Journal
ANNALS OF BIOMEDICAL ENGINEERING
Volume 42, Issue 11, Pages 2289-2302Publisher
SPRINGER
DOI: 10.1007/s10439-014-1060-2
Keywords
Magnetofluidics; Droplet manipulation; Electromagnetic actuation; Surface patterning; DNA extraction; Real-time PCR
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Funding
- NIH [R01CA155305, U54CA151838, R21CA173390]
- NSF [1159771, 0967375]
- Directorate For Engineering
- Div Of Chem, Bioeng, Env, & Transp Sys [1159771] Funding Source: National Science Foundation
- Div Of Chem, Bioeng, Env, & Transp Sys
- Directorate For Engineering [0967375] Funding Source: National Science Foundation
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This review summarizes recent developments in the use of magnetically actuated droplets in point-of-care molecular diagnostic platforms. We discuss the fundamentals of magnetic droplet manipulation and the various modes of actuation. The balance of forces acting on a droplet during transport and particle extraction, as well as the devices and instrumentation developed to perform these operations will be presented and discussed. Furthermore, we review some of the recent advances on the diagnostic applications of platforms utilizing magnetic manipulation for genetic assessment of biological samples.
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