Omics approaches in cystic fibrosis research: a focus on oxylipin profiling in airway secretions

Immune Responses in Cystic Fibrosis

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Cell signalling by reactive lipid species: new concepts and molecular mechanisms

(2012) Ashlee Higdon et al.   BIOCHEMICAL JOURNAL

Lipidomics of polyunsaturated-fatty-acid-derived oxygenated metabolites

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Metabolomic profiling of regulatory lipid mediators in sputum from adult cystic fibrosis patients

(2012) Jun Yang et al.   FREE RADICAL BIOLOGY AND MEDICINE

Molecular Targets of Omega 3 and Conjugated Linoleic Fatty Acids – “Micromanaging” Cellular Response

(2012) Francesco Visioli et al.   Frontiers in Physiology

n–3 PUFAs in cancer, surgery, and critical care: a systematic review on clinical effects, incorporation, and washout of oral or enteral compared with parenteral supplementation

(2011) Barbara S van der Meij et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Genetic Variation and Clinical Heterogeneity in Cystic Fibrosis

(2011) Mitchell L. Drumm et al.   Annual Review of Pathology-Mechanisms of Disease

Increased Δ5- and Δ6-desaturase, cyclooxygenase-2, and lipoxygenase-5 expression and activity are associated with fatty acid and eicosanoid changes in cystic fibrosis

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Oxidative stress and antioxidant therapy in cystic fibrosis

(2011) Francesco Galli et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Lipid Mediator Profiling in Pulmonary Disease

(2011) Susanna L. Lundstrom et al.   CURRENT PHARMACEUTICAL BIOTECHNOLOGY

Enteral Omega-3 Fatty Acid, γ-Linolenic Acid, and Antioxidant Supplementation in Acute Lung Injury

(2011) Todd W. Rice   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Prostaglandin-endoperoxide synthase genesCOX1 andCOX2 — novel modifiers of disease severity in cystic fibrosis patients

(2011) K. Czerska et al.   JOURNAL OF APPLIED GENETICS

Plasma lipidomics reveals potential prognostic signatures within a cohort of cystic fibrosis patients

(2011) Mario Ollero et al.   JOURNAL OF LIPID RESEARCH

DHA and EPA reverse cystic fibrosis-related FA abnormalities by suppressing FA desaturase expression and activity

(2011) Sarah W. Njoroge et al.   JOURNAL OF LIPID RESEARCH

The Human Plasma Lipidome

(2011) Oswald Quehenberger et al.   NEW ENGLAND JOURNAL OF MEDICINE

Effects of an omega-3 fatty acid-enriched lipid emulsion on eicosanoid synthesis in acute respiratory distress syndrome (ARDS): A prospective, randomized, double-blind, parallel group study

(2011) Joan Sabater et al.   Nutrition & Metabolism

NMR spectroscopy metabolomic profiling of exhaled breath condensate in patients with stable and unstable cystic fibrosis

(2011) Paolo Montuschi et al.   THORAX

Novel Lipid Mediators and Resolution Mechanisms in Acute Inflammation

(2010) Charles N. Serhan   AMERICAN JOURNAL OF PATHOLOGY

Glandular Gene Expression of Sinus Mucosa in Chronic Rhinosinusitis with and without Cystic Fibrosis

(2010) Xiaofang Wu et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

The 5-lipoxygenase inhibitor, zileuton, suppresses prostaglandin biosynthesis by inhibition of arachidonic acid release in macrophages

(2010) A Rossi et al.   BRITISH JOURNAL OF PHARMACOLOGY

Lipidomics: New Tools and Applications

(2010) Markus R. Wenk   CELL

Use of a modeling framework to evaluate the effect of a modifier gene (MBL2) on variation in cystic fibrosis

(2010) Kathryn E McDougal et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

Targets for cystic fibrosis therapy: proteomic analysis and correction of mutant cystic fibrosis transmembrane conductance regulator

(2010) James F Collawn et al.   Expert Review of Proteomics

Applications of proteomic technologies for understanding the premature proteolysis of CFTR

(2010) Mark J Henderson et al.   Expert Review of Proteomics

Metabolic Network Analysis of Pseudomonas aeruginosa during Chronic Cystic Fibrosis Lung Infection

(2010) M. A. Oberhardt et al.   JOURNAL OF BACTERIOLOGY

Crystal Structure of the Cystic Fibrosis Transmembrane Conductance Regulator Inhibitory Factor Cif Reveals Novel Active-Site Features of an Epoxide Hydrolase Virulence Factor

(2010) C. D. Bahl et al.   JOURNAL OF BACTERIOLOGY

Biochemical Characterization of the Oxygenation of Unsaturated Fatty Acids by the Dioxygenase and Hydroperoxide Isomerase ofPseudomonas aeruginosa42A2

(2010) Eriel Martínez et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Metabolomic Profiling Reveals Biochemical Pathways and Biomarkers Associated with Pathogenesis in Cystic Fibrosis Cells

(2010) Diana R. Wetmore et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Targeted eicosanoids lipidomics of exhaled breath condensate in healthy subjects

(2010) Marek Sanak et al.   JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES

Design and powering of cystic fibrosis clinical trials using rate of FEV1 decline as an efficacy endpoint

(2010) M.W. Konstan et al.   Journal of Cystic Fibrosis

Year-to-year changes in lung function in individuals with cystic fibrosis

(2010) Theodore G. Liou et al.   Journal of Cystic Fibrosis

Genes that determine immunology and inflammation modify the basic defect of impaired ion conductance in cystic fibrosis epithelia

(2010) F. Stanke et al.   JOURNAL OF MEDICAL GENETICS

Serum proteomics signature of Cystic Fibrosis patients: A complementary 2-DE and LC–MS/MS approach

(2010) Nuno Charro et al.   Journal of Proteomics

Neutrophil unsaturated fatty acid release by GM-CSF is impaired in cystic fibrosis

(2010) Elena Bravo et al.   Lipids in Health and Disease

Lipidomic analysis of variation in response to simvastatin in the Cholesterol and Pharmacogenetics Study

(2010) Rima Kaddurah-Daouk et al.   Metabolomics

Proteomics investigation of human platelets in healthy donors and cystic fibrosis patients by shotgun nUPLC-MSEand 2DE: a comparative study

(2010) Luisa Pieroni et al.   Molecular BioSystems

Lovastatin decreases acute mucosal inflammation via 15-epi-lipoxin A4

(2010) A Planagumà et al.   Mucosal Immunology

Airway Mucus Function and Dysfunction

(2010) John V. Fahy et al.   NEW ENGLAND JOURNAL OF MEDICINE

Metabolomics of Volatile Organic Compounds in Cystic Fibrosis Patients and Controls

(2010) Charlotte M H H T Robroeks et al.   PEDIATRIC RESEARCH

Airway Microbiota and Pathogen Abundance in Age-Stratified Cystic Fibrosis Patients

(2010) Michael J. Cox et al.   PLoS One

Old and new generation lipid mediators in acute inflammation and resolution

(2010) Melanie J. Stables et al.   PROGRESS IN LIPID RESEARCH

Fatty acid metabolism in cystic fibrosis

(2010) Birgitta Strandvik   PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS

Association of cholesterol oxidation and abnormalities in fatty acid metabolism in cystic fibrosis

(2009) Luigi Iuliano et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Quantitative Profiling Method for Oxylipin Metabolome by Liquid Chromatography Electrospray Ionization Tandem Mass Spectrometry

(2009) Jun Yang et al.   ANALYTICAL CHEMISTRY

Generation and Biological Activities of Oxidized Phospholipids

(2009) Valery N. Bochkov et al.   ANTIOXIDANTS & REDOX SIGNALING

Inhibition of soluble epoxide hydrolase enhances the anti-inflammatory effects of aspirin and 5-lipoxygenase activation protein inhibitor in a murine model

(2009) Jun-Yan Liu et al.   BIOCHEMICAL PHARMACOLOGY

Metabolomic analysis of bronchoalveolar lavage fluid from cystic fibrosis patients

(2009) Justyna E. Wolak et al.   BIOMARKERS

Mucins, Mucus, and Sputum

(2009) Judith A. Voynow et al.   CHEST

SELDI-TOF biomarker signatures for cystic fibrosis, asthma and chronic obstructive pulmonary disease

(2009) Patrícia Gomes-Alves et al.   CLINICAL BIOCHEMISTRY

Epoxyeicosatrienoates are the dominant eicosanoids in human lungs upon microbial challenge

(2009) L. Kiss et al.   EUROPEAN RESPIRATORY JOURNAL

Prevalence of dyslipidemia in adults with cystic fibrosis

(2009) Bronwen Rhodes et al.   Journal of Cystic Fibrosis

A New Strategy for the Identification of Novel Molecules with Targeted Proresolution of Inflammation Properties

(2009) R. A. Navarro-Xavier et al.   JOURNAL OF IMMUNOLOGY

Mapping the Lung Proteome in Cystic Fibrosis

(2009) Sina A. Gharib et al.   JOURNAL OF PROTEOME RESEARCH

Resolvin D2 is a potent regulator of leukocytes and controls microbial sepsis

(2009) Matthew Spite et al.   NATURE

Azithromycin Treatment Alters Gene Expression in Inflammatory, Lipid Metabolism, and Cell Cycle Pathways in Well-Differentiated Human Airway Epithelia

(2009) Carla Maria P. Ribeiro et al.   PLoS One

A Novel Lipidomic Strategy Reveals Plasma Phospholipid Signatures Associated with Respiratory Disease Severity in Cystic Fibrosis Patients

(2009) Ida Chiara Guerrera et al.   PLoS One

Cystic Fibrosis Fatty Acid Imbalance Is Linked to Ceramide Deficiency and Corrected by Fenretinide

(2008) Claudine Guilbault et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Update on gene modifiers in cystic fibrosis

(2008) Joseph M Collaco et al.   CURRENT OPINION IN PULMONARY MEDICINE

Lipoxin A4 and interleukin-8 levels in cystic fibrosis sputum after antibiotherapy

(2008) Raphaël Chiron et al.   Journal of Cystic Fibrosis

The role of chloride anion and CFTR in killing of Pseudomonas aeruginosa by normal and CF neutrophils

(2008) R. G. Painter et al.   JOURNAL OF LEUKOCYTE BIOLOGY

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(2008) Minou Adib-Conquy et al.   MOLECULAR MEDICINE

Long-chain carboxychromanols, metabolites of vitamin E, are potent inhibitors of cyclooxygenases

(2008) Q. Jiang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Neutrophils in cystic fibrosis

(2008) D G Downey et al.   THORAX