Angiotensin-converting enzyme gates brain circuit–specific plasticity via an endogenous opioid

μ-Opioid Receptor (Oprm1) Copy Number Influences Nucleus Accumbens Microcircuitry and Reciprocal Social Behaviors

(2021) Carlee Toddes et al.   JOURNAL OF NEUROSCIENCE

Shisa6 mediates cell-type specific regulation of depression in the nucleus accumbens

(2021) Hee-Dae Kim et al.   MOLECULAR PSYCHIATRY

Decoding molecular and cellular heterogeneity of mouse nucleus accumbens

(2021) Renchao Chen et al.   NATURE NEUROSCIENCE

Interruption of continuous opioid exposure exacerbates drug-evoked adaptations in the mesolimbic dopamine system

(2020) Emilia M. Lefevre et al.   NEUROPSYCHOPHARMACOLOGY

Mu-Opioids Suppress GABAergic Synaptic Transmission onto Orbitofrontal Cortex Pyramidal Neurons with Subregional Selectivity

(2020) Benjamin K. Lau et al.   JOURNAL OF NEUROSCIENCE

A dopamine-induced gene expression signature regulates neuronal function and cocaine response

(2020) Katherine E. Savell et al.   Science Advances

Reduced nucleus accumbens enkephalins underlie vulnerability to social defeat stress

(2019) Hyungwoo Nam et al.   NEUROPSYCHOPHARMACOLOGY

Nucleus Accumbens Fast-Spiking Interneurons Constrain Impulsive Action

(2019) Marc T. Pisansky et al.   BIOLOGICAL PSYCHIATRY

Are hormones a “female problem” for animal research?

(2019) Rebecca M. Shansky   SCIENCE

Alcohol exposure disrupts mu opioid receptor-mediated long-term depression at insular cortex inputs to dorsolateral striatum

(2018) Braulio Muñoz et al.   Nature Communications

Molecular Diversity and Specializations among the Cells of the Adult Mouse Brain

(2018) Arpiar Saunders et al.   CELL

In vivo detection of optically-evoked opioid peptide release

(2018) Ream Al-Hasani et al.   eLife

Plasma lipoproteome in Alzheimer’s disease: a proof-of-concept study

(2018) Danni Li et al.   Clinical Proteomics

Pathway- and Cell-Specific Kappa-Opioid Receptor Modulation of Excitation-Inhibition Balance Differentially Gates D1 and D2 Accumbens Neuron Activity

(2017) Hugo A. Tejeda et al.   NEURON

Endogenous opioids regulate moment-to-moment neuronal communication and excitability

(2017) Bryony L. Winters et al.   Nature Communications

Angiotensin-Converting Enzyme in Smooth Muscle Cells Promotes Atherosclerosis—Brief ReportHighlights

(2016) Xiaofeng Chen et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

On being a circuit psychiatrist

(2016) Joshua A Gordon   NATURE NEUROSCIENCE

In vivo imaging identifies temporal signature of D1 and D2 medium spiny neurons in cocaine reward

(2016) Erin S. Calipari et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

μ opioid receptor activation hyperpolarizes respiratory-controlling Kölliker-Fuse neurons and suppresses post-inspiratory drive

(2015) Erica S. Levitt et al.   JOURNAL OF PHYSIOLOGY-LONDON

Enkephalin Disinhibits Mu Opioid Receptor-Rich Striatal Patches via Delta Opioid Receptors

(2015) Matthew Ryan Banghart et al.   NEURON

Refining deep brain stimulation to emulate optogenetic treatment of synaptic pathology

(2015) M. Creed et al.   SCIENCE

Prolonged morphine treatment alters δ opioid receptor post-internalization trafficking

(2014) E W Ong et al.   BRITISH JOURNAL OF PHARMACOLOGY

Autism-Associated Neuroligin-3 Mutations Commonly Impair Striatal Circuits to Boost Repetitive Behaviors

(2014) Patrick E. Rothwell et al.   CELL

Direct inhibition of hypothalamic proopiomelanocortin neurons by dynorphin A is mediated by the μ-opioid receptor

(2014) Reagan L. Pennock et al.   JOURNAL OF PHYSIOLOGY-LONDON

Contrasting forms of cocaine-evoked plasticity control components of relapse

(2014) Vincent Pascoli et al.   NATURE

Opioids induce dissociable forms of long-term depression of excitatory inputs to the dorsal striatum

(2014) Brady K Atwood et al.   NATURE NEUROSCIENCE

Loss of BDNF Signaling in D1R-Expressing NAc Neurons Enhances Morphine Reward by Reducing GABA Inhibition

(2014) Ja Wook Koo et al.   NEUROPSYCHOPHARMACOLOGY

Decreased motivation during chronic pain requires long-term depression in the nucleus accumbens

(2014) N. Schwartz et al.   SCIENCE

Antihypertensive drug Valsartan promotes dendritic spine density by altering AMPA receptor trafficking

(2013) Young In Sohn et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

GENSAT BAC Cre-Recombinase Driver Lines to Study the Functional Organization of Cerebral Cortical and Basal Ganglia Circuits

(2013) Charles R. Gerfen et al.   NEURON

Anhedonia requires MC4R-mediated synaptic adaptations in nucleus accumbens

(2012) Byung Kook Lim et al.   NATURE

A toolbox of Cre-dependent optogenetic transgenic mice for light-induced activation and silencing

(2012) Linda Madisen et al.   NATURE NEUROSCIENCE

Inhibiting the breakdown of endogenous opioids and cannabinoids to alleviate pain

(2012) Bernard P. Roques et al.   NATURE REVIEWS DRUG DISCOVERY

Opioidergic Interactions between Striatal Projection Neurons

(2011) C. P. Blomeley et al.   JOURNAL OF NEUROSCIENCE

Nucleus Accumbens  -Opioid Receptors Mediate Social Reward

(2011) V. Trezza et al.   JOURNAL OF NEUROSCIENCE

Erroneous analyses of interactions in neuroscience: a problem of significance

(2011) Sander Nieuwenhuis et al.   NATURE NEUROSCIENCE

Cell Type-Specific Loss of BDNF Signaling Mimics Optogenetic Control of Cocaine Reward

(2010) M. K. Lobo et al.   SCIENCE

Angiotensin-Converting Enzyme Inhibitors and Cognitive Decline in Older Adults With Hypertension

(2009) Kaycee M. Sink et al.   ARCHIVES OF INTERNAL MEDICINE

Drd1a-tdTomato BAC Transgenic Mice for Simultaneous Visualization of Medium Spiny Neurons in the Direct and Indirect Pathways of the Basal Ganglia

(2008) J. A. Shuen et al.   JOURNAL OF NEUROSCIENCE