Article
Multidisciplinary Sciences
Stephan Christian Moehlhenrich, Kristian Kniha, Zuzanna Magnuska, Benita Hermanns-Sachweh, Felix Gremse, Frank Hoelzle, Gholamreza Danesh, Ali Modabber
Summary: The study compares the bone graft quality of different bone substitutes after cleft repair, finding significant differences in bone morphology and new bone formation among the various grafting materials. Autografts are confirmed as the gold standard in cleft repair, with the human xenografts showing high levels of new bone formation and the synthetic materials demonstrating less resorption.
SCIENTIFIC REPORTS
(2021)
Article
Biochemistry & Molecular Biology
Yong Li, JunKai Zhang, LiFu Chen, HaiTao Li, Jian Wang
Summary: In this study, a RADA16-W9 peptide gel scaffold was designed and its effectiveness in bone defect repair was validated through cell experiments and a mouse model.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2023)
Article
Engineering, Biomedical
Srujan Singh, Ethan L. Nyberg, Aine N. O'Sullivan, Ashley Farris, Alexandra N. Rindone, Nicholas Zhang, Emma C. Whitehead, Yuxiao Zhou, Eszter Mihaly, Chukwuebuka C. Achebe, Wojciech Zbijewski, Will Grundy, David Garlick, Nicolette D. Jackson, Takashi Taguchi, Catherine Takawira, Joseph Lopez, Mandi J. Lopez, Michael P. Grant, Warren L. Grayson
Summary: This study evaluates a point-of-care treatment strategy for midfacial bone defects using autologous stromal vascular fraction (SVF) combined with 3D-printed bioactive scaffolds. The results demonstrate the efficacy of this approach in promoting bone regeneration and restoring the native bone structure.
Review
Engineering, Biomedical
Sophia Dalfino, Paolo Savadori, Marco Piazzoni, Stephen Thaddeus Connelly, Aldo Bruno Gianni, Massimo Del Fabbro, Gianluca Martino Tartaglia, Lorenzo Moroni
Summary: Mandibular tissue engineering aims to develop synthetic substitutes for critical size defects in the mandible, and scaffold design and fabrication using additive manufacturing techniques have become the focus of research efforts. This review discusses scaffolds made with additive manufacturing techniques in mandibular tissue engineering applications, including their chemical composition, structural properties, and strategies to promote osteogenesis and vascularization. In vivo studies comparing new bone formation, defect dimensions, and animal models are also reviewed.
ADVANCED HEALTHCARE MATERIALS
(2023)
Article
Biotechnology & Applied Microbiology
Ru-Lin Huang, Rao Fu, Yuxin Yan, Chuanqi Liu, Jing Yang, Yun Xie, Qingfeng Li
Summary: Developmental engineering of hypertrophic cartilaginous constructs engineered from adipose tissue can effectively heal large bone defects, exhibiting superior regenerative capacity and tissue integration.
BIOENGINEERING & TRANSLATIONAL MEDICINE
(2022)
Article
Biotechnology & Applied Microbiology
W. B. Saunders, L. M. Dejardin, E. V. Soltys-Niemann, C. N. Kaulfus, B. M. Eichelberger, L. K. Dobson, B. R. Weeks, S. C. Kerwin, C. A. Gregory
Summary: This study aimed to refine a canine critical-sized femoral defect model, reduce animal numbers by performing imaging, biomechanics, and histology on the same cohort of dogs. The results showed that the angle-stable interlocking nail provided appropriate fixation, and the autograft group achieved radiographic union by 12 weeks while the negative control group experienced non-union.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Materials Science, Multidisciplinary
Yongke Shao, Fanyan Deng, Yongyun Chang, Songqing Shi, Huiwu Li, Yao Yuan
Summary: This study synthesized a novel silicon material (CPS) with favorable biocompatibility and bioactivity, which could promote osteogenic differentiation of bone marrow-derived mesenchymal stem cells (rBMSCs) and significantly enhance the healing of critical-sized bone defects in vivo.
FRONTIERS IN MATERIALS
(2022)
Article
Chemistry, Multidisciplinary
Sara Targonska, Sebastian Dominiak, Rafal J. Wiglusz, Marzena Dominiak
Summary: This study compares representatives of auto-, allo-, and xenografts and evaluates their differences using various techniques, including SEM, FT-IR, XRD, and TGA. The results show that the origin of the material influences the compact level and porosity of collagen fibers.
Article
Critical Care Medicine
Hening Sun, Charles Godbout, Gareth Ryan, Graeme Hoit, James Higgins, Emil H. Schemitsch, Aaron Nauth
Summary: The study compared two bone grafting procedures in rat models of induced membrane technique (IMT), revealing significantly improved healing outcomes in the second group. This suggests that the revised bone grafting method plays a key role in enhancing healing outcomes and establishing a reliable rat model for IMT.
INJURY-INTERNATIONAL JOURNAL OF THE CARE OF THE INJURED
(2022)
Article
Medicine, General & Internal
Yulei Liu, Janice Havasy, Samuel Green, Xiang-Hua Deng, Daoyun Chen, Alexander Piacentini, Scott A. Rodeo
Summary: By conducting ACL reconstruction in rabbit knees, the study found that B-ACL-B allografts were able to effectively restore the normal anatomy of the ACL, showing progressive graft incorporation and remodeling.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Multidisciplinary Sciences
Yue Wang, Xiaoyan Zhang, Shuang Mei, Yunlong Li, Anas Ameer Khan, Shuai Guan, Xiangjun Li
Summary: A rabbit model of mandibular box-shaped defects created through an intraoral approach was evaluated to determine the minimum size defect that would not spontaneously heal during the rabbit's natural life (critical-sized defect, CSD). The dimensions of the CSD were determined to be 8 mm x 3 mm x 2 mm. This model provides a clinically relevant base for future tissue engineering efforts in the mandible.
Article
Nanoscience & Nanotechnology
Xinchen Wu, Olivia Gauntlett, Tengfei Zhang, Sanika Suvarnapathaki, Colleen McCarthy, Bin Wu, Gulden Camci-Unal
Summary: Scaffold-based bone regeneration using eggshell microparticles in protein-derived hydrogels significantly promotes bone regeneration by inducing osteogenic differentiation and supporting tissue infiltration over a 12-week period.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Article
Orthopedics
Guydo M. H. Duarte, Robinson E. Pires, Carla J. Machado, Marco A. P. Andrade
Summary: The study retrospectively evaluated the clinical and radiographic results of patients who underwent THA/AR procedures, showing that the described technique can effectively reconstruct segmental/combined and cavitary acetabular defects. The success of the technique, especially for segmental/combined defects, was attributed in part to the rigorous postoperative rehabilitation protocol.
JOURNAL OF ARTHROPLASTY
(2021)
Review
Biotechnology & Applied Microbiology
Anjie Guo, Yi Zheng, Yu Zhong, Shuixue Mo, Shanbao Fang
Summary: This study systematically compares the application of chitosan/inorganic nanomaterial scaffolds in bone regeneration, identifying important factors such as baseline characteristics and physicochemical properties of scaffolds. The study suggests that further research should focus on improving the osteogenic performance of the scaffolds and increasing the credibility of studies through rigorous experimental design and normative reports.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Nanoscience & Nanotechnology
Keigo Shibahara, Koichiro Hayashi, Yasuharu Nakashima, Kunio Ishikawa
Summary: The study evaluated the ability of CAp HC scaffolds by reconstructing segmental defects in the rabbit ulnar shaft, showing that the scaffolds promoted bony callus formation at 4 weeks post-surgery and connected to the host bone at 12 weeks post-surgery in 10 and 15 mm defects. The results indicate that CAp HC scaffolds have good potential value for the reconstruction of critical-sized defects.
ACS APPLIED BIO MATERIALS
(2021)
Article
Orthopedics
John Peters, Luke Vest, Matthew Schuelke, Silviya P. Zustiak, Andrew F. Hall, Sarah McBride-Gagyi
JOURNAL OF ORTHOPAEDIC RESEARCH
(2020)
Review
Orthopedics
Andrea I. Alford, Daemeon Nicolaou, Mark Hake, Sarah McBride-Gagyi
Summary: Masquelet's induced membrane technique (MIMT) is a surgical procedure for reconstructing segmental bone defects, showing promise for revolutionizing critical-sized bone defect repair with advantages over distraction osteogenesis (DO). However, MIMT's success in adults lags behind DO, and the mechanism by which the membrane supports bone graft union remains unclear.
JOURNAL OF ORTHOPAEDIC RESEARCH
(2021)
Article
Orthopedics
Andrew Dunn, Gabriel Haas, Joshua Madsen, Natalia Ziemkiewicz, Jeffrey Au, David Johnson, Charles West, Hannah Chauvin, Sara McBride Gagyi, Koyal Garg
Summary: A porous sponge-like scaffold composed of ECM proteins and FK-506 was developed for the treatment of volumetric muscle loss (VML). The scaffold showed promising results in supporting muscle regeneration and fracture healing in a composite trauma model.
JOURNAL OF ORTHOPAEDIC RESEARCH
(2022)