Uncovering the pathogenesis of large granular lymphocytic leukemia—novelSTAT3andSTAT5bmutations

STAT5b in LGL leukemia – a novel therapeutic target?

(2015) Hanna L. M. Rajala et al.   Oncotarget

STAT3exon 21 mutation is rare in common human cancers

(2013) Min Sung Kim et al.   ACTA ONCOLOGICA

STAT3 mutations indicate the presence of subclinical T-cell clones in a subset of aplastic anemia and myelodysplastic syndrome patients

(2013) A. Jerez et al.   BLOOD

Discovery of somatic STAT5b mutations in large granular lymphocytic leukemia

(2013) H. L. M. Rajala et al.   BLOOD

Comprehensive meta-analysis of Signal Transducers and Activators of Transcription (STAT) genomic binding patterns discerns cell-specific cis-regulatory modules

(2013) Keunsoo Kang et al.   BMC GENOMICS

STAT3 mutations identified in human hematologic neoplasms induce myeloid malignancies in a mouse bone marrow transplantation model

(2013) L. Couronne et al.   HAEMATOLOGICA

STAT3 mutations are frequent in CD30+ T-cell lymphomas and T-cell large granular lymphocytic leukemia

(2013) R S Ohgami et al.   LEUKEMIA

Therapeutic modulators of STAT signalling for human diseases

(2013) Gabriella Miklossy et al.   NATURE REVIEWS DRUG DISCOVERY

A Novel Missense (M206K) STAT3 Mutation in Diffuse Large B Cell Lymphoma Deregulates STAT3 Signaling

(2013) Guangzhen Hu et al.   PLoS One

Novel somatic mutations in large granular lymphocytic leukemia affecting the STAT-pathway and T-cell activation

(2013) E I Andersson et al.   Blood Cancer Journal

STAT3 mutations unify the pathogenesis of chronic lymphoproliferative disorders of NK cells and T-cell large granular lymphocyte leukemia

(2012) A. Jerez et al.   BLOOD

Aberrant Overexpression of IL-15 Initiates Large Granular Lymphocyte Leukemia through Chromosomal Instability and DNA Hypermethylation

(2012) Anjali Mishra et al.   CANCER CELL

Large granular lymphocyte leukemia: from dysregulated pathways to therapeutic targets

(2012) Francis LeBlanc et al.   Future Oncology

STAT3 mutations are highly specific for large granular lymphocytic leukemia

(2012) A Fasan et al.   LEUKEMIA

EuroClonality/BIOMED-2 guidelines for interpretation and reporting of Ig/TCR clonality testing in suspected lymphoproliferations

(2012) A W Langerak et al.   LEUKEMIA

A new STATus in CML

(2012) Doriano Fabbro   Nature Chemical Biology

SomaticSTAT3Mutations in Large Granular Lymphocytic Leukemia

(2012) Hanna L.M. Koskela et al.   NEW ENGLAND JOURNAL OF MEDICINE

JAK/STAT signaling in hematological malignancies

(2012) W Vainchenker et al.   ONCOGENE

Orally bioavailable small-molecule inhibitor of transcription factor Stat3 regresses human breast and lung cancer xenografts

(2012) X. Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The STAT5b Pathway Defect and Autoimmunity

(2012) Takahiro Kanai et al.   Frontiers in Immunology

The STAT5 inhibitor pimozide decreases survival of chronic myelogenous leukemia cells resistant to kinase inhibitors

(2011) E. A. Nelson et al.   BLOOD

A STAT3-decoy oligonucleotide induces cell death in a human colorectal carcinoma cell line by blocking nuclear transfer of STAT3 and STAT3-bound NF-κB

(2011) Inès Souissi et al.   BMC CELL BIOLOGY

Epstein-Barr Virus-Associated B-cell Lymphomas: Pathogenesis and Clinical Outcomes

(2011) A. Saha et al.   CLINICAL CANCER RESEARCH

Somatic mutations activating STAT3 in human inflammatory hepatocellular adenomas

(2011) Camilla Pilati et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Small Molecule STAT5-SH2 Domain Inhibitors Exhibit Potent Antileukemia Activity

(2011) Brent D. G. Page et al.   JOURNAL OF MEDICINAL CHEMISTRY

Initial genome sequencing and analysis of multiple myeloma

(2011) Michael A. Chapman et al.   NATURE

Exome Sequencing of Head and Neck Squamous Cell Carcinoma Reveals Inactivating Mutations in NOTCH1

(2011) N. Agrawal et al.   SCIENCE

LGL Leukemia and HTLV

(2010) Anish Thomas et al.   AIDS RESEARCH AND HUMAN RETROVIRUSES

How I treat LGL leukemia

(2010) T. Lamy et al.   BLOOD

Mono/oligoclonal T and NK cells are common in chronic myeloid leukemia patients at diagnosis and expand during dasatinib therapy

(2010) A. Kreutzman et al.   BLOOD

A novel Ncr1-Cre mouse reveals the essential role of STAT5 for NK-cell survival and development

(2010) E. Eckelhart et al.   BLOOD

Aberrant expression and constitutive activation of STAT3 in cervical carcinogenesis: implications in high-risk human papillomavirus infection

(2010) Shirish Shukla et al.   Molecular Cancer

STAT5 Activation Is Critical for the Transformation Mediated by Myeloproliferative Disorder-associated JAK2 V617F Mutant

(2009) Megumi Funakoshi-Tago et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

STAT3 transcription factor is constitutively activated and is oncogenic in nasal-type NK/T-cell lymphoma

(2009) P Coppo et al.   LEUKEMIA

Clonal expansion of T/NK-cells during tyrosine kinase inhibitor dasatinib therapy

(2009) S Mustjoki et al.   LEUKEMIA

Myelodysplastic Syndromes

(2009) Ayalew Tefferi et al.   NEW ENGLAND JOURNAL OF MEDICINE

Diagnosis and therapy of neutropenia in large granular lymphocyte leukemia

(2008) Sanjay R Mohan et al.   CURRENT OPINION IN HEMATOLOGY

Frequent in-frame somatic deletions activate gp130 in inflammatory hepatocellular tumours

(2008) Sandra Rebouissou et al.   NATURE

Network model of survival signaling in large granular lymphocyte leukemia

(2008) R. Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Linking genetic susceptibility to Crohnʼs disease with Th17 cell function: IL-22 serum levels are increased in Crohnʼs disease and correlate with disease activity and IL23R genotype status

(2007) Silke Schmechel et al.   INFLAMMATORY BOWEL DISEASES

Cytokines in arthritis the 'big numbers' move centre stage

(2007) J. S. H. Gaston   RHEUMATOLOGY