Encapsulation of Chondrocytes in High-Stiffness Agarose Microenvironments for In Vitro Modeling of Osteoarthritis Mechanotransduction

Candidate mediators of chondrocyte mechanotransduction via targeted and untargeted metabolomic measurements

(2014) Aaron A. Jutila et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Substratum stiffness and latrunculin B modulate the gene expression of the mechanotransducers YAP and TAZ in human trabecular meshwork cells

(2013) Sara M. Thomasy et al.   EXPERIMENTAL EYE RESEARCH

The mechanical microenvironment of high concentration agarose for applying deformation to primary chondrocytes

(2013) Donald L. Zignego et al.   JOURNAL OF BIOMECHANICS

Liquid chromatography quadrupole time-of-flight mass spectrometry characterization of metabolites guided by the METLIN database

(2013) Zheng-Jiang Zhu et al.   Nature Protocols

Early differentiation patterning of mouse embryonic stem cells in response to variations in alginate substrate stiffness

(2013) Joseph Candiello et al.   Journal of Biological Engineering

Cell Mechanics, Structure, and Function Are Regulated by the Stiffness of the Three-Dimensional Microenvironment

(2012) J. Chen et al.   BIOPHYSICAL JOURNAL

Depth-dependent anisotropy of the micromechanical properties of the extracellular and pericellular matrices of articular cartilage evaluated via atomic force microscopy

(2012) Morgan A. McLeod et al.   JOURNAL OF BIOMECHANICS

A biomechanical role for perlecan in the pericellular matrix of articular cartilage

(2012) Rebecca E. Wilusz et al.   MATRIX BIOLOGY

Metabolomic characterization of metabolic phenotypes in OA

(2012) Francisco J. Blanco et al.   Nature Reviews Rheumatology

Dynamic Compression of Chondrocyte-Agarose Constructs Reveals New Candidate Mechanosensitive Genes

(2012) Carole Bougault et al.   PLoS One

Matrix Stiffness Regulates Endothelial Cell Proliferation through Septin 9

(2012) Yi-Ting Yeh et al.   PLoS One

Transient Supplementation of Anabolic Growth Factors Rapidly Stimulates Matrix Synthesis in Engineered Cartilage

(2011) Kenneth W. Ng et al.   ANNALS OF BIOMEDICAL ENGINEERING

A comparison of cartilage stress-relaxation models in unconfined compression: QLV and stretched exponential in combination with fluid flow

(2011) Ronald K. June et al.   COMPUTER METHODS IN BIOMECHANICS AND BIOMEDICAL ENGINEERING

Finite element prediction of cartilage contact stresses in normal human hips

(2011) Michael D. Harris et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

Spatial Mapping of the Biomechanical Properties of the Pericellular Matrix of Articular Cartilage Measured In Situ via Atomic Force Microscopy

(2010) Eric M. Darling et al.   BIOPHYSICAL JOURNAL

Polymer mechanics as a model for short-term and flow-independent cartilage viscoelasticity

(2010) R.K. June et al.   Materials Science & Engineering C-Materials for Biological Applications

Response of engineered cartilage to mechanical insult depends on construct maturity

(2010) A.R. Tan et al.   OSTEOARTHRITIS AND CARTILAGE

Enzymatic digestion of articular cartilage results in viscoelasticity changes that are consistent with polymer dynamics mechanisms

(2009) Ronald K June et al.   Biomedical Engineering Online

Articular chondrocytes express connexin 43 hemichannels and P2 receptors - a putative mechanoreceptor complex involving the primary cilium?

(2009) M. M. Knight et al.   JOURNAL OF ANATOMY

Investigating conversion of mechanical force into biochemical signaling in three-dimensional chondrocyte cultures

(2009) Carole Bougault et al.   Nature Protocols

Differential Maturation and Structure–Function Relationships in Mesenchymal Stem Cell- and Chondrocyte-Seeded Hydrogels

(2009) Isaac E. Erickson et al.   TISSUE ENGINEERING PART A

Cartilage stress-relaxation proceeds slower at higher compressive strains

(2008) Ronald K. June et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Rho kinase-dependent CCL20 induced by dynamic compression of human chondrocytes

(2008) Dominik R. Haudenschild et al.   ARTHRITIS AND RHEUMATISM

Physiologic deformational loading does not counteract the catabolic effects of interleukin-1 in long-term culture of chondrocyte-seeded agarose constructs

(2008) Eric G. Lima et al.   JOURNAL OF BIOMECHANICS

Cartilage stress–relaxation is affected by both the charge concentration and valence of solution cations

(2008) R.K. June et al.   OSTEOARTHRITIS AND CARTILAGE