Article
Biochemistry & Molecular Biology
Batuer Aikemu, Yanfei Shao, Guang Yang, Junjun Ma, Sen Zhang, Xiao Yang, Hiju Hong, Galiya Yesseyeva, Ling Huang, Hongtao Jia, Chenxing Wang, Lu Zang, Jing Sun, Minhua Zheng
Summary: The study revealed that NDRG1 plays a crucial role in actin reorganization and tumor invasion in colorectal cancer by affecting CDC42 activation. Loss of NDRG1 disrupts the binding between RhoGDI alpha and CDC42, leading to the activation of CDC42 and downstream cascades that promote CRC invasion, and enhances tumor dissemination in vivo.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2021)
Article
Oncology
Mitsuru Sugimoto, Hiroki Irie, Mika Takasumi, Minami Hashimoto, Yuka Oka, Tadayuki Takagi, Rei Suzuki, Naoki Konno, Hiroyuki Asama, Yuki Sato, Jun Nakamura, Tsunetaka Kato, Ryoichiro Kobashi, Yuko Hashimoto, Shigeru Marubashi, Takuto Hikichi, Hiromasa Ohira
Summary: This study indicates that the observation of an irregular (thickened or narrow) LHEL on EUS could be a reliable and simple method of diagnosing GBMTs with ss invasion, which is crucial for choosing the appropriate surgical approach.
Article
Gastroenterology & Hepatology
Daiki Nemoto, Zhe Guo, Shinichi Katsuki, Takahito Takezawa, Ryo Maemoto, Keisuke Kawasaki, Ken Inoue, Takashi Akutagawa, Hirohito Tanaka, Koichiro Sato, Teppei Omori, Kunihiro Takanashi, Yoshikazu Hayashi, Yuki Nakajima, Yasuyuki Miyakura, Takayuki Matsumoto, Naohisa Yoshida, Motohiro Esaki, Toshio Uraoka, Hiroyuki Kato, Yuji Inoue, Boyuan Peng, Ruiyao Zhang, Takashi Hisabe, Tomoki Matsuda, Hironori Yamamoto, Noriko Tanaka, Alan Kawarai Lefor, Xin Zhu, Kazutomo Togashi
Summary: This study aimed to develop a computer-aided diagnosis (CADx) system using nonmagnified endoscopic white-light images to diagnose early-stage colorectal cancers (CRCs). The CADx system showed high specificity and accuracy for diagnosing T1b lesions, surpassing trainees and comparable to experts. The CADx system has promising potential for clinical application.
GASTROINTESTINAL ENDOSCOPY
(2023)
Article
Pharmacology & Pharmacy
Ze Wang, Chenghao Ma, Qiong Teng, Jinyu Man, Xuening Zhang, Xinjie Liu, Tongchao Zhang, Wei Chong, Hao Chen, Ming Lu
Summary: In this study, a machine learning framework was used to construct a Ferroptosis-related gene (FRG) signature, consisting of 23 genes, which showed better performance in predicting the prognosis of colorectal cancer patients compared to other common features and published signatures. The FRG signature enabled the accurate identification of high-risk stage II/III colorectal cancer patients and helped optimize precision treatment to improve their clinical outcomes.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Oncology
Qian Cheng, Shanglei Ning, Lei Zhu, Changlu Zhang, Shaodong Jiang, Yajing Hao, Jiye Zhu
Summary: The study found that NDRG1 enhances the expansion of liver cancer stem cells (CSCs), PVTT formation, and growth capability through the regulation of EpCAM stability. Therefore, NDRG1 may be a promising target for the treatment of patients with HCC and PVTT.
BRITISH JOURNAL OF CANCER
(2023)
Article
Pharmacology & Pharmacy
Zheng Chen, Xiaoyi Zheng, Jiulong Zhao, Jingwen Tang, Lianghao Hu, Shige Wang
Summary: This study proposes a chemical modification method to immobilize glucose oxidase (GOx) on the surface of a photothermal transducing agent for safe and combined starvation and photothermal therapy of colorectal tumors. Under near-infrared laser irradiation, the photothermal transducing agent generates thermal energy to locally kill colorectal cancer cells. The study is expected to provide a new avenue for the rational design of multifunctional nanotherapeutics for tumor therapy.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2023)
Article
Genetics & Heredity
Xianzhe Li, Minghao Xie, Shi Yin, Zhizhong Xiong, Chaobin Mao, Fengxiang Zhang, Huaxian Chen, Longyang Jin, Ping Lan, Lei Lian
Summary: This study developed and validated a novel immune prognostic signature based on six differentially expressed IRGs for predicting disease-free survival and immune status in patients with stage II CRC. The high-risk group exhibited a higher percentage of infiltrated immune cells. The accuracy of the signature was confirmed through experimental validation.
FRONTIERS IN GENETICS
(2021)
Review
Cell Biology
Lincheng Zhang, Ludi Yang, Shuheng Jiang, Minhao Yu
Summary: Nerves play a pivotal role in tumorigenesis and cancer progression, especially in neurotrophic cancers. Perineural invasion in colorectal cancer has been recognized as a strong predictor of prognosis. Nerves can shield and nurture tumor cells, and their precise role and interaction pattern with CRC cells have not been fully revealed yet.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Oncology
Sebastien Gouy, Sophie Maria, Matthieu Faron, Amandine Maulard, Patricia Pautier, Alexandra Leary, Cyrus Chargari, Catherine Genestie, Philippe Morice
Summary: This study aimed to assess the outcomes of conservatively treated stage II/III serous borderline tumors of the ovary (SBOTs) with long-term follow-up. Among 212 patients reviewed, 65 underwent conservative treatment, with 38 experiencing recurrences. Conservative treatment was found to be a prognostic factor for disease-free survival but did not impact overall survival, although three deaths occurred.
ANNALS OF SURGICAL ONCOLOGY
(2021)
Article
Oncology
Jae Hyun Kang, Tae Son, Byung Chun Kim, Jun Ho Park, Jeong Yeon Kim, Jong Wan Kim
Summary: In this study, the combination of T4 tumor, lymphovascular invasion (LVI), and perineural invasion (PNI) was found to indicate a poor prognosis for recurrence-free survival (RFS) in patients with stage II-III colon cancer. The number of risk factors was associated with a decrease in the 5-year RFS rate. Patients with one of these risk factors should be considered for chemotherapy and closely followed up.
CANCER MANAGEMENT AND RESEARCH
(2022)
Article
Medicine, General & Internal
Shuzo Kohno, Masahiro Ikegami, Toru Ikegami, Hiroaki Aoki, Masaichi Ogawa, Fumiaki Yano, Ken Eto
Summary: This retrospective study investigated the characteristics of gastroenteropancreatic neuroendocrine tumors using a unified classification. Tumor size, depth, lymphatic invasion, venous invasion, and neuroendocrine tumor grade were significantly correlated with metastasis. Venous invasion was found to be more strongly correlated with metastasis than lymphatic invasion. These findings highlight the importance of a unified classification and standardized assessment framework in neuroendocrine tumor research.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Multidisciplinary Sciences
Shumin Dong, Huaiming Wang, Hongli Ji, Yaowen Hu, Shuhan Zhao, Botao Yan, Guangxing Wang, Zexi Lin, Weifeng Zhu, Jianping Lu, Jiaxin Cheng, Zhida Wu, Qiong Zhu, Shuangmu Zhuo, Gang Chen, Jun Yan
Summary: This study found that the collagen signature in the tumor microenvironment can be used to predict the prognosis of colorectal cancer, and the combination with the traditional TNM classification system can improve the accuracy of prediction. This is of great significance for the prognosis assessment and individualized treatment of cancer.
Article
Dentistry, Oral Surgery & Medicine
Wataru Kakuguchi, Yuichi Ashikaga, Aya Yanagawa-Matsuda, Kazuyo Kuribayashi, Saki Shinohara, Naohiro Ogawa, Nako Maishi, Kyoko Hida, Chih-Yuan Fang, Yoichi Ohiro
Summary: This study aimed to identify clinicopathological features related to cervical lymph node metastasis (CLNM) in tongue carcinomas. The results showed that clinical T2 stage, depth of invasion, tumor differentiation, and invasion pattern were significantly associated with CLNM. Close follow-up is recommended for high-risk tongue squamous cell carcinoma patients after partial glossectomy.
JOURNAL OF DENTAL SCIENCES
(2023)
Article
Medicine, General & Internal
Min Hoan Moon, Hee Sun Park, Young Jun Kim, Mi Hye Yu, Sungeun Park, Sung Il Jung
Summary: This study aimed to determine computed tomography (CT) features in differentiating stage 1 borderline ovarian tumors (BOTs) from stage I malignant epithelial ovarian tumors (MEOTs). The results showed that a larger tumor size and a smaller solid component were significantly associated with BOTs. In cases with a solid component, smaller and ill-defined solid component was significantly associated with BOTs.
Article
Biochemistry & Molecular Biology
Antonios N. Gargalionis, Kostas A. Papavassiliou, Athanasios G. Papavassiliou
Summary: Mechanical features of cancer cells play a crucial role in tumor development and progression, with mechanosensory proteins potentially mediating oncogenic signaling and response to chemotherapy. Studying changes in tumor microenvironment and matrix rigidity can offer new anti-cancer strategies.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2022)
Review
Biochemistry & Molecular Biology
Tomasz Przybyla, Monika Sakowicz-Burkiewicz, Tadeusz Pawelczyk
ACTA BIOCHIMICA POLONICA
(2018)
Article
Multidisciplinary Sciences
Monika Lesicka, Ewa Jablonska, Edyta Wieczorek, Barbara Seroczynska, Anna Siekierzycka, Jaroslaw Skokowski, Leszek Kalinowski, Wojciech Wasowicz, Edyta Reszka
Article
Oncology
Aleksandra Markiewicz, Anna Nagel, Jolanta Szade, Hanna Majewska, Jaroslaw Skokowski, Barbara Seroczynska, Tomasz Stokowy, Marzena Welnicka-Jaskiewicz, Anna J. Zaczek
TRANSLATIONAL ONCOLOGY
(2018)
Article
Oncology
Aleksandra Markiewicz, Justyna Topa, Anna Nagel, Jaroslaw Skokowski, Barbara Seroczynska, Tomasz Stokowy, Marzena Welnicka-Jaskiewicz, Anna J. Zaczek
Article
Biochemistry & Molecular Biology
Anna Nagel, Jolanta Szade, Mariola Iliszko, Julia Elzanowska, Marzena Welnicka-Jaskiewicz, Jaroslaw Skokowski, Grzegorz Stasilojc, Jacek Bigda, Rafal Sadej, Anna Zaczek, Aleksandra Markiewicz
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2019)
Article
Biology
Monika Lesicka, Ewa Jablonska, Edyta Wieczorek, Barbara Seroczynska, Leszek Kalinowski, Jaroslaw Skokowski, Edyta Reszka
CHRONOBIOLOGY INTERNATIONAL
(2019)
Article
Biochemical Research Methods
Katarzyna Macur, Lars Hagen, Tomasz M. Ciesielski, Lucyna Konieczna, Jaroslaw Skokowski, Bjorn M. Jenssen, Geir Slupphaug, Tomasz Baczek
JOURNAL OF PROTEOMICS
(2019)
Article
Biochemistry & Molecular Biology
Monika Lesicka, Ewa Jablonska, Edyta Wieczorek, Beata Peplonska, Jolanta Gromadzinska, Barbara Seroczynska, Leszek Kalinowski, Jaroslaw Skokowski, Edyta Reszka
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2019)
Article
Nutrition & Dietetics
Magdalena Trzeciak, Berenika Olszewska, Monika Sakowicz-Burkiewicz, Malgorzata Sokolowska-Wojdylo, Jerzy Jankau, Roman Janusz Nowicki, Tadeusz Pawelczyk
Review
Biochemistry & Molecular Biology
Boguslaw Nedoszytko, Edyta Reszka, Danuta Gutowska-Owsiak, Magdalena Trzeciak, Magdalena Lange, Justyna Jarczak, Marek Niedoszytko, Ewa Jablonska, Jan Romantowski, Dominik Strapagiel, Jaroslaw Skokowski, Anna Siekierzycka, Roman J. Nowicki, Iwona T. Dobrucki, Anna Zaryczariska, Leszek Kalinowski
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2020)
Article
Biochemistry & Molecular Biology
Robert Kowalski, Piotr Pikul, Krzysztof Lewandowski, Monika Sakowicz-Burkiewicz, Tadeusz Pawelczyk, Marlena Zysk
Summary: The production and metabolism of N-acetylaspartate are closely related to the interaction between neurons and glial cells, which is of great significance in neurobiology research. The presence of glial cells can protect N-acetylaspartate metabolism from dramatic changes during the maturation process.
Review
Biochemistry & Molecular Biology
Monika Sakowicz-Burkiewicz, Tadeusz Pawelczyk, Marlena Zysk
Summary: Neuroblastoma is a common childhood cancer with a significant risk of death. Recent studies have shown that extracellular vesicles play a crucial role in promoting tumorigenesis by carrying metabolic enzymes that influence energy metabolism. Glycolysis has been identified as playing a primary role in energy metabolism in neuroblastoma.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Medicine, General & Internal
Wojciech Polom, Marcin Migaczewski, Jaroslaw Skokowski, Maciej Swierblewski, Tomasz Cwalinski, Leszek Kalinowski, Michal Pedziwiatr, Marcin Matuszewski, Karol Polom
Summary: This study demonstrates the potential of using two different fluorophores in colorectal surgery. Visualisation with fluorophores aids in intraoperative localization and angiography, optimizing surgical outcomes. The use of two separate dyes may represent a direction for the development of image-guided surgery, showcasing advancements in optical technologies.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Oncology
Oliver Budner, Tomasz Cwalinski, Jaroslaw Skokowski, Luigi Marano, Luca Resca, Natalia Cwalina, Leszek Kalinowski, Richelle Hoveling, Franco Roviello, Karol Polom
Summary: This study is the first clinical series to propose the use of methylene blue as a fluorescent dye for breast cancer sentinel node biopsy. The study demonstrates the feasibility of using methylene blue as a fluorophore and suggests that dilution can improve fluorescence signal.
Article
Oncology
Anna Nagel, Marta Popeda, Anna Muchlinska, Rafal Sadej, Jolanta Szade, Jacek Zielinski, Jaroslaw Skokowski, Magdalena Niemira, Adam Kretowski, Aleksandra Markiewicz, Anna J. Zaczek
Summary: This study uncovers a new subtype of cancer-associated fibroblasts characterized by high levels of ER alpha 36 and secretion of HGF, which can impact triple-negative breast cancer. The findings highlight the importance of the tumor microenvironment in disease progression and emphasize the significance of further research in this area.