Article
Medicine, General & Internal
Jihee Sohn, Yurimi Lee, Hyun-Soo Kim
Summary: This study investigated the histological types and prevalence of gynecological tumors co-existing with endocervical polyps (ECPs) and analyzed the clinicopathological characteristics of ovarian and endometrial endometrioid carcinomas (ECs) involving ECPs. The study found a synchronous occurrence of ovarian and endometrial ECs involving ECPs, with possible implantation metastasis as the pathogenic mechanism.
Article
Pathology
Lawrence Hsu Lin, Douglas H. R. Allison, Gulisa Turashvili, Varshini Vasudevaraja, Ivy Tran, Jonathan Serrano, Britta Weigelt, Marc Ladanyi, Nadeem R. Abu-Rustum, Matija Snuderl, Sarah Chiang
Summary: This study found that co-occurring sporadic endometrioid endometrial carcinoma (EEC) and endometrioid ovarian carcinoma (EOC) are clonally related, but there is a shift in DNA methylation signatures between the ovarian and endometrial tumors. The results also indicate epigenetic overlap between ovarian and peritoneal tumors, suggesting a role for the tumor microenvironment in the epigenetic modulation of metastatic EEC.
Review
Pathology
Karen L. Talia, W. Glenn Mccluggage
Summary: This review discusses the diverse morphologies of ovarian endometrioid carcinoma (EC), including 'metaplastic' changes and various subtypes. It also explores the propensity for transdifferentiation in EC and the association with somatically derived yolk sac tumors. Immunohistochemistry is valuable in diagnosing EC, although the aberrant immunophenotype of ovarian EC can complicate diagnosis. The review also covers the genomic characteristics of EC and the inclusion of seromucinous carcinoma in the EC category.
Article
Pathology
Lina Irshaid, Danielle C. Costigan, Fei Dong, Ursula A. Matulonis, Marisa R. Nucci, David L. Kolin
Summary: This study aimed to characterize the genetic landscape of Mullerian clear cell carcinoma (CCC) and correlate these findings with clinicopathologic features. The results showed that the genetic landscape of CCC is complex, with ARID1A and PIK3CA being the most frequently mutated genes. Furthermore, CCC can be classified into different molecular subgroups, which have different prognostic implications.
Review
Oncology
Nicoletta D'Alessandris, Antonio Travaglino, Angela Santoro, Damiano Arciuolo, Giulia Scaglione, Antonio Raffone, Frediano Inzani, Gian Franco Zannoni
Summary: This study evaluated the distribution and clinicopathological features of the TCGA groups in ovarian endometrioid carcinoma (OEC) and found differences in distribution between OEC and endometrial endometrioid carcinoma (EEC), but similar prognostic value.
GYNECOLOGIC ONCOLOGY
(2021)
Article
Endocrinology & Metabolism
Daqi Zhang, Mingyu Yang, Xin Zhang, Cheng Wang, Kunlin Li, Hongbo Wang, Hao Chi, Chengqiu Sui, Gianlorenzo Dionigi, Hui Sun
Summary: This study presents a rare case series of synchronous occurrence of medullary thyroid carcinoma (MTC) and papillary thyroid carcinoma (PTC) in the same thyroid gland. The synchronous MTC/PTC were classified into 4 subtypes and the clinical and pathological aspects as well as the results were presented.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Medicine, General & Internal
Hyunjin Kim, Kiyong Na, Go Eun Bae, Hyun-Soo Kim
Summary: Research on mesonephric-like adenocarcinoma of the uterine corpus revealed irregularities in immunohistochemical staining, posing challenges for differential diagnosis. Caution should be taken when interpreting immunohistochemical staining results.
Article
Oncology
Amir-Hossein Akbari, Lu Wang, Robert A. Soslow, Rajmohan Murali
Summary: Undifferentiated carcinoma (UC) and dedifferentiated carcinoma (DC) exhibit a spectrum of cytomorphologic appearances in cytologic specimens, with no statistically significant differences observed between the two subtypes.
CANCER CYTOPATHOLOGY
(2021)
Article
Medicine, General & Internal
Michele Paudice, Chiara Maria Biatta, Giulia Scaglione, Alessia Parodi, Serafina Mammoliti, Melita Moioli, Maria Grazia Centurioni, Fabio Barra, Simone Ferrero, Franco De Cian, Katia Mazzocco, Valerio Gaetano Vellone
Summary: Endometrial cancer is a growing disease with an increase in aggressive histotypes. This study investigated potential prognostic markers and found that Bcl-2 and PR may have prognostic significance in high-grade non-endometrioid carcinoma patients.
Article
Oncology
Alberto Farolfi, Amelia Altavilla, Luca Morandi, Laura Capelli, Elisa Chiadini, Giovanna Prisinzano, Giorgia Gurioli, Marianna Molari, Daniele Calistri, Maria Pia Foschini, Ugo De Giorgi
Summary: This study examines the relationship between endometriosis and endometrial cancer. Somatic mutation profile and phylogenetic analysis reveal that tumor cells may retrogradely disseminate to the ectopic sites of endometriosis.
FRONTIERS IN ONCOLOGY
(2022)
Article
Medicine, General & Internal
Tayyiba Wasim, Javeria Mushtaq, Ahmad Zunair Wasim, Gul-e-Raana
Summary: The study found that ovarian cancer is the most common gynecological malignancy, followed by cervical cancer. Most cancer patients presented at advanced stages, with factors like hypertension, diabetes, and heavy menstrual bleeding being associated.
PAKISTAN JOURNAL OF MEDICAL SCIENCES
(2021)
Article
Pathology
Ramtin Edjtemaei, Fatemeh Nili, Issa Jahanzad, Fereshteh Ameli, Dorsa Ghasemi
Summary: This study evaluated the expression of HER2 in clear cell carcinoma using immunohistochemistry and fluorescence in situ hybridization. The results showed that HER2 positivity was associated with lower disease-free and overall survival rates in ovarian and endometrial carcinoma. Therefore, HER2 may serve as a potential biomarker for targeted therapy in clear cell carcinoma.
ANNALS OF DIAGNOSTIC PATHOLOGY
(2023)
Article
Pathology
Amy Joehlin-Price, Jessica Van Ziffle, Nancy K. Hills, Nicholas Ladwig, Joseph T. Rabban, Karuna Garg
Summary: This study evaluated the prognostic impact of molecular classification on FIGO grade 3 endometrioid endometrial carcinoma, using POLE mutation analysis and immunohistochemistry. The POLE mutation group and multiple classifier group showed excellent clinical outcomes, while the p53-ab group showed the worst clinical outcomes. Overall, there was no correlation between molecular grouping and tumor immunophenotypic findings.
AMERICAN JOURNAL OF SURGICAL PATHOLOGY
(2021)
Review
Pathology
Sonia Gatius, Xavier Matias Guiu, Ben Davidson
Summary: Gynecologic pathology has rapidly evolved from lacking molecular testing to becoming a routine diagnostic discipline with the relevance of molecular characterization to treatment choice. Molecular testing is expanding as a tool for diagnosing rare tumors and improving reproducible diagnoses and genetic disease consultation. Despite challenges in studying rare cancers, increased knowledge may lead to new therapeutic options for malignant rare cancers.
Review
Oncology
John J. Peluso, James K. Pru
Summary: Ovarian and endometrial cancers are deadly and prevalent, with PGRMC1 and PGRMC2 being highly expressed and playing key roles in promoting tumor growth and chemoresistance. Reduced expression of PGRMC1 in xenograft studies leads to slower tumor growth, indicating its importance in cancer progression. The molecular mechanisms of PGRMCs in regulating survival pathways and affecting cell fate in ovarian and endometrial cancers are still being explored.
Article
Oncology
Lukas Leiendecker, Tobias Neumann, Pauline S. Jung, Shona M. Cronin, Thomas L. Steinacker, Alexander Schleiffer, Michael Schutzbier, Karl Mechtler, Thibault Kervarrec, Estelle Laurent, Kamel Bachiri, Etienne Coyaud, Rajmohan Murali, Klaus J. Busam, Babak Itzinger-Monshi, Reinhard Kirnbauer, Lorenzo Cerroni, Eduardo Calonje, Arno Rutten, Frank Stubenrauch, Klaus G. Griewank, Thomas Wiesner, Anna C. Obenauf
Summary: This study reveals the presence of human papillomavirus 42 (HPV42) in 96% of digital papillary adenocarcinoma (DPA), a cancer occurring on fingers and toes. It shows that HPV42, previously considered nononcogenic, behaves similarly to oncogenic, high-risk HPVs. Machine learning analysis indicates that HPV-driven transformation induces a germ cell-like transcriptional program conserved across all HPV-driven cancers, with implications for early detection, diagnosis, and therapy.
Article
Oncology
Anjelica Hodgson, Veronica Kim, Rajmohan Murali
Summary: This study aimed to describe the cytologic features of primary gynecologic germ cell tumors and carcinomas exhibiting germ cell differentiation. The researchers reviewed available cytologic material and recorded morphological features, patient age at diagnosis, tumor site, and cytologic preparation type. They found that adult women with germ cell tumors and somatic neoplasms exhibiting germ cell tumor differentiation may share some cytologic features, making it difficult to distinguish between them.
CANCER CYTOPATHOLOGY
(2023)
Article
Oncology
Josephine K. K. Dermawan, Nooshin Dashti, Sarah Chiang, Gulisa Turashvili, Brendan C. C. Dickson, Lora H. H. Ellenson, Martina Kirchner, Albrecht Stenzinger, Gunhild Mechtersheimer, Abbas Agaimy, Cristina R. R. Antonescu
Summary: In this study, we report a series of endometrial stromal sarcoma (ESS) cases with novel gene fusions. These cases demonstrate morphological and molecular heterogeneity. The identified fusion genes play important roles in the regulation of the PRC2 and/or NuA4/TIP60 complexes.
GENES CHROMOSOMES & CANCER
(2023)
Review
Urology & Nephrology
Sherri M. Donat, Yukio Sonoda, Hikmat Al-Ahmadie, Rajmohan Murali, Dianna L. Ng, Samuel A. Funt, Kay J. Park
Summary: Urinary cytology is crucial for evaluating gross hematuria and monitoring urothelial neoplasms. A positive urine cytology typically indicates the presence of urothelial carcinoma in the urinary tract, but it may also suggest involvement of the lower gynecologic tract or rectum in women. Guidelines for evaluating women with positive cytology and normal urinary tract are lacking. This review aims to raise clinicians' awareness of this diagnostic dilemma with case scenarios. UROLOGY 173: 10-16, 2023. (c) 2023 Elsevier Inc.
Article
Hematology
Kitsada Wudhikarn, Ana Alarcon Tomas, Jessica R. Flynn, Sean M. Devlin, Jamie Brower, Veronika Bachanova, Loretta J. Nastoupil, Joseph P. McGuirk, Richard T. Maziarz, Olalekan O. Oluwole, Stephen J. Schuster, David L. Porter, Michael R. Bishop, Peter A. Riedell, Miguel-Angel Perales, Cell Therapy Consortium
Summary: CD19 CAR T-cell therapy is effective in inducing sustained remissions in patients with R/R DLBCL, but can lead to significant toxicities. Treating patients in complete remission at the time of CAR T-cell infusion is feasible, safe, and associated with favorable disease control. Further exploration in larger clinical trials is needed.
Article
Hematology
Michael Scordo, Leah J. Gilbert, Danielle M. Hanley, Jessica R. Flynn, Sean M. Devlin, Linh K. Nguyen, Josel D. Ruiz, Gunjan L. Shah, Craig S. Sauter, David J. Chung, Heather J. Landau, Oscar B. Lahoud, Richard J. Lin, Parastoo B. Dahi, Miguel-Angel Perales, Sergio A. Giralt, Gerald A. Soff
Summary: There is currently no standard treatment for severe thrombocytopenia after autologous hematopoietic cell transplantation (auto-HCT). A pilot study was conducted to evaluate the use of romiplostim, a thrombopoietin receptor agonist, in enhancing platelet recovery in patients undergoing auto-HCT for multiple myeloma or lymphoma. Results showed that romiplostim-treated patients had improved platelet recovery compared to those who did not receive romiplostim. However, the improvement occurred later than expected. Overall, romiplostim demonstrated promising activity and safety in this setting. (ClinicalTrials.gov identifier: NCT04478123)
Article
Pathology
Cherry Pun, Gulisa Turashvili, Anna Marie Mulligan, Elzbieta Slodkowska
Summary: Mammary spindle cell proliferations (SCPs) cover a wide range of lesions and are difficult to diagnose accurately on core needle biopsies (CNBs). Most SCPs require excision for definitive diagnosis, but in some cases, conservative follow-up may be possible. This study aimed to examine SCPs diagnosed on CNB and evaluate the necessity of excision for benign/indeterminate SCPs. Among 197 SCPs that met the inclusion criteria, 53% were classified as benign, 26% as indeterminate, and 19% as malignant on CNB. Excision was performed in 47% of benign, 87% of indeterminate, and 86% of malignant CNBs. Of the 123 excised SCPs, 63% were benign and 36% were malignant. Most benign lesions showed no suspicious radiological features, while indeterminate and malignant lesions were more likely to be suspicious. Proper ancillary tests can safely exclude some malignant entities, and accurate pathological diagnosis with correlation to imaging and clinical data can potentially spare surgery for patients with mammary SCPs.
AMERICAN JOURNAL OF SURGICAL PATHOLOGY
(2023)
Article
Oncology
Amir Momeni-Boroujeni, Chad Vanderbilt, Elham Youse, Nadeem R. Abu-Rustum, Carol Aghajanian, Robert A. Soslow, Lora H. Ellenson, Britta Weigelt, Rajmohan Murali
Summary: This study investigated the prevalence and clinicopathological associations of chromatin remodeling gene (CRG) alterations in endometrial carcinoma (EC). The results showed that about 66.4% of EC patients had CRG alterations, with ARID1A being the most commonly altered gene. These CRG alterations were associated with the clinicopathological features of EC and likely played a crucial role in its development.
GYNECOLOGIC ONCOLOGY
(2023)
Article
Cell Biology
Joep M. A. Bogaerts, Majke H. D. van Bommel, Rosella P. M. G. Hermens, Miranda P. Steenbeek, Joanne A. de Hullu, Jeroen A. W. M. van Der Laak, Michiel Simons
Summary: It is crucial to diagnose or exclude serous tubal intraepithelial carcinoma (STIC), a precursor lesion of tubo-ovarian high-grade serous carcinoma (HGSC), in a reliable and safe manner. This study aimed to optimize STIC diagnosis and increase reproducibility through a three-round Delphi study involving an international panel of expert gynecologic pathologists. The resulting consensus statements provide recommendations for more consistent STIC diagnosis.
Article
Pathology
Gulisa Turashvili, Qingqing Ding, Yi Liu, Limin Peng, Miralem Mrkonjic, Haider Mejbel, Yihong Wang, Huina Zhang, Gloria Zhang, Jigang Wang, Shi Wei, Xiaoxian Li
Summary: The latest World Health Organization classification of breast tumors recommends diagnosing malignant phyllodes tumors (MPTs) when all 5 morphologic features are present. However, a retrospective study found that the current recommendation may miss a significant number of MPTs with distant metastases, suggesting the need for refined diagnostic criteria.
AMERICAN JOURNAL OF SURGICAL PATHOLOGY
(2023)
Article
Oncology
Jennifer K. Litton, Meredith M. Regan, Lajos Pusztai, Hope S. Rugo, Sara M. Tolaney, Elizabeth Garrett-Mayer, Laleh Amiri-Kordestani, Reva K. Basho, Ana F. Best, Jean-Francois Boileau, Carsten Denkert, Jared C. Foster, Nadia Harbeck, Heather A. Jacene, Tari A. King, Ginny Mason, Ciara C. O'Sullivan, Tatiana M. Prowell, Andrea L. Richardson, Karla A. Sepulveda, Mary Lou Smith, Judy A. Tjoe, Gulisa Turashvili, Wendy A. Woodward, Lynn Pearson Butler, Elena I. Schwartz, Larissa A. Korde
Summary: The STEEP criteria, updated as STEEP 2.0 in 2021, provide standardized definitions for adjuvant breast cancer end points. A working group called NeoSTEEP was established to evaluate and align neoadjuvant breast cancer trial end points.
JOURNAL OF CLINICAL ONCOLOGY
(2023)
Article
Pathology
Gulisa Turashvili, Yuan Gao, Di (Andy) Ai, Abdulwahab M. Ewaz, Sandra Gjorgova Gjeorgjievski, Qun Wang, Thi T. A. Nguyen, Chao Zhang, Xiaoxian Li
Summary: This study evaluated the interobserver agreement among subspecialised breast pathologists for the assessment of HLBC and developed a practical algorithm. The results showed suboptimal agreement among the pathologists, highlighting the need for a new reliable evaluation method for HLBC.
JOURNAL OF CLINICAL PATHOLOGY
(2023)
Article
Pathology
Lawrence Hsu Lin, Douglas H. R. Allison, Gulisa Turashvili, Varshini Vasudevaraja, Ivy Tran, Jonathan Serrano, Britta Weigelt, Marc Ladanyi, Nadeem R. Abu-Rustum, Matija Snuderl, Sarah Chiang
Summary: This study found that co-occurring sporadic endometrioid endometrial carcinoma (EEC) and endometrioid ovarian carcinoma (EOC) are clonally related, but there is a shift in DNA methylation signatures between the ovarian and endometrial tumors. The results also indicate epigenetic overlap between ovarian and peritoneal tumors, suggesting a role for the tumor microenvironment in the epigenetic modulation of metastatic EEC.
Article
Hematology
Michael Scordo, Jessica R. Flynn, Mithat Gonen, Sean M. Devlin, Allison Parascondola, Ana Alarcon Tomas, Roni Shouval, Jamie Brower, David L. Porter, Stephen J. Schuster, Veronika Bachanova, Joseph Maakaron, Richard T. Maziarz, Andy I. Chen, Loretta J. Nastoupil, Joseph P. Mcguirk, Olalekan O. Oluwole, Andrew Lp, Lori A. Leslie, Michael R. Bishop, Peter A. Riedell, Miguel-Angel Perales
Summary: Using a population pharmacokinetic model, researchers estimated the exposure of fludarabine in lymphodepleted patients before receiving CD19 chimeric antigen receptor T cells. They found that an optimal fludarabine exposure was associated with the highest progression-free survival and lowest risk of disease relapse/progression, without increasing the risk of cytokine release syndrome or immune effector cell-associated neurotoxicity syndrome. On the other hand, a high fludarabine exposure was linked to a higher risk of neurotoxicity. These findings suggest that personalized dosing based on fludarabine exposure could improve outcomes for patients receiving axicel therapy.
Meeting Abstract
Medicine, Research & Experimental
Rofieda Alwaqfi, Gulisa Turashvili, Varshini Vasudevaraja, Ivy Tran, Jonathan Serrano, M. Herman Chui, Britta Weigelt, Robert Soslow, Lora Ellenson, Nadeem Abu-Rustum, Matija Snuderl, Sarah Chiang
LABORATORY INVESTIGATION
(2023)