Article
Oncology
Yangxun Pan, Zhiwei Ye, Yihong Ling, Lingheng Kong, Chenwei Wang, Gong Chen, Desen Wan, Minshan Chen, Dandan Hu
Summary: This study investigated the characteristics of lipid metabolism parameters in patients with colorectal cancer (CRC) and identified the independent prognostic factors for long-term prognosis. The results showed that blood circulating apolipoprotein A-I (apoA1), apolipoprotein B (apoB), and the apoB/A ratio were independent prognostic factors for overall survival (OS) in CRC patients.
FRONTIERS IN ONCOLOGY
(2023)
Article
Clinical Neurology
Sara A. Galle, Jan Berend Deijen, Maarten V. Milders, Mathieu H. G. De Greef, Erik J. A. Scherder, Cornelia M. van Duijn, Madeleine L. Drent
Summary: This study found that a physical activity intervention aimed at increasing step count in elderly with low physical activity levels can increase physical activity level, but has no significant effect on physical fitness and cognition. However, individuals who increased their physical activity by 35% or more showed significant improvements in aerobic capacity, gait speed, verbal memory, executive functioning, and global cognition.
ALZHEIMERS RESEARCH & THERAPY
(2023)
Article
Medical Laboratory Technology
Qing Liu, Li Wu, Lulin Wang, Kai Chen, Yuntao Wu, Jianhong Xia, Youjie Wang
Summary: Elevated maternal levels of ApoB and ApoB/ApoA-1 ratio during mid-pregnancy are associated with increased risk of preterm birth.
CLINICA CHIMICA ACTA
(2022)
Article
Public, Environmental & Occupational Health
Sara A. Galle, Jun Liu, Bruno Bonnechere, Najaf Amin, Maarten M. Milders, Jan Berend Deijen, Erik J. A. Scherder, Madeleine L. Drent, Trudy Voortman, M. Arfan Ikram, Cornelia M. van Duijn
Summary: This study investigated the long-term association between physical activity, cognition, and the rate of age-associated cognitive decline. The findings suggest that higher levels of physical activity in late adulthood are related to higher levels of executive functioning and may mitigate the accelerated decline of executive abilities observed in individuals with the ApoE-epsilon 4 allele.
EUROPEAN JOURNAL OF EPIDEMIOLOGY
(2023)
Article
Nutrition & Dietetics
Soo Lim, Yoon Ji Kim, Ah Reum Khang, Robert H. Eckel
Summary: This study found that abdominal visceral obesity and low HDL-cholesterol concentrations were associated with increased postprandial triglycerides (TG) and apolipoprotein B (ApoB), and these elevated concentrations were linked with subclinical atherosclerosis.
CLINICAL NUTRITION
(2021)
Article
Biochemistry & Molecular Biology
Rebecca Frankel, Emma Sparr, Sara Linse
Summary: This study investigates the aggregation of ApoA-I protein and finds that it can form globular protein-only condensates. Conversion into amyloid fibrils rich in beta-sheet structure is facilitated by oxidation or mutation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cell Biology
Wenwang Rao, Yunshu Zhang, Keqing Li, Xiang Yang Zhang
Summary: The ApoE gene polymorphism may impact changes in blood lipid levels and cognitive impairment in the general population, but its effects in schizophrenia have not been extensively studied. This research investigated the association of ApoE rs429358 with schizophrenia using the RBANS test and SNPStats analysis. The study found that levels of ApoA1 and ApoB were predictors for various cognitive domains in schizophrenia, with the association being regulated by the ApoE rs429358 genotype.
Article
Biochemistry & Molecular Biology
Eliana Dell'Olmo, Rosa Gaglione, Angela Arciello, Renata Piccoli, Valeria Cafaro, Antimo Di Maro, Sara Ragucci, Raffaele Porta, C. Valeria L. Giosafatto
Summary: The study demonstrated that r(P)ApoB(L) can be enzymatically modified by mTG, specifically with highly selective crosslinking at Lys-18. However, the antimicrobial activity of the peptide was found to be lost when grafted into protein films after mTG-catalyzed crosslinking.
BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS
(2021)
Review
Nutrition & Dietetics
Gregory S. Nacarelli, Tracy Fasolino, Stephanie Davis
Summary: Genetic predisposition and dietary factors play a role in cardiovascular disease (CVD) risk. Evaluating the levels of apolipoprotein B and apolipoprotein A1 in plasma helps assess CVD risk. Different dietary and lifestyle interventions can impact CVD risk markers, such as these apolipoproteins. Additionally, genetic variations may affect the response to dietary interventions on these markers.
Article
Immunology
Myriam Fernandez-Sendin, Claudia Augusta Di Trani, Angela Bella, Marcos Vasquez, Nuria Ardaiz, Celia Gomar, Leire Arrizabalaga, Sergio Ciordia, Fernando J. Corrales, Fernando Aranda, Pedro Berraondo
Summary: Apolipoprotein A-I mimetic peptide L37pA modulates the gene expression program of interferon alpha, reducing inflammatory pathways activation and inducing an anti-inflammatory effect in the liver. This modulation allows for the silencing of interferon alpha expression mediated by an adeno-associated virus, preventing lethal hematological toxicity in mice. The proteomic analysis confirms the impact of L37pA on several inflammatory pathways and indicates the activation of LXR/RXR and PPPAR alpha/gamma nuclear receptors.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Hongli Dong, Ping Hu, Jie Wang, Yaju Zhang, Nan Lu
Summary: In patients with coronary artery disease, serum calcium and magnesium levels are positively associated with ApoA1 levels but inversely associated with ApoB levels and ApoB/A1 ratio. Serum Ca/Mg ratio may be a more precise marker than serum Mg or serum Ca measures alone in assessing Apos measures of CAD risk.
BIOLOGICAL TRACE ELEMENT RESEARCH
(2022)
Article
Endocrinology & Metabolism
Marja-Riitta Taskinen, Niina Matikainen, Elias Bjornson, Sanni Soderlund, Jussi Inkeri, Antti Hakkarainen, Helka Parviainen, Carina Sihlbom, Annika Thorsell, Linda Andersson, Martin Adiels, Chris J. Packard, Jan Boren
Summary: This study investigated the hypothesis that individuals with type 2 diabetes on statin therapy may have significant abnormalities in the metabolism of intestinally derived lipoproteins. The findings suggest that in these individuals, there are increased production and longer circulation time of ApoB-48-containing lipoproteins, which may contribute to residual cardiovascular disease risk.
Article
Chemistry, Organic
Masaya Honda, Minoru Inagaki, Yuichi Masuda
Summary: The total synthesis of PF1171B, D, and E, and avellanins A, B, and C was achieved through solid-phase peptide elongation and solution-phase macrolactamization. Among them, PF1171B exhibited the most potent inhibitory activity against apolipoprotein B production.
TETRAHEDRON LETTERS
(2021)
Article
Biochemistry & Molecular Biology
Rita Del Giudice, Paola Imbimbo, Federico Pietrocola, Isabelle Martins, Fatima Domenica Elisa De Palma, Jose Manuel Bravo-San Pedro, Guido Kroemer, Maria Chiara Maiuri, Daria Maria Monti
Summary: Amyloidoses are characterized by the accumulation and aggregation of misfolded proteins. In this study, a specific variant of Apolipoprotein A-I protein sequence, L75P-ApoA-I, was found to inhibit autophagy and induce excessive mitochondrial stress and cell death. Induction of autophagy or overexpression of the pro-autophagic transcription factor (TFEB) can alleviate the amyloidosis and reduce oxidative stress.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Ophthalmology
Haixiang Huang, Zhuang Li, Jun Huang, Yanyan Xie, Zhiqiang Xiao, Yunwei Hu, Guanyu Chen, Minzhen Wang, Zuoyi Li, Qian Chen, Wenjie Zhu, Wenru Su, Yan Luo, Xiaoqing Chen, Dan Liang
Summary: In this study, researchers investigated the role of apolipoprotein A1 (APOA1) in experimental autoimmune uveitis (EAU), a representative animal model of human uveitis. They found that APOA1 administration ameliorated EAU by regulating the expansion and infiltration of pathogenic T cells, as well as the production of inflammatory cytokines. The results suggest that APOA1 could be a therapeutic alternative for autoimmune uveitis.
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Jenny Vikgren, Mohammad Khalil, Kerstin Cederlund, Karen Sorensen, Marianne Boijsen, John Brandberg, Erik Lampa, Magnus C. Skold, Per Wollmer, Eva Lindberg, Jan E. Engvall, Goran Bergstrom, Kjell Toren, Ase A. Johnsson
ACADEMIC RADIOLOGY
(2020)
Article
Public, Environmental & Occupational Health
Carl Bonander, Anton Nilsson, Goran M. L. Bergstrom, Jonas Bjork, Ulf Stromberg
Summary: This study provides guidance on how adequate bias correction can be achieved by using auxiliary register data without disclosing sensitive information on invited non-participants. The results show that inverse-probability-of-sampling weights estimated within a random sample of the target population are equivalent to analogous weights in scenarios where non-participants and uninvited individuals are indistinguishable. It is suggested to consider inverse-odds-of-sampling weights to minimize the risk of disclosure when the entire population is invited to participate.
SCANDINAVIAN JOURNAL OF PUBLIC HEALTH
(2021)
Article
Respiratory System
Kjell Toren, Linus Schioler, Jonas Brisman, Andrei Malinovschi, Anna-Carin Olin, Goran Bergstrom, Bjorn Bake
BMC PULMONARY MEDICINE
(2020)
Article
Cardiac & Cardiovascular Systems
Carl J. Ostgren, Stefan Soderberg, Karin Festin, Oskar Angeras, Goran Bergstrom, Anders Blomberg, John Brandberg, Kerstin Cederlund, Mats Eliasson, Gunnar Engstrom, David Erlinge, Erika Fagman, Emil Hagstrom, Lars Lind, Maria Mannila, Ulf Nilsson, Jonas Oldgren, Ellen Ostenfeld, Anders Persson, Jonas Persson, Margaretha Persson, Annika Rosengren, Johan Sundstrom, Eva Swahn, Jan E. Engvall, Tomas Jernberg
Summary: The study examined the association between Systematic Coronary Risk Evaluation risk estimates and prevalent subclinical atherosclerosis, finding that a doubling of risk estimates was associated with an increased probability of coronary artery calcium score >0 and >1 carotid plaques. This suggests that the Systematic Coronary Risk Evaluation risk chart may be useful for estimating the risk of subclinical atherosclerosis in the general population.
EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY
(2021)
Article
Environmental Sciences
Demir Djekic, Erika Fagman, Oskar Angeras, George Lappas, Kjell Toren, Goeran Bergstroem, Annika Rosengren
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2020)
Article
Cardiac & Cardiovascular Systems
Lennart Bergfeldt, Gabriel Bergqvist, Markus Lingman, Gunilla Lundahl, Goran Bergstrom, Lennart Gransberg
JOURNAL OF ELECTROCARDIOLOGY
(2020)
Article
Medicine, General & Internal
M. Langenskiold, K. Smidfelt, J. Nordanstig, G. Bergstrom, A. Tivesten
JOURNAL OF INTERNAL MEDICINE
(2020)
Article
Hematology
Joakim Sandstedt, Karin Vargmar, Kristina Bjorkman, Ulla Ruetschi, Goran Bergstrom, Lillemor Mattsson Hulten, Eva Skioldebrand
Summary: The study found that changes in COMP in symptomatic carotid stenosis are associated with the development of cardiovascular disease, and COMPneo may serve as a novel biomarker for identifying this condition.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2021)
Article
Hematology
Jenny M. Kindblom, Maria Bygdell, Ola Hjelmgren, Jari Martikainen, Annika Rosengren, Goran Bergstrom, Claes Ohlsson
Summary: The study found that pubertal BMI change is associated with adult male coronary artery calcification score and risk of acute coronary events. Excessive BMI increase during puberty may initiate the coronary atherosclerotic process, thereby increasing the risk and severity of adult acute coronary events.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Goran Bergstrom, Margaretha Persson, Martin Adiels, Elias Bjornson, Carl Bonander, Hakan Ahlstrom, Joakim Alfredsson, Oskar Angeras, Goran Berglund, Anders Blomberg, John Brandberg, Mats Borjesson, Kerstin Cederlund, Ulf de Faire, Olov Duvernoy, Orjan Ekblom, Gunnar Engstrom, Jan E. Engvall, Erika Fagman, Mats Eriksson, David Erlinge, Bjorn Fagerberg, Agneta Flinck, Isabel Goncalves, Emil Hagstrom, Ola Hjelmgren, Lars Lind, Eva Lindberg, Per Lindqvist, Johan Ljungberg, Martin Magnusson, Maria Mannila, Hanna Markstad, Moman A. Mohammad, Fredrik H. Nystrom, Ellen Ostenfeld, Anders Persson, Annika Rosengren, Anette Sandstrom, Anders Sjalander, Magnus C. Skold, Johan Sundstrom, Eva Swahn, Stefan Soderberg, Kjell Toren, Carl Johan Ostgren, Tomas Jernberg
Summary: Through conducting a study using CCTA on a random sample of individuals aged 50 to 64, we found that silent coronary atherosclerosis is common in this population, particularly in individuals with higher CAC scores.
Article
Hematology
Maria J. Iglesias, Larissa D. Kruse, Laura Sanchez-Rivera, Linnea Enge, Philip Dusart, Mun-Gwan Hong, Mathias Uhlen, Thomas Renne, Jochen M. Schwenk, Goran Bergstrom, Jacob Odeberg, Lynn M. Butler
Summary: This study identified 216 proteins associated with cardiovascular disease risk factor exposure, and showed a relationship between individual cardiovascular disease risk and corresponding biomarker profiles. The findings indicate that EC proteins in plasma could reflect vascular health status.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2021)
Article
Endocrinology & Metabolism
Claes Ohlsson, Marcus Langenskiold, Kristian Smidfelt, Matti Poutanen, Henrik Ryberg, Anna-Karin Norlen, Joakim Nordanstig, Goran Bergstrom, Asa Tivesten
Summary: The study found that male patients with AAA had lower levels of dehydroepiandrosterone, progesterone, 17 alpha-hydroxyprogesterone, testosterone, and estradiol, with progesterone and estradiol being inversely associated with the presence of AAA. Low levels of progesterone and estradiol increased the odds of AAA in men.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Cardiac & Cardiovascular Systems
Araz Rawshani, Naveed Sattar, Darren K. McGuire, Oskar Wallstrom, Ulf Smith, Jan Boren, Goran Bergstrom, Elmir Omerovic, Annika Rosengren, Bjorn Eliasson, Deepak L. Bhatt, Aidin Rawshani
Summary: The study found that the incidence of valvular disease is increasing among patients with diabetes. In type 2 diabetes, systolic blood pressure, body mass index, and renal function were found to be associated with valvular lesions.
Article
Cardiac & Cardiovascular Systems
Lennart Bergfeldt, Adnan Noor Baloch, Gunilla Lundahl, Lennart Gransberg, Goran Bergstrom
Summary: This study investigated the relationship between cardiac electrophysiology parameters and body size in a population sample of apparently healthy subjects. The results showed that most electrophysiological parameters did not have an association with body size, except for QRS duration and QRSarea. Therefore, explanations for sex-related electrophysiological differences should be sought elsewhere.
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Goran Bergstrom, Annika Rosengren, Elin Bacsovics Brolin, John Brandberg, Kerstin Cederlund, Gunnar Engstrom, Jan E. Engvall, Maria J. Eriksson, Isabel Goncalves, Emil Hagstrom, Stefan K. James, Tomas Jernberg, Mikael Lilja, Martin Magnusson, Anders Persson, Margaretha Persson, Anette Sandstrom, Caroline Schmidt, Linn Skoglund Larsson, Johan Sundstrom, Eva Swahn, Stefan Soderberg, Kjell Toren, Carl Johan Ostgren, Erik Lampa, Lars Lind
Summary: This study aims to assess the risk of midlife coronary atherosclerosis being associated with body weight at age 20, body weight in midlife, and body weight change. The results showed that body weight at age 20 and weight in midlife were strongly associated with coronary atherosclerosis, while weight increase from age 20 until midlife was only modestly related to coronary atherosclerosis.
