Article
Surgery
Jia-Bin Wang, Man-Qiang Lin, Jian-Wei Xie, Jian-Xian Lin, Jun Lu, Qi-Yue Chen, Long-Long Cao, Mi Lin, Ru-Hong Tu, Ping Li, Chao-Hui Zheng, Chang-Ming Huang
Summary: This study evaluated the prognostic impact of body mass index (BMI) on signet ring cell gastric carcinoma (SRC) patients. The results showed that as BMI decreases, SRC has a worse prognostic impact. Different BMI levels can lead to differing prognosis of SRC compared with tubular adenocarcinoma.
ASIAN JOURNAL OF SURGERY
(2021)
Review
Oncology
Chi Zhang, Ran Liu, Wei-Han Zhang, Xin-Zu Chen, Kai Liu, Kun Yang, Xiao-Long Chen, Lin-Yong Zhao, Zhi-Xin Chen, Zong-Guang Zhou, Jian-Kun Hu
Summary: The study found that patients with signet ring cell gastric cancer are typically younger and more commonly female compared to those with non-signet ring cell gastric cancer. For early stage signet ring cell gastric cancer patients, they have a lower lymph nodes metastasis rate and comparable prognosis with non-signet ring cell cancers; however, in advanced tumor stage, signet ring cell gastric cancer has a significantly worse prognosis.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
Luigi Marano, Maria Raffaella Ambrosio, Luca Resca, Ludovico Carbone, Osvaldo Carpineto Samorani, Roberto Petrioli, Vinno Savelli, Maurizio Costantini, Lara Malaspina, Karol Polom, Ivano Biviano, Daniele Marrelli, Franco Roviello
Summary: This study investigated the role of signet ring cells (SRCs) as a prognostic marker in mixed-histotype gastric carcinoma. The results showed that the proportion of SRCs is inversely related to aggressive behavior and poor prognosis in mixed-type gastric cancers, highlighting the role of SRC amount as an independent predictor of survival.
FRONTIERS IN ONCOLOGY
(2022)
Article
Oncology
Franco Roviello, Luigi Marano, Maria Raffaella Ambrosio, Luca Resca, Alessia D'Ignazio, Federica Petrelli, Roberto Petrioli, Maurizio Costantini, Karol Polom, Raffaele Macchiarelli, Ivano Biviano, Daniele Marrelli
Summary: This study evaluated the impact of the percentage of signet ring cells (SRC) on the clinical, pathological, and prognostic features of poorly cohesive gastric cancer. The results showed that the percentage of SRCs is inversely related to tumor aggressiveness, and SRC pattern serves as an independent predictor of survival.
Article
Multidisciplinary Sciences
Weizhu Zhao, Yanfei Jia, Guangyu Sun, Haiying Yang, Luguang Liu, Xianlin Qu, Jishuang Ding, Hang Yu, Botao Xu, Siwei Zhao, Ligang Xing, Jie Chai
Summary: Gastric signet ring cell carcinoma (GSRC) is a distinct subtype of gastric cancer with poor prognosis, but there is a lack of in-depth and systematic study on GSRC. In this study, single-cell RNA sequencing was performed on GC samples, revealing the presence of signet ring cell carcinoma (SRCC) cells. These SRCC cells showed upregulation of genes involved in cancer-related and immune response signaling pathways. They also demonstrated lower cell adhesion, higher immune evasion capabilities, and an immunosuppressive microenvironment, which may contribute to the relatively poor prognosis of GSRC. Overall, GSRC exhibits unique cytological characteristics and a distinct immune microenvironment, which could be beneficial for accurate diagnosis and treatment.
NATURE COMMUNICATIONS
(2023)
Article
Oncology
L. Bobrzynski, K. Sedlak, K. Rawicz-Pruszynski, P. Kolodziejczyk, A. Szczepanik, W. Polkowski, P. Richter, M. Sierzega
Summary: The study evaluated the importance of textbook outcome (TO) in gastric cancer and found that a definition combining complete tumor resection with uneventful postoperative course had good predictive performance and prognostic value. TO can be used as a reference indicator for quality improvement programs.
Article
Oncology
Qing Wei, Yiding Gao, Changsong Qi, Xing Yuan, Jingjing Li, Qi Xu, Cong Luo, Lei Chen, Wei Zhuo, Zhiyuan Xu, Jieer Ying
Summary: A total of 11,363 gastric cancer patients were enrolled, with SRC patients more likely to occur in female and young patients. Significant factors for prognosis included age, tumor site, tumor size, T classification, N classification, TNM stage, and primary site surgery, as identified through univariate and multivariate analyses.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
Yu Yang, Yuxuan Li, Xiaohui Du
Summary: This study compared the prognosis of hepatoid adenocarcinoma of the stomach (HAS) and gastric signet ring cell carcinoma (SRC) patients, showing no significant difference in overall survival between the two. However, in patients with advanced tumor stage, HAS may have a worse prognosis than SRC.
FRONTIERS IN ONCOLOGY
(2021)
Article
Gastroenterology & Hepatology
Jan Grosek, Hana Zavrtanik, Ales Tomazic
Summary: This study found that the extent of resection did not affect daily functioning in gastric cancer patients, but those who underwent total gastrectomy may experience more dysphagia and eating restrictions. Moreover, patients with Roux-en-Y reconstruction after subtotal distal gastrectomy had better physical and role functioning compared to those with Billroth II reconstruction.
WORLD JOURNAL OF GASTROENTEROLOGY
(2021)
Article
Oncology
Yang Li, Yuxin Zhong, Quan Xu, Zhikai Zhu, Yantao Tian
Summary: This study demonstrates that different proportions of signet ring cells in GSRC can impact the survival of patients, with those in the high proportion group having a significantly higher overall survival rate compared to those in the low proportion group. Further clinical studies are needed to develop appropriate treatment strategies for GSRC.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
Roberto Fiocca, Luca Mastracci, Marialuisa Lugaresi, Federica Grillo, Antonietta D'Errico, Deborah Malvi, Paola Spaggiari, Anna Tomezzoli, Luca Albarello, Ari Ristimaki, Luca Bottiglieri, Elena Bonora, Kausilia K. Krishnadath, Gian Domenico Raulli, Riccardo Rosati, Uberto Fumagalli Romario, Giovanni De Manzoni, Jari Rasanen, Sandro Mattioli, EACSGE Study Grp
Summary: The study reassessed nearly 300 EA/EGJAs and identified a two-tiered grading approach based on a cut off of 6% poorly differentiated components. Two morphologic risk groups (lower risk and higher risk) were identified, adding significant prognostic value to the stage. Accurate morphologic description is essential for a better understanding of prognosis, molecular events, and treatment response.
Article
Oncology
Hokun Kim, Dong Hwan Kim, In Hye Song, Bohyun Kim, Soon Nam Oh, Joon-Il Choi, Sung Eun Rha
Summary: In patients with pancreatic ductal adenocarcinoma (PDAC), intratumoral necrosis detected on CT or MRI scans significantly correlates with histopathological necrosis of the tumor. Additionally, MRI-detected necrosis is associated with poor overall survival after curative resection of PDAC, suggesting its potential as an imaging predictor for survival outcomes.
Article
Oncology
Song Wang, Yiyuan Zhang, Fangxu Yin, Xiangsheng Zhang, Zhenlin Yang, Xiaohong Wang
Summary: Primary breast signet ring cell carcinoma (SRCC) patients have distinct clinical features and a worse prognosis compared with mucinous breast adenocarcinoma (MBC) patients. Different treatment methods result in different prognoses for SRCC and MBC types, emphasizing the importance of distinguishing between these two types of breast cancer for optimal treatment efficacy.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
Gaya Spolverato, Danila Azzolina, Alessandro Paro, Giulia Lorenzoni, Dario Gregori, George Poultsides, Ryan C. Fields, Sharon M. Weber, Konstantinos Votanopoulos, Shishir K. Maithel, Salvatore Pucciarelli, Timothy M. Pawlik
Summary: This study designed and validated an online dynamic prognostic tool to predict overall survival (OS) and disease-free survival (DFS) following resection of gastric adenocarcinoma. The landmark analysis based on follow-up time may be helpful for surgeons and patients.
Article
Oncology
Ke Peng, Suyao Li, Qian Li, Chenlu Zhang, Yitao Yuan, Menglin Liu, Lei Zhang, Yichen Wang, Shan Yu, Haisheng Zhang, Tianshu Liu
Summary: Gastric cancer (GC) has a poor prognosis and phosphorylated FAK (pFAK) is identified as a negative prognostic factor in GC. This study demonstrates that pFAK is an independent risk factor for a worse prognosis in GC and a nomogram based on pFAK can help predict overall survival in GC patients, improving the accuracy of prognosis prediction.
FRONTIERS IN ONCOLOGY
(2022)
Article
Surgery
Eran Sadot, Jian Zheng, Rami Srouji, Vivian E. Strong, Mithat Gonen, Vinod P. Balachandran, Michael I. D'Angelica, Peter J. Allen, Ronald P. DeMatteo, T. Peter Kingham, Yuman Fong, Martin R. Weiser, William R. Jarnagin
WORLD JOURNAL OF SURGERY
(2019)
Article
Oncology
Ieva Kurilova, Regina G. H. Beets-Tan, Jessica Flynn, Mithat Gonen, Gary Ulaner, Elena N. Petre, F. Edward Boas, Etay Ziv, Hooman Yarmohammadi, Elisabeth G. Klompenhouwer, Andrea Cercek, Nancy A. Kemeny, Constantinos T. Sofocleous
CLINICAL COLORECTAL CANCER
(2019)
Article
Radiology, Nuclear Medicine & Medical Imaging
Marc J. Gollub, Ivana Blazic, Seth Felder, Andrea Knezevic, Mithat Gonen, Julio Garcia-Aguilar, P. Phillip Paty, J. Joshua Smith
EUROPEAN RADIOLOGY
(2019)
Article
Gastroenterology & Hepatology
Lauren S. Tufts, Emma D. Jarnagin, Jessica R. Flynn, Mithat Gonen, Jose G. Guillem, Philip B. Paty, Garrett M. Nash, Joshua J. Smith, Iris H. Wei, Emmanouil Pappou, Michael I. D'Angelica, Peter J. Allen, T. Peter Kingham, Vinod P. Balachandran, Jeffrey A. Drebin, Julio Garcia-Aguilar, William R. Jarnagin, Martin R. Weiser
Article
Gastroenterology & Hepatology
Marc A. Attiyeh, Jayasree Chakraborty, Lior Gazit, Liana Langdon-Embry, Mithat Gonen, Vinod P. Balachandran, Michael I. D'Angelica, Ronald P. DeMatteo, William R. Jarnagin, T. Peter Kingham, Peter J. Allen, Richard K. Do, Amber L. Simpson
Article
Oncology
Raja R. Narayan, John M. Creasy, Debra A. Goldman, Mithat Gonen, Cyriac Kandoth, Ritika Kundra, David B. Solit, Gokce Askan, David S. Klimstra, Olca Basturk, Peter J. Allen, Vinod P. Balachandran, Michael D'Angelica, Ronald P. DeMatteo, Jeffrey A. Drebin, T. Peter Kingham, Amber L. Simpson, Ghassan K. Abou-Alfa, James J. Harding, Eileen M. O'Reilly, Jean M. Butte, Ryusei Matsuyama, Itaru Endo, William R. Jarnagin
Article
Medicine, Research & Experimental
Kristen M. Cunanan, Alexia Iasonos, Ronglai Shen, Mithat Gonen
Article
Radiology, Nuclear Medicine & Medical Imaging
Marc J. Gollub, Ivana Blazic, David D. B. Bates, Naomi Campbell, Andrea Knezevic, Mithat Gonen, Patricio Lynn, Martin R. Weiser, Julio Garcia-Aguilar, Andreas M. Hoetker, Andrea Cercek, Leonard Saltz
EUROPEAN RADIOLOGY
(2019)
Article
Oncology
Gulisa Turashvili, Natalia R. Gomez-Hidalgo, Jessica Flynn, Mithat Gonen, Mario M. Leitao, Robert A. Soslow, Rajmohan Murali
GYNECOLOGIC ONCOLOGY
(2019)
Article
Gastroenterology & Hepatology
Alessandra Pulvirenti, Deepthi Rao, Caitlin A. Mcintyre, Mithat Gonen, Laura H. Tang, David S. Klimstra, Martin Fleisher, Lakshmi V. Ramanathan, Diane Reidy-Lagunes, Peter J. Allen
Article
Oncology
J. Joshua Smith, Paul Strombom, Oliver S. Chow, Campbell S. Roxburgh, Patricio Lynn, Anne Eaton, Maria Widmar, Karuna Ganesh, Rona Yaeger, Andrea Cercek, Martin R. Weiser, Garrett M. Nash, Jose G. Guillem, Larissa K. F. Temple, Sree B. Chalasani, James L. Fuqua, Iva Petkovska, Abraham J. Wu, Marsha Reyngold, Efsevia Vakiani, Jinru Shia, Neil H. Segal, James D. Smith, Christopher Crane, Marc J. Gollub, Mithat Gonen, Leonard B. Saltz, Julio Garcia-Aguilar, Philip B. Paty
Article
Oncology
Raja R. Narayan, Debra A. Goldman, Mithat Gonen, Jonathan Reichel, Kety H. Huberman, Sandeep Raj, Agnes Viale, Nancy E. Kemeny, Peter J. Allen, Vinod P. Balachandran, Michael I. D'Angelica, Ronald P. DeMatteo, Jeffrey A. Drebin, William R. Jarnagin, T. Peter Kingham
ANNALS OF SURGICAL ONCOLOGY
(2019)
Article
Oncology
Campbell S. D. Roxburgh, Paul Strombom, Patricio Lynn, Mithat Gonen, Philip B. Paty, Jose G. Guillem, Garrett M. Nash, J. Joshua Smith, Iris Wei, Emmanouil Pappou, Julio Garcia-Aguilar, Martin R. Weiser
ANNALS OF SURGICAL ONCOLOGY
(2019)
Article
Multidisciplinary Sciences
Kimiyo N. Yamamoto, Akira Nakamura, Lin L. Liu, Shayna Stein, Angela C. Tramontano, Uri Kartoun, Tetsunosuke Shimizu, Yoshihiro Inoue, Mitsuhiro Asakuma, Hiroshi Haeno, Chung Yin Kong, Kazuhisa Uchiyama, Mithat Gonen, Chin Hur, Franziska Michor
Article
Radiology, Nuclear Medicine & Medical Imaging
David Aramburu Nunez, Yonggang Lu, Ramesh Paudyal, Vaios Hatzoglou, Andre L. Moreira, Jung Hun Oh, Hilda E. Stambuk, Yousef Mazaheri, Mithat Gonen, Ronald A. Ghossein, Ashok R. Shaha, R. Michael Tuttle, Amita Shukla-Dave