Article
Oncology
Xu Cao, Bolei Li, Jing Chen, Jessica Dang, Siqi Chen, E. Gulsen Gunes, Bo Xu, Lei Tian, Sabina Muend, Mustafa Raoof, Christiane Querfeld, Jianhua Yu, Steven T. Rosen, Yingyu Wang, Mingye Feng
Summary: The study found that blocking CD47 and using cabazitaxel can significantly promote the programmed cell removal of TNBC cells, inhibiting tumor development and metastasis, providing a promising new strategy for TNBC treatment.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2021)
Article
Immunology
Jing Chen, Xu Cao, Bolei Li, Zhangchen Zhao, Siqi Chen, Seigmund W. T. Lai, Sabina A. Muend, Gianna K. Nossa, Lei Wang, Weihua Guo, Jian Ye, Peter P. Lee, Mingye Feng
Summary: Research has shown that cancer cells evade macrophage-mediated phagocytosis through extracellular acidification, a mechanism independent of CD47. Targeting V-ATPase can reverse this acidic microenvironment, inhibiting tumor growth and metastasis. In addition, blockade of extracellular acidification enhances cell surface exposure of CD71, promoting cancer cell phagocytosis.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Genetics & Heredity
Chiao-Yun Lin, Chia-Lung Tsai, Angel Chao, Li-Yu Lee, Wei-Chun Chen, Yun-Hsin Tang, An-Shine Chao, Chyong-Huey Lai
Summary: Despite recent therapeutic breakthroughs, advanced and/or recurrent endometrial cancer remains a significant health burden globally. Our study suggests that NPM/B23-induced CD24 expression in endometrial cancer cells plays a role in immune evasion by inhibiting macrophage-mediated phagocytosis. CD24 may serve as a novel target for endometrial cancer immunotherapy.
JOURNAL OF MOLECULAR MEDICINE-JMM
(2021)
Article
Oncology
Kirti Kaul, Swati Misri, Bhuvaneswari Ramaswamy, Ramesh K. Ganju
Summary: The complex mechanisms linking obesity and aggressive triple negative breast cancer pose a challenge in establishing causative role of obesity in risk of TNBC. Understanding the pathological mechanisms could pave the way for personalized therapies against TNBC progression.
Article
Oncology
Kai Huang, Wenwu Luo, Jinmei Fang, Changjun Yu, Guangjie Liu, Xiaodong Yuan, Yun Liu, Wenyong Wu
Summary: Our study found that Notch3 is highly expressed in colon tumor tissues and regulates the infiltration of macrophages. The expression of Notch3 is positively correlated with macrophage recruitment-related cytokines in colon tumor tissues. Depletion of Notch3 attenuated colon cancer tumor growth and reduced infiltration of immunosuppressive cells in the tumor microenvironment.
Review
Biochemistry & Molecular Biology
Yang Liu, Yueting Hu, Jinqi Xue, Jingying Li, Jiang Yi, Jiawen Bu, Zhenyong Zhang, Peng Qiu, Xi Gu
Summary: Immunotherapy has emerged as a promising strategy for treating triple-negative breast cancer (TNBC), which stimulates the immune system to kill tumor cells and offers new hope for patients. Breakthroughs in immune checkpoint inhibitors (ICIs) have led to individualized immunotherapy schedules and the combination with other treatment methods to overcome drug resistance.
Article
Biochemistry & Molecular Biology
Jimena Alvarez Freile, Natasha Ustyanovska Avtenyuk, Macarena Gonzalez Corrales, Harm Jan Lourens, Gerwin Huls, Tom van Meerten, Ewa Cendrowicz, Edwin Bremer
Summary: This study investigates the expression and therapeutic effects of CD24 and CD47, two immune checkpoints, in B-cell lymphoma. The results show that CD24 is associated with poor survival in MCL patients, while CD47 is associated with survival in DLBCL patients. CD24 antibody treatment exhibits potent phagocytic effects in MCL, but not in DLBCL.
Review
Biochemistry & Molecular Biology
Pengfei Xu, Logan J. Wasielewski, Joy C. Yang, Demin Cai, Christopher P. Evans, William J. Murphy, Chengfei Liu
Summary: Prostate cancer is a common malignant tumor in men that currently has limited treatment options. Immunotherapy, especially with immune checkpoint inhibitors, brings hope for the treatment of this type of cancer. However, the tumor's immune evasion poses a challenge. Understanding the molecular mechanisms of immune evasion will help develop more effective treatments.
Review
Immunology
Yiwen Zheng, Shujin Li, Hongchao Tang, Xuli Meng, Qinghui Zheng
Summary: The emergence of immunotherapy has revolutionized the treatment of triple-negative breast cancer (TNBC). However, the heterogeneity of TNBC leads to varying efficacy of immunotherapy, with only certain patients benefiting from it. This article focuses on the mechanisms of immune response and summarizes the immune evasion mechanisms in TNBC, including loss of tumor-specific antigen, antigen presentation deficiency, and failure to initiate an immune response. Moreover, the aberrant activation of immune-critical signaling pathways contributes to an immunosuppressive tumor microenvironment. The review aims to elucidate the molecular mechanisms of drug resistance in TNBC, identify potential targets to reverse drug resistance, and lay a foundation for biomarker research to predict immune efficacy and select breast cancer populations for immunotherapy.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Oncology
Si-Yu Wu, Yi Xiao, Jin-Li Wei, Xiao-En Xu, Xi Jin, Xin Hu, Da-Qiang Li, Yi-Zhou Jiang, Zhi-Ming Shao
Summary: This study identified two distinct microenvironment phenotypes, 'inflamed' and 'non-inflamed', within the classic basal-like subtype of TNBC, and revealed that MYC amplification and overexpression led to the formation of the non-inflamed TIME. Combination therapy with a DNA methyltransferase inhibitor and immunotherapy reversed T cell exhaustion and improved T cell function, resulting in potent antitumor activity in MYC-overexpressing TNBC.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2021)
Article
Health Care Sciences & Services
Yiqun Han, Jiayu Wang, Binghe Xu
Summary: By analyzing the gene expression of 592 patients with triple-negative breast cancer, researchers were able to curate a gene signature for cytotoxic lymphocytes (CLs) and explore the heterogeneity based on this CL-related (CLR) gene signature. The CLR signature was associated with tumor size and patients in the CLR-low group had worse overall survival. In addition, the CLR signature was also associated with immune characteristics, tumor shrinkage, and survival outcomes following cancer immunotherapy, as well as prognostic heterogeneity across different malignancies.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Article
Oncology
Ran Ding, Yuhan Wang, Jinyan Fan, Ziyue Tian, Shuang Wang, Xiujuan Qin, Wei Su, Yanbo Wang
Summary: This study analyzed RNA-seq data from 303 TNBC samples and identified a significant T cell depletion signature in the TNBC tumor microenvironment. It also found that some TNBC patients exhibit an immunosuppressive state and have a poor prognosis and resistance to ICB treatment. These findings can be used to construct prognostic models and study the immune mechanisms within the tumor microenvironment.
FRONTIERS IN ONCOLOGY
(2023)
Article
Immunology
Shengnan Sha, Luyi Si, Xinrui Wu, Yuanbiao Chen, Hui Xiong, Ying Xu, Wangrui Liu, Haijun Mei, Tao Wang, Mei Li
Summary: This study investigates the potential role of cuproptosis-related genes (CRGs) in the tumor microenvironment (TME) of triple-negative breast cancer (TNBC). The results show that CRGs are closely associated with tumor immunity in TNBC and can be used to evaluate tumor immune cell infiltration, clinical features, and prognosis. This research provides new directions for the development of novel drugs in the future.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Jun-Long Liang, Xiao-Kang Jin, Guo-Feng Luo, Shi-Man Zhang, Qian-Xiao Huang, Yan-Tong Lin, Xin-Chen Deng, Jia-Wei Wang, Wei-Hai Chen, Xian-Zheng Zhang
Summary: Researchers successfully designed a hydrogel called TCCaGM, which enhanced macrophage-mediated phagocytosis through the encapsulation of GM-CSF and TCCaN. The hydrogel also improved the tumor microenvironment and accelerated the polarization of tumor-associated macrophages, leading to enhanced antitumor immune responses.
Article
Oncology
Cong Li, Shi Qiu, Kun Jin, Xiaonan Zheng, Xianghong Zhou, Di Jin, Binghe Xu, Xun Jin
Summary: The study revealed that tumor cells in triple-negative breast cancer can release microparticles loaded with PD-L1, leading to tumor progression. These PD-L1-loaded microparticles can suppress the activation and function of immune cells through various mechanisms.
Article
Cell Biology
Mingyu Pan, Yue Yin, Tongyu Hu, Xinxia Wang, Tian Jia, Jing Sun, Quanyi Wang, Wei Meng, Juanjuan Zhu, Chunsun Dai, Haiyang Hu, Chen Wang
Summary: This study identifies the important role of UXT in regulating the autophagic degradation of STING1, which helps prevent excessive activation of STING1-mediated type I interferon signaling. The findings from experimental models and SLE patients suggest that UXT could be a potential therapeutic target for treating autoimmune diseases.
Article
Pharmacology & Pharmacy
Jiulong Zhang, Xiaoyan Sun, Xiufeng Zhao, Chunrong Yang, Menghao Shi, Benzhuo Zhang, Haiyang Hu, Mingxi Qiao, Dawei Chen, Xiuli Zhao
Summary: A versatile ICD amplifier was developed to enhance tumor immunotherapy by amplifying the eat me signal during tumor immunogenic cell death cascade. The amplifier enables chemotherapy-sensitized immuno-therapy and activates immune response against tumors.
ACTA PHARMACEUTICA SINICA B
(2022)
Article
Engineering, Biomedical
Menghao Shi, Jiulong Zhang, Yu Wang, Yanyan Han, Xiuli Zhao, Haiyang Hu, Mingxi Qiao, Dawei Chen
Summary: This study successfully engineered acidity-triggered nanoparticles to enhance tumor immunotherapy. The nanoparticles improved tumor penetration and cellular uptake, and released anti-tumor drugs and siRNA to activate the immune response for better anti-tumor capability.
ACTA BIOMATERIALIA
(2022)
Article
Materials Science, Multidisciplinary
Jiulong Zhang, Xiaoyan Sun, Lin Liu, Xiufeng Zhao, Chunrong Yang, Kexin Li, Haiyang Hu, Mingxi Qiao, Dawei Chen, Xiuli Zhao
Summary: Increasing extracellular ATP can amplify immunogenic cell death cascade for cancer immunotherapy, but its intra-tumoral delivery is challenging due to the enzyme environment and tumor immunosuppressive microenvironment. To overcome these limitations, researchers have developed a tumor-permeated ATP-based immunogenic cell death amplifier.
APPLIED MATERIALS TODAY
(2022)
Article
Pharmacology & Pharmacy
Chengcheng Wang, Jiao Wang, Xue Pan, Shuang Yu, Meiqi Chen, Yan Gao, Zilin Song, Haiyang Hu, Xiuli Zhao, Dawei Chen, Fei Han, Mingxi Qiao
Summary: Ferroptosis is a potential strategy to overcome cancer chemotherapy resistance, but cancer cells can develop resistance to ferroptosis through antioxidative defense mechanisms. In this study, a BSO-loaded metal organic framework (BMH) was prepared to enhance oxidative damage and inhibit antioxidative defense. The results showed that BMH restored the susceptibility of cancer cells to ferroptosis under irradiation and exhibited superior anti-tumor performance in vivo.
ASIAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2023)
Article
Multidisciplinary Sciences
Yiqun Huang, Lingyu Wen, Lige Zhang, Jijun Xu, Weiwei Wang, Haiyang Hu, Ping Xu, Zhao Li, Hongzhi Tang
Summary: This study investigated the microbial community composition and potential organohalide dehalogenation bacteria (OHDBs) in industrial saponification wastewater using 16S rRNA sequencing and metagenomic sequencing. The study found that the dominant microbial phyla in the wastewater were Proteobacteria and Patescibacteria, and identified six bacterial groups as biomarkers for organohalide removal. A total of 105 hydrolytic dehalogenase genes were also identified in 42 reconstructed metagenomes, indicating the potential for organohalide hydrolytic dehalogenation in the microbial community. Additionally, the study characterized the dehalogenation activities of an isolated OHDB, Microbacterium sp. J1-1.
Article
Chemistry, Multidisciplinary
Min Liu, Siyi Liu, Lin Liu, Jingya Xiu, Tian Zhang, Dawei Chen, Mingxi Qiao, Haiyang Hu, Jiulong Zhang, Xiuli Zhao
Summary: Rheumatoid arthritis (RA) is characterized by inflammation outbreak and joint destruction. Neutrophils play a crucial role in RA by releasing excess neutrophil extracellular traps (NETs), but preventing NETs formation is still challenging. In this study, a method using sivelestat-conjugated bovine serum albumin nanoparticles (BTST NPs) was established to selectively inhibit neutrophil elastase (NE) and prevent NETs production. Additionally, the BTST NPs were loaded with dexamethasone palmitate (DP) for synergistic treatment of RA. The results showed that DP/BTST NPs could effectively target inflamed neutrophils, hinder NETs generation, and improve RA symptoms.
Article
Biochemistry & Molecular Biology
Yang Tian, Ning Wan, Hanqing Zhang, Chang Shao, Ming Ding, Qiuyu Bao, Haiyang Hu, Huiyong Sun, Chenguang Liu, Kun Zhou, Shuai Chen, Guangji Wang, Hui Ye, Haiping Hao
Summary: Hyperactivated glycolysis is a metabolic characteristic of cancer cells, and glycolytic metabolites have nonmetabolic functions as signaling molecules. However, how these metabolites interact with their targets remains unclear. This study introduces a new approach called TRAP to identify target candidates and interactions of glycolytic metabolites in cancer cells, revealing diverse regulatory modalities and potential for cancer therapy.
NATURE CHEMICAL BIOLOGY
(2023)
Article
Multidisciplinary Sciences
Ling Lei, Hong Pan, Hai-Yang Hu, Xian-Wei Fan, Zhen-Bo Wu, You-Zhi Li
Summary: It was found that overexpression of the ZmPMP3g gene in transgenic maize lines enhanced drought tolerance by improving root growth, increasing antioxidant capacity, maintaining membrane lipid integrity, and regulating intracellular osmotic pressure. Additionally, ZmPMP3g overexpression affected the balance of ABA-GA1-GA3, resulting in increased drought tolerance. These findings provide insights into the mechanisms underlying maize drought tolerance and suggest a potential strategy for improving crop resilience to abiotic stresses.
SCIENTIFIC REPORTS
(2023)
Article
Agronomy
Mingsheng Pan, Hengtong Wang, Shiqi Hu, Jian Cai, Qin Zhou, Tingbo Dai, Weixing Cao, Dong Jiang, Yingxin Zhong
Summary: This study investigated the effects of spraying different combinations of exogenous regulators on the breadmaking quality of flour. Three spraying schemes were screened out to improve protein contents and yield in the flour. The amounts of different proteins in the flour were increased, and bread volume was also increased. The M treatment showed superior gluten quality and breadmaking quality in comparison to G and C treatments.
ARCHIVES OF AGRONOMY AND SOIL SCIENCE
(2023)
Article
Biotechnology & Applied Microbiology
Chaojun Wang, Haiyang Hu, Jiajia Shi, Linxia Chen, Lixin Wang, Zhihua Bao
Summary: In this study, a halotolerant bacterium Halomonas sp. 3H was isolated from a eutrophic saline lake sediment, which could remove ammonium nitrogen and nitrate/nitrite nitrogen via aerobic denitrification in high-salinity wastewater and reduce the production of greenhouse gas N2O. The strain could also remove added N2O with the further addition of Cu2+, showing its potential to mitigate complex and significant climate changes.
ENVIRONMENTAL TECHNOLOGY & INNOVATION
(2023)
Article
Cell Biology
Mingyu Pan, Tongyu Hu, Jiao Lyu, Yue Yin, Jing Sun, Quanyi Wang, Lingxiao Xu, Haiyang Hu, Chen Wang
Summary: CSNK1A1 plays a key role in the autophagic degradation of STING1 to maintain immune homeostasis. Activating CSNK1A1 can effectively suppress the production of type I interferons mediated by STING1 in autoimmune diseases.
Review
Biotechnology & Applied Microbiology
Yiqun Huang, Haiyang Hu, Tingting Zhang, Weiwei Wang, Wenzhao Liu, Hongzhi Tang
Summary: Human activities have caused the release of environmental pollutants, leading to ecological challenges. However, the majority of genes and microorganisms in these contaminated environments remain uncharacterized and uncultured. The emergence of meta-omics has provided a culture-independent approach to explore functional genes and microorganisms in complex microbial communities. This review highlights the applications and methodologies of meta-omics in uncovering genes and microbes from contaminated environments, which may contribute to future bioremediation research.
ENGINEERING IN LIFE SCIENCES
(2023)
Article
Optics
Ning Xi, Jiaxun Ye, Chao Ping Chen, Qiang Chu, Haiyang Hu, Seak Pang Zou
Summary: We propose an implantable metaverse with retinal prostheses that work in tandem with bionic vision processing. Our approach differs from conventional retinal prostheses by rearranging electrodes to match the distribution of ganglion cells. To emulate human vision, we develop a scheme for bionic vision processing that visualizes monocular image, binocular image fusion, and parallax-induced depth map on a three-dimensional eye model.
Review
Chemistry, Multidisciplinary
Zhiyuan Shi, Yong Hu, Xin Li
Summary: Controlled drug delivery systems that can respond to mechanical force offer a unique solution for on-demand drug activation and release. Among various mechanical stimuli, ultrasound (US) has advantages in achieving spatiotemporally controlled drug release. Traditional US-triggered drug release relies on heat-induced phase transitions or chemical transformations, while the cutting-edge approach of Sonopharmacology leverages polymer mechanochemistry. The remaining challenges and potential future directions in this field are also discussed.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Lijie Zheng, Yuanzheng Chen, Xun Gu, Yingying Li, Hanqing Zhao, Wenjun Shao, Tao Ma, Chuanbin Wu, Qingqing Wang
Summary: In this study, a novel dosage form consisting of dissolving microneedles and an adhesive transdermal patch was developed for the treatment of rheumatoid arthritis. In vitro and in vivo experiments demonstrated that the combination of drugs delivered by this dosage form effectively reduced joint inflammation and damage.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Kyungjik Yang, Hwa Seung Han, Seung Hwan An, Kyung Hoon Park, Keonwook Nam, Shinha Hwang, Yuyeon Lee, Sung Yeon Cho, Taehyung Kim, Deokyeong Choe, Sang Won Kim, Wonkyu Yu, Hyunah Lee, Jiyong Park, Sangguan You, Dong- Gyu Jo, Ki Young Choi, Young Hoon Roh, Jae Hyung Park
Summary: This study developed CP-loaded CS microcapsules to enhance the oral bioavailability of CP through controlled gastrointestinal delivery. The optimized microcapsules exhibited desirable physicochemical properties, showed anti-photoaging effects via antioxidant activity, and achieved controlled release in the gastrointestinal tract. This research provides a simple and economical approach for enhancing the oral bioavailability of CP for customized bioactive compound administration.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Huiyang Li, Shuo Liu, Wenjin Dai, Bingmei Yao, Yong Zhou, Sujia Si, Hairong Yu, Riguang Zhao, Fang Jin, Liqun Jiang
Summary: Changes in bodily fluid pressures are crucial in diseases like high-altitude pulmonary edema (HAPE). Researchers have developed hydrostatic pressure-sensitive multivesicular liposomes (PSMVLs) that can release drugs in response to pressure changes, with potential applications in HAPE treatment. Animal experiments showed that this system provides better protection for lung tissues and respiratory function, reducing the occurrence of pulmonary edema.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Qian Hu, Hongbing Lan, Yinmei Tian, Xiaonan Li, Mengmeng Wang, Jiao Zhang, Yulin Yu, Wei Chen, Li Kong, Yuanyuan Guo, Zhiping Zhang
Summary: Coacervate droplets formed through liquid-liquid phase separation have potential as delivery vesicles for therapeutics. However, their lack of physiological stability and membranes are challenges. In this study, polylysine-polynucleotide complex coacervate droplets with favorable stability were formulated to concentrate molecules and nanoparticles. Phospholipid membranes were further coated on the droplets to create coacervate-based artificial protocells (ArtPC) with membrane-like structures. These biofunctional ArtPC effectively reduced blood uric acid levels and prevented renal injuries.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Xiaowei Wang, Hongwei Lu, Fang Luo, Dan Wang, Apeng Wang, Xuelei Wang, Wenkai Feng, Xiaobo Wang, Jiayi Su, Mingliang Liu, Guimin Xia
Summary: Four novel lipid-like GEM diesters were synthesized and encapsulated into liposomes to improve the antitumor efficacy of Gemcitabine. The liposomes loaded with dimyristoyl GEM (LipodmGEM) showed enhanced cellular uptake, improved inhibition of cell migration, and a greatly extended half-life compared to free Gemcitabine. LipodmGEM successfully enriched the drug in the tumor and exhibited excellent anticancer efficacy in vivo with negligible systemic toxicity.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Pengyu Li, Jieyi Pan, Yating Dong, Yingying Sun, Yalong Wang, Kang Liao, Yili Chen, Xin Deng, Shihui Yu, Haiyan Hu
Summary: Chronic pulmonary infection caused by Pseudomonas aeruginosa is a serious public health problem with high mortality rates. In this study, infection-microenvironment responsive nanoparticles were developed to eradicate biofilms and inhibit virulence. These nanoparticles showed promising results in treating chronic pulmonary infections.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Yajing Sun, Ze Lu, John A. Taylor, Jessie L. S. Au
Summary: A recent development in cancer chemotherapy is the use of cytotoxics to induce tumor-specific immune response through immunogenic cell death (ICD). This study describes a method that utilizes immunostaining and machine-learning to identify cells with ecto-CRT in intact 3-dimensional tissues. The method was successfully applied to study drug-induced ICD in human bladder cancer.
JOURNAL OF CONTROLLED RELEASE
(2024)
Review
Chemistry, Multidisciplinary
Rafat Ali, Shantanu Sen, Rohil Hameed, Aamir Nazir, Sandeep Verma
Summary: This review provides a focused overview of emerging strategies for delivering gasotransmitters in a controlled and sustained manner to reestablish neurophysiological homeostasis.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Jing Chen, Xinyi Zhang, Jinshen Zhang, Zhaoxia Wang, Guilan Zhu, Ming Geng, Jinmiao Zhu, Yajun Chen, Wei Wang, Youcui Xu
Summary: In this study, a multifunctional responsive hydrogel system was developed for synergistic reoxygenation and chemo/photothermal therapy. The hydrogel system showed both therapeutic effects against metastatic breast cancer and wound infection, making it a promising strategy for treating and preventing tumor recurrence and associated wound infection.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Baoshan Huang, Na Zhang, Xinying Qiu, Rui Zeng, Shuimiao Wang, Mengxia Hua, Qing Li, Kaihui Nan, Sen Lin
Summary: This study revealed that robust ROS can oxidize mitochondrial DNA (ox-mtDNA) and cause its release into the cytosol, resulting in the activation of NLRP3 inflammasome. By using the mitochondria-targeted antioxidant SkQ1 and a novel mitochondria-targeted nanoparticle (SkQ1 NP), it was found that mitochondrial ROS scavenging could in situ inhibit DED-induced mtDNA oxidation and suppress NLRP3-mediated inflammation.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Wenqi Liu, Cheng Hu, Linyu Long, Shuyi He, Wen Zhang, Zhicun Wang, Li Yang, Yunbing Wang
Summary: Myocardial infarction is the leading cause of cardiovascular mortality, and current treatment methods have limitations. This study developed a smart carrier that can release different therapeutic substances for different pathological processes, effectively improving cardiac function, promoting cardiac repair, and preventing ventricular remodeling.
JOURNAL OF CONTROLLED RELEASE
(2024)