Review
Hematology
Mohammad Sayyadi, Saeed Hassani, Mahmood Shams, Akbar Dorgalaleh
Summary: COVID-19 disrupts the balance of the coagulation, fibrinolytic, anticoagulation, and complement systems, leading to coagulopathy. This study investigates the effects of COVID-19 on key hemostatic components, including platelets, endothelial cells, coagulation factors, fibrinolytic system, anticoagulant protein system, and complement system, to enhance understanding of the pathophysiological processes underlying COVID-19 coagulopathy based on evidence.
ANNALS OF HEMATOLOGY
(2023)
Review
Hematology
Natasha Letunica, Suelyn Van den Helm, Conor McCafferty, Ella Swaney, Tengyi Cai, Chantal Attard, Vasiliki Karlaftis, Paul Monagle, Vera Ignjatovic
Summary: Proteomics is an innovative approach to study all proteins in a given cell, tissue or organism. Recent technological advancements have increased its application in thrombosis and hemostasis research, allowing for the identification of novel markers associated with disease diagnosis and prognosis.
THROMBOSIS AND HAEMOSTASIS
(2022)
Article
Pharmacology & Pharmacy
Sixuan Zhang, Xiang Gui, Yangyang Ding, Huan Tong, Wen Ju, Yue Li, Zhenyu Li, Lingyu Zeng, Kailin Xu, Jianlin Qiao
Summary: Matrine inhibits platelet function, arterial and venous thrombosis, possibly by inhibiting ROS generation, suggesting that matrine might be used as an antiplatelet agent for treating thrombotic or cardiovascular diseases.
FRONTIERS IN PHARMACOLOGY
(2021)
Review
Cardiac & Cardiovascular Systems
Charles Hsu, Edward Hutt, Daniel M. Bloomfield, David Gailani, Jeffrey I. Weitz
Summary: Hemostasis and thrombosis are closely linked, with factor XI inhibitors potentially providing a safer alternative to current anticoagulants. Clinical studies are ongoing to determine the efficacy of factor XI inhibitors in attenuating thrombosis without disrupting hemostasis.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2021)
Article
Hematology
David S. Paul, Tasha N. Blatt, Wyatt J. Schug, Emily G. Clark, Tomohiro Kawano, Nigel Mackman, Sebastian Murcia, Kathryn O. Poe, Jean Marie N. Mwiza, T. Kendall Harden, Wolfgang Bergmeier, Robert A. Nicholas
Summary: Rapid desensitization of the P2Y1 receptor plays a critical role in platelet function and thrombus formation, but does not affect platelet adhesion and aggregation at sites of vascular injury.
JOURNAL OF THROMBOSIS AND HAEMOSTASIS
(2023)
Article
Materials Science, Biomaterials
Xiongfeng Nie, Chunyan Cui, Tengling Wu, Yang Wu, Xinyu Bian, Rong Yang, Xiaoping Zhang, Yage Sun, Yang Liu, Wenguang Liu
Summary: The study develops an indwelling needle with dual functions of anticoagulation and hemostasis by coating an anticoagulant heparin on the inner surface and a hemostatic hydrogel on the outer surface. In vitro tests and animal experiments demonstrate the effectiveness of the indwelling needle, showing good anticoagulant and hemostatic effects.
BIOMATERIALS SCIENCE
(2022)
Review
Hematology
Joseph E. Aslan
Summary: Platelets rapidly change in form and function to repair vascular damage, but in chronic inflammatory conditions, diverse platelet subpopulations with various activated or inhibited phenotypes emerge, potentially indicating disease. The origins and significance of these platelet phenotypic variations remain unclear. Understanding the protein-level relationships of platelets in inflammation, immune response, and aging may help define platelet phenotypes.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2021)
Article
Medicine, General & Internal
Ivo M. B. Francischetti, Kevin Toomer, Yifan Zhang, Jayesh Jani, Zishan Siddiqui, Daniel J. Brotman, Jody E. Hooper, Thomas S. Kickler
Summary: This study found that COVID-19 patients have thrombotic and microvascular complications, and the coagulation abnormalities have a multifactorial etiology. Biomarkers of endothelial cell, neutrophil activation, and fibrinolysis were elevated in severe disease group, correlating with severity. Postmortem specimens demonstrated potential links to immunothrombosis with upregulation of pulmonary TF and loss of thrombomodulin staining.
Article
Hematology
Dong Chen, Rajiv Pruthi
Summary: Coagulation is a crucial biological mechanism in human bodies to prevent blood loss. Abnormal coagulation can cause bleeding diathesis or thrombosis, common pathologic conditions in clinical practice. The Mayo Clinic coagulation group has made significant contributions in understanding coagulation mechanisms, developing testing tools and treatment options, and advancing collaboration and knowledge in this field. This review aims to share their history and inspire medical professionals to improve care for patients with coagulation disorders.
SEMINARS IN THROMBOSIS AND HEMOSTASIS
(2023)
Article
Sport Sciences
Paul R. Nagelkirk, Kayla Soave, Cody Altherr, Andrew Del Pozzi
Summary: The 8-week resistance training program led to increased muscle mass and strength, along with decreased fibrinolysis inhibition, suggesting potential benefits in reducing the risk of thrombotic events. Further research is needed to understand the mechanisms through which resistance training affects hemostasis.
MEDICINE & SCIENCE IN SPORTS & EXERCISE
(2021)
Review
Cardiac & Cardiovascular Systems
Martha M. S. Sim, Semekidus Shiferawe, Jeremy P. Wood
Summary: Antithrombotic therapy requires balancing the benefits of preventing thrombotic events with the risks of major bleeds. Traditional approaches involve carefully dosing and monitoring antiplatelet and anticoagulant medications, all of which carry bleeding risk. Recent advancements have identified new targets to mitigate bleeding risk. This review discusses the current state of antithrombotic therapy and explores new generation drugs and strategies to reverse anticoagulants, moving closer to a treatment that prevents clots without bleeding risk.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Review
Biochemistry & Molecular Biology
Alina Scridon
Summary: This article comprehensively explores the complex role of platelets in hemostasis and thrombosis, discussing their importance in clinical medicine, and studying hemostatic platelet-related disorders and antithrombotic therapies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Daniel Villalobos-Garcia, Hamdy E. A. Ali, Ahmed B. Alarabi, Medhat S. El-Halawany, Fatima Z. Alshbool, Fadi T. Khasawneh
Summary: Smoking is a risk factor for various diseases. In recent years, the residual smoke after smoking, known as thirdhand smoke, has received more attention. This study found that exposing mice to thirdhand smoke for three months is sufficient to increase the risk of thrombosis, and the response to it differs between males and females.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Hematology
Xiang Gui, Xiang Chu, Yuwei Du, Yuhan Wang, Sixuan Zhang, Yangyang Ding, Huan Tong, Mengdi Xu, Yue Li, Wen Ju, Zengtian Sun, Zhenyu Li, Lingyu Zeng, Kailin Xu, Jianlin Qiao
Summary: PDE5A deficiency prolongs bleeding time and delays arterial and venous thrombus formation. It inhibits platelet aggregation and activation, reduces phosphatidylserine exposure, calcium mobilization, and reactive oxygen species production, increases intracellular cGMP level, and modulates platelet function and thrombus formation.
THROMBOSIS AND HAEMOSTASIS
(2023)
Review
Hematology
Funda Tamer, Bibian M. E. Tullemans, Marijke J. E. Kuijpers, Theodora A. M. Claushuis, Johan W. M. Heemskerk
Summary: This article provides a systematic overview of the effects of common phytochemicals on platelet activation and signaling pathways, as well as their potential clinical relevance in thrombosis and hemostasis.
THROMBOSIS AND HAEMOSTASIS
(2022)
Article
Hematology
M. Lehmann, K. Ashworth, M. Manco-Johnson, J. Di Paola, K. B. Neeves, C. J. Ng
JOURNAL OF THROMBOSIS AND HAEMOSTASIS
(2018)
Article
Hematology
Marcus Lehmann, Rogier M. Schoeman, Patrick J. Krohl, Alison M. Wallbank, Joseph R. Samaniuk, Martine Jandrot-Perrus, Keith B. Neeves
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2018)
Article
Environmental Sciences
Kenton Rod, Wooyong Um, Jaehun Chun, Ning Wu, Xialong Yin, Guohui Wang, Keith Neeves
JOURNAL OF CONTAMINANT HYDROLOGY
(2018)
Article
Multidisciplinary Sciences
Kathryn G. Link, Michael T. Stobb, Jorge Di Paola, Keith B. Neeves, Aaron L. Fogelson, Suzanne S. Sindi, Karin Leiderman
Article
Robotics
Tao Yang, Andrew Tomaka, Tonguc O. Tasci, Keith B. Neeves, Ning Wu, David W. M. Marr
Editorial Material
Hematology
Hunter B. Moore, Keith B. Neeves
JOURNAL OF THROMBOSIS AND HAEMOSTASIS
(2019)
Article
Chemistry, Analytical
Matthew G. Sorrells, Keith B. Neeves
Article
Instruments & Instrumentation
E. J. Roth, C. J. Zimmermann, D. Disharoon, T. O. Tasci, D. W. M. Marr, K. B. Neeves
REVIEW OF SCIENTIFIC INSTRUMENTS
(2020)
Article
Hematology
Robert C. Gosselin, Annette Bowyer, Emmanuel J. Favaloro, Jill M. Johnsen, Giuseppe Lippi, Richard A. Marlar, Keith Neeves, Marian A. Rollins-Raval
Summary: Recent shortage of 3.2% sodium citrate blood collection tubes has led stakeholders to seek suitable alternatives, with laboratories particularly concerned about variability between manufacturers and the challenges associated with transitioning to new blood collection methods. This provisional guidance document provides recommendations for validating alternative sources of sodium citrate blood collection tubes before clinical implementation.
JOURNAL OF THROMBOSIS AND HAEMOSTASIS
(2021)
Article
Hematology
Dante Disharoon, Brian G. Trewyn, Paco S. Herson, David W. M. Marr, Keith B. Neeves
Summary: This study developed a platform for co-delivering tPA and plasminogen using microwheels to accelerate clot lysis, surpassing the biochemical speed limit through corkscrew motion. The results demonstrated significant efficacy in lysing plasma clots with this approach.
JOURNAL OF THROMBOSIS AND HAEMOSTASIS
(2022)
Article
Biotechnology & Applied Microbiology
Cara L. Sake, Alexander J. Metcalf, Michelle Meagher, Jorge Di Paola, Keith B. Neeves, Nanette R. Boyle
Summary: This study used isotopically nonstationary C-13 metabolic flux analysis to measure carbon fluxes in resting and activated platelets. The results showed significant differences in metabolic fluxes between activated and resting platelets, providing important insights into the mechanisms of platelet activation.
METABOLIC ENGINEERING
(2022)
Article
Chemistry, Multidisciplinary
Matthew J. Osmond, Elizabeth Korthals, Coy J. Zimmermann, Eric J. Roth, David W. M. Marr, Keith B. Neeves
Summary: Inflammatory bowel disease (IBD) is caused by the over-expression of tumor necrosis factor-alpha (TNF) in the intestinal mucosa. Oral delivery of anti-TNF is hindered by degradation and poor bioavailability. To overcome these issues, researchers have developed magnetically powered hydrogel particles that can roll along mucosal surfaces, release anti-TNF, and repair damaged cell junctions. This method has the potential to be used for the treatment of IBD.
Article
Chemistry, Multidisciplinary
Aaron K. Ishiki, Keith B. Neeves, David W. M. Marr
Summary: High-molecular-weight polymers that approach the size scale of the gap between the microbots and surfaces can be excluded, impacting microbot transport. This exclusion leads to a reversal in the microbot translation direction.
Article
Biochemical Research Methods
Jess Berry, Francois J. Peaudecerf, Nicole A. Masters, Keith B. Neeves, Raymond E. Goldstein, Matthew T. Harper
Summary: Cardiovascular disease is a leading cause of death worldwide, with myocardial infarction being triggered by blood clots. Developing new anti-platelet drugs is an active area of research, with in vitro models using human blood showing potential in improving relevance. The study developed a microfluidic device for generating occlusive thrombi and demonstrated its ability to monitor the effect of anti-thrombotic drugs in an unbiased and objective manner.
Review
Hematology
Jessica Lin, Matthew G. Sorrells, Wilbur A. Lam, Keith B. Neeves
Summary: This illustrated review delves into the physical forces regulating hemostasis and thrombosis, spanning from vessel to cellular to molecular scales. Blood flow exerts forces on vessel walls and blood cells, impacting the kinetics, structure, and stability of thrombi. External forces and environmental stiffness play crucial roles in platelet function and clot formation.
RESEARCH AND PRACTICE IN THROMBOSIS AND HAEMOSTASIS
(2021)