Article
Multidisciplinary Sciences
Saman Ebrahimi, Prosenjit Bagchi
Summary: This study investigates the feasibility of using machine learning techniques to predict blood flow and red blood cell (RBC) distributions in physiologically realistic vascular networks. By acquiring data from high-fidelity simulations, machine learning models can accurately predict the changes in blood flow, RBC distributions, and hemodynamics at different vascular levels and time scales.
JOURNAL OF THE ROYAL SOCIETY INTERFACE
(2022)
Article
Biology
S. Schoenborn, T. Lorenz, K. Kuo, D. F. Fletcher, M. A. Woodruff, S. Pirola, M. C. Allenby
Summary: Vascular compliance, both a cause and consequence of cardiovascular disease, is important in the patency of vascular grafts. However, studying the biomechanical effects of localized changes in compliance has been challenging due to limited medical imaging technologies and surgical simulation materials. To address this, a coupled silico-vitro platform was developed to validate numerical fluid-structure interaction results with physical prototypes. The results of this study provide insights into the mechanical behavior of arterial phantoms and have promising applications in studying diseases and optimizing vascular prostheses.
COMPUTERS IN BIOLOGY AND MEDICINE
(2023)
Article
Cell Biology
Brian S. Ferguson, Leslie E. Neidert, Matthew J. Rogatzki, Keith R. Lohse, L. Bruce Gladden, Heidi A. Kluess
Summary: The study found no significant difference in the release of ATP from RBCs of different densities under hypoxic and normoxic conditions, and the release of ATP was linearly correlated with the release of Hb.
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
(2021)
Article
Mechanics
Shanqin Jin, Heather Peng, Wei Qiu, Chad Oldfield, Barton Stockdill
Summary: This paper presents the development of best Reynolds-Averaged Navier-Stokes (RANS) modeling practices for simulations of propeller-hull interaction using Star-CCM+. The best propeller modeling methods and parameters were recommended based on convergence studies and validation experiments.
Article
Biochemical Research Methods
Yuncheng Man, Debnath Maji, Ran An, Sanjay P. Ahuja, Jane A. Little, Michael A. Suster, Pedram Mohseni, Umut A. Gurkan
Summary: This study introduces a novel microfluidic testing method, MIRCA, for standardized assessment of RBC-mediated microvascular occlusion. The technology shows promise in diseases like SCD and hereditary spherocytosis, correlating electrical impedance measurement with high-resolution imaging and clinical treatment outcomes. Impedance measurement obviates the need for high-resolution imaging, making it portable and suitable for point-of-care use in the future.
Article
Computer Science, Interdisciplinary Applications
K. Nagata, N. Ikegaya, J. Tanimoto
Summary: The paper discusses a new explicit method for unsteady fluid flow numerical simulation, utilizing compressible continuity and Navier-Stokes equations with density replacing pressure as a major variable. Validation results show that the proposed method aligns well with results from conventional incompressible methods and Lattice-Boltzmann methods under different Reynolds numbers.
JOURNAL OF COMPUTATIONAL PHYSICS
(2021)
Article
Biochemistry & Molecular Biology
Hock Chin Low, Bee Huah Lim
Summary: As unitised regenerative proton exchange membrane fuel cell (URPEMFC) is progressing, the understanding of the interaction between multiphase reactants and products during the switching mode is important. This study used a 3D transient computational fluid dynamics model to simulate the supply of liquid water into the flow field during the switch from fuel cell mode to electrolyser mode. Different water velocities were investigated, and 0.5 m/s was found to achieve optimal distribution. The serpentine design achieved the best flow distribution among different flow field configurations.
Article
Engineering, Mechanical
Dongmin Kim, Jinyul Hwang, Too-Jae Min, Won-Min Jo
Summary: Recent research has shown evidence of turbulence in physiological blood flow, particularly in stenosed carotid arteries. In this study, direct numerical simulation was used to investigate transitional flow in a stenosed carotid artery. The results demonstrate the frequent occurrence of extreme retrograde wall-shear stress (WSS) events and their relationship to vortical structures. These findings have important implications for platelet activation and red blood cell damage.
JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY
(2023)
Article
Physiology
Gyu-Han Lee, Hyun Jung Koo, Kyung Jin Park, Dong Hyun Yang, Hojin Ha
Summary: This study aimed to characterize the hemodynamics of Fontan patients using 4D Flow MRI and CFD. Hemodynamic parameters were estimated and compared between the two modalities. The results showed that there were discrepancies between 4D Flow MRI and CFD in terms of PFD and VD, highlighting the need for careful consideration when analyzing hemodynamic data from different modalities in Fontan patients.
FRONTIERS IN PHYSIOLOGY
(2023)
Article
Mathematics, Applied
Jedrzejczak Krystian, Makowski Lukasz, Orciuch Wojciech
Summary: This study developed a universal rheological blood model that can simulate physiological processes related to blood in any blood vessel. The model can simulate the agglomeration and deagglomeration of red blood cells, and is applicable for simulating hemolysis flows caused by atherosclerotic changes in arteries. The results demonstrated that the model accurately predicted the distribution of red blood cell agglomerates in arteries and the smooth transition of viscosity before and after stenosis. Additionally, the model can predict the concentration of deagglomerated single red blood cells and the size of red blood cell agglomerates.
COMMUNICATIONS IN NONLINEAR SCIENCE AND NUMERICAL SIMULATION
(2023)
Article
Multidisciplinary Sciences
Ilya O. Starodumov, Sergey Yu Sokolov, Dmitri Alexandrov, Andrey Yu Zubarev, Ivan S. Bessonov, Vasily V. Chestukhin, Felix A. Blyakhman
Summary: This study conducted patient-specific hemodynamics modelling of severe coronary artery disease, taking into account standard angiographic data obtained before and after myocardial revascularization by stenting. By using a non-Newtonian fluid model and an original algorithm, key characteristics of blood flow were determined to analyze the features of coronary disease and its treatment consequences. The results of hemodynamic modelling near bifurcation sites were presented, emphasizing on physical, physiological, and clinical phenomena to demonstrate the feasibility of the proposed approach. The main limitations and potential ways to minimize them were also discussed.
PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY A-MATHEMATICAL PHYSICAL AND ENGINEERING SCIENCES
(2022)
Article
Multidisciplinary Sciences
Pietro Dirix, Stefano Buoso, Eva S. Peper, Sebastian Kozerke
Summary: This study proposes a method to synthesize patient-specific 4D flow MRI datasets of turbulent flow paired with ground truth flow data for training of inference methods. The results demonstrate the importance of paired ground truth and 4D flow MRI data for accurately assessing turbulent flow inference using 4D flow MRI exams.
SCIENTIFIC REPORTS
(2022)
Article
Surgery
Yue Qiu, Jiarong Wang, Jichun Zhao, Tiehao Wang, Tinghui Zheng, Ding Yuan
Summary: This study proposes a novel classification of blood flow pattern in abdominal aortic aneurysms (AAA) based on computational fluid dynamics (CFDs), which shows a significant predictive value for AAA rupture. The type III flow pattern is associated with a significantly increased risk of aneurysm rupture. The combination of blood flow pattern and other hemodynamic parameters improves the identification of high-risk aneurysms.
EUROPEAN JOURNAL OF VASCULAR AND ENDOVASCULAR SURGERY
(2022)
Article
Physiology
Zhong Yun, Jinfu Yao, Liang Wang, Xiaoyan Tang, Yunhao Feng
Summary: The study evaluated the effect of four different outflow structures on the hydraulic performance and shear stress distribution of a microaxial blood pump through computational fluid dynamics and hydraulic experiments. The results showed that the outflow structure with curved bridges and bladeless diffuser exhibited relatively better shear stress distribution and a lower hemolysis index, providing support for further research on optimizing microaxial blood pumps.
FRONTIERS IN PHYSIOLOGY
(2023)
Article
Thermodynamics
Reza Roohi, Homayoun Emdad, Khosrow Jafarpur
Summary: A novel approach is proposed to reconstruct the 3D vascular system using angiography data and simulate blood flow with the combination of CFD tool and GMDH algorithm. The results show its excellent capability to predict the flow field within the tissue.
INTERNATIONAL COMMUNICATIONS IN HEAT AND MASS TRANSFER
(2021)
Article
Biology
Azusa Kage, Toshihiro Omori, Kenji Kikuchi, Takuji Ishikawa
JOURNAL OF EXPERIMENTAL BIOLOGY
(2020)
Article
Gastroenterology & Hepatology
Kenji Kikuchi, Hyeongtak Noh, Keiko Numayama-Tsuruta, Takuji Ishikawa
AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY
(2020)
Article
Mechanics
Junichi Manabe, Toshihiro Omori, Takuji Ishikawa
JOURNAL OF FLUID MECHANICS
(2020)
Review
Cell Biology
Takuji Ishikawa, Hironori Ueno, Toshihiro Omori, Kenji Kikuchi
Summary: This article explores the roles of cilia and centrosomes in eukaryotic cells and their dynamics, motions, and forces at the molecular, organelle, and tissue levels. The structure and function of cilia and centrosomes are closely related, requiring a comprehensive understanding from the molecular level to the tissue level.
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
(2021)
Article
Biochemical Research Methods
Satoshi Ii, Hiroki Kitade, Shunichi Ishida, Yohsuke Imai, Yoshiyuki Watanabe, Shigeo Wada
PLOS COMPUTATIONAL BIOLOGY
(2020)
Article
Physics, Fluids & Plasmas
Tomoki Oyama, Shunichi Ishida, Kohei Maeyama, Taimei Miyagawa, Yohsuke Imai
Summary: The study focuses on the effects of clustered contractions propagating along a circular channel on fluid flow, finding that clustered contractions cause retrograde flow and fluid trapping in the upstream and downstream regions of the cluster. Flow rate is not proportional to the number of peristaltic waves, particularly for large contraction ratios.
PHYSICAL REVIEW FLUIDS
(2021)
Article
Physics, Fluids & Plasmas
Shunichi Ishida, Ryota Matsumoto, Daiki Matsunaga, Yohsuke Imai
Summary: In this study, a lattice Boltzmann simulation was used to investigate the crystal-like structure of deformable particles in a wall-bounded shear flow. It was found that this crystal structure can be effectively utilized for the segregation of capsules of different sizes. The movement of the smaller capsules varied significantly with the size ratio, and their behavior changed from diffusive to advective depending on the ratio.
PHYSICAL REVIEW FLUIDS
(2022)
Article
Mechanics
Kohei Maeyama, Shunichi Ishida, Yohsuke Imai
Summary: Peristaltic pumping is the primary mechanism of food transport in the human intestine. This study investigates the peristaltic transport of a power-law fluid with a low behavior index, and finds that inertia effects can increase the discharge flow rate, while the sharpness of the contraction wave can affect the symmetry of the flow field. The results suggest that an isolated contraction wave with a shorter wavelength can transport intestinal contents more quickly when the contents have low consistency indices or when the contraction wave has a large propagation velocity.
Article
Multidisciplinary Sciences
Rika Ebara, Shunichi Ishida, Taimei Miyagawa, Yohsuke Imai
Summary: The amplitude and frequency of peristaltic contractions have a significant impact on gastric mixing and emptying. Increasing or decreasing the amplitude affects mixing strength and emptying rate, with higher amplitude increasing the emptying rate and lower amplitude decreasing it. The emptying rate also increases with the peristaltic frequency. The closest contraction wave to the pylorus and subsequent waves promote gastric emptying. It is important to maintain these parameters within normal ranges for healthy gastric function.
JOURNAL OF THE ROYAL SOCIETY INTERFACE
(2023)
Article
Multidisciplinary Sciences
Haruki Yoshida, Shunichi Ishida, Taiki Yamamoto, Takayuki Ishikawa, Yuichi Nagata, Kazuhito Takeuchi, Hironori Ueno, Yohsuke Imai
Summary: In this study, computational fluid dynamics was used to investigate the effects of cilia-induced surface velocity on cerebrospinal fluid (CSF) flow. The results showed that ciliary motility disorder could delay CSF exchange in the lateral ventricles.
JOURNAL OF THE ROYAL SOCIETY INTERFACE
(2022)
Article
Physiology
Tim Hsu-Han Wang, Timothy R. Angeli, Shunichi Ishida, Peng Du, Armen Gharibans, Niranchan Paskaranandavadivel, Yohsuke Imai, Taimei Miyagawa, Thomas L. Abell, Gianrico Farrugia, Leo K. Cheng, Gregory O'Grady
Summary: Loss of interstitial cells of Cajal (ICC) and aging are associated with higher gastric slow wave velocity, but the exact reasons for these relationships are still unknown. Increased slow wave velocity may modulate gastric emptying higher, although in gastroparesis other pathological factors must dominate to prevent emptying.
PHYSIOLOGICAL REPORTS
(2021)
Article
Physics, Fluids & Plasmas
Zhihan Huang, Toshihiro Omori, Takuji Ishikawa
Article
Physics, Fluids & Plasmas
Takeru Morita, Toshihiro Omori, Yohei Nakayama, Shoichi Toyabe, Takuji Ishikawa
Article
Cardiac & Cardiovascular Systems
Hiroki Kamada, Hideki Ota, Masanori Nakamura, Yohsuke Imai, Shunichi Ishida, Wenyu Sun, Ko Sakatsume, Ichiro Yoshioka, Yoshikatsu Saiki, Kei Takase
SEMINARS IN THORACIC AND CARDIOVASCULAR SURGERY
(2020)
Article
Physics, Fluids & Plasmas
Helene de Maleprade, Frederic Moisy, Takuji Ishikawa, Raymond E. Goldstein
