering

(2012) Thomas Billiet et al.   BIOMATERIALS

The role of the paracrine/autocrine mediator endothelin-1 in regulation of cardiac contractility and growth

(2012) Faye M Drawnel et al.   BRITISH JOURNAL OF PHARMACOLOGY

Functional vascular smooth muscle cells derived from human induced pluripotent stem cells via mesenchymal stem cell intermediates

(2012) Vivek K. Bajpai et al.   CARDIOVASCULAR RESEARCH

Serum-free differentiation of functional human coronary-like vascular smooth muscle cells from embryonic stem cells

(2012) Omar El-Mounayri et al.   CARDIOVASCULAR RESEARCH

Production of De Novo Cardiomyocytes: Human Pluripotent Stem Cell Differentiation and Direct Reprogramming

(2012) Paul W. Burridge et al.   Cell Stem Cell

Distinct Metabolic Flow Enables Large-Scale Purification of Mouse and Human Pluripotent Stem Cell-Derived Cardiomyocytes

(2012) Shugo Tohyama et al.   Cell Stem Cell

Inefficient Reprogramming of Fibroblasts into Cardiomyocytes Using Gata4, Mef2c, and Tbx5

(2012) Jenny X. Chen et al.   CIRCULATION RESEARCH

Global and regional mortality from 235 causes of death for 20 age groups in 1990 and 2010: a systematic analysis for the Global Burden of Disease Study 2010

(2012) Rafael Lozano et al.   LANCET

Heart repair by reprogramming non-myocytes with cardiac transcription factors

(2012) Kunhua Song et al.   NATURE

In vivo reprogramming of murine cardiac fibroblasts into induced cardiomyocytes

(2012) Li Qian et al.   NATURE

Generation of human vascular smooth muscle subtypes provides insight into embryological origin–dependent disease susceptibility

(2012) Christine Cheung et al.   NATURE BIOTECHNOLOGY

ERBB2 Inhibition and Heart Failure

(2012) Gregory M. Cote et al.   NEW ENGLAND JOURNAL OF MEDICINE

Withaferin-A Reduces Type I Collagen Expression In Vitro and Inhibits Development of Myocardial Fibrosis In Vivo

(2012) Azariyas A. Challa et al.   PLoS One

Cozzarelli Prize Winner: Robust cardiomyocyte differentiation from human pluripotent stem cells via temporal modulation of canonical Wnt signaling

(2012) X. Lian et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

In vitro microvessels for the study of angiogenesis and thrombosis

(2012) Y. Zheng et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Limited Gene Expression Variation in Human Embryonic Stem Cell and Induced Pluripotent Stem Cell-Derived Endothelial Cells

(2012) Mark P. White et al.   STEM CELLS

Vascular differentiation from embryonic stem cells: Novel technologies and therapeutic promises

(2012) Betty Descamps et al.   VASCULAR PHARMACOLOGY

Engineering fibrin-binding TGF-β1 for sustained signaling and contractile function of MSC based vascular constructs

(2011) Mao-Shih Liang et al.   BIOMATERIALS

Stage-Specific Optimization of Activin/Nodal and BMP Signaling Promotes Cardiac Differentiation of Mouse and Human Pluripotent Stem Cell Lines

(2011) Steven J. Kattman et al.   Cell Stem Cell

Optimizing Dynamic Interactions between a Cardiac Patch and Inflammatory Host Cells

(2011) Donald O. Freytes et al.   CELLS TISSUES ORGANS

Signaling During Epicardium and Coronary Vessel Development

(2011) José María Pérez-Pomares et al.   CIRCULATION RESEARCH

The identification of different endothelial cell populations within the mouse proepicardium

(2011) Stephanie Cossette et al.   DEVELOPMENTAL DYNAMICS

Human embryonic stem cell-derived vascular smooth muscle cells in therapeutic neovascularisation

(2011) Christine Cheung et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Endothelial Cell-Pericyte Interactions Stimulate Basement Membrane Matrix Assembly: Influence on Vascular Tube Remodeling, Maturation, and Stabilization

(2011) Amber N. Stratman et al.   MICROSCOPY AND MICROANALYSIS

Heart regeneration

(2011) Michael A. Laflamme et al.   NATURE

SIRPA is a specific cell-surface marker for isolating cardiomyocytes derived from human pluripotent stem cells

(2011) Nicole C Dubois et al.   NATURE BIOTECHNOLOGY

Engineered Human Cardiac Tissue

(2011) Kareen L. Kreutziger et al.   PEDIATRIC CARDIOLOGY

Combination of Extrinsic and Intrinsic Pathways Significantly Accelerates Axial Vascularization of Bioartificial Tissues

(2011) Andreas Arkudas et al.   PLASTIC AND RECONSTRUCTIVE SURGERY

Efficient and Scalable Purification of Cardiomyocytes from Human Embryonic and Induced Pluripotent Stem Cells by VCAM1 Surface Expression

(2011) Hideki Uosaki et al.   PLoS One

Three-dimensional reconstruction of the human capillary network and the intramyocardial micronecrosis

(2010) Noboru Kaneko et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Derivation of Endothelial Cells From Human Embryonic Stem Cells by Directed Differentiation

(2010) Nicole M. Kane et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Intramyocardial Fibroblast Myocyte Communication

(2010) Rahul Kakkar et al.   CIRCULATION RESEARCH

Origins of Cardiac Fibroblasts

(2010) Elisabeth M. Zeisberg et al.   CIRCULATION RESEARCH

Potential Therapeutic Targets for Cardiac Fibrosis

(2010) Andrew Leask   CIRCULATION RESEARCH

Vascular endothelial growth factors in cardiovascular medicine

(2010) Ugo Testa et al.   Journal of Cardiovascular Medicine

Human embryonic stem cell-derived cardiomyocytes engraft but do not alter cardiac remodeling after chronic infarction in rats

(2010) S. Fernandes et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Growth factor delivery-based tissue engineering: general approaches and a review of recent developments

(2010) K. Lee et al.   Journal of the Royal Society Interface

Endogenous Wnt/β-Catenin Signaling Is Required for Cardiac Differentiation in Human Embryonic Stem Cells

(2010) Sharon L. Paige et al.   PLoS One

Bioartificial matrices for therapeutic vascularization

(2010) Edward A. Phelps et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Proangiogenic scaffolds as functional templates for cardiac tissue engineering

(2010) L. R. Madden et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Developing Vasculature and Stroma in Engineered Human Myocardium

(2010) Kareen L. Kreutziger et al.   TISSUE ENGINEERING PART A

Bioengineering Challenges for Heart Valve Tissue Engineering

(2009) Michael S. Sacks et al.   Annual Review of Biomedical Engineering

VEGF Induces Differentiation of Functional Endothelium From Human Embryonic Stem Cells

(2009) Marilyn B. Nourse et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Human microvasculature fabrication using thermal inkjet printing technology

(2009) Xiaofeng Cui et al.   BIOMATERIALS

Evaluation of a Peritoneal-Generated Cardiac Patch in a Rat Model of Heterotopic Heart Transplantation

(2009) Gabriel Amir et al.   CELL TRANSPLANTATION

Origin of Cardiac Fibroblasts and the Role of Periostin

(2009) Paige Snider et al.   CIRCULATION RESEARCH

Classically and alternatively activated macrophages contribute to tissue remodelling after myocardial infarction

(2009) C. Troidl et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Nongenetic method for purifying stem cell–derived cardiomyocytes

(2009) Fumiyuki Hattori et al.   NATURE METHODS

Functional and Transcriptional Characterization of Human Embryonic Stem Cell-Derived Endothelial Cells for Treatment of Myocardial Infarction

(2009) Zongjin Li et al.   PLoS One

Physiological function and transplantation of scaffold-free and vascularized human cardiac muscle tissue

(2009) K. R. Stevens et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Prevascularization of cardiac patch on the omentum improves its therapeutic outcome

(2009) T. Dvir et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Non-Cardiomyocytes Influence the Electrophysiological Maturation of Human Embryonic Stem Cell-Derived Cardiomyocytes During Differentiation

(2009) Changsung Kim et al.   STEM CELLS AND DEVELOPMENT

The cardiovascular unit as a dynamic player in disease and regeneration

(2009) Simonetta Ausoni et al.   TRENDS IN MOLECULAR MEDICINE

Improvement of Vascularization of PLGA Scaffolds by Inosculation of In Situ-Preformed Functional Blood Vessels With the Host Microvasculature

(2008) Matthias W. Laschke et al.   ANNALS OF SURGERY

Angiomyogenesis using liposome based vascular endothelial growth factor-165 transfection with skeletal myoblast for cardiac repair

(2008) Lei Ye et al.   BIOMATERIALS

Differentiation of Embryonic Stem Cells to Clinically Relevant Populations: Lessons from Embryonic Development

(2008) Charles E. Murry et al.   CELL

Connexin43 Expression Levels Influence Intercellular Coupling and Cell Proliferation of Native Murine Cardiac Fibroblasts

(2008) Yan Zhang et al.   CELL COMMUNICATION AND ADHESION

Endothelial Cell Coculture Within Tissue-Engineered Cardiomyocyte Sheets Enhances Neovascularization and Improves Cardiac Function of Ischemic Hearts

(2008) H. Sekine et al.   CIRCULATION

Tissue engineering using autologous microcirculatory beds as vascularized bioscaffolds

(2008) Edward I. Chang et al.   FASEB JOURNAL

Evaluation of blood vessel ingrowth in fibrin gel subject to type and concentration of growth factors

(2008) A. Arkudas et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Systems approaches to preventing transplanted cell death in cardiac repair

(2008) Thomas E. Robey et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

An endogenously deposited fibrin scaffold determines construct size in the surgically created arteriovenous loop chamber model of tissue engineering

(2008) Zerina Lokmic et al.   JOURNAL OF VASCULAR SURGERY

Human cardiovascular progenitor cells develop from a KDR+ embryonic-stem-cell-derived population

(2008) Lei Yang et al.   NATURE

Perfusion-decellularized matrix: using nature's platform to engineer a bioartificial heart

(2008) Harald C Ott et al.   NATURE MEDICINE

Endothelial Cells in Allograft Rejection

(2008) Rafia S. Al-Lamki et al.   TRANSPLANTATION