Article
Oncology
Fen Xu, Jiamin Zhang, Xiaoyan Zhou, Hua Hao
Summary: Excessive oxidative stress and decreased antioxidant capacity of macrophages are key factors in the transformation of macrophages to foam cells, a crucial event in the progression of atherosclerosis. The analog of lipoxin A(4), BML-111, can attenuate HF diet-induced atherosclerosis by activating Nrf2, independent of a specific LXA(4) receptor. In addition, BML-111 can inhibit the promotion of MDA level, increase HDL level, and decrease levels of IL-1, MCP-1, IL-6, VCAM, ICAM, and TNF-alpha in the aorta. In vitro experiments also showed that LXA(4) can inhibit the transformation of THP-1 cells to foam cells through the Nrf2 pathway.
EXPERIMENTAL CELL RESEARCH
(2022)
Article
Immunology
Jixiang Yuan, Feihong Lin, Lichen Chen, Weikang Chen, Xiaodong Pan, Yongheng Bai, Yong Cai, Hong Lu
Summary: LXA4 regulates macrophage polarization by modulating the FPR2-IRF pathway, inhibiting inflammatory polarization of M1 macrophages and promoting IL-4-induced polarization of M2 macrophages.
INFLAMMOPHARMACOLOGY
(2022)
Article
Neurosciences
Qian-Qian Li, Dan-Hua Ding, Xin-Yu Wang, Yu-Ying Sun, Jun Wu
Summary: Microglia are rapidly activated after acute ischemic stroke, and their polarization is associated with prognosis. Lipoxin A4 may have a protective effect by regulating microglial polarization. The study found that LXA4 protected against cerebral ischemia-reperfusion injury and influenced the expression of proinflammatory cytokines and genes associated with microglial polarization.
EXPERIMENTAL NEUROLOGY
(2021)
Article
Obstetrics & Gynecology
Mei Han, Shaoyang Lai, Yimeng Ge, Xuan Zhou, Jie Zhao
Summary: During parturition, there is a decrease in pro-inflammatory cytokines and cells due to increased stress and adrenaline production. Lipoxin A4 (LXA4) induced by adrenaline plays a crucial role in inhibiting inflammation and protecting the body from excessive inflammatory damages during labor.
REPRODUCTIVE SCIENCES
(2022)
Article
Neurosciences
Xiuzhe Wang, Zhijuan Miao, Xiaofeng Xu, Marianne Schultzberg, Yuwu Zhao
Summary: The study showed that in patients with acute ischemic stroke, the levels of SPM lipoxin A4 were significantly reduced in those with PSCI compared to those with PSNCI. Interestingly, the levels of LXA(4) were positively correlated with cognitive function.
JOURNAL OF ALZHEIMERS DISEASE
(2021)
Article
Biochemical Research Methods
Minghui Ou, Qian Zhang, Huidong Zhao, Chang Shu
Summary: The study revealed that PUFAs and LXA4 have an impact on PE by regulating LOX and inflammatory responses.
JOURNAL OF PROTEOME RESEARCH
(2021)
Article
Immunology
Chaojin Chen, Rongzong Qiu, Jing Yang, Qian Zhang, Guoliang Sun, Xiaofeng Gao, Ziqing Hei, Haocong Ji
Summary: The study demonstrates that LXA4 can attenuate septic AKI by blocking the crosstalk between inflammation and premature senescence, thus restoring renal function and improving survival rate. Premature senescence plays a critical role in septic AKI, and inhibiting the crosstalk between inflammation and premature senescence may represent a new and major mechanism by which LXA4 attenuates septic AKI.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Xiaojia Zhu, Xudong Peng, Jing Lin, Yingxue Zhang, Hong He, Guiqiu Zhao
Summary: LXA4 alleviated inflammatory response in Aspergillus fumigatus keratitis by suppressing neutrophil infiltration, downregulating the expression of pro-inflammatory mediators, and reducing ROS production through ALX/FPR2 receptor.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Dentistry, Oral Surgery & Medicine
Muhanad Ali, Nathan Kucko, John A. Jansen, Fang Yang, X. Frank Walboomers
Summary: The study showed that PDLCs stimulated by LPS can significantly increase osteoclastogenesis and enhance specific gene expression, while treatment with LXA4 exhibits strong anti-inflammatory activity and can reverse these effects. This suggests that PDLCs may be a potential target for treating bacterial-induced bone resorption in patients with periodontal disease, and LXA4 is a promising candidate for such therapy.
CLINICAL ORAL INVESTIGATIONS
(2021)
Article
Immunology
Telma Saraiva-Santos, Tiago H. Zaninelli, Marilia F. Manchope, Ketlem C. Andrade, Camila R. Ferraz, Mariana M. Bertozzi, Nayara A. Artero, Anelise Franciosi, Stephanie Badaro-Garcia, Larissa Staurengo-Ferrari, Sergio M. Borghi, Graziela S. Ceravolo, Avacir Casanova Andrello, Janaina Menezes Zanoveli, Michael S. Rogers, Rubia Casagrande, Felipe A. Pinho-Ribeiro, Waldiceu A. Verri Jr
Summary: LXA(4) has analgesic and anti-inflammatory effects in a model of prosthesis-induced joint inflammation and pain, mainly through reducing nuclear factor κB activation and modulating cytokine production.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Immunology
Zhi-Xiong Huang, Xiao-Rong He, Xin-Yu Ding, Jia-Hao Chen, Yi-Hong Lei, Jian-Bing Bai, Dian-Chao Lin, Yi-Huang Hong, Jian-Fa Lan, Qiong-Hua Chen
Summary: The study found that autophagy is suppressed by inflammation in endometriosis. LXA4 regulates autophagy by inhibiting inflammatory response through the AhR/AKT/mTOR pathway.
AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY
(2023)
Article
Cell Biology
Wen-Hao Pan, Xin Hu, Ben Chen, Qi-Chao Xu, Hong-Xia Mei
Summary: The study found that Lipoxin A4 (LXA4) has an important impact on the pulmonary inflammatory response and neutrophil function in acute respiratory distress syndrome (ARDS) rats. LXA4 can reduce lung injury and inhibit the release of pro-inflammatory factors in the lung tissue of ARDS rats. It can also inhibit the production of reactive oxygen species and neutrophil extracellular traps in peripheral blood neutrophils, while promoting neutrophil phagocytosis and apoptosis. Its effects on neutrophil function are mediated by its receptor ALX.
Review
Immunology
Rafael I. Jaen, Sergio Sanchez-Garcia, Maria Fernandez-Velasco, Lisardo Bosca, Patricia Prieto
Summary: Inflammation is a physiological response to injury, but excessive inflammation can lead to chronic inflammation and fibrosis. Specialized pro-resolving mediators (SPMs) such as lipoxins are considered to have therapeutic potential for inflammatory diseases. Increasing endogenously generated lipoxins may emerge as a new therapeutic approach for preventing and treating many diseases associated with an increased inflammatory response.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Pharmacology & Pharmacy
Catherine Godson, Patrick Guiry, Eoin Brennan
Summary: Inflammation and its resolution are vital for host defense and tissue repair. Lipoxins, specifically arachidonate-derived lipoxins, are generated in self-limiting inflammatory responses to promote resolution of inflammation and repair without compromising host defense. This article discusses the proresolving actions of lipoxins, efforts to develop novel lipoxin mimetics, and their potential applications in limiting inflammation and reversing fibrosis.
ANNUAL REVIEW OF PHARMACOLOGY AND TOXICOLOGY
(2023)
Article
Cell Biology
Fabiola Gonzalez-Herrera, Renatto Anfossi, Mabel Catalan, Renata Gutierrez-Figueroa, Juan Diego Maya, Guillermo Diaz-Araya, Raul Vivar
Summary: Cardiac cells respond to various pathophysiological stimuli, synthesizing inflammatory molecules that allow tissue repair and proper functioning of the heart; however, perpetuation of the inflammatory response can lead to cardiac fibrosis and heart dysfunction. High concentration of glucose (HG) induces an inflammatory and fibrotic response in the heart. Cardiac fibroblasts (CFs) are resident cells of the heart that respond to deleterious stimuli, increasing the synthesis and secretion of both fibrotic and proinflammatory molecules. The molecular mechanisms that regulate inflammation in CFs are unknown, thus, it is important to find new targets that allow improving treatments for HG-induced cardiac dysfunction.
CELLULAR SIGNALLING
(2023)
Article
Biochemistry & Molecular Biology
Marco Casciaro, Eleonora Di Salvo, Sebastiano Gangemi
Summary: Psoriasis is a pathology characterized by systemic inflammation, enhanced keratinocytes proliferation, and abnormal cell maturation. Several proinflammatory mediators and alarmins, including HMGB1, are increased in the skin and blood of psoriasis patients. Blocking HMGB1 has shown effectiveness in ameliorating psoriasis.
Article
Medicine, General & Internal
Antonio Giovanni Versace, Alessandra Bitto, Carmelo Ioppolo, Caterina Oriana Aragona, Daniela La Rosa, William Neal Roberts, Tommaso D'Angelo, Antonella Cinquegrani, Santa Cirmi, Natasha Irrera, Michele Navarra, Salvatore Corrao, Sebastiano Gangemi, Gianluca Bagnato
Summary: The study aimed to investigate the levels of IL-33 and IL-13 in patients with diffuse SSc and interstitial lung disease (SSc-ILD) compared to SSc patients without ILD and healthy controls. The results showed that both IL-13 and IL-33 levels were elevated in SSc patients and were significantly associated with each other. Additionally, higher levels of IL-33 and IL-13 were observed in SSc patients with reduced pulmonary function compared to those with normal lung function. This suggests that the IL-13/IL-33 axis may play a role in the development and severity of SSc-ILD.
FRONTIERS IN MEDICINE
(2022)
Letter
Chemistry, Applied
Nicola Cicero, Sebastiano Gangemi, Alessandro Allegra
NATURAL PRODUCT RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Alessandro Allegra, Claudia Petrarca, Mario Di Gioacchino, Marco Casciaro, Caterina Musolino, Sebastiano Gangemi
Summary: Raised oxidative stress and abnormal redox status are typical features of multiple myeloma cells. Understanding the mechanisms that regulate the relationship between neoplastic cells and redox homeostasis can help identify new therapeutic targets for anti-myeloma drugs and improve treatment effectiveness.
Article
Biochemistry & Molecular Biology
Eleonora Nucera, Giuseppe Parrinello, Sebastiano Gangemi, Alessandro Buonomo, Arianna Aruanno, Franziska Michaela Lohmeyer, Riccardo Inchingolo, Angela Rizzi
Summary: This study compared hypersensitivity reactions to different types of contrast media and explored the possibility of new reactions in a long-term follow-up. It was found that patients with hypersensitivity reactions to gadolinium-based contrast media had a higher prevalence of asthma, food allergy, non-allergic drug hypersensitivity, and neurologic disease. Some patients reported new reactions despite negative skin test results.
Review
Chemistry, Applied
Eleonora Di Salvo, Francesca Conte, Marco Casciaro, Sebastiano Gangemi, Nicola Cicero
Summary: Mammalian milk contains various components that have chemical and functional activities, which positively impact human health. In addition to their nutritional value, the biologically active compounds in milk play important roles in physiological and biochemical functions in the human body. Donkey and camel milk contain bioactive molecules that have the potential to benefit human health.
NATURAL PRODUCT RESEARCH
(2023)
Article
Chemistry, Applied
Luca Gammeri, Claudia Panzera, Fabrizio Calapai, Nicola Cicero, Sebastiano Gangemi
Summary: Chronic urticaria is a pathological condition characterized by wheals and angioedema lasting for more than six weeks. Treatment commonly involves antihistamines, but corticosteroids and monoclonal antibodies can also be used. Herbal medicine is an alternative approach, with some herbs possessing anti-inflammatory, anti-allergic, and antioxidant properties.
NATURAL PRODUCT RESEARCH
(2023)
Review
Biochemistry & Molecular Biology
Alessandro Allegra, Alessandro Tonacci, Laura Giordano, Caterina Musolino, Sebastiano Gangemi
Summary: Redox adaptation is crucial for human health, as abnormal oxidative stress can lead to biological injury. Treating diseases like leukemia requires consideration of changes in oxidative stress to inhibit tumor cell growth.
Review
Biochemistry & Molecular Biology
Giuseppe Murdaca, Francesca Paladin, Marco Casciaro, Carmelo Mario Vicario, Sebastiano Gangemi, Gabriella Martino
Summary: Inflammaging refers to a low degree of chronic and systemic tissue inflammation associated with aging, which is closely linked to pro-inflammatory mediators. Neuro-inflammaging occurs when inflammation and aging affect the brain. Inflammation plays a crucial role in the symptoms of psychopathological diseases by altering the metabolism of biogenic monoamines involved in their pathogenesis.
Review
Biochemistry & Molecular Biology
Francesco Borgia, Paolo Custurone, Federica Li Pomi, Mario Vaccaro, Clara Alessandrello, Sebastiano Gangemi
Summary: IL-37 and IL-33 are newly identified cytokines that play a role in various inflammatory conditions. This review aims to collect and organize data from multiple studies to establish a comprehensive understanding of their role. The studies assessed mainly focused on atopic dermatitis and immunologic pathways. The collective data suggests a pro-inflammatory role for IL-33 and an anti-inflammatory role for IL-37, potentially linked in an IL-33/IL-37 axis. Early results indicate that both cytokines may serve as markers of disease activity.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Alessandro Allegra, Giuseppe Murdaca, Luca Gammeri, Roberta Ettari, Sebastiano Gangemi
Summary: It is known that airway inflammation plays a crucial role in various respiratory diseases. This review focuses on the changes in respiratory diseases related to alarmins, such as HMGB1 and IL-33, and their relationships with genetic non-coding material like microRNAs. The role of these alarmins in certain pathophysiological processes confirms the existence of an axis composed of HMGB1 and IL-33, which are implicated in ferroptosis, type 2 inflammation, and airway alterations. Additionally, both factors can influence non-coding genetic material that affects respiratory function. Finally, the review outlines alarmins and RNA-based therapeutics proposed for the treatment of respiratory pathologies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Multidisciplinary Sciences
Roberto Plebani, Alessandra D'Alessandro, Paola Lanuti, Pasquale Simeone, Massimiliano Cinalli, Ilaria Righi, Alessandro Palleschi, Matteo Mucci, Marco Marchisio, Francesco Cappabianca, Marina Camera, Felice Mucilli, Mario Romano
Summary: The availability of cells isolated from healthy and diseased tissues and organs is crucial for personalized medicine. Biobanks provide a wide range of cells, but not all experimental needs are covered, especially those related to specific diseases or genotypes. Vascular endothelial cells (ECs) play a central role in various disorders, and obtaining specific EC types is essential for reliable experiments. This article illustrates simple procedures to obtain human macrovascular and microvascular endothelial cells, which can be cost-effective and independent of commercial sources.
JOVE-JOURNAL OF VISUALIZED EXPERIMENTS
(2023)
Review
Oncology
Alessandro Allegra, Claudia Petrarca, Mario Di Gioacchino, Giuseppe Mirabile, Sebastiano Gangemi
Summary: Early diagnosis of leukemia is crucial for effective treatment. DNA biosensors, specifically electrochemical biosensors, can help identify specific genetic alterations and improve diagnostic accuracy. This review evaluates the potential use of electrochemical biosensors in diagnosing hematological neoplasms, with a focus on leukemias.
Editorial Material
Biochemistry & Molecular Biology
Giuseppe Murdaca, Sebastiano Gangemi
Article
Medicine, Research & Experimental
Remo Poto, Vincenzo Patella, Gjada Criscuolo, Gianni Marone, Enrico Coscioni, Gilda Varricchi
Summary: Mast cells have complex functions in tissue homeostasis and disease. Cardiac mast cells express the high-affinity receptor for IgE and can be activated by anti-IgE. The presence of functional anti-IgE autoantibodies can strongly activate mast cells to release proinflammatory and vasoactive mediators.
CLINICAL AND EXPERIMENTAL MEDICINE
(2023)
