Journal
ADVANCED MATERIALS
Volume 34, Issue 19, Pages -Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/adma.202201263
Keywords
fluorescence imaging; molecular programming; nanoparticles; NIR-II; semiconducting oligomers
Categories
Funding
- Animal Ethics Committee of Zhejiang University [ZJU20190076]
- City University of Hong Kong [JLFS/P-101/18]
- National Natural Science Foundation of China [52173135, 61975172, 61735016]
- University Grants Committee/Research Grants Council of the Hong Kong Special Administrative Region, China [JLFS/P-101/18]
- Zhejiang Provincial Natural Science Foundation of China [LR17F050001]
- Fundamental Research Funds for the Central Universities [2020-KYY-511108-0007]
- Priority Academic Program Development (PAPD) of Jiangsu Higher Education Institutions
Ask authors/readers for more resources
A series of highly fluorescent semiconducting oligomers (SOMs) with tunable NIR-IIb emissions were developed for in vivo dynamic visualization of microstructures in deep tissues using an atom-programming strategy. These SOMs self-assembled into nanoparticles (NPs) and exhibited good brightness, high photostability, and satisfactory biocompatibility. They were successfully applied as probes for high-resolution imaging of blood vessels, biliary tract, and bladder with emissions over 1500 nm.
Materials with long-wavelength second near-infrared (NIR-II) emission are highly desired for in vivo dynamic visualizating of microstructures in deep tissues. Herein, by employing an atom-programming strategy, a series of highly fluorescent semiconducting oligomers (SOMs) with tunable NIR-IIb emissions are developed for bioimaging applications. After self-assembly into nanoparticles (NPs), they show good brightness, high photostability, and satisfactory biocompatibility. The SOM NPs are applied as probes for high-resolution imaging of whole-body and hind-limb blood vessels, biliary tract, and bladder with their emissions over 1500 nm. This work demonstrates an atom-programming strategy for constructing semiconducting small molecules with enhanced NIR-II fluorescence for deep-tissue imaging, affording new insight for advancing molecular design of NIR-II fluorophores.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available