Article
Medicine, General & Internal
Miriam M. Duell, Katharina Wolf, Marcel Vetter, Peter Dietrich, Markus F. Neurath, Andreas E. Kremer
Summary: This study investigated the levels of important endogenous opioids in patients with immune-mediated hepatobiliary disorders and found that they do not correlate with itch intensity or differentiate pruritic from non-pruritic patients. This suggests that endogenous opioids may modulate signaling pathways involved in hepatic pruritus, but are unlikely to represent the major pruritogens in liver disease.
FRONTIERS IN MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Adrian Martyniak, Andrzej Wedrychowicz, Przemyslaw J. Tomasik
Summary: Caring for patients with Crohn's disease is a serious challenge, and new methods of diagnosis and therapy are needed. Endogenous opioids, such as β-endorphin and proenkephalin (A), may have beneficial effects on the disease. This study found that the concentrations of these endo-opioids were reduced in CD patients, suggesting modulation of the endogenous opioid system as a promising future treatment for CD.
Review
Biochemistry & Molecular Biology
Anna Abrimian, Tamar Kraft, Ying-Xian Pan
Summary: Endogenous opioid peptides, including enkephalins, dynorphins, and beta-endorphin, act through MOR, DOR, and KOR receptors, playing important roles in analgesia and various biological processes. The OPRM1 gene undergoes extensive pre-mRNA splicing, generating multiple splice variants, with the 7TM C-terminal variants playing a key role in the pharmacological functions of endogenous opioid peptides.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Yoo Jung Yi, Do Hee Kim, Suchan Chang, Yeonhee Ryu, Sang Chan Kim, Hee Young Kim
Summary: Neurogenic spots in the rat model of liver injury induced by bile duct ligation function as acupoints and have therapeutic effects on hepatic injury.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Immunology
Hai Huang, Bing Liu, Na Qu, Shuling Zhang, Xueli Bai, Mike Handley, Fengping Shan
Summary: MENK, known as an opioid growth factor (OGF), plays important roles in regulating cell cycle, cell proliferation, and immune function. Researches have shown that OGF has potential applications in various autoimmune diseases and cancer treatments.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Manuel Lisardo Sanchez, Francisco D. D. Rodriguez, Rafael Covenas
Summary: Peptides play a crucial role in cancer progression, promoting mitogenesis, migration, invasion, metastasis, and anti-apoptotic mechanisms. Peptide receptors are overexpressed in tumor cells, making them potential targets for specific cancer treatments and apoptosis induction. Opioids have both anti-tumoral and pro-tumoral effects, and their involvement in cancer development is still not well understood.
Review
Biochemistry & Molecular Biology
Nandita Menon, Anil Kishen
Summary: Periradicular tissues contain trigeminal nociceptors that play a role in both relaying pain signals and modulating immune responses in apical periodontitis. Studies have investigated the neuroanatomy and biomolecules profiles to understand the contributions and mechanisms of these nociceptors in inflammation and tissue regeneration. This narrative review aims to address the complex interactions between trigeminal nociceptors and macrophages in the clinical manifestations of apical periodontitis.
Article
Neurosciences
Fu-Jun Zhai, Song-Ping Han, Tian-Jia Song, Ran Huo, Xing-Yu Lan, Rong Zhang, Ji-Sheng Han
Summary: The analgesic effect of spinal cord stimulation (SCS) in a spared nerve injury model was characterized and its underlying mechanisms were examined. Different frequencies of SCS were found to mediate analgesic effects through different endorphins and opioid receptors.
NEUROSCIENCE BULLETIN
(2022)
Article
Multidisciplinary Sciences
Brian H. Trieu, Bailey C. Remmers, Carlee Toddes, Dieter D. Brandner, Emilia M. Lefevre, Adrina Kocharian, Cassandra L. Retzlaff, Rachel M. Dick, Mohammed A. Mashal, Elysia A. Gauthier, Wei Xie, Ying Zhang, Swati S. More, Patrick E. Rothwell
Summary: This study found that ACE degrades an unconventional enkephalin heptapeptide in the nucleus accumbens of mice and regulates neuronal function by affecting the activation of opioid receptors. Systemic ACE inhibition not only reduces preference for fentanyl but also enhances social interaction.
Article
Neurosciences
Alden Y. Huang, Anna M. W. Taylor, Atefeh Ghogha, Mochtar Pribadi, Qing Wang, Tanya S. J. Kim, Catherine M. Cahill, Giovanni Coppola, Christopher J. Evans
Summary: This study identified and characterized the opioid receptor and opioid precursors in the Pacific hagfish, demonstrating their presence in the common ancestor of vertebrates 550 million years ago. It suggests that the opioid systems in cyclostomes and vertebrates might have evolved from invertebrate systems related to antimicrobial defense.
JOURNAL OF NEUROSCIENCE RESEARCH
(2022)
Review
Medicine, General & Internal
Daniel Duck-Jin Hwang, Seok-Jae Lee, Jeong-Hun Kim, Sang-Mok Lee
Summary: Neuropeptides play a crucial role in the pathogenesis of dry eye disease, as demonstrated by their interaction with the nervous and immune systems. Recent studies have revealed previously unknown mechanisms involving neuropeptides secreted from the corneal nerves in dry eye disease. Neurogenic inflammation is emerging as a key pathogenic mechanism for future research on dry eye disease.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Orthopedics
Soo-Hong Han, Hyung Kyung Kim, Yoon Jang, Hyeon Hae Lee, Jeongbae Rhie, Donghun Han, Jongbeom Oh, Soonchul Lee
Summary: In this study, it was found that increased expression of SP and CGRP in biopsy samples of lateral epicondylitis patients was associated with tendon degeneration severity. The levels of SP and CGRP expression were significantly correlated with Movin score, with higher levels associated with more severe degeneration. Additionally, elevated SP or CGRP expression levels were also linked with higher preoperative VAS scores.
BMC MUSCULOSKELETAL DISORDERS
(2021)
Article
Biochemistry & Molecular Biology
C. B. Ganesh, Vijayalaxmi
Summary: Enkephalins, a type of opioid peptides, are widely distributed in the central nervous system of cichlid fish, playing a role in regulating neuroendocrine control of reproduction and modulation of sensory-motor functions.
JOURNAL OF CHEMICAL NEUROANATOMY
(2021)
Article
Medicine, Legal
Antonio Guzam, Araceli Tortajada, Ana-Paz Marin, Cristina Vila, Gregorio Encina
Summary: Cizolirtine, a substance used for pain and urinary incontinence, showed an increased incidence of tumors in mice and rats. In mice, it was associated with an increase in skin fibrosarcomas and sarcomas, while in rats, it was associated with liver adenomas and carcinomas, possibly due to increased liver metabolism and related changes. However, the relevance of these findings to humans remains uncertain.
REGULATORY TOXICOLOGY AND PHARMACOLOGY
(2022)
Article
Medicine, Legal
Antonio Guzman, Gregorio Encina, Antonio R. Fernandez de Henestrosa, Cristina Vila, Araceli Tortajada, Ana-Paz Marin
Summary: Cizolirtine treatment in rats showed adverse effects such as decreased bodyweight gain and increased plasma concentrations. High doses led to liver and ovarian issues in some animals. The dosages of 20 and 60 mg/kg/day were considered as the No-Observed-Adverse-Effect Levels for males and females respectively.
REGULATORY TOXICOLOGY AND PHARMACOLOGY
(2021)
Article
Dentistry, Oral Surgery & Medicine
Joselyn Sosa-Soto, Ana Isabel Padron-Covarrubias, Raul Marquez-Preciado, Socorro Ruiz-Rodriguez, Amaury Pozos-Guillen, Isaac Murisi Pedroza-Uribe, Ruben Alberto Bayardo-Gonzalez, Arturo Garrocho-Rangel
Summary: The prevalence of MIH in 8-year-old children in an endemic fluorosis area was estimated to be 12.4 percent, with the first permanent molars being the most affected tooth group. Degree 2 was the most frequently detected severity level at 76.4 percent. There were no significant statistical differences in MIH prevalence by gender or by maxillary/mandible arches.
JOURNAL OF PUBLIC HEALTH DENTISTRY
(2022)
Article
Dentistry, Oral Surgery & Medicine
Daniel Chavarria-Bolanos, Vicente Esparza-Villalpando, Karol Ramirez
Summary: This study aimed to evaluate the antimicrobial and antifungal capacity of three commercially available mouthwashes with different concentrations of chlorhexidine in Costa Rica. The results showed that all samples had some degree of antibacterial and antifungal effect. These findings suggest that oral hygiene regimens may include mouthwashes with low doses of chlorhexidine to maintain reasonable antibacterial and antifungal efficacy.
ODOVTOS INTERNATIONAL JOURNAL OF DENTAL SCIENCES
(2022)
Article
Dentistry, Oral Surgery & Medicine
Carolina Estefania De Anda-Cuellar, Socorro Ruiz-Rodriguez, Marine Ortiz-Magdaleno, Diana Maria Escobar-Garcia, Amaury Pozos-Guillen
Summary: Eugenol can cause morphological changes in hDPFs in a dose-dependent manner, with higher concentrations potentially promoting overexpression of apoptotic genes.
ACTA ODONTOLOGICA SCANDINAVICA
(2022)
Article
Dentistry, Oral Surgery & Medicine
Daniel Chavarria-Bolanos, Takashi Komabayashi, Ivy Shen, Jose Vega-Baudrit, Maria G. Gandolfi, Carlo Prati, Mauricio Montero-Aguilar
Summary: The purpose of this study was to examine the surface features, chemical composition, and thermodynamic profile of seven endodontic sealers exposed to high-temperature changes. The results showed that AH Plus and GuttaFlow BioSeal exhibited minimal changes upon high-temperature exposure, suggesting their suitability for thermal endodontic obturation techniques.
JOURNAL OF ORAL SCIENCE
(2022)
Article
Dentistry, Oral Surgery & Medicine
Daniel Chavarria-Bolanos, Amaury Pozos-Guillen, Mauricio Montero-Aguilar
Summary: In 2020, the international health community introduced two important changes: a new definition of pain and a new classification for orofacial pain conditions. These changes brought new tasks and challenges as clinicians from various disciplines began to adopt and reconsider traditional paradigms and policies. This perspective article examines the positive impact and future prospects of the new definition of pain proposed by the International Association for the Study of Pain, as well as the new International Classification of Orofacial Pain.
ODOVTOS INTERNATIONAL JOURNAL OF DENTAL SCIENCES
(2022)
Article
Dentistry, Oral Surgery & Medicine
Melissa Jimenez-Hernandez, Daniel Chavarria-Bolanos, Fabian Murillo-Gomez, Jose Vega-Baudrit, Amaury Pozos-Guillen, David Lafuente-Marin, Mauricio Montero-Aguilar
Summary: Using a diamond bur multiple times can result in a smoother surface on dentin compared to using a new bur, but it may affect the adhesion with resin-based materials. The number of previous uses of a diamond bur does not seem to have a significant effect on the bond strength between dentin and resin composite when using a self-etch adhesive.
ODOVTOS INTERNATIONAL JOURNAL OF DENTAL SCIENCES
(2022)
Review
Dentistry, Oral Surgery & Medicine
Arturo Garrocho-Rangel, Guadalupe Serrano-Aguilar, Yolanda Hernandez-Molinar, Saray Aranda-Romo, Vanessa Alejandri-Gamboa, Amaury Pozos-Guillen
Summary: This paper provides a scoping review on the diagnosis and oral management of EEC syndrome, highlighting the need for a multidisciplinary approach in the medical/dental field. The study identifies gaps in the existing research and emphasizes the important role of pediatric dentists in the prevention and treatment of oral diseases.
SPECIAL CARE IN DENTISTRY
(2023)
Editorial Material
Dentistry, Oral Surgery & Medicine
Daniel Chavarria-Bolanos
ODOVTOS INTERNATIONAL JOURNAL OF DENTAL SCIENCES
(2022)
Article
Dentistry, Oral Surgery & Medicine
Febe C. Vazquez Vazquez, Lourdes Y. Avalos Pina, Alejandra Rodriguez Hidalgo, Amaury Pozos-Guillen, Patricia Gonzalez-Alva, Mauricio Montero-Aguilar, Daniel Chavarria-Bolanos, Marco A. Alvarez Perez
Summary: The study compared the adhesion and proliferation of human periodontal ligament fibroblasts (hPDL) in transverse sections of the teeth sealed with BioRoot RCS/hydraulic obturation (HO) and AH-Plus/continuous-wave condensation (CWC). The results showed that both techniques allowed cell adhesion, with a greater response in the BioRoot RCS/HO group. Cell proliferation also differed between the experimental groups, with the BioRoot RCS/HO group showing a better response.
ODOVTOS INTERNATIONAL JOURNAL OF DENTAL SCIENCES
(2023)
Review
Otorhinolaryngology
Arturo Garrocho-Rangel, Miguel Angel Rosales-Berber, Adriana Ballesteros-Torres, Zaira Hernandez-Rubio, Joselin Flores-Velazquez, Esthela Yanez-Gonzalez, Socorro Ruiz-Rodriguez, Amaury Pozos-Guillen
Summary: This study aims to identify, qualify, and summarize the evidence from different systematic reviews regarding the outcomes of Rapid Maxillary Expansion (RME) on upper airway dimensions and breathing function in young patients. The findings suggest that significant and stable increases in nasal and oropharyngeal space volumes, as well as a decrease in airway resistance, occur immediately after RME and at 3, 6, and 12-months follow-up in growing children and adolescents.
INTERNATIONAL JOURNAL OF PEDIATRIC OTORHINOLARYNGOLOGY
(2023)
Article
Engineering, Biomedical
Diana Sofia Nolasquez-Cruz, Hector Flores, Amaury de Jesus Pozos-Guillen, Marco Antonio Alvarez-Perez
Summary: Autologous grafts are the current standard for tissue regeneration, but they face limitations such as availability, donor site morbidity, and postoperative complications. Tissue engineering proposes a new approach using acellular grafts obtained through decellularization of native extracellular matrices to overcome these limitations. This review focuses on the potential use of acellular grafts, methods of decellularization and recellularization, and their application in bioinks as a breakthrough for tissue regeneration.
BIOINSPIRED BIOMIMETIC AND NANOBIOMATERIALS
(2023)
Article
Public, Environmental & Occupational Health
Vicente Esparza-Villalpando, Amaury Pozos-Guillen, Juan Ramon Zapata-Morales, Antonio Vertiz-Hernandez, Victor Manuel Martinez-Aguilar, Daniel Chavarria-Bolanos
Summary: The study aimed to evaluate the local effect of a DXT-CHX combination in a formalin pain model in rats. The results showed that both DXT and CHX had a local antinociceptive effect and exhibited synergistic behavior when combined.
PUERTO RICO HEALTH SCIENCES JOURNAL
(2023)
Article
Biochemistry & Molecular Biology
Raquel Sanchez-Gutierrez, Janeth Araujo-Perez, Diana Lorena Alvarado-Hernandez, Ana Maria Gonzalez-Amaro, Veronica Mendez-Gonzalez, Bruno Rivas-Santiago, Roberto Gonzalez-Amaro, Amaury Pozos-Guillen, Marlen Vitales-Noyola
Summary: This study aimed to evaluate the effect of endodontic-causative microorganisms on mononuclear cells. The presence of Actinomyces spp. and Streptococcus spp. was found to increase the percentage of CD14(+) cells. This demonstrates the role of the innate immune system in the pathogenesis of endodontic primary infections.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)