Article
Immunology
Jie-Fang Gao, Liu Tang, Fei Luo, Yi-Yuan Zhang, Lu Chen, Hong Ding, Zu-Dong Meng
Summary: Nicotinamide mononucleotide (NMN) exhibits potential anti-atopic activities in atopic dermatitis (AD). It can alleviate AD-like symptoms, inhibit the overexpression of inflammatory cytokines, and block the activation of the ROS-mediated JAK2/STAT5 signaling pathway.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Pharmacology & Pharmacy
Miao Zhang, Xiaowen Bi, Shuai Liu, Yu Liu, Qiyu Wang
Summary: This study reveals for the first time that OBS triggers senescence in pituitary cells via the p53-p21-RB signaling pathway. OBS inhibits cell proliferation, induces cell cycle arrest at the G1 phase, and downregulates the expression of key proteins involved in the G1/S transition. This study provides new perspectives for understanding the potential toxicity of OBS.
Article
Biochemistry & Molecular Biology
Sabine Jurado, Anna S. Fedl, Markus Jaritz, Daniela Kostanova-Poliakova, Stephen G. Malin, Charles G. Mullighan, Sabine Strehl, Maria Fischer, Meinrad Busslinger
Summary: PAX5 is an important tumor suppressor gene in B-cell acute lymphoblastic leukemia, but it is also involved in coding for various PAX5 fusion proteins. A study found that the PAX5-JAK2 fusion protein can promote leukemia development in a mouse model.
Article
Cell Biology
Qian Hao, Jiaxiang Chen, Junming Liao, Yingdan Huang, Yu Gan, Sarit Larisch, Shelya X. Zeng, Hua Lu, Xiang Zhou
Summary: ARTS and p53 collaborate closely in mitochondria-engaged apoptosis, with ARTS inducing apoptosis by antagonizing anti-apoptotic proteins and p53 activating the expression of ARTS.
CELL DEATH & DISEASE
(2021)
Article
Immunology
Yingying Wei, Zachary Braunstein, Jun Chen, Xinwen Min, Handong Yang, Lihua Duan, Lingli Dong, Jixin Zhong
Summary: Multiple sclerosis (MS) is an autoimmune disease mediated by T cells, but the exact signaling pathways involved in effector T cells in MS are not well understood. This study investigated the role of Janus kinase 2 (JAK2) and its potential as a therapeutic target in MS. The results showed that knockout of JAK2 in T cells prevented the development of MS in mice. In vitro experiments also demonstrated that JAK2 disruption suppressed the differentiation of TH1 cells and the production of IFN gamma. These findings suggest that overactive JAK2 signaling in T lymphocytes plays a critical role in MS and could be targeted for therapeutic intervention.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Biology
Xiaoxiao Liu, Li Zhang, Pyone Myat Thu, Wenjian Min, Peng Yang, Ji Li, Ping Li, Xiaojun Xu
Summary: Sodium cantharidinate is identified as a potential anti-pancreatic cancer agent that activates p53 function, reducing cell viability and inducing apoptosis in pancreatic cancer cells. It perturbs the p53 signaling pathway and affects apoptosis-related protein expression, ultimately showing promising efficacy against pancreatic cancer.
SCIENCE CHINA-LIFE SCIENCES
(2021)
Article
Plant Sciences
Shang Guo, Nannan Qin, Xiuying Wang, Zanwen Zuo, Qizhang Li, Yuliang Wang
Summary: This study aimed to investigate the prolactin effects and mechanisms of freeze-dried powder of daylily buds in rats. It was found that daylily buds can improve lactation deficiency in rats induced by bromocriptine through the PRLR/JAK2/STAT5 pathway, and the freeze-dried processing method better retains the flavonoids and phenols that promote milk production.
JOURNAL OF ETHNOPHARMACOLOGY
(2023)
Article
Cell Biology
Badri Krishnan, Ioannis Sanidas, Nicholas J. Dyson
Summary: This study found that active forms of RB can cause widespread changes in nuclear architecture, which are not correlated with cell cycle arrest or repression of the E2F transcriptional program. Instead, these changes appear later and are associated with autophagy or senescence markers in IMR-90 cells. This perspective discusses the relative timing of these RB-induced events, the mechanisms underlying RB-induced chromatin dispersion, and the potential connection between dispersion and cell cycle exit.
Article
Oncology
Rona Yaeger, Riccardo Mezzadra, Jenna Sinopoli, Yu Bian, Michelangelo Marasco, Esther Kaplun, Yijun Gao, HuiYong Zhao, Arnaud Da Cruz Paula, Yingjie Zhu, Almudena Chaves Perez, Kalyani Chadalavada, Edison Tse, Sudhir Chowdhry, Sydney Bowker, Qing Chang, Besnik Qeriqi, Britta Weigelt, Gouri J. Nanjangud, Michael F. Berger, Hirak Der-Torossian, Kenna Anderes, Nicholas D. Socci, Jinru Shia, Yonina R. Murciano-Goroff, Bob Li, James G. Christensen, Jorge S. Reis-Filho, David B. Solit, Elisa de Stanchina, Scott W. Lowe, Neal Rosen, Sandra Misale
Summary: Combining KRASG12C and EGFR inhibitors is an effective treatment for colorectal cancer. However, secondary resistance can reduce its efficacy. Our study found that resistance alterations preventing inhibition of ERK signaling are detected at a low frequency, except for KRASG12C amplification, which increases over time. Upon drug withdrawal, resistant cells undergo senescence, but mTOR signaling remains elevated. Targeting the senescence response may be a potential therapeutic vulnerability to overcome acquired resistance.
Article
Multidisciplinary Sciences
Stella Pearson, Rognvald Blance, Fei Yan, Ya-Ching Hsieh, Bethany Geary, Fabio M. R. Amaral, Tim C. P. Somervaille, Kristina Kirschner, Anthony D. D. Whetton, Andrew Pierce
Summary: Myelofibrosis is a neoplasm that affects the bone marrow and results in reduced life quality and length. Existing drugs provide some benefit, but there is a need for new therapies to better treat myelofibrosis. By re-analyzing proteomic data, researchers identified CBL0137 as a potential drug to target Jak2 mutation-driven malignancies.
Article
Endocrinology & Metabolism
Anna Juliane Vesting, Alexander Jais, Paul Klemm, Lukas Steuernagel, Peter Wienand, Morten Fog-Tonnesen, Henning Hvid, Anna-Lena Schumacher, Christian Kukat, Hendrik Nolte, Theodoros Georgomanolis, Janine Altmueller, Manolis Pasparakis', Andreas Schmidt', Marcus Krueger', Marc Schmidt Supprian, Ari Waisman, Beate Katharina Straub, Nathanael Raschzok, Michel Bernier, Andreas L. Birkenfeld, Nadine Hoevelmeyer, Jens C. Bruening, F. Thomas Wunderlich
Summary: The non-canonical NFKB-inducing kinase (NIK/MAP3K14) plays a crucial role in metabolic nonalcoholic fatty liver disease (NAFLD) and the progression from NAFLD to hepatocellular carcinoma (HCC) by modulating JAK2/STAT5 signaling.
MOLECULAR METABOLISM
(2022)
Article
Biochemistry & Molecular Biology
Kaier Zhang, Guohu Di, Bin Li, Huanhuan Ge, Ying Bai, Wenhan Bian, Dianqiang Wang, Peng Chen
Summary: This study revealed that AQP5 deficiency promotes the senescence of primary LECs through mitochondrial dysfunction. This provides a new perspective for the treatment of cataracts by regulating AQP5 expression.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2023)
Article
Multidisciplinary Sciences
Ephrath Tesfaye, Elena Martinez-Terroba, Jordan Bendor, Lauren Winkler, Christiane Olivero, Kevin Chen, David M. Feldser, Jesse R. Zamudio, Nadya Dimitrova
Summary: The p53 pathway serves as a universal tumor suppressor mechanism that can be targeted for therapy in cancer treatment. Understanding the downstream mediators of p53 reactivation in different oncogenic contexts is crucial, with studies showing that activation of certain genes and regulatory mechanisms play key roles. In particular, repression of E2F and Myc target genes is identified as a key feature of p53-induced senescence.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Review
Biochemistry & Molecular Biology
Helene Martini, Joao F. Passos
Summary: The article discusses how the accumulation of senescent cells in multiple tissues leads to tissue dysfunction and age-related diseases, and emphasizes the important role and mechanisms of mitochondria in senescence. It also proposes the establishment of a detailed road map of mitochondrial biology to guide future research on treatments.
Article
Environmental Sciences
Yung-Ken Hsu, Hsuan-Ying Chen, Chia-Chieh Wu, Ying-Chih Huang, Cheng-Pu Hsieh, Po-Feng Su, Yi-Fu Huang
Summary: The flavonoid butein demonstrates anti-proliferative effects in human osteosarcoma cells by activating the tumor suppressor p53 and inducing senescence. Additionally, exposure to butein increases reactive oxygen species levels in the cells, leading to enhanced p53 activation and anti-proliferative effects. This suggests that butein is a promising candidate for cancer therapy against osteosarcoma.
ENVIRONMENTAL TOXICOLOGY
(2021)
Article
Cell Biology
Malika Oubaha, Khalil Miloudi, Agnieszka Dejda, Vera Guber, Gaelle Mawambo, Marie-Anne Germain, Guillaume Bourdel, Natalija Popovic, Flavio A. Rezende, Randal J. Kaufman, Frederick A. Mallette, Przemyslaw Sapieha
SCIENCE TRANSLATIONAL MEDICINE
(2016)
Article
Multidisciplinary Sciences
Melissa Carbonneau, Laurence M. Gagne, Marie-Eve Lalonde, Marie-Anne Germain, Alena Motorina, Marie-Christine Guiot, Blandine Secco, Emma E. Vincent, Anthony Tumber, Laura Hulea, Jonathan Bergeman, Udo Oppermann, Russell G. Jones, Mathieu Laplante, Ivan Topisirovic, Kevin Petrecca, Marc-Etienne Huot, Frederick A. Mallette
NATURE COMMUNICATIONS
(2016)
Article
Cell Biology
Mathieu Neault, Frederick A. Mallette, Stephane Richard
Editorial Material
Genetics & Heredity
Erlinda Fernandez, Frederick A. Mallette
Review
Cell Biology
Laurence M. Gagne, Karine Boulay, Ivan Topisirovic, Marc-Etienne Huot, Frederick A. Mallette
TRENDS IN CELL BIOLOGY
(2017)
Article
Oncology
Yong Yu, Kolja Schleich, Bin Yue, Sujuan Ji, Philipp Lohneis, Kristel Kemper, Mark S. Silvis, Nouar Qutob, Ellen van Rooijen, Melanie Werner-Klein, Lianjie Li, Dhriti Dhawan, Svenja Meierjohann, Maurice Reimann, Abdel Elkahloun, Steffi Treitschke, Bernd Doerken, Christian Speck, Frederick A. Mallette, Leonard I. Zon, Sheri L. Holmen, Daniel S. Peeper, Yardena Samuels, Clemens A. Schmitt, Soyoung Lee
Review
Cell Biology
Przemyslaw Sapieha, Frederick A. Mallette
TRENDS IN CELL BIOLOGY
(2018)
Editorial Material
Biochemistry & Molecular Biology
Karine Boulay, Ivan Topisirovic, Frederick A. Mallette
TRENDS IN BIOCHEMICAL SCIENCES
(2018)
Article
Biochemistry & Molecular Biology
Anna Roth, Karine Boulay, Matthias Gross, Maria Polycarpou-Schwarz, Frederick A. Mallette, Marine Regnier, Or Bida, Doron Ginsberg, Arne Warth, Philipp A. Schnabel, Thomas Muley, Michael Meister, Heike Zabeck, Hans Hoffmann, Sven Diederichs
Article
Multidisciplinary Sciences
Khalil Miloudi, Malika Oubaha, Catherine Menard, Agnieszka Dejda, Vera Guber, Gael Cagnone, Ariel M. Wilson, Nicolas Tetreault, Gaelle Mawambo, Francois Binet, Rony Chidiac, Chantal Delisle, Manuel Buscarlet, Agustin Cerani, Sergio Crespo-Garcia, Katie Bentley, Flavio Rezende, Jean-Sebastien Joyal, Frederick A. Mallette, Jean-Philippe Gratton, Bruno Larrivee, Przemyslaw Sapieha
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2019)
Article
Biochemistry & Molecular Biology
Nicolas Malaquin, Marc-Alexandre Olivier, Aurelie Martinez, Stephanie Nadeau, Christina Sawchyn, Jean-Philippe Coppe, Guillaume Cardin, Frederick A. Mallette, Judith Campisi, Francis Rodier
Article
Genetics & Heredity
Eline A. Verberne, Shuxiang Goh, Jade England, Manon van Ginkel, Louise Rafael-Croes, Saskia Maas, Abeltje Polstra, Yuri A. Zarate, Katherine A. Bosanko, Kieran B. Pechter, Emma Bedoukian, Kosuke Izumi, Ayeshah Chaudhry, Nathaniel H. Robin, Megan Boothe, Natalie C. Lippa, Vimla Aggarwal, Darryl C. De Vivo, Anna Lehman, Sylvia Stockler, Ange-Line Bruel, Bertrand Isidor, Jennifer Lemons, David F. Rodriguez-Buritica, Christopher M. Richmond, Zornitza Stark, Pankaj B. Agrawal, R. Frank Kooy, Marije E. C. Meuwissen, David A. Koolen, Rolf Pfundt, Agne Lieden, Britt-Marie Anderlid, Dagmar Glatz, Marcel M. A. M. Mannens, Madhura Bakshi, Frederick A. Mallette, Mieke M. van Haelst, Philippe M. Campeau
Summary: This study confirms JARID2 as a human disease gene and further elucidates the associated clinical phenotype. Results from 16 individuals suggest that deletions or variants in JARID2 may lead to developmental delay and/or intellectual disability.
GENETICS IN MEDICINE
(2021)
Article
Cell Biology
Sergio Crespo-Garcia, Pamela R. Tsuruda, Agnieszka Dejda, Rathi D. Ryan, Frederik Fournier, Shawnta Y. Chaney, Frederique Pilon, Taner Dogan, Gael Cagnone, Priyanka Patel, Manuel Buscarlet, Sonali Dasgupta, Gabrielle Girouard, Surabhi R. Rao, Ariel M. Wilson, Robert O'Brien, Rachel Juneau, Vera Guber, Alexandre Dubrac, Christian Beausejour, Scott Armstrong, Frederick A. Mallette, Christopher B. Yohn, Jean-Sebastien Joyal, Dan Marquess, Pedro J. Beltran, Przemyslaw Sapieha
Summary: The study reveals that pathological blood vessels engage pathways of cellular senescence, while healthy blood vessels do not. Eliminating p16(INK4A)-expressing cells or inhibiting the anti-apoptotic protein BCL-xL can suppress pathological angiogenesis, promoting physiological vascular repair in the retina. These findings suggest that BCL-xL inhibitors may hold potential as treatments for neovascular retinal diseases.
Article
Multidisciplinary Sciences
Francois Binet, Gael Cagnone, Sergio Crespo-Garcia, Masayuki Hata, Mathieu Neault, Agnieszka Dejda, Ariel M. Wilson, Manuel Buscarlet, Gaelle Tagne Mawambo, Joel P. Howard, Roberto Diaz-Marin, Celia Parinot, Vera Guber, Frederique Pilon, Rachel Juneau, Remi Laflamme, Christina Sawchyn, Karine Boulay, Severine Leclerc, Afnan Abu-Thuraia, Jean-Francois Cote, Gregor Andelfinger, Flavio A. Rezende, Florian Sennlaub, Jean-Sebastien Joyal, Frederick A. Mallette, Przemyslaw Sapieha
Article
Cell Biology
Macha Samba-Mondonga, Annie Calve, Frederick A. Mallette, Manuela M. Santos
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2018)