Article
Immunology
Tao Zhao, Nan Hu, Xiaojuan Yu, Tao Su
Summary: Large granular T lymphocyte leukemia (T-LGLL) is a rare chronic lymphocyte leukemia characterized by clonal proliferation of T cells, which is related to STAT3 gene mutation and abnormal apoptosis pathway. Studies have suggested that exogenous and continuous stimulation, such as virus infection, may be related to the pathogenesis of T-LGLL.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Francesco Gaudio, Pierluigi Masciopinto, Emilio Bellitti, Pellegrino Musto, Elena Arcuti, Olga Battisti, Gerardo Cazzato, Alessandra Solombrino, Filomena Emanuela Laddaga, Giorgina Specchia, Eugenio Maiorano, Giuseppe Ingravallo
Summary: Large granular lymphocyte leukemia is a rare chronic disease characterized by neutropenia, anemia, and thrombocytopenia. It is often associated with various autoimmune conditions and has an indolent course.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Rheumatology
Ann Cavers, Matthias Christian Kugler, Yesim Ozguler, Arshed Fahad Al-Obeidi, Gulen Hatemi, Beatrix M. Ueberheide, Didar Ucar, Olivier Manches, Johannes Nowatzky
Summary: The study revealed that the ERAP1-Hap10 haplotype is significantly associated with Behcet's disease risk in individuals with HLA-B*51, leading to changes in immunogenicity of CD8 T cells and alterations in T cell populations in affected carriers.
ANNALS OF THE RHEUMATIC DISEASES
(2022)
Article
Multidisciplinary Sciences
Shouguo Gao, Zhijie Wu, Bradley Arnold, Carrie Diamond, Sai Batchu, Valentina Giudice, Lemlem Alemu, Diego Quinones Raffo, Xingmin Feng, Sachiko Kajigaya, John Barrett, Sawa Ito, Neal S. Young
Summary: T-cell large granular lymphocyte leukemia (T-LGLL) is a lymphoproliferative disease characterized by reduced TCR diversity and deregulation of cell survival genes. After alemtuzumab treatment, apoptosis genes are upregulated, particularly in responders, and TCR diversity is further skewed. Analysis of single cell data provides insights into the clonal expansion and persistence mechanisms in T-LGLL.
NATURE COMMUNICATIONS
(2022)
Article
Medicine, General & Internal
Fawzi Abu Rous, Radhika Gutta, Rebecca Chacko, Philip Kuriakose, Vrushali Dabak
Summary: Large granular lymphocytic (LGL) leukemia is a rare chronic lymphoproliferative disorder that typically occurs in the sixth decade of life. Most cases of T-cell LGL leukemia (T-LGL) are associated with autoimmune disorders, and patients with T-LGL are generally asymptomatic but may present symptoms related to the immune system.
CUREUS JOURNAL OF MEDICAL SCIENCE
(2022)
Article
Pharmacology & Pharmacy
Wei Zhang, Ruohao Zhang, Zhiguang Chang, Xiaobo Wang
Summary: Resveratrol, a natural product, has been shown to have anti-tumor effects. This study found that resveratrol inhibits the growth of lung adenocarcinoma by modulating the activation of tumor-associated macrophages and CD8T cells.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Oncology
Zachary Braunstein, Eric McLaughlin, Miguel Ruiz, Lai Wei, Naresh Bumma, Don Benson, Srinivas Devarakonda, Maria Chaudhry, Abdullah Khan, Francesca Cottini, Walter Hanel, Robert Baiocchi, Catherine Chung, Daniel Addison, Nina Couette, Alexa Meara, Wael Jarjour, Pierluigi Porcu, Anjali Mishra, John C. Reneau, Ashley E. Rosko, Jonathan E. Brammer
Summary: This study reported a group of patients with combined T-cell malignancies and plasma cell dyscrasias (PCD), including 26 patients. The results showed that there was no significant difference in survival for patients with CTCL or T-LGLL and concomitant PCD, but patients with PTCL and concomitant PCD had worse outcomes. Treatment directed at the T-cell malignancy resulted in the eradication of the PCD clone in some patients.
FRONTIERS IN ONCOLOGY
(2022)
Article
Oncology
Dipabarna Bhattacharya, Antonella Teramo, Vanessa Rebecca Gasparini, Jani Huuhtanen, Daehong Kim, Jason Theodoropoulos, Gianluca Schiavoni, Gregorio Barila, Cristina Vicenzetto, Giulia Calabretto, Monica Facco, Toru Kawakami, Hideyuki Nakazawa, Brunangelo Falini, Enrico Tiacci, Fumihiro Ishida, Gianpietro Semenzato, Tiina Kelkka, Renato Zambello, Satu Mustjoki
Summary: CD4+ T-cell large granular lymphocyte leukemia is a rare subtype of T-LGLL with unknown etiology. This study found multiple STAT5B mutations and abnormal T-cell receptor repertoire and mutation profile in patients, suggesting aberrant antigen response underlying the disease.
BLOOD CANCER JOURNAL
(2022)
Review
Hematology
Gianpietro Semenzato, Giulia Calabretto, Gregorio Barila, Vanessa Rebecca Gasparini, Antonella Teramo, Renato Zambello
Summary: Large Granular Lymphocyte (LGL) Leukemia is a rare chronic lymphoproliferative disorder characterized by clonal expansion of T- or NK-LGLs. Genomic features, such as STAT3 and STAT5B mutations, play a role in the diagnosis and clinical features of LGL disorders. Understanding different disease variants is important for better management of patients with LGL disorders.
Article
Medicine, General & Internal
Guillemette Fouquet, Julien Rossignol, Laure Ricard, Flavia Guillem, Lucile Couronne, Vahid Asnafi, Manon Vavasseur, Melanie Parisot, Nicolas Garcelon, Frederic Rieux-Laucat, Arsene Mekinian, Olivier Hermine
Summary: We present a case study of a female patient with a heterozygous somatic BLNK mutation, T-cell LGL leukemia, and multiple autoimmune diseases. This mutation, although uncommon in this clinical observation, could represent a new mechanism for autoimmune diseases associated with LGL leukemia. The patient developed various autoimmune diseases and required treatment, but had no notable infectious history. The study found B-cell deficiency and deficiencies in CD4+ and Treg cells in this patient, possibly linked to the BLNK mutation.
FRONTIERS IN MEDICINE
(2022)
Review
Oncology
Nina Couette, Wael Jarjour, Jonathan E. Brammer, Alexa Simon Meara
Summary: There exists a complex relationship between rheumatic diseases and cancer, involving chronic inflammation and malignant cell transformation. The association between Large Granular Lymphocyte leukemia and rheumatic diseases like rheumatoid arthritis has been well studied, but more research is needed to understand the molecular mechanisms underlying this connection.
FRONTIERS IN ONCOLOGY
(2022)
Article
Immunology
Cecile Apert, Ariel O. Galindo-Albarran, Sarah Castan, Claire Detraves, Heloise Michaud, Nicola McJannett, Bart Haegeman, Simon Fillatreau, Bernard Malissen, Georg Hollander, Saulius Zuklys, Jeremy C. Santamaria, Olivier P. Joffre, Paola Romagnoli, Joost P. M. van Meerwijk
Summary: This study reevaluated the role of IL-2 and IL-15 in the development of regulatory T-lymphocytes (Treg) and found that IL-2 and IL-15 play important non-redundant quantitative and qualitative roles in intrathymic Treg development.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Hematology
HeeJin Cheon, Jeffrey C. Xing, Katharine B. Moosic, Johnson Ung, Vivian W. Chan, David S. Chung, Mariella F. Toro, Omar Elghawy, John S. Wang, Cait E. Hamele, Ross C. Hardison, Thomas L. Olson, Su-Fern Tan, David J. Feith, Aakrosh Ratan, Thomas P. Loughran Jr
Summary: This study investigated the molecular landscape in a large cohort of LGL leukemia patients and identified several recurrent mutations and gene expression differences. The findings shed light on the clinical and molecular heterogeneity of this rare disorder.
Review
Oncology
Gaelle Drillet, Cedric Pastoret, Aline Moignet, Thierry Lamy, Tony Marchand
Summary: Large granular lymphocytic leukemia is a rare lymphoproliferative disorder characterized by clonal expansion of T-lineage or natural killer (NK) cells. It presents with cytopenia and autoimmune manifestations, and often requires treatment.
FRONTIERS IN ONCOLOGY
(2022)
Review
Immunology
Huimin Zhou, Jun Yang, Jie Tian, Shengjun Wang
Summary: Primary Sjogren's syndrome (pSS) is a chronic autoimmune disease characterized by damage to multiple organs and glands, with dry eyes, dry mouth, and enlarged salivary glands being common clinical manifestations. CD8(+) T lymphocytes have been found to play a significant role in acinar injury in the exocrine glands, contributing to the pathophysiology of the disease. Targeting CD8(+) T cells in treatment strategies can offer promising new approaches for managing pSS.
FRONTIERS IN IMMUNOLOGY
(2021)
