Review
Orthopedics
J. Samuels, M. H. Pillinger, D. Jevsevar, D. Felson, L. S. Simon
Summary: Intra-articular injections of glucocorticoids have been shown to be effective and relatively safe in patients with knee osteoarthritis, with few contraindications and rare injection-associated complications when delivered with proper technique. However, there are still important unanswered questions regarding the long-term effects and predictive factors of response to intra-articular glucocorticoids in knee osteoarthritis patients, highlighting the need for further research in this area.
OSTEOARTHRITIS AND CARTILAGE
(2021)
Review
Orthopedics
Michael McLarnon, Neil Heron
Summary: IA-PRP injections show superior outcomes compared to CS injections in symptomatic management of knee OA, with better pain management, less joint stiffness, and improved participation in exercise/sporting activity at 12 months follow-up. Triple IA-PRP injections, separated by a week, are more effective than a single IA-PRP injection.
BMC MUSCULOSKELETAL DISORDERS
(2021)
Article
Rheumatology
Bora Nam, Tae-Hwan Kim, Sung Won Lee, Hyunah Kim, Yun Jin Kim, Jae-Bum Jun, Seunghun Lee
Summary: This study assessed the efficacy and safety of intra-articular sacroiliac glucocorticoid injection in ankylosing spondylitis (AS). The results showed that this treatment option was effective in relieving pain, reducing acute phase reactants, and improving disease activity without any serious adverse events.
JCR-JOURNAL OF CLINICAL RHEUMATOLOGY
(2022)
Review
Pharmacology & Pharmacy
Jingjing Gao, Ziting Xia, Helna B. Mary, John Joseph, James N. Luo, Nitin Joshi
Summary: Although there has been significant research in intra-articular drug delivery systems and disease-modifying osteoarthritis drugs, there is still a lack of clinically available therapies for osteoarthritis. Multiple barriers hinder the delivery of disease-modifying drugs, but there are promising approaches to overcome these barriers. A patient-centered workflow is proposed to guide the development of intra-articular therapies, with the aim of inspiring innovative solutions for future clinical translation.
TRENDS IN PHARMACOLOGICAL SCIENCES
(2022)
Article
Orthopedics
Laura Elisa Streck, Sebastian Braun, Kimi Spilo, Cosima Sue Boettner, Marco Brenneis, Friedrich Boettner
Summary: This retrospective study evaluated 682 cases of intra-articular corticosteroid injections (ICSI) for hip osteoarthritis. The results showed that 0.6% of patients developed rapidly progressive osteoarthritis (RPIO) following the injections, but there was minimal risk for septic arthritis or periprosthetic joint infections (PJI), even in patients with multiple injections or injections within 3 months prior to total hip arthroplasty (THA).
BMC MUSCULOSKELETAL DISORDERS
(2023)
Article
Rehabilitation
Terin T. Sytsma, Rozalina G. McCoy, Karen M. Fischer, Kelly R. Dean, Laura S. Greenlund
Summary: This study examined the odds of influenza in patients who received intra-articular corticosteroid (IACS) treatment compared to matched controls. The results showed that patients receiving IACS during influenza season had higher odds of influenza, but vaccination seemed to mitigate this risk.
AMERICAN JOURNAL OF PHYSICAL MEDICINE & REHABILITATION
(2023)
Review
Medicine, General & Internal
Maciej Checinski, Kamila Checinska, Natalia Turosz, Anita Brzozowska, Dariusz Chlubek, Maciej Sikora
Summary: This mapping review aims to discuss the current research directions on intracavitary temporomandibular joints (TMJs) injections for patients with temporomandibular joint disorders (TMDs). A total of 152 qualified reports were identified from 2712 records, and the results showed that viscosupplementation with hyaluronic acid (HA) was the best-documented injectable administered into TMJ cavities, but there is a growing trend in the use of centrifuged blood preparations for injections.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Engineering, Biomedical
Juan Wen, Huimin Li, Huan Dai, Shu Hua, Xing Long, Huang Li, Saso Ivanovski, Chun Xu
Summary: This review systematically summarizes nanoparticle-based therapies for the management of osteoarthritis (OA) and rheumatoid arthritis (RA). The interaction between nanoparticles and joint tissues, including articular fluids and cells, is explored. Current nanoparticles designed for OA/RA treatment are analyzed, and challenges and future clinical translation of nanoparticle-based therapies are discussed.
MATERIALS TODAY BIO
(2023)
Article
Rheumatology
Giovanni Adami, Angelo Fassio, Francesca Pistillo, Camilla Benini, Ombretta Viapiana, Maurizio Rossini, Davide Gatti
Summary: This study aimed to investigate the factors associated with radiological progression in rheumatoid arthritis (RA) patients treated with biological DMARDs (bDMARDs). The results showed that baseline erosive disease, higher disease activity during treatment, younger age, and monotherapy were independently associated with the development of bone erosions. Additionally, the study team developed a predictive model that accurately forecasted the occurrence of new erosions in patients receiving bDMARDs.
THERAPEUTIC ADVANCES IN MUSCULOSKELETAL DISEASE
(2023)
Article
Orthopedics
Nathan H. Varady, Troy B. Amen, Paul F. Abraham, Ahab Chopra, David M. Freccero, Eric L. Smith, Scott D. Martin
Summary: Intra-articular hip injections within 3 months before hip arthroscopy were not associated with an increased risk of postoperative infection, and there was no significant difference in infection rates between patients who received injections and those who did not. Additionally, the type of imaging modality used (FL or US) did not impact infection risk.
AMERICAN JOURNAL OF SPORTS MEDICINE
(2021)
Review
Pharmacology & Pharmacy
Xin Chen, Chengcheng Lu, Yanwen Duan, Yong Huang
Summary: Sinomenine is a benzyltetrahydroisoquinoline-type alkaloid with potent anti-inflammatory and analgesic effects, used for over 25 years in China to treat rheumatoid arthritis. However, its commercial hydrochloride form has low oral bioavailability and allergic reactions, requiring pharmaceutical strategies to improve delivery efficiency and reduce side effects.
Review
Pharmacology & Pharmacy
Zhe Feng, Ling Fu, Junqin Wang, Yamei Zhu, Xiaojin He, Lingling Zhou, Xueping Zhou
Summary: This study aims to explore the efficacy and safety of the combination of TG and conventional DMARD in treating RA. The results showed that the combination of TG was superior to monotherapy with conventional DMARD in improving RA conditions, with a good safety profile. The efficacy of TG was related to its ability to suppress IL-1, IL-6, and TNF-alpha. Furthermore, the combination of TG showed significant advantages in improving joint signs, symptoms, inflammatory indicators, and overall health. However, factors such as age, treatment course, type of combined DMARDs, and risk of bias were important factors influencing the efficacy.
PHARMACOLOGICAL RESEARCH
(2022)
Article
Rheumatology
Sizheng Steven Zhao, Lianne Kearlsey-Fleet, Ailsa Bosworth, Kath Watson, Kimme L. Hyrich
Summary: This study aimed to investigate the treatment outcomes for rheumatoid arthritis patients undergoing repeated trials of biologic or targeted synthetic DMARDs (b/tsDMARDs). The results showed that many patients eventually benefited from multiple rounds of treatment. Further research is needed to improve treatment selection and prevent prolonged trial and error approaches in some patients.
Article
Medicine, General & Internal
Pin-Chieh Fang, Tak-Yu-Yubie Lo, Chun-Ying Cheng, Chun-Te Wu, Alvin Chao-Yu Chen
Summary: This study evaluates the differences in radiographic parameters after fixation using variable-angle volar locking plate (VAVLP) according to extra-articular and intra-articular distal radial fracture. The results demonstrate that VAVLP fixation effectively maintains the stability of most radiographic parameters and reduces the risk of tendon rupture in both extra-articular and intra-articular distal radial fractures.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Chemistry, Medicinal
Mariam Zewail, Noha Nafee, Nabila Boraie
Summary: Intra-articular delivery of leflunomide and dexamethasone using nanostructured lipid carriers and PLGA nanoparticles in thermosensitive hydrogels showed promising therapeutic outcomes in a rat model of rheumatoid arthritis, indicating potential for enhancing joint healing and minimizing side effects.
JOURNAL OF PHARMACEUTICAL SCIENCES
(2021)
Letter
Rheumatology
Maja Skov Kragsnaes, Jens Kjeldsen, Hans Christian Horn, Heidi Lausten Munk, Jens Kristian Pedersen, Soren Andreas Just, Palle Ahlquist, Jesper Romhild Davidsen, Anna Christine Nilsson, Richard Rottger, Mogens Kruhoffer, Julian R. Marchesi, Karsten Kristiansen, Robin Christensen, Torkell Ellingsen
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Article
Rheumatology
T. Thomsen, B. A. Esbensen, M. L. Hetland, M. Aadahl
Summary: A randomized controlled trial aimed to reduce sedentary behaviour and increase light-intensity physical activity in patients with rheumatoid arthritis. The study found that patients who are less educated and have certain types of comorbidity are less motivated to participate in physical activity interventions. The findings can help improve recruitment processes and implementation of physical activity interventions in rheumatology clinical practice.
SCANDINAVIAN JOURNAL OF RHEUMATOLOGY
(2023)
Article
Rheumatology
M. A. Nielsen, D. Koster, S. Greisen, A. Troldborg, K. Stengaard-Pedersen, P. Junker, K. Horslev-Petersen, M. L. Hetland, M. Ostergaard, M. Hvid, H. Leffler, T. W. Kragstrup, B. Deleuran
Summary: The study found that patients with rheumatoid arthritis (RA) had persistently increased levels of galectin-3 (Gal-3) in their plasma, and changes in Gal-3 levels were associated with long-term disease activity. Gal-3 levels in synovial fluid were also significantly elevated. In vitro experiments showed that a Gal-3 inhibitor could reduce the activity of inflammatory cells.
SCANDINAVIAN JOURNAL OF RHEUMATOLOGY
(2023)
Article
Rheumatology
Daniel Aletaha, Andreas Kerschbaumer, Kastriot Kastrati, Christian Dejaco, Maxime Dougados, Iain B. McInnes, Naveed Sattar, Tanja A. Stamm, Tsutomu Takeuchi, Michael Trauner, Desiree van der Heijde, Marieke Voshaar, Kevin L. Winthrop, Angelo Ravelli, Neil Betteridge, Gerd-Ruediger R. Burmester, Johannes W. J. Bijlsma, Vivian Bykerk, Roberto Caporali, Ernest H. Choy, Catalin Codreanu, Bernard Combe, Mary K. Crow, Maarten de Wit, Paul Emery, Roy M. Fleischmann, Cem Gabay, Merete Lund Hetland, Kimme L. Hyrich, Annamaria Iagnocco, John D. Isaacs, Joel M. Kremer, Xavier Mariette, Peter Merkel, Eduardo F. Mysler, Peter Nash, Michael T. Nurmohamed, Karel Pavelka, Gyula Poor, Andrea Rubbert-Roth, Hendrik Schulze-Koops, Anja Strangfeld, Yoshiya Tanaka, Josef S. Smolen
Summary: This paper is an updated consensus document on the medical use of IL-6 pathway inhibition in the treatment of inflammatory diseases. The document provides comprehensive consensus statements based on systematic literature research and expert opinion, covering various aspects of IL-6 pathway inhibitors, including dosing, indications, and clinical considerations.
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Article
Rheumatology
Bente Glintborg, Daniela Di Giuseppe, Johan K. Wallman, Sella A. Provan, Dan Nordstrom, Anna-Mari Hokkanen, Jenny Osterlund, Eirik Kristianslund, Tore K. Kvien, Bjorn Gudbjornsson, Merete Lund Hetland, Brigitte Michelsen, Lennart Jacobsson, Johan Askling, Ulf Lindstrom
Summary: This study aims to assess the safety of secukinumab and TNF inhibitors in the treatment of SpA and PsA. The study found that the risk of hospitalized infection during the first year of treatment with secukinumab was higher compared to adalimumab, potentially due to confounding factors.
Article
Rheumatology
M. Pfeiffer-Jensen, D. Liao, U. Tarp, B. Deleuran, K. Stengaard-Pedersen, J. Venborg, B. Brock, C. Brock
Summary: This study examines the use of therapeutic drug monitoring (TDM) to personalize the dosing of TNF-alpha inhibitors, finding that it reduces drug prescription and prolongs treatment intervals. Additionally, TDM allows for the identification of patients who would benefit from a drug switch, minimizing treatment failure and unnecessary adverse events.
SCANDINAVIAN JOURNAL OF RHEUMATOLOGY
(2023)
Correction
Rheumatology
Lykke M. Ornbjerg, Louise Linde, Stylianos Georgiadis, Simon H. Rasmussen, Ulf Lindstrom, Johan Askling, Brigitte Michelsen, Daniela Di Giuseppe, Johan K. Wallman, Karel Pavelka, Jakub Zavada, Michael J. Nissen, Gareth T. Jones, Heikki Relas, Laura Pirila, Matija Tomsic, Ziga Rotar, Arni Jon Geirsson, Bjorn Gudbjornsson, Eirik K. Kristianslund, Irene van der Horst-Bruinsma, Anne Gitte Loft, Karin Laas, Florenzo Iannone, Addolorata Corrado, Adrian Ciurea, Maria J. Santos, Helena Santos, Catalin Codreanu, Nurullah Akkoc, Ozgul S. Gunduz, Bente Glintborg, Mikkel Ostergaard, Merete Lund Hetland
SEMINARS IN ARTHRITIS AND RHEUMATISM
(2023)
Article
Cell Biology
Morten A. A. Nielsen, Ditte Koster, Akul Y. Y. Mehta, Kristian Stengaard-Pedersen, Pierre Busson, Peter Junker, Kim Horslev-Petersen, Merete Lund Hetland, Mikkel ostergaard, Malene Hvid, Hakon Leffler, Tue W. W. Kragstrup, Richard D. D. Cummings, Bent Deleuran
Summary: This study evaluated the clinical and pathogenic aspects of Gal-9 in rheumatoid arthritis (RA) and found that it plays a role in modulating synovial FLS activities and maintaining subclinical disease activity.
Review
Public, Environmental & Occupational Health
Kristina Laugesen, Jonas Mengel-From, Kaare Christensen, Jorn Olsen, David M. Hougaard, Lasse Boding, Anja Olsen, Christian Erikstrup, Merete Lund Hetland, Estrid Hogdall, Alisa Kjaergaard, Erik Sorensen, Anja Brugmann, Eva Rabing Brix Petersen, Ivan Brandslund, Borge Nordestgaard, Gorm B. Jensen, Nils Skajaa, Frederikke Schonfeldt Troelsen, Cecilia Hvitfeldt Fuglsang, Lise Skovgaard Svingel, Henrik T. Sorensen
Summary: Denmark has a rich source of biobanks and a comprehensive healthcare system, which allows for the integration of biological specimens with clinical and demographic data for biobank research. This can contribute to a better understanding of disease etiology and personalized medicine.
CLINICAL EPIDEMIOLOGY
(2023)
Article
Rheumatology
Annemarie Lyng Lyng Svensson, Hanne-Dorthe Emborg, Lars Erik Bartels, Torkell Ellingsen, Thomas Adelsten, Rene Cordtz, Lene Dreyer, Niels Obel
Summary: In a Danish study, patients with inflammatory rheumatic diseases (IRD) were found to have a similar risk of contracting SARS-CoV-2 compared to the general population, but a significantly higher risk of hospitalization, severe COVID-19, requiring assisted ventilation, and death, especially in patients with comorbidities.
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Article
Rheumatology
Helga Westerlind, Bente Glintborg, Hilde Berner Hammer, Saedis Saevarsdottir, Niels Steen Krogh, Merete Lund Hetland, Ellen-Margrethe Hauge, Isabel Martinez Tejada, Joseph Sexton, Johan Askling
Summary: This study aims to describe how data harmonization can be achieved in rheumatoid arthritis (RA) and found that the proportion of patients reaching remission in RA treatment is low.
Article
Rheumatology
Janni Maria Pedersen, Aida Solhoj Hansen, Caecilie Skejo, Kristian Juul-Madsen, Peter Junker, Kim Horslev-Petersen, Merete Lund Hetland, Kristian Stengaard-Pedersen, Mikkel ostergaard, Bjarne Kuno Moller, Lene Dreyer, Ellen-Margrethe Hauge, Malene Hvid, Stinne Greisen, Bent Deleuran
Summary: This study investigated the role of lymphocyte activation gene-3 (LAG-3) as a serological marker and mediator in the pathogenesis of rheumatoid arthritis (RA). The results showed increased levels of LAG-3 in both early and chronic RA patients, particularly in the inflamed joint. LAG-3 plays a biological role in reducing inflammatory cytokine production in chronic RA, and this function is not affected by Gal-3 interference. Our findings suggest that LAG-3 is a multifaceted regulator of inflammation in early and chronic RA.
ARTHRITIS RESEARCH & THERAPY
(2023)
Letter
Rheumatology
Brian Bridal Logstrup, Kevin Kris Warnakula Olesen, Dzenan Masic, Christine Gyldenkerne, Pernille Gro Thrane, Torkell Ellingsen, Hans Erik Botker, Michael Maeng
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Article
Rheumatology
Tanja Thomsen, Mette Aadahl, Merete Lund Hetland, Bente Appel Esbensen
Summary: A higher proportion of rheumatoid arthritis patients are physically inactive. Lack of consistent physical activity guidance from health professionals may be a barrier. This study explores patients' perspectives on current and future guidance and emphasizes the importance of integrated physical activity focus in rheumatology clinics, with adequate training for health professionals.
RHEUMATOLOGY INTERNATIONAL
(2023)