Journal
ANNALS OF BIOMEDICAL ENGINEERING
Volume 39, Issue 1, Pages 559-569Publisher
SPRINGER
DOI: 10.1007/s10439-010-0168-2
Keywords
Fasciculation; Dorsal root ganglia; In vitro; Image processing; Fourier filter
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Funding
- New Jersey Commission on Spinal Cord Research (NJCSCR) [06-3055-SCR-E-0, 07-2929-SCR-E-0]
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We describe experiments of fasciculation, i.e., bundling, of chick sensory neurites on 2D striped substrates. By Fourier decomposition, we separate left-going and right-going neurite components from in vitro images, and we find first that neurite bundles orient toward preferred angles with respect to the stripe direction, and second that in vitro bundles travel in leftward and rightward directions nearly uninterrupted by crossings of bundles traveling in the opposing direction. We explore mechanisms that lead to these behaviors, and summarize implications for future models for neurite outgrowth and guidance.
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