Journal
ACS APPLIED MATERIALS & INTERFACES
Volume 8, Issue 6, Pages 3609-3614Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acsami.5b07877
Keywords
dendrimer; selenium; platinum; anticancer; coordination
Funding
- National Science Foundation for Distinguished Young Scholars [21425416]
- National Natural Science Foundation of China [91427301]
- National Basic Research Program of China [2013CB834502]
- Foundation for Innovative Research Groups of the National Natural Science Foundation of China [21421064]
- Tsinghua-Leuven joint project
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Dendrimers are considered as good vectors for drug delivery in cancer treatment. However, most anticancer drugs are conjugated to the peripheral surface of dendrimers, sacrificing the advantages of monodispersity and stability belonging to dendrimers. Furthermore, dendrimers in current studies of cancer treatment are mostly used as vectors for drugs, whereas the anticancer activity of dendrimers on their own is less studied. Here we have prepared monodisperse selenium platinum coordination dendrimers with a selenium platinum core buried inside. Structures of the dendrimers were determined by various characterizations. The coordination dendrimers showed controlled anticancer activity by themselves, without loading additional drugs. The in vivo study further demonstrated their anticancer activity and low toxicity to normal tissues.
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