Article
Chemistry, Physical
Risa Fujita, Mai Yotsumoto, Yuta Yamaguchi, Muneyuki Matsuo, Koichi Fukuhara, Osamu Takahashi, Shinobu Nakanishi, Mitsuhiro Denda, Satoshi Nakata
Summary: The study found that odorants with an aromatic ring can form complexes with NE and be eliminated from the DOPC membrane, contributing to the masking effect on the DOPC-NE mixed monolayer.
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
(2022)
Article
Biotechnology & Applied Microbiology
Nabil Adrar, Fatemeh Bahadori, Fatma D. Ceylan, Gulacti Topcu, Fatiha Bedjou, Esra Capanoglu
Summary: Combination of different phospholipids in formulations resulted in interdigitated liposomes with good physical stability, showing minimal changes in size and PDI during storage.
JOURNAL OF CHEMICAL TECHNOLOGY AND BIOTECHNOLOGY
(2021)
Article
Materials Science, Biomaterials
Agata Ladniak, Malgorzata Jurak, Agnieszka E. Wiacek
Summary: The aim of this study was to investigate the effect of two polysaccharides and inorganic material on the membrane structure and behavior. The results showed that these substances had a slight impact on the structure of the membrane, but did not disrupt it.
BIOMATERIALS ADVANCES
(2022)
Article
Instruments & Instrumentation
Zhe Li, Xin Gao, Xinyang Yan, Yihui Deng, Haiying Ma
Summary: Injections of PEG-modified nanomedicines can result in an accelerated clearance, known as the accelerated blood clearance (ABC) phenomenon. Anti-PEG IgM plays a crucial role in inducing this phenomenon, but the addition of 1,2-distearoyl-snglycero-3-phosphoglycerol (DSPG) can inhibit the recognition and binding of anti-PEG IgM, thereby weakening the ABC phenomenon.
DRUG DELIVERY AND TRANSLATIONAL RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Monika L. Girase, Vrashabh V. Sugandhi, Pradum P. Ige, Prashant D. Jain, Sopan N. Nangare
Summary: This study designed a new nanoconjugate of paclitaxel, which significantly reduces drug toxicity and can be used for the treatment of lung cancer.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Biology
Guangyi Gao, Wenhang Zhou, Xuan Jiang, Jun Ma
Summary: FA-BSA-Au@PTX/CUR nanoparticles, modified by bovine serum albumin (BSA) and folic acid (FA) and loaded with paclitaxel (PTX) and curcumin (CUR), were successfully prepared. The nanoparticles exhibited good stability and spherical morphology. They specifically targeted EC cancer cells and exerted inhibitory effects on proliferation, while showing no obvious toxicity on healthy cells. Moreover, compared with X-rays alone, the nanoparticles combined with X-rays demonstrated stronger radiotherapy sensitization and anti-tumor activity.
INTERNATIONAL JOURNAL OF RADIATION BIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Wisnu Arfian A. Sudjarwo, Jose L. Toca-Herrera
Summary: This study examines the hysteresis phenomenon in DPPC monolayers, focusing on the impact of various variables on key indicators such as the pi-A isotherm curve and compression modulus. The findings reveal that these factors significantly influence the structural and dynamic properties of the monolayers, with the hysteresis loop providing valuable insights into their viscoelasticity and phase transition changes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Chemistry, Physical
Alicja Sek, Paulina Perczyk, Aleksandra Szczes, Pawel Wydro
Summary: The influence of different surfactants (DTAB, TTAB, CTAB, SDS) on mixed DPPC/cholesterol layers was investigated. The study found that even tiny amounts of surfactants can significantly alter the zeta potential of cholesterol-containing liposomes, with a greater effect observed for anionic surfactants. The surfactant effect increased with increasing concentration and carbon chain length. Langmuir monolayer studies provided additional evidence of surfactant interactions with membrane lipids. The presence of cholesterol molecules favored the penetration of DTAB and SDS surfactants in DPPC layers.
JOURNAL OF MOLECULAR LIQUIDS
(2022)
Article
Spectroscopy
Yu Zaytseva, N. Surovtsev
Summary: The use of deuterocarbons is an effective method in Raman spectroscopy for studying multicomponent lipid materials and biological samples. This study investigated the Raman spectra of hydrated multilamellar vesicles and mixtures of certain lipids to identify the indicators of conformational and lateral orders. The results showed that the intensity ratio of specific peaks can be used to evaluate the conformational order of the lipid chains, and the lateral order can enhance the effect of conformational ordering.
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2022)
Article
Chemistry, Applied
Daniel Zuniga-Nunez, Francisco Mura, Nory Marino-Ocampo, Patricio Briones-Rebolledo, Horacio Poblete, Jean-Maurice Mallet, Denis Fuentealba, Alexis Aspee
Summary: A fluorescent probe C-DMPE was synthesized to monitor interfacial membrane properties. The probe showed shorter fluorescence lifetimes and rotational correlation times in mixed vesicles containing DPPC and DOPC, indicating favorable sensing of lipid domain boundaries.
Article
Chemistry, Applied
Ryo Ishiguro, Keiichi Kameyama
Summary: In this study, the evolution of solid-supported lipid bilayers was investigated by studying the phase equilibrium between the supported assembly phase and the ambient solution system. The properties of the supported assembly were found to depend on the composition of the dispersed assembly and the concentration of monomerically dissolved surfactant. Additionally, a transition from micellar to bilayer state was observed in the supported assembly, which was roughly synchronized with the transition in the dispersed assembly.
JOURNAL OF OLEO SCIENCE
(2022)
Article
Chemistry, Medicinal
Noriyuki Uchida, Masayoshi Yanagi, Hiroki Hamada
Summary: The mixture of DPPC phospholipid and sodium chelate formed bicelles at around 50 degrees C. Quadrupole splitting of D2O, an index of the ability to orient molecules, was observed in the H-2 nuclear magnetic resonance measurement of the dispersion of DPPC-SC bicelle.
NATURAL PRODUCT COMMUNICATIONS
(2022)
Article
Chemistry, Multidisciplinary
Dong Han, Baolin Zhang, Jianghui Dong, Boning Yang, Yuntao Peng, Junfeng Wang, Liping Wang
Summary: DMPC-modified SPIONs have advantages in faster transport to the brain and easier cellular uptake, with potential applications in drug delivery and activation of neuronal membrane channels.
Article
Chemistry, Multidisciplinary
Jinju Jeong, Chul Kim
Summary: The study investigated the flip-flop movement using dithionite assay of NBD-PE fluorescence in vesicles with varying DMPC/DHPC ratios. Results showed that adding DHPC increased activation energy, but changes in thermodynamic functions did not exhibit a consistent trend, indicating DHPC promoted the flip-flop movement of NBD-PE.
BULLETIN OF THE KOREAN CHEMICAL SOCIETY
(2021)
Article
Chemistry, Multidisciplinary
Wouter J. M. Lokerse, Artur Lazarian, Alisa Kleinhempel, Matteo Petrini, Patricia Schwarz, Martin Hossann, Lesca M. Holdt, Volker Mailaender, Lars H. Lindner
Summary: Various thermosensitive liposome formulations have been described, and it remains unclear which is optimal for solid tumor treatment. Most liposomes achieve sufficient circulation half-life through polyethylene glycol surface modification, while DPPG(2) has been identified as a promising alternative. In vitro and in vivo studies suggest that higher mol% DPPG(2) increases Apolipoprotein E adsorption, decreases complement activation, and does not exhibit accelerated blood clearance, potentially offering advantages over PEG-TSL. Additionally, low complement activation for 20-30 mol% DPPG(2)-TSL presents a unique attribute for clinical evaluation.
JOURNAL OF CONTROLLED RELEASE
(2021)
Article
Cell Biology
Mingyu Pan, Yue Yin, Tongyu Hu, Xinxia Wang, Tian Jia, Jing Sun, Quanyi Wang, Wei Meng, Juanjuan Zhu, Chunsun Dai, Haiyang Hu, Chen Wang
Summary: This study identifies the important role of UXT in regulating the autophagic degradation of STING1, which helps prevent excessive activation of STING1-mediated type I interferon signaling. The findings from experimental models and SLE patients suggest that UXT could be a potential therapeutic target for treating autoimmune diseases.
Article
Cell Biology
Hao Chen, Chunlin Li, Haiyang Hu, Bin Zhang
Summary: This study demonstrates that activating TRPA1 in glioma cells leads to mitochondrial damage and dysfunction, ultimately resulting in apoptosis, which may decrease TMZ resistance in GBM cells.
BMC MOLECULAR AND CELL BIOLOGY
(2022)
Article
Pharmacology & Pharmacy
Chengcheng Wang, Jiao Wang, Xue Pan, Shuang Yu, Meiqi Chen, Yan Gao, Zilin Song, Haiyang Hu, Xiuli Zhao, Dawei Chen, Fei Han, Mingxi Qiao
Summary: Ferroptosis is a potential strategy to overcome cancer chemotherapy resistance, but cancer cells can develop resistance to ferroptosis through antioxidative defense mechanisms. In this study, a BSO-loaded metal organic framework (BMH) was prepared to enhance oxidative damage and inhibit antioxidative defense. The results showed that BMH restored the susceptibility of cancer cells to ferroptosis under irradiation and exhibited superior anti-tumor performance in vivo.
ASIAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2023)
Article
Multidisciplinary Sciences
Yiqun Huang, Lingyu Wen, Lige Zhang, Jijun Xu, Weiwei Wang, Haiyang Hu, Ping Xu, Zhao Li, Hongzhi Tang
Summary: This study investigated the microbial community composition and potential organohalide dehalogenation bacteria (OHDBs) in industrial saponification wastewater using 16S rRNA sequencing and metagenomic sequencing. The study found that the dominant microbial phyla in the wastewater were Proteobacteria and Patescibacteria, and identified six bacterial groups as biomarkers for organohalide removal. A total of 105 hydrolytic dehalogenase genes were also identified in 42 reconstructed metagenomes, indicating the potential for organohalide hydrolytic dehalogenation in the microbial community. Additionally, the study characterized the dehalogenation activities of an isolated OHDB, Microbacterium sp. J1-1.
Article
Chemistry, Multidisciplinary
Ming Zhao, Ji Li, Fan Chen, Yanyan Han, Dawei Chen, Haiyang Hu
Summary: Engineering nanoparticles (P-aCD24/CEL + P/shMFN1) were designed to deliver anti-CD24 monoclonal antibody (aCD24), celastrol (CEL), and mitofusin 1 shRNA (shMFN1) for the treatment of triple-negative breast cancer (TNBC), aiming to overcome the lack of tumor immunogenicity and the strong immunosuppressive tumor microenvironment (ITM) and improve therapeutic efficacy.
JOURNAL OF CONTROLLED RELEASE
(2023)
Article
Chemistry, Multidisciplinary
Min Liu, Siyi Liu, Lin Liu, Jingya Xiu, Tian Zhang, Dawei Chen, Mingxi Qiao, Haiyang Hu, Jiulong Zhang, Xiuli Zhao
Summary: Rheumatoid arthritis (RA) is characterized by inflammation outbreak and joint destruction. Neutrophils play a crucial role in RA by releasing excess neutrophil extracellular traps (NETs), but preventing NETs formation is still challenging. In this study, a method using sivelestat-conjugated bovine serum albumin nanoparticles (BTST NPs) was established to selectively inhibit neutrophil elastase (NE) and prevent NETs production. Additionally, the BTST NPs were loaded with dexamethasone palmitate (DP) for synergistic treatment of RA. The results showed that DP/BTST NPs could effectively target inflamed neutrophils, hinder NETs generation, and improve RA symptoms.
Article
Biochemistry & Molecular Biology
Yang Tian, Ning Wan, Hanqing Zhang, Chang Shao, Ming Ding, Qiuyu Bao, Haiyang Hu, Huiyong Sun, Chenguang Liu, Kun Zhou, Shuai Chen, Guangji Wang, Hui Ye, Haiping Hao
Summary: Hyperactivated glycolysis is a metabolic characteristic of cancer cells, and glycolytic metabolites have nonmetabolic functions as signaling molecules. However, how these metabolites interact with their targets remains unclear. This study introduces a new approach called TRAP to identify target candidates and interactions of glycolytic metabolites in cancer cells, revealing diverse regulatory modalities and potential for cancer therapy.
NATURE CHEMICAL BIOLOGY
(2023)
Article
Multidisciplinary Sciences
Ling Lei, Hong Pan, Hai-Yang Hu, Xian-Wei Fan, Zhen-Bo Wu, You-Zhi Li
Summary: It was found that overexpression of the ZmPMP3g gene in transgenic maize lines enhanced drought tolerance by improving root growth, increasing antioxidant capacity, maintaining membrane lipid integrity, and regulating intracellular osmotic pressure. Additionally, ZmPMP3g overexpression affected the balance of ABA-GA1-GA3, resulting in increased drought tolerance. These findings provide insights into the mechanisms underlying maize drought tolerance and suggest a potential strategy for improving crop resilience to abiotic stresses.
SCIENTIFIC REPORTS
(2023)
Article
Agronomy
Mingsheng Pan, Hengtong Wang, Shiqi Hu, Jian Cai, Qin Zhou, Tingbo Dai, Weixing Cao, Dong Jiang, Yingxin Zhong
Summary: This study investigated the effects of spraying different combinations of exogenous regulators on the breadmaking quality of flour. Three spraying schemes were screened out to improve protein contents and yield in the flour. The amounts of different proteins in the flour were increased, and bread volume was also increased. The M treatment showed superior gluten quality and breadmaking quality in comparison to G and C treatments.
ARCHIVES OF AGRONOMY AND SOIL SCIENCE
(2023)
Article
Biotechnology & Applied Microbiology
Chaojun Wang, Haiyang Hu, Jiajia Shi, Linxia Chen, Lixin Wang, Zhihua Bao
Summary: In this study, a halotolerant bacterium Halomonas sp. 3H was isolated from a eutrophic saline lake sediment, which could remove ammonium nitrogen and nitrate/nitrite nitrogen via aerobic denitrification in high-salinity wastewater and reduce the production of greenhouse gas N2O. The strain could also remove added N2O with the further addition of Cu2+, showing its potential to mitigate complex and significant climate changes.
ENVIRONMENTAL TECHNOLOGY & INNOVATION
(2023)
Article
Cell Biology
Mingyu Pan, Tongyu Hu, Jiao Lyu, Yue Yin, Jing Sun, Quanyi Wang, Lingxiao Xu, Haiyang Hu, Chen Wang
Summary: CSNK1A1 plays a key role in the autophagic degradation of STING1 to maintain immune homeostasis. Activating CSNK1A1 can effectively suppress the production of type I interferons mediated by STING1 in autoimmune diseases.
Review
Biotechnology & Applied Microbiology
Yiqun Huang, Haiyang Hu, Tingting Zhang, Weiwei Wang, Wenzhao Liu, Hongzhi Tang
Summary: Human activities have caused the release of environmental pollutants, leading to ecological challenges. However, the majority of genes and microorganisms in these contaminated environments remain uncharacterized and uncultured. The emergence of meta-omics has provided a culture-independent approach to explore functional genes and microorganisms in complex microbial communities. This review highlights the applications and methodologies of meta-omics in uncovering genes and microbes from contaminated environments, which may contribute to future bioremediation research.
ENGINEERING IN LIFE SCIENCES
(2023)
Article
Optics
Ning Xi, Jiaxun Ye, Chao Ping Chen, Qiang Chu, Haiyang Hu, Seak Pang Zou
Summary: We propose an implantable metaverse with retinal prostheses that work in tandem with bionic vision processing. Our approach differs from conventional retinal prostheses by rearranging electrodes to match the distribution of ganglion cells. To emulate human vision, we develop a scheme for bionic vision processing that visualizes monocular image, binocular image fusion, and parallax-induced depth map on a three-dimensional eye model.
Correction
Engineering, Biomedical
Wei Hong, Dawei Chen, Xiaojun Zhang, Jianfu Zeng, Haiyang Hu, Xiuli Zhao, Mingxi Qiao
Article
Materials Science, Biomaterials
Xiaoyan Sun, Jiulong Zhang, Jingya Xiu, Xiufeng Zhao, Chunrong Yang, Dan Li, Kexin Li, Haiyang Hu, Mingxi Qiao, Dawei Chen, Xiuli Zhao
Summary: A phenolic-based tumor-permeated nano-framework (EGPt-NF) was developed to improve tumor immunogenicity and enhance the efficacy of cancer immunotherapy. This approach induces immunogenic cell death, downregulates PD-L1 expression, and relieves tumor hypoxia, resulting in an increased antitumor immune response and inhibition of primary tumor and metastasis.
BIOMATERIALS SCIENCE
(2022)
Article
Pharmacology & Pharmacy
Greta Camilla Magnano, Marika Quadri, Elisabetta Palazzo, Roberta Lotti, Francesca Loschi, Stefano Dall'Acqua, Michela Abrami, Francesca Larese Filon, Alessandra Marconi, Dritan Hasa
Summary: This study aimed to investigate the loading of sildenafil citrate in three commercial transdermal vehicles using 3D full-thickness skin equivalent and compare the results with permeability experiments using porcine skin. The results showed that the results obtained using the 3D skin equivalent were comparable to those obtained using porcine skin, suggesting that the 3D skin model can be a valid alternative for ex-vivo skin absorption experiments.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2024)
Article
Pharmacology & Pharmacy
James W. Mckeage, Andrew Z. H. Tan, Andrew J. Taberner
Summary: Needle-free jet injection is a promising alternative drug delivery technique that offers rapid, non-invasive, and large-volume injections. The study presents a prototype multi-orifice nozzle and a computational fluid dynamic model to demonstrate the feasibility and effectiveness of this technology.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2024)
