Article
Chemistry, Applied
Feng Li, Yang-Yang Zhang, Tian-Zhen Liu, Bing-Yu Wei, Jun-Ying Miao, Bao-Xiang Zhao, Zhao-Min Lin
Summary: SO2, an important gaseous signaling molecule in cells, is also used as a preservative in food and drinks. A fluorescent probe CPO was developed to detect SO2 derivatives in body and food, showing high energy transfer efficiency and selectivity. It had fast response time and low detection limit, and could detect SO2 derivatives in various substances.
Article
Materials Science, Multidisciplinary
Jincheng Zhang, Huatian Duan, Ying Hong, Jingyu Deng, Li-Juan Fan
Summary: A series of cationic conjugated polymers were synthesized for the detection of ATP, and the fluorescence of the polymers was quenched upon adding ATP. The sensitivity of the polymer to ATP increased with the density of the quaternary ammonium group. The study provides a general strategy for designing sensing systems for biomolecules with complex structures.
ACS APPLIED POLYMER MATERIALS
(2023)
Article
Multidisciplinary Sciences
Vivien Walter, Dadi Bi, Ali Salehi-Reyhani, Yansha Deng
Summary: The authors designed and constructed a liquid-based microfluidic molecular communication platform for chemical concentration signal processing and digital signal transmission. By specific chemical reactions and microfluidic geometry, the platform enables modulation and demodulation of molecular signals, reliable transmission of text messages over long distances, and optimization for maximizing data rate while minimizing communication error.
NATURE COMMUNICATIONS
(2023)
Article
Chemistry, Analytical
Lidan Zhang, Chuang Wang, Yunhan Jiang, Huidong Li, Huizhen Wang, Haiyue Long, Pingxian Liu, Xiaoqiu Xu, Tao Yang
Summary: In this study, a new fluorescent probe IMQU-8 was developed for the selective and sensitive detection of Pd2+ under physiological conditions. The sensing mechanism of IMQU-8 was revealed, and its applicability for Pd2+ imaging and detoxification in living cells was demonstrated.
ANALYTICA CHIMICA ACTA
(2022)
Article
Chemistry, Analytical
Shuai Wang, Liyan Zhang, Ailing Kan, Xiaowen Xu, Nan Zhang, Wei Jiang
Summary: In this study, a MnO2 nanosheet-mediated target-binding-induced fluorescence resonance energy transfer (FRET) strategy was developed for detection and imaging of multiplexed miRNAs in living cells. The strategy successfully enabled simultaneous imaging of miRNA-373 and miRNA-96 in MDA-MB-231 and L02 cells, revealing higher expression levels of target miRNAs in MDA-MB-231 cells compared to L02 cells. This approach provides an alternative method for simultaneous accurate detection and imaging of multiplexed miRNAs with potential biomedical applications.
Review
Energy & Fuels
Zhuangfei Qian, Kai A. I. Zhang
Summary: Conjugated microporous polymers (CMPs), as metal-free, pure organic and heterogeneous photocatalysts, have attracted attention due to their organic nature, ease of synthesis, structural diversity, and low costs. Researchers focus on crucial factors affecting the catalytic performance of CMPs, such as band structure, charge transfer, morphology, as well as specific applications like water splitting, CO2 reduction, and organic photoredox reactions.
Article
Nanoscience & Nanotechnology
Uttam Manna, Yashira M. Zavala, Nicholas L. Abbott, David M. Lynn
Summary: This study demonstrates the use of micrometer-scale droplets of liquid crystals as chemical sensors inside living mammalian cells to detect toxins in extracellular environments. The droplets are stable and respond to low concentrations of toxic substances, suggesting a potential new method for sensitive and selective detection of chemical agents outside cells. The activation of droplets involves the transport and co-adsorption of toxins and cell components to the surfaces of internalized droplets, providing a foundation for future applications in sensing and reporting on biochemical processes inside cells.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Article
Spectroscopy
Chen Chen, Changrui Zhou, Wenge Yang, Yonghong Hu
Summary: Chinese herbal medicine is gaining more attention both domestically and internationally, and the preservation of herbal medicines is crucial. Fumigation with sulfur is a common method, but it can leave behind SO2 residues that create sulfites when exposed to water. Excessive sulfites have negative effects on health and reduce the quality and effectiveness of therapeutic plants. This study developed a ratiometric fluorescent probe CPA using coumarin derivatives and pyridinium acrylonitrile structures with the FRET effect. The probe showed excellent detection properties for SO32- and low cytotoxicity, making it suitable for detecting endogenous sulfites in living cells.
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2023)
Article
Biochemistry & Molecular Biology
Ignacio A. Jessop, Josefa Cutipa, Yasmin Perez, Cesar Saldias, Denis Fuentealba, Alain Tundidor-Camba, Claudio A. Terraza, Maria B. Camarada, Felipe A. Angel
Summary: By introducing a fluorescein derivative to the side group of a polymer, the photovoltaic performance of the polymer can be improved, leading to higher performance in organic solar cell applications.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Materials Science, Multidisciplinary
Anne A. Y. Guilbert, Yang Bai, Catherine M. Aitchison, Reiner Sebastian Sprick, Mohamed Zbiri
Summary: The stiffness of the nodes of the CMPs is found to be correlated with an increase in trapped water, highlighting additional interactions between water and the CMP. The study shows that the addition of the polar sulfone group alters the translational diffusion of water within the CMPs, while no changes in triethylamine motions could be observed.
ACS APPLIED POLYMER MATERIALS
(2021)
Article
Biochemistry & Molecular Biology
Yufei Liu, Suyu Meng, Jingjing Qin, Ruiying Zhang, Ningning He, Yaoyao Jiang, Hong Chen, Na Li, Ying Zhao
Summary: A simple analytical approach using a fluorescence sensor for the detection of acrylamide in foods was proposed. The sensor utilized exonuclease III to detect the presence of acrylamide and achieved successful quantitative analysis through fluorescence resonance energy transfer. The method showed good performance in water extract samples.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Chemistry, Analytical
Rong Sheng Li, Jiahui Liu, Yuan Yan, Chuanyang Su, Tiancheng Lai, Yunwen Liao, Yuan Fang Li, Na Li, Cheng Zhi Huang
Summary: The study introduces an aggregation-enhanced energy transfer strategy to overcome obstacles in effective energy transfer, achieving enhanced FRET efficiency.
ANALYTICAL CHEMISTRY
(2021)
Article
Chemistry, Analytical
Arvin Sain Tanwar, Mst Nasima Khatun, Moirangthem Anita Chanu, Tapashi Sarmah, Yeon-Ho Im, Parameswar Krishnan Iyer
Summary: In this study, a highly fluorescent water-soluble conjugated polyelectrolyte PPMI was synthesized and applied as a fluorescence sensor for monitoring traces of carcinogenic Cr(vi) ions in water. PPMI exhibited a rapid, selective, and sensitive turn-off fluorescence signal in response to Cr(vi) through static quenching mechanism.
Article
Spectroscopy
Xufeng Hou, Zhensheng Li, Yunqiang Li, Qihang Zhou, Chunhui Liu, Dang Fan, Jinjin Wang, Ruijie Xu, Zhihong Xu
Summary: A novel near-infrared optical and fluorescent probe (NTC) was designed for sensing cysteine with high selectivity and sensitivity. Upon reaction with cysteine, the probe exhibited about 40-fold fluorescence enhancement due to the recovery of intramolecular charge transfer.
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2021)
Article
Chemistry, Analytical
Chunxian Zhang, Shuai Li, Zhiqiang Duan, Qin Li, Mengxuan Zhao, Yulong Chen, Xiurong Zhai, Guojiang Mao, Hua Wang
Summary: Water-soluble non-conjugated polymer dots were synthesized using hyperbranched polyethyleneimine and dihydroxybenzaldehyde for the first time. These polymer dots exhibited strong green fluorescence in aqueous media and could be quenched by MnO2 nanosheets and restored by thiocholine. A highly selective fluorimetric method for detecting organophosphorus pesticides was developed based on these characteristics.
ANALYTICA CHIMICA ACTA
(2022)
Article
Chemistry, Multidisciplinary
Xiaozhen Li, Di Zhang, Guihong Lu, Tingchao He, Yingpeng Wan, Man-Kit Tse, Can Ren, Pengfei Wang, Shengliang Li, Jingdong Luo, Chun-Sing Lee
Summary: Recent progress has been made in developing photothermal agents (PTAs) for biomedical and energy applications. Photochemical synthesis offers a cost-effective and environmentally friendly alternative to traditional methods. The synthesized nonplanar small molecules (NSMs) show promising photophysical properties and excellent photothermal performance, making them suitable for in vivo applications such as photoacoustic imaging and tumor ablation.
ADVANCED MATERIALS
(2021)
Article
Chemistry, Multidisciplinary
Zhongming Huang, Jinchao Wei, Yingpeng Wan, Peng Li, Jie Yu, Jiayi Dong, Shuangpeng Wang, Shengliang Li, Chun-Sing Lee
Summary: The study demonstrated a simple solar evaporator technology utilizing an array of millineedles for efficient solar water evaporation and controlled salt formation, achieving an energy conversion efficiency of 94.5% and salt harvesting capacity.
Article
Nanoscience & Nanotechnology
Ya-Fang Xiao, Wen-Cheng Chen, Jia-Xiong Chen, Guihong Lu, Shuang Tian, Xiao Cui, Zhen Zhang, Huan Chen, Yingpeng Wan, Shengliang Li, Chun-Sing Lee
Summary: This study develops two phenanthro[9,10-d]imidazole derivatives, AQPO and AQPI, with aggregation-induced emission characteristics, and enhances their reactive oxygen species (ROS) generation efficiency by reducing singlet-triplet splitting. The results demonstrate that AQPO exhibits higher type-I ROS generation capacity compared to AQPI, and effectively eliminates tumor cells in vitro and in vivo with good biosafety.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Chemistry, Multidisciplinary
Yi Yuan, Zhe Feng, Shengliang Li, Zhongming Huang, Yingpeng Wan, Chen Cao, Sien Lin, Lan Wu, Jing Zhou, Liang-Sheng Liao, Jun Qian, Chun-Sing Lee
Summary: A series of highly fluorescent semiconducting oligomers (SOMs) with tunable NIR-IIb emissions were developed for in vivo dynamic visualization of microstructures in deep tissues using an atom-programming strategy. These SOMs self-assembled into nanoparticles (NPs) and exhibited good brightness, high photostability, and satisfactory biocompatibility. They were successfully applied as probes for high-resolution imaging of blood vessels, biliary tract, and bladder with emissions over 1500 nm.
ADVANCED MATERIALS
(2022)
Article
Chemistry, Analytical
Liu Yang, Guopan Liu, Qingxin Chen, Yingpeng Wan, Zhiyang Liu, Jie Zhang, Chen Huang, Zhiqiang Xu, Shengliang Li, Chun-Sing Lee, Liang Zhang, Hongyan Sun
Summary: Cellular senescence plays a significant role in various physiological processes, and the accumulation of senescent cells can lead to age-related diseases. In this study, a beta-gal-activated probe, MB-beta gal, was designed to detect and eliminate senescent cells, demonstrating fast response, high sensitivity, and high selectivity.
ANALYTICAL CHEMISTRY
(2022)
Article
Chemistry, Multidisciplinary
Shengliang Li, Xiangquan Deng, Hui Cheng, Xiaozhen Li, Yingpeng Wan, Chen Cao, Jie Yu, Ying Liu, Yi Yuan, Ke Wang, Chun-Sing Lee
Summary: Researchers have developed a designed and synthesized fluorescent molecule (OFET) for in vivo mouse brain imaging using three-photon microscopy. The OFET molecule, integrated as water dispersible nanoparticles (OFET NPs), has high fluorescence brightness and maximum emission at 820 nm. Under 1720 nm excitation, OFET NPs exhibit a large three-photon action crosssection, more than twice that of commonly used SR101 dye. With the advantages of long excitation and emission wavelength, and high tissue penetration depth, OFET NPs show good deep-brain imaging performance.
Article
Chemistry, Multidisciplinary
Shuang Tian, Jihua Tan, Tianxing Kang, Chen Cao, Jie Pan, Yafang Xiao, Xiao Cui, Shengliang Li, Chun-Sing Lee
Summary: This study discovers that the library of NIR-transparent organic materials can be expanded by forming a charge-transfer complex (CTC) between commercially available donor (D) and acceptor (A) molecules. By regulating the D-A interaction, the CTC filter shows tunable absorption from visible to NIR region with high penetration of NIR radiation. It can successfully highlight NIR information and provide a convenient tool for anti-counterfeiting and viewing protected NIR information.
ADVANCED MATERIALS
(2022)
Article
Chemistry, Multidisciplinary
Weihui Ou, Yulong Fan, Junda Shen, Yunkun Xu, Dongqing Huang, Binbin Zhou, Tsz Wing Lo, Shengliang Li, Yang Yang Li, Dangyuan Lei, Jian Lu
Summary: This study reveals the crucial role of plasmoelectric potential in plasmon-mediated electrochemistry and develops a method to quantify the contributions of plasmoelectric potential and other factors to the oxygen reduction reaction. The findings contribute to the optimization of high-performance plasmonic electrocatalyst design.
Review
Chemistry, Physical
Zhongming Huang, Ying Liu, Shengliang Li, Chun-Sing Lee, Xiao-Hong Zhang
Summary: This review summarizes the recent developments in enhancing the efficiency of solar-driven water vaporization through diverse rational designs. It also highlights emerging technologies derived from solar vaporization, such as energy generation, photocatalysis, dehumidification, salt harvesting, sterilization, and biofuel production. The review provides new insights for the development of solar technologies and practical applications.
Article
Chemistry, Multidisciplinary
Huanxiang Yuan, Zelin Li, Qi Zhao, Shaochuan Jia, Ting Wang, Li Xu, Haitao Yuan, Shengliang Li
Summary: Infectious diseases caused by pathogenic microorganisms can have serious consequences and threaten life. Drug-resistant bacteria have made traditional antibiotics less effective. This study develops conjugated oligomers with tunable backbones for regulating their photo-thermal conversion, which show high photothermal conversion efficiency. The resulting nanoparticles have strong antimicrobial activity against drug-resistant bacteria under near-infrared irradiation, promoting wound healing in diabetic mice. This work provides ideas for designing efficient antimicrobial agents against drug-resistant microbial infections activated by near-infrared.
ADVANCED FUNCTIONAL MATERIALS
(2023)
Review
Chemistry, Multidisciplinary
Ka-Wai Lee, Yingpeng Wan, Zhongming Huang, Qi Zhao, Shengliang Li, Chun-Sing Lee
Summary: This review summarizes the recent development of organic optoelectronic materials (OOMs) for biomedical applications, specifically in fluorescence imaging, photoacoustic imaging, photothermal therapy, and photodynamic therapy. The relationships between the molecular structures, nanoaggregation structures, photophysical mechanisms, and properties of OOMs for different biomedical applications are discussed. The review also highlights the challenges and future perspectives of OOMs for efficient biomedical applications.
ADVANCED MATERIALS
(2023)
Article
Materials Science, Biomaterials
Qi Long, Yuliang Yang, Fangling Liao, Haoting Chen, Dongyue He, Shengliang Li, Pengcheng Li, Weisheng Guo, Yafang Xiao
Summary: Photothermal immunotherapy has potential for efficient cancer treatment, but the immunosuppressive tumor microenvironment and lack of reliable imaging modalities are challenges. The theranostic thermosensitive liposome (PLDD) we designed can boost the adaptive anti-tumor immunity and provide real-time multimodal imaging.
JOURNAL OF MATERIALS CHEMISTRY B
(2023)
Article
Chemistry, Multidisciplinary
Liu Yang, Qingxin Chen, Yingpeng Wan, Shenglong Gan, Shengliang Li, Chun-Sing Lee, Yin Jiang, Huatang Zhang, Hongyan Sun
Summary: In this study, two mitochondria-targeting photosensitizers that exhibit fluorescence response to increasing viscosity were reported. Specifically, CCVJ-Mito-2, which absorbs in the near-infrared region, can be used as a NIR photosensitizer targeting mitochondria and a fluorescent probe for tracking viscosity changes during photodynamic therapy.
CHEMICAL COMMUNICATIONS
(2022)
Review
Nanoscience & Nanotechnology
Rongjie Wu, Haotao Li, Yuliang Yang, Qiujian Zheng, Shengliang Li, Yuanfeng Chen
Summary: Silk-based hybrid biomaterials show great potential in musculoskeletal tissue engineering with superior mechanical and biological performance when hybridized with other biomaterials. Studies mainly focus on the physical and biological performances, providing a research perspective for further improvement of silk hybrid biomaterials.
ACS APPLIED BIO MATERIALS
(2021)
Article
Chemistry, Multidisciplinary
Jipsa Chelora, Yuchao Liang, Wei-Chih Wei, Xiao Cui, Yafang Xiao, Yingpeng Wan, Zhongming Huang, Shuang Tian, Shengliang Li, Yi-Hsuan Huang, Ken-Tsung Wong, Chun-Sing Lee
Summary: The development of small molecule-based nanoparticles that can perform effective photothermal therapy and overcome hypoxia for cancer photodynamic therapy shows promising results in vitro and in vivo studies.
