Article
Biophysics
Pengyu Zhu, Muhammad Rizwan Younis, Guiqi Ma, Qianting Zhang, Ruibing An, Kaiqi Wang, Jian Dong
Summary: Dendritic polymer-platinum conjugates (G5-PEG-Pt) were designed as pH-responsive nanovesicles for target delivery of platinum drugs. The G5-PEG-Pt exhibited a well-defined structure, intrinsic fluorescence, and acid-responsive drug release. They were able to enter cancer cells and achieve comparable cytotoxicity to free cisplatin. Furthermore, the nanovesicles showed enhanced tumor platinum uptake compared to free cisplatin, potentially improving the therapeutic efficacy of platinum drugs.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2023)
Article
Biochemistry & Molecular Biology
Robert Czarnomysy, Anna Muszynska, Jakub Rok, Zuzanna Rzepka, Krzysztof Bielawski
Summary: Transition metal coordination compounds, when conjugated with drug carriers such as dendrimers, can enhance their bioavailability, exhibit higher cytotoxic activity against breast cancer cells, and induce apoptosis and autophagy through various pathways, thus overcoming drug resistance and increasing cellular accumulation in cancer cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Chemistry, Medicinal
Sandra Ramos-Inza, Daniel Plano, Carmen Sanmartin
Summary: In recent years, there has been a growing interest in the therapeutic properties of metal-based complexes and selenium-containing compounds. However, there is currently no review that explores the potential use of combining these entities to design new therapeutic derivatives. This review focuses on the latest achievements in this field, specifically compounds with anticancer and/or antimicrobial properties. The formation of coordination compounds involving metals and selenium, either through direct interaction with the metal center or as part of an organic ligand, is discussed. The review also evaluates coordination compounds with a Se(IV) center and discusses the biological properties of various selenium-containing organometallic complexes.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2022)
Article
Polymer Science
Ibrahim Bargathulla, Babu Aadhil Ashwaq, S. Sathiyaraj, A. Sultan Nasar, ElangovanVellaichamy
Summary: PEGylated polyurethane dendrimers showed significant cytotoxicity in human cancer cells, especially in breast and lung cancer cells. Protein marker analysis revealed that the PEGylated dendrimers induced apoptosis in cancer cells, suggesting potential anticancer activity.
EUROPEAN POLYMER JOURNAL
(2021)
Article
Materials Science, Multidisciplinary
Shani Ben-Zichri, May Meltzer, Shiran Lacham-Hartman, Sofiya Kolusheva, Uzi Hadad, Niv Papo, Raz Jelinek
Summary: Noncationic, amphiphilic dendrimer nanoparticles embedding curcumin and resveratrol effectively target and slowly release the anticancer polyphenols, exhibiting promising potential as an anticancer therapeutic platform.
ACS APPLIED POLYMER MATERIALS
(2022)
Article
Chemistry, Inorganic & Nuclear
Juan Sanchez-Camacho, Sonia Infante-Tadeo, Ana C. Carrasco, Stefano Scoditti, A'lvaro Martinez, Fabienne Barroso-Bujans, Emilia Sicilia, Ana M. Pizarro, Luca Salassa
Summary: In this study, two new asymmetric Pt(IV) derivatives were designed and synthesized, which could be effectively activated into toxic Pt(II) species by incubation with nicotinamide adenine dinucleotide, sodium ascorbate, and glutathione in the dark and under light irradiation. One of the derivatives displayed enhanced toxicity in MDA-MB-231 breast cancer cells preincubated with ascorbate, suggesting selective triggering of oxaliplatin generation through redox activation. Covalent binding of the flavin to the Pt complex was shown to be pivotal for this effect.
INORGANIC CHEMISTRY
(2023)
Review
Engineering, Biomedical
Tianyuan Zhong, Jie Yu, Yong Pan, Ning Zhang, Yanxin Qi, Yubin Huang
Summary: Platinum drugs are widely used in cancer treatment, but their toxicity and drug resistance pose challenges. Combination therapy with platinum drugs can effectively inhibit tumor growth and metastasis, reducing toxicity and overcoming resistance. This review summarizes the current progress and challenges in platinum-based combination therapy, including gene editing, ROS-based therapy, thermal therapy, immunotherapy, and imaging modality. It hopes to inspire researchers for the development of more effective platinum-based anti-cancer complexes in the future.
ADVANCED HEALTHCARE MATERIALS
(2023)
Article
Chemistry, Multidisciplinary
Tushar Ranjan Panda, M. Manikandan, Shreyas P. Vaidya, Sushanta Chhatar, Suman Sinha, Megha Mehrotra, Sourav Chakraborty, Shubhankar Gadre, Prakash Duari, Pritha Ray, Malay Patra
Summary: Even in the era of precision medicine and immunotherapy, chemotherapy with platinum drugs is still widely used against various cancers. However, the efficacy of these drugs is limited by resistance and toxicity. In this study, we designed kinetically inert organometallic platinum anticancer agents with a novel mechanism of action. Our best candidate showed promising antitumor efficacy and could mitigate nephrotoxicity associated with cisplatin. This study demonstrates the importance of kinetic inertness in improving the therapeutic benefits of platinum-based anticancer therapy.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Review
Biochemistry & Molecular Biology
Juan Pablo Davila-Vega, Ana Carolina Gastelum-Hernandez, Sayra N. Serrano-Sandoval, Sergio O. Serna-Saldivar, Janet A. Guitierrez-Uribe, Jorge Milan-Carrillo, M. Carmen Martinez-Cuesta, Daniela Guardado-Felix
Summary: Selenium is an important micronutrient with various functions in anticancer processes. It can act as a modulator in anticancer mechanisms depending on its chemical form and dosage. Different selenocompounds have been reported to have crucial roles as chemopreventive agents and show promising results in cancer therapies. This review compiles studies on the molecular-level anticancer effects of Selenium and its potential as a chemopreventive and cancer treatment.
BIOLOGICAL TRACE ELEMENT RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Brondwyn S. McGhie, Jennette Sakoff, Jayne Gilbert, Christopher P. Gordon, Janice R. Aldrich-Wright
Summary: Cancer is a significant global health threat and new treatments are needed to improve patient prognosis. Unconventional platinum complexes, consisting of polypyridyl ligands and diaminocyclohexane, have shown anticancer activity in previously undruggable KRAS mutated cells, with cytotoxicity values up to 100 times better than cisplatin. Inspired by these complexes, six novel cyclometallated examples were designed and their fluorescence was used to study the mechanism of action of platinum drugs. The cytotoxicity results showed that these cyclometallated complexes have different activity compared to the inspiring complexes, but are as cytotoxic as cisplatin and have higher selectivity indices in breast cancer cell lines. Complexes 1b, 2a, and 3b exhibited particularly high selectivity indexes. Further investigation revealed their good affinity to ctDNA, especially CMCs 1a and 3b. The fluorescence of these complexes was successfully utilized in calculating their DNA binding affinity.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Chemistry, Multidisciplinary
Milan Kumar Bisai, V. S. Ajithkumar, K. Vipin Raj, Kumar Vanka, Rajesh G. Gonnade, Sakya S. Sen
Summary: Compound 1 reacts with Me3SiCH(2)Cl to generate an unsymmetrical sp(2)-sp(3) disilene, 2, with the elimination of Me3SiCl. The reaction of compound 1 with PhC(NtBu)2SiCl undergoes oxidative addition of the C-Cl bond at the Si(II) atom, resulting in compound 3. Compound 2 reacts with sulfur and selenium to form compounds with Si=E (E=S (4) and Se (5)) double bonds. Tellurium reacts differently with compound 2 and forms a zwitterionic compound, 6.
CHEMICAL COMMUNICATIONS
(2023)
Article
Chemistry, Physical
Liwen Zhu, Leung Chan, Junping Wang, Mingkai Chen, Fei Cai, Yuan Tian, Li Ma, Tianfeng Chen
Summary: In this study, carboxylate-containing organic ligands were used to construct one-dimensional high-Z lanthanide chains, and the morphology and activity of the synthesized nanoframeworks were regulated through selenium atom engineering. This study presents a promising approach for effective radiotherapy by using stable lanthanide nanoframeworks with precise coordination structures as radiosensitizers to mitigate X-ray side effects.
Article
Chemistry, Organic
Irving Osiel Castillo-Rodriguez, Teresa Ramirez-Apan, Marcos Martinez-Garcia
Summary: This study reported the easy synthesis of dendrimer conjugates with four and eight naproxen moieties at the periphery. The cytotoxicity of these dendrimer conjugates was compared to that of dendron-naproxen conjugates. The results showed that dendron conjugates were less toxic than dendrimer conjugates, but dendrimer conjugates exhibited higher cytotoxicity and selectivity against K-562 and SKLU-1.
CURRENT ORGANIC CHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Nora Astrain-Redin, Asif Raza, Ignacio Encio, Arun K. Sharma, Daniel Plano, Carmen Sanmartin
Summary: Oxidative stress provides cancer cells with advantages for disease progression. Se-containing molecules with anticancer and antioxidant activity were synthesized and showed potent radical scavenging and anticancer activity. New Se derivatives resembling natural products exhibited high radical scavenging activity and antiproliferative effects.
Review
Pharmacology & Pharmacy
Guillermo Leobardo Rodriguez-Acosta, Carlos Hernandez-Montalban, Maria Fernanda Sabrina Vega-Razo, Irving Osiel Castillo-Rodriguez, Marcos Martinez-Garcia
Summary: In recent years, there has been increasing interest in the application of polymeric materials that can self-assemble into micelles, particularly in biomedicine. The morphology of micelles plays a crucial role in drug transport and delivery, as they can encapsulate hydrophobic molecules, improve drug solubility, and incorporate bioactive molecules. Amphiphilic dendrimer micelles have shown promising results in nanotherapies.
CURRENT DRUG TARGETS
(2022)
Article
Engineering, Biomedical
Yawen Ma, Huimin Lin, Peng Wang, Haocheng Yang, Jie Yu, Hao Tian, Tianyu Li, Shengfang Ge, Yilong Wang, Renbing Jia, Kam W. Leong, Jing Ruan
Summary: MicroRNA-based gene therapy using biocompatible nanocarriers shows promise in treating ocular melanoma by up-regulating tumor suppressor miR-30a-5p and inhibiting malignant phenotypes. The nanocarrier with high miRNA loading and redox-responsive release capabilities enhances the therapeutic effect. Furthermore, it promotes M1 macrophage polarization and activates Fenton reaction, synergistically enhancing anti-tumor immunity. The study demonstrates the potential of this nanocarrier for targeted gene therapy in melanoma and other cancers.
ACTA BIOMATERIALIA
(2023)
Article
Engineering, Biomedical
Baoding Huang, Qianfen Wan, Tianyu Li, Lexiang Yu, Wen Du, Carmen Calhoun, Kam W. Leong, Li Qiang
Summary: As a solution to the chronic inflammation and local adiposity caused by obesity, cationic polyamidoamine (PAMAM) treatment has shown promising results in improving metabolic functions and reducing body weight in diet-induced obese (DIO) mice. The treatment involves the use of PAMAM generation 3 (P-G3) scavenger and complexing P-G3 with human serum albumin (HSA) to achieve sustained release. Local injection of HSA-PG3 successfully restricts the distribution of the complex within the targeted adipose tissue and reduces focal adiposity.
Article
Materials Science, Characterization & Testing
Chao Zhang, Bowei Du, Zihao Song, Guiya Deng, Yan Shi, Tianyu Li, Yaqin Huang
Summary: This study finds that magnesium can chelate with bovine bone collagen peptides, leading to changes in their structures and functional properties, as well as improving their antioxidant activities and reparative effects against oxidative damage. These findings provide mechanistic insights for the further development of peptide-magnesium chelates for mitigating oxidative stress.
Article
Chemistry, Multidisciplinary
Chengfei Liu, Banruo Xianyu, Yiheng Dai, Shuojiong Pan, Tianyu Li, Huaping Xu
Summary: Polymerization inside living cells provides chemists with a multitude of possibilities to modulate cell activities. We reported a hyperbranched polymerization in living cells based on the oxidative polymerization of organotellurides and intracellular redox environment. The obtained hyperbranched polymer aggregated into branched nanostructures in cells, which could effectively evade drug pumps and decrease drug efflux, ensuring the polymerization for persistent treatment.
Article
Chemistry, Multidisciplinary
Shuojiong Pan, Jun Guan, Banruo Xianyu, Yizheng Tan, Tianyu Li, Huaping Xu
Summary: Self-assembled selenium-containing nanoparticles are developed to reverse NK cell exhaustion and enhance NK-cell-mediated immunotherapy, effectively inhibiting tumor growth.
ADVANCED MATERIALS
(2023)
Article
Environmental Sciences
You Ma, Tian -Yu Li, Han Meng, Guo-Xiang Wang, Li-Min Zhang, Guo-Zheng Jia, Jie Ma, Yan Xiao, Wei-Hua Li, Wen-Ming Xie
Summary: This study investigated the adsorption of the antibiotic trimethoprim (TMP) by extracellular polymeric substances (EPS) in anaerobic activated sludge. The results showed that loosely-bound EPS had a positive effect on TMP adsorption, while tightly-bound EPS had a negative effect.
JOURNAL OF ENVIRONMENTAL MANAGEMENT
(2023)
Review
Polymer Science
Yiheng Dai, Jun Guan, Shenghan Zhang, Shuojiong Pan, Banruo Xianyu, Zhuoxin Ge, Jinyan Si, Chaowei He, Huaping Xu
Summary: Significant progress has been made in the field of tellurium-containing polymers in recent decades. These polymers exhibit unique properties and have promising applications. This review provides an overview of the diversification of tellurium-containing polymers and their synthetic methods, as well as a detailed discussion of their properties and applications in various fields. By summarizing the recent developments and trends, this review aims to popularize the concepts and serve as a comprehensive handbook for researchers in the field of chemistry and materials.
PROGRESS IN POLYMER SCIENCE
(2023)
Article
Chemistry, Multidisciplinary
Chengfei Liu, Jinyan Si, Muqing Cao, Peng Zhao, Yiheng Dai, Huaping Xu
Summary: Visualizing polymer chain growth is always a hot topic in polymer chemistry. However, current characterization methods are limited in their ability to differentiate the degree of polymerization without isolating the samples from the reaction vessel, let alone to detect insoluble polymers. This study establishes a reliable relationship between polymer chain growth and fluorescence properties through polymerization induced emission, enabling real-time monitoring of the polymerization reaction. The method can also be applied to observe the polymerization process of insoluble polymers, opening a new avenue for visualizing polymer chain growth in real-time, regardless of polymer solubility.
Article
Multidisciplinary Sciences
Ningyue Chen, Shuwei Li, Peng Zhao, Ran Liu, Yu Xie, Jin-Liang Lin, Christian A. Nijhuis, Bingqian Xu, Liang Zhang, Huaping Xu, Yuan Li
Summary: This study introduces a method to form stable gold-based self-assembled monolayers (SAMs) using selenide anchoring groups, resulting in highly stable molecular tunnel junctions. The findings demonstrate the potential application of selenide-derived stable SAMs in long-lived molecular electronic devices.
Article
Environmental Sciences
Yun Xue, Huitao Lv, Jianzhang Gao, Yi Liang, Tianyu Li, Yanghai Zheng, Guixiang Wang, Yongde Yan, Fuqiu Ma
Summary: In this study, a new strategy using NaOH-based molten salts as decontaminants was developed for the rapid removal of uranium-containing contaminants from metal surfaces. The addition of Na2CO3 and NaCl to NaOH greatly enhanced the decontamination performance, achieving a decontamination rate of 93.8% within 12 minutes, surpassing the performance of single NaOH molten salt. The synergistic effects of CO32- and Cl- promoted the corrosion efficiency, accelerating the decontamination rate. By optimizing the experimental conditions using the response surface method (RSM), the decontamination efficiency was further improved to 94.9%. Notably, this technology also showed remarkable results in decontaminating specimens with different uranium oxides at varying levels of radioactivity.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Review
Chemistry, Multidisciplinary
Muqing Cao, Yizheng Tan, Huaping Xu
Summary: In recent years, there has been extensive research and development on the mechanochemistry of polymers, specifically the reactivity of polymers under mechanical stimuli. More attention has been given to dynamic chalcogen-containing polymers due to their sensitive responsiveness and precise biofunction. This perspective provides an overview of mechanochemistry in dynamic chalcogen-containing polymers, covering fundamental mechanochemistry and applications. It focuses on mechanically induced color/fluorescence changes, drug release, and material strengthening and toughening of functional mechano-responsive polymeric materials. Additionally, currently unsolved issues, challenges, and potential opportunities for the future are summarized and discussed.
NEW JOURNAL OF CHEMISTRY
(2023)
Article
Chemistry, Multidisciplinary
Banruo Xianyu, Shuojiong Pan, Shiqian Gao, Huaping Xu, Tianyu Li
Summary: This study developed a selenium-containing nanocomplex that can act as a dual immune checkpoint inhibitor in cancer immunotherapy. The nanocomplex targets PD-L1 and HLA-E on tumor cells to block immune checkpoints, promoting NK cell-mediated antitumoral activity.
Article
Plant Sciences
He Luo, Tianyu Li, Yuhan Guan, Zhuo Zhang, Zihui Zhang, Zhihong Zhang, He Li
Summary: This study reveals the important role of the FvemiR160-FveARF18A-FveAP1/FveFUL module in the flowering process of woodland strawberry and provides a new pathway for studying flowering.
Article
Environmental Sciences
Huitao Lv, Jianzhang Gao, Jiaqi Chen, Tianyu Li, Yi Liang, Bin Hu, Fuqiu Ma, Yun Xue, Yongde Yan
Summary: An innovative decontamination strategy using molten salts as a solvent was demonstrated to clean stubborn uranium contaminants on stainless steel surfaces. The evolutionary path of contaminants in molten salts and the decontamination mechanism were investigated, and a multiple decontamination strategy was implemented to achieve high decontamination rates and low residual radioactivity.
ENVIRONMENTAL RESEARCH
(2023)
